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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik Asian Journal of Health Research Bali Dermatology Venereology and Aesthetic Journal

Dwi Murtiastutik

Associate Professor Department Of Dermatology And Venereology Faculty Of Medicine, Universitas Airlangga/ Dr Soetomo General Academic Hospital;

Author-ID : 563391

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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A Retrospective Study of Demographic, Clinical, and Histopathological Profiles of Cutaneous Tumors Bintanjoyo, Lunardi; Hidayati, Afif Nurul; Cita Rosita Sigit Prakoeswa; Murtiastutik, Dwi; Bagus Haryo Kusumaputra; Listiawan, Muhammad Yulianto; Irmadita Citrashanty; Maylita Sari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.149-155

Background: In 2007, skin cancers were third most common malignancies in Indonesia. However, profile of cutaneous tumors in our institution has not been studied. Purpose: To evaluate profile of cutaneous tumors in Dermatology and Venerology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya, Indonesia. Methods: This is a descriptive retrospective study. Inclusion criteria was new cutaneous tumor patients. Exclusion criteria was incomplete data. Medical record and photograph database from 2019-2020 were assessed for demography, clinical features, histopathological examination and final diagnosis. Results: There were 379 (5,5%) cutaneous tumors among 6896 new patients at Dermatology and Venereology Outpatient Clinic. Overall, there were more female patients (53.7%) and age group of 0-45 years old (70.4%). Cutaneous tumors more commonly presented as papular (50.4%), multiple (56.5%), nonpigmented (58.3%), asymptomatic lesions (62.5%), with time from onset 0-24 months (66.2%) and location on head and face (61.2%). Benign cutaneous tumors showed similar findings. Malignant cutaneous tumors showed differences including predominantly male sex, age above 45 years old, nodular, solitary, pigmented and easily bleeding lesions. Malignant tumors were less common (6.9%). Most common malignant tumor was BCC. Most common benign and overall cutaneous tumor was seborrheic keratosis. Conclusion: Cutaneous tumors presented across gender and ages, showing heterogenous clinical manifestations. Malignant and benign cutaneous tumors showed similarity on time from onset and location of lesions. However, differences were seen in demographic profiles and majority of clinical features. BCC was the most common malignant cutaneous tumors, while seborrheic keratosis was the most common benign and overall cutaneous tumors.

Antifungal Activity of Rosemary (Rosmarinus officinalis L.) Emulsion Gel Compared to Nystatin on Candida albicans Stored Isolate from HIV/AIDS Patients with Oral Candidiasis Wardiana, Maya; Astindari; Ervianti, Evy; Afif Nurul Hidayati; Diah Mira Indramaya; Pepy Dwi Endraswari; Budi Utomo; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.88-92

Background: Oral candidiasis (OC), frequently caused by Candida albicans, is the most common opportunistic infection in HIV/AIDS patients. Topical treatment for OC is limited. In vitro study revealed rosemary (Rosmarinus officinalis L.) essential oil has an antifungal effect. However, the essential oil is volatile and is not recommended to be applied to the skin and mucosa; therefore, emulsion gel (emulgel) is made. Purpose: This study was conducted to evaluate the antifungal activity of rosemary emulgel 6.25%, 25%, 37.5%, and 50% compared to nystatin. Methods: This study is an in vitro test using the disk diffusion method to d etermine the antifungal activity shown by the inhibitory zones of rosemary emulgel at 6.25%, 25%, 37.5%, and 50% compared to nystatin to stored isolates of C. albicans from HIV/AIDS patients with OC. Result: Rosemary emulgel 6.25% dan 25% did not show antifungal activity because no inhibitory zone was shown. The inhibitory zone diameter provided by rosemary emulgel 37.5%; 50%; and nystatin against C. albicans isolates were 3.17±3.763 mm; 7.00±4.107 mm; and 30.13±5.319 mm respectively. Significant differences in antifungal activity were shown by the inhibitory zone diameter provided between rosemary emulgel 37.5%, 50%, and nystatin (p<0,05). Conclusion: Rosemary emulgel 37.5% dan 50% had antifungal activity showed by the formation of inhibitory zone against Candida species isolates in disk diffusion method even though it was weaker compared to nystatin as a standard antifungal.

