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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik Asian Journal of Health Research Bali Dermatology Venereology and Aesthetic Journal
Dwi Murtiastutik
Associate Professor Department Of Dermatology And Venereology Faculty Of Medicine, Universitas Airlangga/ Dr Soetomo General Academic Hospital;
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Chickenpox Mimicking Monkeypox in Adult with Diabetes Mellitus and Acute Kidney Injury: Diagnosis and Management Maya Wardiana; Rahmadewi Rahmadewi; Dwi Murtiastutik; Sawitri Sawitri; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.213-223

Abstract

Background: Chickenpox caused by the varicella-zoster virus (VZV) in diabetes mellitus patients might exhibit similar clinical features with monkeypox, caused by monkeypox virus (MPXV). In May 2019, Singapore notified World Health Organization (WHO) of one laboratory-confirmed case of monkeypox. Considering Singapore is located near Indonesia, awareness about the possibility of an outbreak in Indonesia should be raised. Purpose: To report a case of chickenpox mimicking monkeypox in an adult with diabetes mellitus and acute kidney injury. Case: A 51-year-old male with poorly controlled diabetes mellitus was suspected to have a chickenpox differential diagnosis with monkeypox. His chief complaint was multiple blisters on his body and vomiting. There was a history of feeding a monkey. From dermatological status on facial, trunk, and extremities there were multiple pleomorphic vesicles. Laboratory results showed elevated renal function. Polymerase chain reaction (PCR) examination using VZV as primer revealed a positive result in the range of 810 bp. He was treated with intravenous acyclovir for 3 days and oral acyclovir for 7 days then discharged with improvement in skin lesions and normal renal function. Discussion: Chickenpox in adult and diabetes mellitus patients can give severe clinical manifestation mimicking monkeypox. PCR has a significant role especially when diagnosis could not be established from the physical examination. Acyclovir can be given as the therapy. Conclusion: Adult and poorly controlled diabetes mellitus are important risk factors associated with the severity and complication of chickenpox. A careful diagnostic approach and management are needed.
In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients Eva Lydiawati; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Rahmadewi Rahmadewi; Cita Rosita Sigit Prakoeswa; Christina Avanti; Endang Wahyu Fitriani; Erwin Astha Triyono; Linda Astari; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.189-194

Abstract

Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp.  Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P < 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.
Antifungal Activity of Rosmarinus Officinalis Essential Oil and Nystatin on Store Isolate of Candida species from HIV/AIDS Patients with Oral Candidiasis Bernadya Yogatri Anjuwita; Iskandar Zulkarnain; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Pepy Dwi Endraswari; Damayanti Damayanti; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.167-173

Abstract

Background: Oral candidiasis is caused by the mycotic activity of Candida albicans present in the oral cavity, and it is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/acquired immune deficiency syndrome (AIDS). The growing resistance and side effects to common antifungal drugs have promoted herbal essential oils as antifungal agents in recent years. In this study, essential oils (EO) of Rosmarinus officinalis (Lamiaceae) were examined for in vitro antifungal activ­ity against Candida species. Purpose: To evaluate the antifungal activity of essential oils of Rosmarinus officinalis (Lamiaceae) and nystatin using the microdilution technique by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of Candida spesies. Methods: This was an experimental laboratory study with a post-test-only design conducted in Dr. Soetomo General Academic Teaching Hospital, Surabaya. Forty isolates consisted of twenty isolates of Candida albicans and twenty isolates of Candida non-albicans were collected. The isolates were tested for antifungal activity using the microdilution on 96-well plates. Result: There was a significant difference from the results of the MIC concentration of rosemary essential 100% to 6.25% microdilution method between nystatin and rosemary essential oil (p < 0.05). Conclusion: The antifungal activity of rosemary essential oil was better than nystatin that the lowest MIC value, which was 6.25%, has been obtained the microdilution method. The minimum fungicidal concentration of rosemary essential oil was 25%, while the minimum fungicidal concentration nystatin was higher than 100%.
Comparison of In Vitro Testing Antifungal Activity between Rosemary Essentials Oil and Fluconazol on Candida species Isolate from HIV/AIDS Patients with Candidiasis Oral Putri Intan Primasari; Dwi Murtiastutik; Pepy Dwi Endraswari; Cita Rosita Sigit Prakoeswa; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.182-188

