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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology CHEMPUBLISH JOURNAL IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Community Development Journal: Jurnal Pengabdian Masyarakat MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of The Indonesian Society of Integrated Chemistry Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Anis Yohana Chaerunisaa, Anis Yohana
Fakultas Farmasi, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Functional Food Development: Cassia fistula Stem Bark Ethanol Extract as a Potential Antioxidant and Anticancer Agent Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana; Lestari, Uce; Hirzan, Rifanza; Syahri, Wilda
Indonesian Food Science and Technology Journal Vol. 9 No. 2 (2026): Volume 9 Number 2, July 2026 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v9i2.53230

Abstract

This study investigates the pharmacological potential of Cassia fistula (Tilai), a plant traditionally used by Indonesian tribes as both medicine and food. The ethnobotanical significance of this species has inspired scientific exploration of its bioactive compounds. The ethanol extract of Cassia fistula stem bark demonstrated strong antioxidant activity, with an IC50 of 7.512 μg/mL, comparable to Vitamin C's IC50 of 4.716 μg/mL, indicating effective free radical scavenging. Additionally, the extract exhibited notable cytotoxicity against MCF-7 breast cancer cells, with an IC50 of 51.26 μg/mL. UHPLC-HRMS analysis revealed nine bioactive compounds, mainly flavonoids, phenolics, and quinones, which may contribute to its biological activities. These findings support the hypothesis that Cassia fistula stem bark contains potent antioxidant and anticancer constituents, highlighting its potential as a natural source for developing therapeutic agents. This research provides valuable insights into the phytochemical profile of Cassia fistula and its cytotoxic effects, encouraging further studies to explore its mechanisms and applications in cancer treatment.
Co-Authors Ade Zuhrotun Adrian Suparman Amelia Soyata Anas Subarnas Andrie, Agus Angga Prawira Kautsar Apriani, Diana Kurnia Aprilian, Salsa Aristokrat, Aria ASTRI SULASTRI Barmi Hartesi Bayu Suryana Hanggara Chaniago, Rahadatul Aisy Desy Nawangsari Dolih Gozali Dwiya, Reiva Farah ELVIE RIFKE RINDENGAN, ELVIE RIFKE Erlianti, Karina Fairuzati Anisah Murthadiah Handayani, Retty Harsanti, Bunga Dacilia Hayatus Sa'adah Hazrina, Aghnia Hindun, Siti Hirzan, Rifanza Ina Widia Ira Safitri Khairinisa, Miski Aghnia Kurniawan Syah, Insan Sunan LINDA APRIYANTI, LINDA Maisyarah, Intan Timur Mardiana, Lia Maria Elvina Tresia Butar-Butar Marline Abdassah Marline Abdassah Marline Abdassah Marline Abdassah, Marline Mayang Kusuma Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA Muhaimin Muhaimin Nor Latifah Patihul Husni Patihul Husni Pitriani Raden Maya Febriyanti Reiva Farah Dwiyana Rosmiati, Meiti Septiyani Mustikawati SHEILA FRIZQIA JELITA Sinthiya Eka Wijayanti Siska Sari Marvita Siti Fauziyah ZD Sutisna Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sulistiyaningsih Sulistiyaningsih Taofik Rusdiana TIANA MILANDA Tina Rostinawati Triyono Triyono Uce Lestari VALENTINE SOFIANI Wedi Akbari Widayanti Supraba Wilda Syahri Wulantresna, Dewi Yasmiwar Susilawati Yoga Windhu Wardhana Yoga Windu Wardhana, Yoga Windu Yuni Elsa Hadisaputri