Dermatology Life Quality Index (DLQI) Score in Acne Vulgaris after Epigallocatechin-3-Gallate (EGCG) 3% as an Adjuvant of Tretinoin 0,025% Cream Fajrin, Farah Meriana; Citrashanty, Irmadita; Listiawan, Muhammad Yulianto; Rahmadewi, Rahmadewi; Utomo, Budi; Murtiastutik, Dwi; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.177-181

Background: Acne vulgaris (AV) often occurs at the age of puberty, most people with AV feel ashamed of their appearance. It has been believed that green tea contains high level antioxidant, such as Epigallocatechin-3-gallate (EGCG). Purpose: This study is to compare quality of life from the patient of acne vulgaris before and after using 3% Epigallocatechin-3-Gallate (EGCG) cream as adjuvant therapy of 0,025% tretinoin cream with 0,025% tretinoin cream alone in the treatment of AV. Methods: This study is a quasi-experimental study with a pre-test and post-test design, and a control group design aiming to know the difference in quality of life of 46 samples after administration of EGCG cream combined with tretinoin cream compared to the group that was given tretinoin cream alone in patients with AV for 12 weeks, and then evaluate patients satisfaction and change in quality of life after treatment using the Dermatology Life Quality Index (DLQI). Result: Statistical analysis found that there was a significant difference (p-value <0.05) in the quality-of-life value of research subjects in the treatment group when compared between the initial arrival to week 12 with a p-value of 0.000. Distribution of DLQI values in research subjects who were given 3% EGCG cream therapy as adjuvant therapy with 0.025% tretinoin cream. Conclusion: Both groups showed an improvement in the DLQI value with the interpretation of the DLQI value at week 12 being both 100%, but the treatment groups DLQI decline faster than the control groups.

Evaluation of Histopathology Findings of Clinically Confirmed Psoriasis Vulgaris Sawitri; Fadila, Arisia; M. Yulianto Listiawan; Priangga Adi Wiratama; Dwi Murtiastutik; Evy Ervianti; Linda Astari; Damayanti; Diah Mira Indramaya; Afif Nurul Hidayati; Medhi Denisa Alinda
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 1 (2023): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.1.2023.21-26

Background: Psoriasis vulgaris can be diagnosed clinically. A biopsy is usually used to confirm non-classic cases. The findings of the histopathology feature are not usually present, thus clinical relevance is needed to confirm the diagnosis. Purpose: To describe the histopathology findings from tissue samples of histopathologically confirmed psoriasis vulgaris reported in the Department of Pathology and Anatomy of Dr. Soetomo General Hospital. Methods: A descriptive-retrospective study of pathology-ascertained tissue samples of histopathologically confirmed psoriasis vulgaris was reported in the Department of Pathology and Anatomy from patients who were also previously diagnosed clinically with psoriasis vulgaris in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital over a period of 2 years. Morphological parameters were observed after histopathology sections were stained with hematoxylin and eosin. Result: Thirty-three tissue samples were examined. Parakeratosis (86%) and hypogranulosis (70.3%) were the most observed findings. Club-shaped rete ridges, suprapapillary plate thinning, and spongiform pustules of Kogoj were the least observed findings (each by 2.7%). Three tissue samples (8.1%) showed only parakeratosis. Only 1 tissue sample (2.7%) showed 4 features (absence of the granular layer, parakeratosis, microabscess of Munro, and spongiform pustules of Kogoj). No tissue sample showed every histopathology finding of psoriasis vulgaris. Conclusion: All of the histopathology features of psoriasis vulgaris are rarely found in one tissue section. Albeit histopathology is believed to be the gold standard diagnosis of psoriasis vulgaris, relevance with clinical findings is still mandatory to support the diagnosis.