Abstract

Background: The most common opportunistic infection obtained in patients with Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) is Oral Candidiasis (OC). Currently widely reported about increased fluconazole resistance, as a therapy that is often used in patients with HIV/AIDS with OC. For this reason, effective antifungal agents are needed as alternative therapies. Several studies have reported some antifungal activity from rosemary essential oils. Purpose: The aim of this study is to evaluate the antifungal activity between rosemary essential oils and fluconazole against the isolates used by Candida sp. taken from HIV / AIDS patients with OC. Methods: This research was an experimental laboratory study with a post-test only design of 40 Candida sp. isolates from HIV / AIDS patients with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo General Academic Teaching Hospital, Surabaya. Examination of antifungal activity using conventional test methods with disk diffusion. Result: Disk diffusion test result revealed average inhibition zone of rosemary essential oil in Candida albicans 1,75±3,64 mm and Candida non-albicans 1,5±3,08 mm, while the average inhibition zone of fluconazole in Candida albicans 17,9±8,62 mm and Candida non-albicans 4,85±7,9 mm. There was significant difference (p <0.001) between the inhibition zone formed in Candida albicans by fluconazole and rosemary essential oil, but no significant difference of inhibition zone formed in Candida non-albicans. Conclusion: Antifungal activity fluconazole has greater than Rosemary essential oils in Candida albicans.
The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial Ridha Ramadina Widiatma; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Cita Rosita Sigit Prakoeswa; Sawitri Sawitri; Ingrid Suryanti Suryono; Linda Astari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.214-220

Abstract

Background: Bacterial vaginosis (BV) is a clinical syndrome caused by the changing of Lactobacillus spp., a producer of hydrogen peroxide, in the normal vagina with a high concentration of anaerobic bacteria, Gardnerella vaginalis and Mycoplasma hominis. This study reports a resistance of BV therapy regimens, high recurrence rates, and side effects of an antibiotic. Therefore, adjunctive therapy for BV management is needed. Research has reported the therapeutic effects of probiotic in BV; however, the results are inconsistent. Purpose: To evaluate the efficacy of standard therapy using metronidazole and Lactobacillus plantarum for BV measured by the cure rate and vaginal flora balance. Methods: A randomized, double-blind, placebo-controlled trial, 30 subjects were randomized to take metronidazole 500 mg twice a day for seven days with weekly evaluation. The Lactobacillus plantarum or placebo group was evaluated every 4 weeks. The cure rate and vaginal flora balance were evaluated using the Amsel criteria and Nugent score before and after the intervention. Result: A total of 30 subjects returned for 28-day follow-up, of which 60% subjects of the antibiotic/probiotic group were cured compared to 40% in the antibiotic/placebo group (p>0.05). Conclusion: There was no difference in the increase of cure rate and vaginal flora balance between the treatment group and significant control group.
A Retrospective Study: Characteristics and Management of Gonorrhea Indah Purnamasari; Dwi Murtiastutik; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Budiono Budiono; Astindari Astindari; Maylita Sari; Septiana Widyantari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.1-7

Abstract

Background: Gonorrhea (GO) is a sexually transmitted infection that remains an important clinical and public health problem worldwide. Its incidence tends to increase both in males and females. Given the scale of the public health impact of GO, the selection of appropriate therapy is essential. Purpose: This study aimed to evaluate the characteristics, management, and recovery of gonorrhea patients. Methods: The research material was obtained from the medical record of gonorrhea patients at the Sexually Transmitted Infections (STI) Outpatient Clinic, Dermatology and Venerelogy Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya, from January 2016 to December 2018. Result: We found 84 new GO patients (0.02%) out of the total new outpatients at the Dermatology and Venereology Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya. Most of them were males (92.9%), 17–25 years age group (52.4%), unmarried (67.9%), and heterosexual (90.5%). The majority of therapy is dual therapy, was combination of doxycycline and cefixime (78%). Only 34 patients (40.5%) attended the follow-up visits, and 94.1% of them recovered, and 5.9% presented with cystitis. Conclusion: The characteristics features of GO varies in each variable. One of important to control GO is provide effective and appropriate treatment and routinely clinical and laboratories were needed control.
The Comparison of Candida spp. Colonization on Psoriasis Vulgaris Patient and Control Amanda Gracia Manuputty; Dwi Murtiastutik; Sawitri Sawitri; Muhammad Yulianto Listiawan; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Pepy Dwi Endraswari; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.40-47

