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All Journal Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medicine JFIOnline Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Journal : International Journal Of Science, Technology

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Utilization Of Glycerol By Product From Transesterification Of Waste Cooking Oil As A Cosurfactant In Nanocream Preparation Rani, Zulmai; Julia Reveny; Urip Harahap
International Journal of Science, Technology & Management Vol. 2 No. 4 (2021): July 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i4.264

Abstract

Waste cooking oil (used cooking oil ) is oil derived from leftover cooking oil for frying food. Waste cooking oil is still considered as waste by some people and waste cooking oil that should not be suitable for consumption is sometimes still widely reused in food processing, this can endanger health and reduce the nutritional value of food. In order to be used and have economic value, it is overcome by synthesizing waste cooking oil into glycerol so it can be used as cosurfactant. Besides as cosurfactant, this waste cooking oil glycerol also can be used for various chemical industies, foods, cosmetics, and pharmaceuticals industries. For cosmetic preparation, it can make a nanocream preparation. The purpose of this research was to utilize waste cooking oil into a glycerol which is used as a cosurfactant, to characterize the synthesis results based on IR Spectroscopy data and to formulate it to nanocream preparation. The research was conducted in an experimentally by making glycerol from side product of waste cooking oil. Separating glycerol process conducted by transesterification reaction. Glycerol of waste cooking oil by product was characterized with IR Spectroscopy and evaluated include organoleptic, glycerol contents, density, viscosity, ash content, and moisture content. Formulation of nanocream preparation using 30% of Tween 80 as surfactant, glycerol by-product as cosurfactant 7,5% concentration, and 20% of VCO as oil phase. The nanocream preparation was measured for its particle size with the aim of being able to determine the particle size of the formula to form nanoparticle size. The results showed that glycerol of waste cooking oil by product shows the presence of OH, CH-aliphatic, C=O carbonyl and C-O. particle size of nanocream preparation obtained was 397,76 nm. Based on the result of this research, the conclusion is glycerol of waste cooking oil by-product can form nano size with presence of glycerol as cosurfactant. The particle size of the nanocream preparation obtained was still in the nanocream requirement range, namely 20-500 nm.
Potential Drug Interactions Of Oral Antidiabetic In Prescriptions Of Type 2 Diabetes Mellitus Patients At Kumpulan Pane Hospital Rumanda Nurhasanah; Khairunnisa; Urip Harahap
International Journal of Science, Technology & Management Vol. 2 No. 4 (2021): July 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i4.278

Abstract

Diabetes Mellitus is a disease that can cause complications of other diseases so that the treatment to be given becomes more and this has the potential for interactions between drugs that can affect the physiological condition of the patient. The aim of this study is to analyze the potential of oral antidiabetic interactions on prescription at Kumpulan Pane Hospital. Analysis of potential oral antidiabetic interactions on a prescription using quantitative research methods is retrospective descriptive. Prescriptions used are inpatient and outpatient prescriptions for the period January-December 2020 that get oral antidiabetics. Analyze data using Medscape and Drugs.com sites. Based on analysis of 9.818 prescription sheets of diabetes mellitus patients, there were found 6.454 (65.73%) prescription of potential oral antidiabetic interactions. Potential interaction of an oral antidiabetic group of 10.759 (91.45%) drug, the pattern of interaction mechanisms most often is pharmacodynamic 73.25%. The most common type of oral antidiabetic drugs that have potential interactions is the biguanide group (metformin) 36.76%. The severity of the most frequent interactions was 92.21%. The conclusion of the potential interactions oral antidiabetic are still found in prescriptions that is 65.73% at Kumpulan Pane Hospital. Keyword: Potential Drug Interactions, Oral Antidiabetics, Prescription
Isolation Of Chitosan From Cuttlefish Bones Ningrum, Siti Rahmi; Sinaga, Siti Morin; Harahap, Urip
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.523