Validation and Reliability of Indonesian Version of Vitiligo-Specific Health-Related Quality of Life Instrument (VITIQoL) Indramaya, Diah Mira; Devi, Aprilin Krista; Sawitri; Utomo, Budi; Fithriyah, Izzatul; Murtiastutik, Dwi; Hidayati, Afif Nurul; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.148-157

Background: Vitiligo is a long-term autoimmune disorder marked by the loss of melanocytes and the formation of white macules. Vitiligo can have an impact on the patient's look and quality of life. The Dermatology Life Quality Index (DLQI) is a questionnaire that analyzes the quality of life of skin patients in general, but it is not disease-specific. To assess the quality of life of vitiligo patients in Indonesia, a disease-specific instrument is required. Purpose: This study aims to analyze the validity and reliability of the Vitiligo Quality of Life (VitiQol) questionnaire in Indonesia and translate the VitiQol questionnaire into Indonesian. Methods: Using cross-sectional analytic observation, this study was performed on 39 participants with vitiligo at Dr. Soetomo Surabaya between December 2021 and January 2022. The investigation consisted of three phases: the Indonesian translation of VitiQol, testing for validity, and assessing reliability. Result: The VitiQol questionnaire is a valid and reliable questionnaire. Valid with a correlation coefficient between 0.40 and 0.80 and reliability close to perfection. There was a significant correlation between VitiQol and DLQI (r=0.511, p=0.001). Conclusion: According to the findings of this study, the Indonesian VitiQol is a valid and reliable instrument for measuring the life quality of vitiligo patients in Indonesia.

Profile of Mild Acne Vulgaris Patients at Tertiary Hospital at Surabaya, Indonesia Arifin Saiboo, Alvian; Muhammad Yulianto Listiawan; Sari, Maylita; Indramaya, Diah Mira; Murtiastutik, Dwi; Damayanti; Anggaraeni, Sylvia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.26-30

Background: One of the most prevalent skin conditions worldwide is acne vulgaris (AV). Even mild forms of AV could have an adverse impact on psychological wellbeing. Purpose: To explore the profile of mild AV patients in a tertiary care facility in Surabaya, Indonesia. Method: This was a descriptive study conducted for eight weeks. Data regarding the patient's identity, history, skin type, and complaints related to AV or other complaints that arose were noted on the sample's medical record and collected for analysis. The Lehmann classification was used to assess the AV degree. Result: A total of 34 patients were included. Gender equality was similar in our study, and late adolescence (17-25 years) is the most dominant age group (73.5%). Genetics plays the biggest precipitating factor (73.5%), followed by stress (70.6%). Most patients had an oily skin type (91.2%) with Fitzpatrick's phototype 4 (85.3%). Comedone is the most prevalent lesion in our study (median = 10, range = 4-20). Conclusion: Most patients with mild AV had an oily skin type, and late adolescent is most dominant age group.

Large acrochordon of labium majora: an unusual location Citrashanty, Irmadita; Luthfidyaningrum, Hamidah; Murtiastutik, Dwi; Hidayati, Afif Nurul; Widyantari, Septiana; Astindari, Astindari; Sari, Maylita
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/93p62v41

Background: Acrochordon is a soft, round or oval, pedunculated papilloma that can be tan or brown in color. Although acrochordons most commonly appear in the neck, axilla, and groin, they can also appear in unusual sites, such as penis, vulva, and perineum. Most of the lesions are small pedunculated papules or nodules approximately 2–6 mm, but rarely, particularly on the lower section of the trunk, large pedunculated acrochordons can be found. Here we present a large acrochordon on the labium majora. Case Description: A 25 years old woman came to an outpatient clinic because there was a mass on her right labium majora ever since she gave birth three years prior. The size of the mass started off relatively small but has grown significantly over time. From dermatological examination in external genitalia region, there was a solitary, pedunculated, skin-colored mass measuring 10 × 3 cm, attached to right labium majora. There was no redness, ulceration, bleeding or discharge. Cautery excision with local anesthetic was performed to removed the mass. The histopathological examination of the specimen revealed polypoidal tissue lined by epidermal layer, there are proliferation and dilation of capillaries containing erythrocytes in the dermis layer, mild infiltration of lymphocytes and histiocytes. No evidence of malignancy. Conclusion: We report an unusual location of acrochordon presenting with large size. Due to its atypical presentation, it may be confused with a malignancy, necessitating a pathological test. Total excision of the mass is recommended.

The Genotype of Human Papilloma Virus of Male Patient with Anogenital Warts Murtiastutik, Dwi; Mastutik, Gondo; Rahniayu, Alphania; Arista, Afria; Setyaningrum, Trisniartami
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. HPV high risk (HPVHR) were HPV16,18 related with invasive penile carcinomas, and HPV low risk (HPVLR) were HPV6,11 related to anogenital warts. Male infection is usually asymptomatic that it would be explain increasing the incidence of HPV associated cancers. Identification HPV genotype is very important for predicting the development of the diseases, to be benign or malignant cancer. The objective of this study was to identify the genotype of HPV that infect men with anogential warts. This research used 12 biopsy specimens from men patient with anogenital warts at Outpatient clinic of Department Dermatology and Venereology, Dr. Soetomo General Hospital period 2016-2017. The specimens were diagnozed by pathologist and HPV gentoyping was done to detect 40 HPV genotype including HPVHR and HPVLR. The result showed that 58% (7/12) were positive for HPVLR and 42% (5/12) were positive for HPV LR/HR. The genotype HPV that infected men patient with anogenital warts is HPVLR (HPV6,11) and HPVHR (HPV18,51,52,82) with single infection of HPVLR or mutiple infection HPVLR/LR or HPVLR/HR. The infection of HPVHR would be develops to be malignant transformation. It suggested that HPV genotype needs to be checked the for the anogenital warts cases for predicting the development of the diseases.

Sexually Transmitted Infections among Human Immunodeficiency Virus Patients in a Tertiary Hospital in Surabaya, Indonesia Suryanegara, Jose; Pilar, Nissa Avina; Riswanto, Cintya Dipta; Agusni, Regitta Indira; Sari, Maylita; Astindari; Widyantari, Septiana; Nurul Hidayati, Afif; Murtiastutik, Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.119-124

Background: Human immunodeficiency virus (HIV) remains a significant global public health concern. One of its primary modes of transmission is sexual contact, leading to frequent co-infection with other sexually transmitted infections (STIs). Understanding the profile of STIs among HIV patients is essential for improving management and prevention strategies. Purpose: This study aims to describe the prevalence, types, and basic demographic characteristics (age and sex) of STIs among HIV patients treated at a tertiary referral hospital in Indonesia, to enhance understanding and optimize patient care. Methods: A retrospective observational study was conducted at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Researchers analyzed the medical records of HIV patients who had coexisting STIs and visited the dermatology and venereology outpatient clinic between January 2021 and December 2022. Data collected included patient demographics, STI diagnoses, and clinical characteristics. Result: A total of 222 HIV patients with STIs were included, with a male predominance (85.6%) and a mean age of 28.64 years. The most common STIs were anogenital warts (47.7%), latent syphilis (18.0%), unspecified syphilis (10.8%), secondary syphilis (10.4%), and molluscum contagiosum (7.7%). The findings highlight the variations in STI prevalence based on sex and age distribution among HIV patients. Conclusion: This study points out that there are integrated management and prevention strategies targeting both HIV and STIs. Although our study did not specifically assess sexual orientation, previous research highlights men who have sex with men (MSM) as a key high-risk population.

Diagnosis of Kaposi’s sarcoma Alvian Arifin Saiboo; Dwi Murtiastutik; Etty Hary Kusumastuti; Putri Halla Shavira
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 2 (December 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/9hqvm129