Abstract

Background: Psoriasis is an inflammatory, chronic, and recurring skin disease that affects patient’s quality of life. Environment, drugs, and infections in the form of antigen and toxin such as Candida spp. are assumed responsible for triggering and exacerbating psoriasis. Purpose: To compare the prevalence of skin colonization of Candida spp. on psoriasis vulgaris patient and control. Methods: This study was observational analytic research involving 33 psoriasis vulgaris patients and 33 healthy individuals. They were matched up based on sex, age, and lesion location. Swab of skin lesions on the Koebner area of both groups was cultured on CHROMagar media. Candida spp. was later identified and the colonization was calculated. Result: Candida spp. was found on 51.5% of lesions in psoriasis vulgaris patients and 21.2% in the control group with a significant difference of p < 0.05. The average colony number of Candida spp. in psoriasis vulgaris group was lower than the control group with no significant difference of p > 0.05. The predominant Candida spp. in the psoriasis vulgaris and control groups was Candida krusei, which were 35.5% and 85.6%, respectively. No significant difference between sex, age, period of complaints, age onset, degree of severity (Psoriasis Area and Severity Index), and therapy history, with positive culture of Candida spp. Conclusion: There was no difference in the number of Candida spp. colonization in the psoriasis vulgaris group and the control group. However, the culture positivity of Candida spp. in the psoriasis vulgaris patients was higher than in the control group.
A Retrospective Study: Risk Factor Analysis of Secondary Bacterial Infection in Pediatric Atopic Dermatitis Patients Desiana Widityaning Sari; Sawitri Sawitri; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Linda Astari; Alpha Fardah Athiyyah; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.83-87

Abstract

Background: Atopic Dermatitis (AD) is a complex multifactorial disease that includes defects in skin architecture, immune dysregulation, and changes of skin flora, and it predominantly occurs in infancy and childhood. The defects in skin barrier structures are mentioned as one of the factors that facilitates bacterial colonization. Bacterial infection in AD can worsen the inflammation. It requires treatment with antibiotics, which takes longer therapy time, higher costs, and ultimately affects the patient’s quality of life and his/her family members. Purpose: To find out the epidemiology, diagnosis, management of AD, and analyze the risk factors of secondary bacterial infection in new AD patients at the Pediatric Dermatology Division, Dermatovenereology Outpatient Clinic, Dr. Soetomo General Academic Hospital. Methods: This was a retrospective study with a total sampling method. The research data were medical records of new AD patients at the Pediatric Dermatology Division, Dermatovenereology Outpatient Clinic, Dr. Soetomo General Academic Hospital Surabaya from January 2012 to December 2018. Result: There were 404 new patients with AD at the Pediatric Dermatology Division from January 2012 to December 2018, and 210 of them were accompanied by secondary bacterial infection. There was a correlation between a history of dry skin (p=0.000) with the incidence of secondary bacterial infection in AD patients. Conclusion: In this study, AD patients with a history of dry skin had a risk of complication such as bacterial secondary infection.
Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular 3, Evy Ervianti1 , Afif N
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13548