Abstract

One of the potential natural resources in Indonesia is the abundance of natural resources in the marine sector. The survey results show that the sale of cuttlefish in the market indicates that the demand for cuttlefish is very high. Cuttlefish is a type of marine animal that is widely consumed by the public because of its very high protein content, but the part used from this cuttlefish is the meat, while the squid bones are discarded. Cuttlefish bone is one of the natural ingredients that contains chitin, and when the isolation process is carried out with the stages of deproteinization, demineralization, and deacetylation, it can produce chitosan compounds. The aim of the study was to isolate chitosan from cuttlefish bones. Isolation of chitosan includes 3 basic stages, namely deproteinization, demineralization, and deacetylation. Then the characteristics of chitosan from cuttlefish bones are analyzed, namely water content analysis, ash content, protein content, ninhydrin test, and FT-IR characteristics. The results of characteristic testing of 8.04% water content, 1.73% ash content, and 4.8% protein content, ninhydrin test results showed that cuttlefish bone chitosan had an amine group, and FT-IR results showed that the absorption bands of C-O and C-N groups. The conclusion of this study shows that chitosan can be isolated from cuttlefish bones.
Phytochemical Screening and Antibacterial Potential Ethanol Extract of Kemangi Leaves (Ocimum basilicum L.) Towards Staphylococcus aureus Sanjaya, Angga Nugraha; Harahap, Urip; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.630

Abstract

An infectious disease is a disease with the highest prevalence in the world, with a great risk of transmission. Staphylococcus aureus is a pathogen that can cause several infectious diseases. The use of kemangi leaves as vegetables can be used as an invention in treating infections caused by bacteria. The purpose of this study was a phytochemical screening test to determine what metabolites are contained and their potential activity against Staphylococcus aureus. The research method is to carry out a qualitative phytochemical screening test using reagents and an antibacterial potential test against Staphylococcus aureus using the Kirby-Bauer method (diffusion agar) with varying concentrations. The results showed that kemangi leaves extract showed positive results on the secondary metabolite compounds, were alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The diameter of the inhibition zone at a concentration of 500 mg/mL showed the diameter of the inhibition zone was 11.93 ± 0.25 mm with the strong category group. The conclusion is that the ethanolic extract of kemangi leaves shows the ethanolic extract of kemangi leaves has potential as an antibacterial.
Formulation and Evaluation of Sustained Release Microcapsule of Metronidazole Leo, Natassya Manda; Bangun, Hakim; Harahap, Urip
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.643

Abstract

The oral conventional metronidazole dosage forms have a short duration of action due to gastric emptying process, hence the treatment of ulcus pepticum using metronidazole become less effective. Due to retaining the dosage form in the stomach, a preparation form of sustained released drug delivery systems has been developed. The aim of this study was to developed a sustained released drug delivery systems of metronidazole using alginate and chitosan as polymers that could last longer in stomach. The formulation consisted of variatons in chitosan 0.5%, 0.75% and 1%. The drug released test was carried out using paddle method in simulated gastric medium pH 1.2 at 37°C. The dissolution test results showed that formula with 0.75% of chitosan giving the best sustained released effect and the kinetics drug realeased of microcapsule followed Higuchi order. Based on the results of the study, it can be concluded that microcapsules of metronidazole with a combination of alginate and chitosan can be prepared as sustained released formulation.
Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Putri Aisyia Fauzi, Ziza; Harahap, Urip; Yuandani, Yuandani; Berkat Waruwu, Syukur; Purnomo, Hari; Satria, Denny
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Phytochemical Screening of Phaleria macrocarpa (Scheff.) Boerl.) and Antibacterial Activity Test of Ethanol Extract Against Staphylococcus aureus Bacteria Rizki, Muhammad; Harahap, Urip; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.781

Abstract

Phaleria macrocarpa is known as one of the medicinal plants in Indonesia. Almost all parts of the plant have chemical content that is useful for being used as medicine. The growing use of crown plants by the community for various diseases requires a series of tests to obtain traditional medicine preparations that are safe for human use. The purpose of this study was to identify the content of secondary metabolite compounds (alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and glycosides) and the antibacterial activity of Staphylococcus aureus with the good method because the good method has the advantage that it is easier to measure the area of the inhibition zone formed because an antibacterial activity is not only on the upper surface of nutrient agar but also at the bottom. The results of phytochemical screening showed that the flesh of Phaleria macrocarpa (Scheff). The results of testing the antibacterial activity of an ethanol extract of crown Phaleria macrocarpa (Scheff) fruit flesh (Boerl) were positive for alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Boerl.) showed effective results at a concentration of 40 mg/ml against Staphylococcus aureus bacteria with an inhibition zone diameter of 14 mm; the antibacterial activity was categorized as strong.
Phytochemical Screening Of Ethanol Extract Of Temu Kunci (Boesenbergia Rotunda (L.) Mansf) Rhizome Extract And Testing Of Bilirubin Levels In Male White Mice Harahap, Mawandha Sari; Harahap, Urip; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 4 No. 3 (2023): May 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i3.819

Abstract

Liver Disease Is A Deadly Disease That Has Attacked Many People. Liver Disease Is A Disease That Occurs As A Result Of An Unhealthy Lifestyle. Usually, The Patient Will Consume Drugs With Chemical Compounds To Overcome The Problem Of This Disease. The Long-Term Use Of Chemical Drugs Will Certainly Cause Side Effects Or, Even Worse, Cause New Diseases. Therefore, The Latest Treatment Methods Must Be Developed To Minimize Side Effects, Namely The Use Of Traditional Medicines. The Purpose Of This Study Was To Determine The Use Of Temu Kunci Rhizome As An Alternative To Reduce Total Bilirubin Levels In Rats As Experimental Animals. This Study Used Rats As Experimental Animals, Which Were Divided Into 6 Test Groups, Namely Group 1 Without Treatment, Group 2 With 0.5% CMC Suspension, Group 3 With 200 Mg Acetylcysteine, Group 4 With 250 Mg/Kg BW Ethanol Extract Of Temukunci, Group 5 Treated With A 500 Mg/Kg BW Dose Of Ethanol Extract Of Temukunci, And Group 6 With A 750 Mg/Kg BW Ethanol Extract Of Temukunci. From The Results Of The Research Conducted, The Ethanol Extract Of Temu Kunci At A Dose Of 750 Mg/Kg BW Was The Best Treatment For Reducing Total Bilirubin Levels In Rats As Experimental Animals.
Antioxidant Potential Of Ethanol Extract Of Kendondong Leaves (Spondias Dulcis), Characterization And Examination Of Quercetin By TLC Method Cahya, Cucu Arum Dwi; Harahap, Urip; Nasution, M. Pandapotan
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.854

Abstract

Indonesia has a variety of plants that can be used to cure various diseases. Natural therapies offer little negative effect, especially in degenerative diseases, due to decreased function of body cells damaged by oxidation. Antioxidants have a vital role in counteracting free radicals to prevent degenerative diseases. One of the most abundant sources of antioxidant compounds is flavonoids. Kedondong leaf (Spondias dulcis) is one of the plants which is also suspected to contain flavonoids. Spondias species contain triterpenoids, namely oleanolic acid and flavonoids such as quercetin, kaempferol, kaempferida and rhamnetin. Examination of simplicia characteristics, phytochemical screening, examination of quercetin with Thin Layer Chromatography, and determination of antioxidant activity and IC50 value of Kedondong leaves using the DPPH method were carried out in this study. The results of the characteristic examination showed that simplicia met the requirements with a water content of 8.63%, a water-soluble extract content of 19.42%, an ethanol-soluble extract content of 5.17%, a total ash content of 12.43%, an acid-insoluble ash content of 7 .81%. Phytochemical screening showed that the bright kedondong leaves contained flavonoids, alkaloids, glycosides, saponins, tannins, and steroids/triterpenes. Examination of quercetin thin layer chromatography with chloroform: methanol (70: 30) as eluent produced six stains with Rf values (0.5; 1; 1.2; 3; 4.3; 6.6), and compared with quercetin raw material on the sixth stain with an Rf value of 6.6 has the same stain as the ethanol extract of kendondong leaves. The results of antioxidant testing at a 400 – 800 nm wavelength using UV-Vis spectrophotometry obtained a maximum wavelength of 515 nm. IC50 value obtained an IC50 value of 68.6260 ppm, so it can be concluded that the ethanol extract of kendondong leaves has antioxidant activity in the strong category.
Phytochemical Screening And Antidiabetic Test Of Ethanol Extract Of Turmeric Leaves (Curcuma domestica Val.) On Decreasing Blood Glucose Of Diabetic Rats Br Turnip, Nur Ulina M; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.866