Kaposi’s sarcoma has a picture reminiscent of several skin conditions, so further testing is needed to show the diagnosis of Kaposi’s sarcoma. Lymphatic endothelium cells infected with KSHV or human herpesvirus 8 form the basis of Kaposi’s sarcoma (KS), a multicentric tumor (HHV-8). These macules and plaques might be purple, reddish-blue or dark brown-black in color. KS is distinguished by this look.” Inflamed, ulcerated nodular lesions are common. They are neither unpleasant or uncomfortable, and the overlying skin or underlying tissues seldom die as a result of them. The gold standard examination in establishing the diagnosis of KS is histopathology. Several techniques that can be used for histopathological tissue retrieval are punch biopsy, shave biopsy, excision biopsy and incision biopsy. Immunohistochemical examination can also be performed to rule out the differential diagnosis. Immunohistochemical examination that we can do is with LANA-1, CD 34, CD 31, D2-40. Diagnosis of Kaposi’s sarcoma is difficult to diagnose only from a clinical picture, so similar diagnoses, i.e. histopathological and immunohistochemical examinations, are required.

Co-Authors Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Afria Arista Afria Arista Afria Arista Afria Arista, Afria Agatha Anindhita Ardhaninggar Agatha Anindhita Ayu Ardhaninggar Agustina Tri Pujiastuti Agustina Tri Pujiastuti, Agustina Tri Alpha Fardah Athiyyah Alphania Rahniayu Alvian Arifin Saiboo Amanda Gracia Manuputty Amira Suryani Rahmatika Anggaraeni, Sylvia Ardsari Azminingrum Arifin Saiboo, Alvian Astindari Astindari Astindari Astindari Astindari, Astindari Bagus Haryo Kusumaputra Bernadya Yogatri Anjuwita Bernadya Yogatri Anjuwita Saputri Bintanjoyo, Lunardi Brama Rachmantyo Budi Utomo BUDI UTOMO Budi Utomo Budiono Budiono Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Desiana Widityaning Sari Devi, Aprilin Krista Dhelya Widasmara Diah Mira Indaramaya Diah Mira Indramaya Diana Kartika Sari Diana Kartika Sari, Diana Kartika Dyatiara Devy Rahadiyanti Emma Hidayati Sasmito Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Fajrin, Farah Meriana Farhat Surya Ningrat Febrina Dewi Pratiwi Gondo Mastutik Hari Sukanto, Hari Hariani, Lynda Harningtyas, Citra Dwi Hasnikmah Mappamasing Huvi, Indira Indah Purnamasari Indah Purnamasari INDROPO AGUSNI Ingrid Suryanti Suryono Intan Primasari Irmadita Citrashanty Irmadita Citrashanty Irmadita Citrashanty, Irmadita Isamahendra, Naufal Agus Iskandar Zulkarnain Iswinarno Doso Saputro Izzatul Fithriyah Jusuf Barakbah, Jusuf Kurniati Kurniati KUSUMASTUTI, ETTY HARY Laissa Bonita Lia Kinasih Ayuningati Linda Astari, Linda Lita Setyowatie Luthfidyaningrum, Hamidah M. Yulianto Listiawan Marsoedi Hoetomo Martodiharjo, Sunarko Maya Wardiana Maylita Sari Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Menul Ayu Umborowati Muhammad Vitanata Arfijanto, Muhammad Vitanata Nabiha Missaoui Nurul Hidayati, Afif Pepy Dwi Endraswari, Pepy Dwi Permana, Putu Bagus Dharma Pilar, Nissa Avina Prameshvari, Putu Lovina Indra Priangga Adi Wiratama Putri Halla Shavira Rahmadewi Rahmadewi Rahmadewi Regitta Indira Agusni Ridha Ramadina Widiatma Riswanto, Cintya Dipta Riyana Noor Oktaviyanti Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri SEPTIANA SEPTIANA Septiana Widyantari Septiana Widyantari Sjahjenny Mustokoweni, Sjahjenny Sudjarwo Sudjarwo Suhartono Taat Putra Sunarso Suyoso Sunarso Suyoso, Sunarso Suryanegara, Jose Tanojo, Natalia Tengku Riza Zarzani N Tessa Thendria Tjokorde Istri Nindya Vaniary Trisiswati Indranarum Trisniartami Setyaningrum Umi Miranti Umi Miranti, Umi Wahyunita Desi Ratnaningtyas Wardiana, Maya Widyantari, Septiana Willy Sandhika Yuli Wahyu Rahmawati Yusuf Wibisono

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