Abstract

Background: Candida sp. is the most common opportunistic pathogen found during the development ofHuman immunodeficiency virus (HIV) & Acquired immune deficiency syndrome (AIDS) disease. Theclinical severity of oral candidiasis and the prevalence profile of Candida species reflect immunologicalchanges in HIV / AIDS patients. Objective: Evaluating the relationship between CD4 T lymphocyte cellscounts and the number of Candida species. Methods: A cross-sectional analytical study was carried outat Dr. Soetomo, Surabaya, Indonesia. For identification of Candida species, culture was carried out onChromagar media followed by culture with vitek 2. Results: There were 114 study subjects who weredivided into three groups based on the number of CD4 T lymphocyte cells, with 158 isolates of Candidaspecies growing in culture. The highest number of Candida species was Candida albicans with a total of 107isolates (67.7%). Candida non-albicans were 51 isolates (32.3%). Statistical test results showed a significantcorrelation between the number of CD4 T lymphocyte cells and the number of Candida species (p <0.001).Conclusion: The decrease in CD4 lymphocyte cell counts is influenced by various types of Candida sp. inoral candidiasis patients.
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole Dwi Murtiastutik1 , Cita Rosita Sigit Prakoswa2 , Indah Setyawati Tantular3 , Yusuf Wibisono1 , Afif
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13549

Abstract

Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients.Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have beenmany studies focusing on natural substances and its antifungal properties. In this study, a form of green teaextract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective:To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates takenfrom HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patientswith OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit(UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results:The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC offluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MICvalues for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value offluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidaleffect is better than fluconazole.
Co-Authors Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Afria Arista Afria Arista Afria Arista Afria Arista, Afria Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agustina Tri Pujiastuti Agustina Tri Pujiastuti, Agustina Tri Alpha Fardah Athiyyah Alphania Rahniayu Alvian Arifin Saiboo Amanda Gracia Manuputty Amira Suryani Rahmatika Anggaraeni, Sylvia Ardsari Azminingrum Arifin Saiboo, Alvian Astindari Astindari Astindari Astindari Astindari, Astindari Bagus Haryo Kusumaputra Bernadya Yogatri Anjuwita Bernadya Yogatri Anjuwita Saputri Bintanjoyo, Lunardi Brama Rachmantyo Budi Utomo BUDI UTOMO Budi Utomo Budiono Budiono Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Desiana Widityaning Sari Devi, Aprilin Krista Dhelya Widasmara Diah Mira Indaramaya Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika Dyatiara Devy Rahadiyanti Emma Hidayati Sasmito Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Fajrin, Farah Meriana Farhat Surya Ningrat Febrina Dewi Pratiwi Gondo Mastutik Hari Sukanto, Hari Hariani, Lynda Harningtyas, Citra Dwi Hasnikmah Mappamasing Huvi, Indira Indah Purnamasari Indah Purnamasari INDROPO AGUSNI Ingrid Suryanti Suryono Intan Primasari Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Isamahendra, Naufal Agus Iskandar Zulkarnain Iswinarno Doso Saputro Izzatul Fithriyah Jusuf Barakbah, Jusuf Kurniati Kurniati KUSUMASTUTI, ETTY HARY Laissa Bonita Lia Kinasih Ayuningati Linda Astari, Linda Lita Setyowatie Luthfidyaningrum, Hamidah M. Yulianto Listiawan Marsoedi Hoetomo Martodiharjo, Sunarko Maya Wardiana Maylita Sari Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Menul Ayu Umborowati Muhammad Vitanata Arfijanto, Muhammad Vitanata Nabiha Missaoui Nurul Hidayati, Afif Pepy Dwi Endraswari, Pepy Dwi Permana, Putu Bagus Dharma Pilar, Nissa Avina Prameshvari, Putu Lovina Indra Priangga Adi Wiratama Putri Halla Shavira Rahmadewi Rahmadewi Rahmadewi Regitta Indira Agusni Ridha Ramadina Widiatma Riswanto, Cintya Dipta Riyana Noor Oktaviyanti Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri SEPTIANA SEPTIANA Septiana Widyantari Septiana Widyantari Sjahjenny Mustokoweni, Sjahjenny Sudjarwo Sudjarwo Suhartono Taat Putra Sunarso Suyoso Sunarso Suyoso, Sunarso Suryanegara, Jose Tanojo, Natalia Tengku Riza Zarzani N Tessa Thendria Tjokorde Istri Nindya Vaniary Trisiswati Indranarum Trisniartami Setyaningrum Umi Miranti Umi Miranti, Umi Wahyunita Desi Ratnaningtyas Wardiana, Maya Widyantari, Septiana Willy Sandhika Yuli Wahyu Rahmawati Yusuf Wibisono