Abstract

The turmeric plant (Curcuma domestica Val.) is a tropical plant that grows a lot on the Asian continent with is use as a food coloring and fragrance. The use of turmeric leaves by residents is only a cooking ingredient not used in large quantities. Even most of these turmeric leaves are considered waste and have minimal utilization. Turmeric leaf methanol extract can be used to lower blood glucose. Turmeric leaf extract has the potential as a valuable food source of its antioxidant components, such as total phenolic compounds and flavonoids which increase radical scavenging activity. In particular, the water extract of turmeric leaves contains high total phenolic compounds (2.741?±?0.099?mg GAE/g) and flavonoids (4.776?±?0.010?mg QCE/g). Diabetes mellitus is a metabolic disorder associated with several chronic complications, such as nephropathy, neuropathy, retinopathy and cardiomyopathy. Part of the turmeric plant leaves is reported to have the ability as an antioxidant. Antioxidant compounds can control blood glucose levels and prevent diabetes complications. This study was conducted to test the ability of turmeric leaf ethanol extract (EEDK) to reduce blood glucose levels in diabetic rats induced by nicotinamide and streptozotocin and to perform phytochemical screening to determine the compounds contained in turmeric leaves so that it becomes an alternative as a diabetes treatment and can prevent damage. or diabetic complications. The results showed that turmeric leaves contained secondary metabolites, namely flavonoids, glycosides, tannins, and triterpenoids/steroids, but there were no alkaloids or saponins. The characterization results show that the sample meets the requirements. Turmeric leaf ethanol extract doses of 400 mg/kg, 200 mg/kg, and 100 mg/kg could reduce the Blood Glucose Level of NA and STZ-induced rats from the fourth day of treatment.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Anayanti Arianto Arfayani Isna Azmi Sarriff Berkat Waruwu, Syukur Br Turnip, Nur Ulina M Cahya, Cucu Arum Dwi Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria, Denny dharma Lindarto, dharma Dharmawan, Hariyadi Edy Fachrial Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Fitri, Raissa Hakim Bangun* Harahap, Mawandha Sari Harefa, Herman Syukur HARI PURNOMO Hari Purnomo4 Hasibuan, Poppy Anjelisa Zaitun Husori, Dadang Irfan Jansen Silalahi Julia Reveny Julia Reveny Julianti, Maelani Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Leo, Natassya Manda Linda Margata Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Muhammad Rizki Nadroh br Sitepu Nasri Nasri Nasri, Nasri Nasution, Azizah Nasution, M. Pandapotan Nasution, Salli Roseffi Nasution, Salli Roseffi Ningrum, Siti Rahmi Novidawati Boru Situmorang Nurmaini Nurmaini Poppy Anjelisa Z. Hasibuan Purba, Novandi R. Hamdani Harahap R. Hamdani Harahap Ricke Loesnihari Rifda Amaliya Ma’ruf Rizki Doli Hartama Harahap Rumanda Nurhasanah Sanjaya, Angga Nugraha Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sitorus, Panal Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani