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All Journal Jurnal NERS Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medicine JFIOnline JURNAL FARMASIMED (JFM) Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Journal : Universa Medicina

 1 
Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats Sunarti Sunarti; Edy Fachrial; Urip Harahap; Delyuzar Delyuzar; Tri Widyawati; Lokot Donna Lubis
Universa Medicina Vol. 36 No. 3 (2017)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.228-235

Abstract

BACKGROUNDNon-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.METHODSA study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.RESULTS    The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p<0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p>0.05).CONCLUSIONDeep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Anayanti Arianto Ardinata, Dedi - Arfayani Isna Azizah nasution Azmi Sarriff Br Turnip, Nur Ulina M Cahya, Cucu Arum Dwi Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria, Denny dharma Lindarto, dharma Dharmawan, Hariyadi Edy Fachrial Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Fitri, Raissa Hakim Bangun* Harahap, Ikhsanuddin Ahmad Harahap, Mawandha Sari Harefa, Herman Syukur HARI PURNOMO Hari Purnomo4 Hasibuan, Poppy Anjelisa Zaitun Husori, Dadang Irfan Jansen Silalahi Julia Reveny Julianti, Maelani Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Leo, Natassya Manda Linda Margata Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Mirna Risna Lovinanda Lubis Muhammad Rizki Nadroh br Sitepu Nasri Nasri Nasri, Nasri Nasution, Azizah Nasution, M. Pandapotan Nasution, Salli Roseffi Nasution, Salli Roseffi Ningrum, Siti Rahmi Novidawati Boru Situmorang Nurmaini Nurmaini Perangin-angin, Arihta Sri Poppy Anjelisa Z. Hasibuan Purba, Novandi Putri Chairani Eyanoer, Putri Chairani R. Hamdani Harahap R. Hamdani Harahap Ricke Loesnihari Rifda Amaliya Ma’ruf Rizki Doli Hartama Harahap Rumanda Nurhasanah Sanjaya, Angga Nugraha Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sitorus, Panal Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Tampubolon, Frengki Daniel Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani