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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Human Nutrition Global Medical and Health Communication Biomedical Journal of Indonesia Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Abdimas Universal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Pengabdian Masyarakat: Humanity and Medicine Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Conferences of Medical Sciences Dies Natalis JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Kreativitas Pada Pengabdian Masyarakat (Krepa) JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Ella Amalia, Ella
Bagian Mikrobiologi, Fakultas Kedokteran,Universitas Sriwijaya, Palembang, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Biomedical Journal of Indonesia

 1 
Identifikasi Mutasi Gen rpob Ser531Leu Mycobacterium tuberculosis Yang Berhubungan Dengan Resistensi Rifampisin Amalia, Ella; Nindatama, Maghfiroh Rahayu; Hayati, Lusia; Handayani, Dwi
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 1, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Tuberkulosis (TB) adalah penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis. Kasus resistensi M. tuberculosis terhadap rifampisin sudah banyak dilaporkan di dunia termasuk Indonesia. Resistensi terhadap rifampisin pada  M. tuberculosis sebagian besar disebabkan mutasi gen rpoB yang menyandi RNA polymerase subunit ß. Mutasi gen rpoB Ser531Leu yang berhubungan dengan resistensi terhadap Rifampisin paling sering terjadi. Adanya mutasi pada rpoB akan  menyebabkan perubahan pada struktur dan aktivitas target obat. Penelitian ini bertujuan untuk mengidentifikasi mutasi gen rpoB Ser531Leu Mycobacterium tuberculosis pada sampel yang diambil dari penderita tuberkulosis paru di RSUP dr. Mohammad Hoesin Palembang. Penelitian ini merupakan penelitian deskriptif terhadap 40 penderita tuberkulosis paru di RSUP dr. Mohammad Hoesin Palembang. Identifikasi mutasi gen rpoB Ser531Leu Mycobacterium tuberculosis dilakukan dengan teknik Multiplex Polymerase Chain Reaction menggunakan primer rpoB531. Dari 40 isolat gen rpoB kodon 531 didapatkan 70% (21 dari 30) terjadi mutasi, wild type sebanyak 9 isolat (30%) dan isolat yang tidak menghasilkan pita sebanyak 10 isolat. Telah ditemukan mutasi gen rpoB Ser531Leu Mycobacterium tuberculosis pada penderita tuberkulosis paru di RSUP dr. Mohammad Hoesin Palembang.
Physical Activity and Body Composition Profiles in Elderly Individuals: Insights from a Community-Based Study Sayisvir, Nadia Farah; Kurniati, Ardesy Melizah; Santoso, Budi; Husin, Syarif; Amalia, Ella; Izzulhaq, Muhammad Agung
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.251

Abstract

Introduction. Obesity and sarcopenia are two metabolic disorders that can result from an increase in body fat and a reduction in muscle mass that are not balanced by enough physical exercise.  The goal of this study was to examine whether there is a link between physical activity and body composition in the elderly.  Methods.  This cross-sectional study was carried out in the elderly community of RSUP Dr. Mohammad Hoesin Palembang from October to November 2019.  The study's sample consisted of older persons over the age of 60 who were able to speak clearly and carry out daily tasks independently.  Respondents who agreed to participate signed informed consent. Physical activity data were collected by PASE questionnaire interviews, and body composition was measured using the BIA Tanita.  Results.  The Chi-Square test was used in all analyses.  In this study, there were 94 old people: 12 men and 82 women.  Physical activity was found to have a significant link with muscle mass (p=0,001) as well as fat mass (p=0,001).  Conclusion.  There is a strong link between physical activity and body composition in the elderly. Physical activity data were obtained through interviews based on the PASE questionnaire and body composition measurements using the BIA Tanita.
Co-Authors ., Mariana Ahmad, Qaedi Ahmad, Zen Al-Fayed, Muhammad Sadad Ali Djamhuri Annisa Rahmawaty Ansyori, Achmad Rifky Ardesy Melizah Kurniati Azhari, Dalilah Beauty Novianty Citra Dewi Citra Dewi Diba, Masayu Farah Dwi Budi Santoso Dwi Handayani Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Eka Febri Zulissetiana Eka Putra Pratama Faradillah Dillah Farah Diba, Masayu Fatmawati Fenny Etrawati Gita Dwi Prasasty Hermansyah Hutabarat, Yosafat Beltsazar Ika Kartika Irnanda, Andi Izzulhaq, Muhammad Agung Karim, Fatmawati Kemas Ya'kub Rahadiyanto Krisna Murti Krisna Murti Lionita, Widya Lusia Hayati Lusia Hayati, Lusia M. Hafizh Arrafi M. Nadhif Prasetyo M. Yogi Riyantama Isjoni Maghfiroh Rahayu Nindatama, Maghfiroh Rahayu Mansur, M. Syafi'i Maria Ulfa, Maria Ulfa, Maria Ulfa,, Maria Ulfa, Medina Athiah Medina Athiah Meilinda, Nurly Misnaniarti Misna Muhammad Irsan Saleh Muhammad Syahrul Ramadhan Nawawi, Rizki Andini Nita Parisa Nyiayu Fauziah Kurniawati pariyana, Pariyana Pratama, Eka Putra Putra, Ramadhan Ananditia RACHMAT HIDAYAT Rahma Kurnia Lestari Rahma Nur Islami Rahmawati, Fuji Rara Inggarsih Rasyid, Riana Sari Puspita Rivani, Erizka Rizma Adlia Syakurah Sabrina, Tia Sadakata Sinulingga Safira Azahra Safyudin Sayisvir, Nadia Farah Septi Purnamasari Setyorini, Dwi Indira SRI RAHAYU Subandrate Susilawati Susilawati Susilawati, Susilawati Syarif Husin Syarifah Aini Syauki Ikhsan, Diyaz Theresy, Elzabet Tri Suciati Usman, Doni Venny Larasati Yundari, Yundari Yuwono Yuwono Yuwono Zanaria, Rima Zefianto, Zefianto Ziske Maritska