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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Narra J JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Pengabdian Kefarmasian Media Farmasi Jurnal Kefarmasian Indonesia
Syamsu Nur, Syamsu
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan: Correlation Between Total Phenolic and Flavonoid Contents of Jati Putih (Gmelina arborea Roxb.) Leaves Extract and Fraction Toward Antioxidant Activity Nur, Syamsu; Sami, Fitriyanti Jumaetri; Awaluddin, Akbar; Afsari, Mutiara Indah Ayu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.042 KB) | DOI: 10.22487/j24428744.2019.v5.i1.12034

Abstract

This experiment aims to determine the correlation of total phenolic and flavonoid content of jati putih leaves fraction (Gmelina arborea Roxb.) towards Antioxidant activity . Sample was extracted by maceration method using ethanol 70% to obtain the ethanol extract (EE), followed by liquid-liquid extraction method to obtain fraction of ethyl acetate (EA) and n-Hexane (EH). The phytochemical screening and determination of total phenolic and flavonoid content were done by colorimetric method. Antioxidant activity were done by DPPH, FRAP and ABTS methods. Phytochemical screening showed positive results for flavonoids, phenolic and saponins. The largest total phenolic content was found on EA (11,59 µg/ml ± 0,3 %b/b EAG) and the largest total flavonoid content was on EA (3,88 µg/ml ± 0,02 %b/b EK). The total phenolic and flavonoid content of Jati putih leaves has a correlation with antioxidant activity. The coefficient correlation of activity on reducingDPPH radical was 56,7% (total of phenolic content) and 57,8% (total of flavonoid content) and on iron reduction power in FRAP method was 99,9% (total of phenolics and flavonoids content). The relationship with the activity in reducing radical ABTS obtained coefficient correlation of 57,0% and 58,1% for total phenolic and flavonoids contents, respectively.
In Silico Evaluation of the Glioma Activity of Reported Compounds from the Extract Rhodomyrtus tomentosa (Aiton) Hassk.) Marwati, Marwati; Alam, Gemini; Yulianty, Risfah; Sami, Fitriyanti J.; Nur, Syamsu; Nursamsiar; Rifai, Yusnita
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10809

Abstract

The plant Rhodomyrtus tomentosa is empirically treated and can be developed in vitro as an anticancer. To see the interaction and evaluate the compound of Rhodomyrtus tomentosa as glioma inhibition, especially on Smoothened receptor by using the in silico. 44 compounds from Rhodomyrtus tomentosa leaf plants obtained from previous studies and native ligands and target proteins were generated through PubChem and RSCB protein database. In silico analysis was performed using various, absorption, distribution, toxicity prediction, and molecular tethering of compounds to smoothened (SMO) target proteins. Drug similarity showed that most of the compounds conformed to Lipinski's rule. The absorption and Distribution analysis of the compounds for each parameter gave different pharmacokinetic profiles according to the physicochemical properties of the compounds. Quercetin, β-sitosterol, and Quercetrin are prediction mutagenic, and Rhodomyrtoxin C and β-amyrenonol compounds are What follows is a prediction genotoxic carcinogenic. The results of docking analysis showed that the leaf compounds of Rhodomyrtus tomentosa leaf compounds that can interact with SMO receptors with the best interaction shown by compound 13 (Rhodomyrtoxin C) with a free bond energy of -9.29 kcal/mol, Quercitrin of-12.72 kcal/mol, 2-(4-hydroxyphenyl)acetic acid -14.24 kcal/mol and β-Sitosterol of -11,61 kcal/mol and has the same key amino acid residues as the native ligand LY2940680 (4-fluro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazine-1yl]piperidin-4-yl} 2 (trifluoromethyl) benzamide )namely Arg400, Asp473 and Glu518. His470, and Asn521. Specific compounds from Rhodomyrtus tomentosa are predicted to be developed as candidates for glioma inhibitors predicted to have the same mechanism of action as Smoothened inhibitors and further research is needed.
Efek Sitotoksik Ekstrak dan Fraksi Umbi Paku Atai Merah (Angiopteris ferox Copel) Terhadap Sel Kanker Payudara T47D: Cytotoxic Effects of Paku Atai Merah (Angiopteris ferox Copel) Tuber Extract and Fractions against T47D Breast Cancer Cells Aisyah, Andi Nur; Nur, Syamsu; Lukitaningsih, Endang; Rumiyati, Rumiyati; Burhan, Asril; Adjara, Syafia Mustika; Rahim, Kurnia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15255

Abstract

The use of natural products has been widely used as a resource of new bioactive chemical compounds. One of them is the Paku Atai Merah (Angiopteris ferox Copel) tuber which has long been used empirically by the Dayak tribe of East Kalimantan as an anti-cancer. The purpose of this study was to determine the anticancer cytotoxic activity of the extract and fractions of Paku Atai Merah tuber against T47D breast cancer cells in vitro. Extract of Paku Atai Merah tubers was obtained by maceration method using ethanol solvent until obtained the ethanolic extract then fractionated using various solvents to obtain n-hexane, ethyl acetate, and aqueous-ethanol fractions. The cytotoxic effect was carried out based on the MTT assay. Phytochemical screening tests showed positive results for the presence of flavonoid, phenolic, tannin, saponin and steroid compounds. The results of the cytotoxic activity study showed that the ethyl acetate fraction had moderate cytotoxic activity in T47D cancer cells with an IC50 value of 84.8 µg/ml. Ethanol extract (513.06 µg/ml) and n-Hexane frsction (881.97 µg/ ml) were also included in the weak category. This study indicates that ethyl acetate fraction can be developed as a supportive therapy for breast cancer treatment.
Screening Bioactivity of Kersen Fruits (Muntingia calabura L.) as a Sunscreens Candidate: Skrining Bioaktivitas dari Buah Kersen (Muntingia calabura L.) sebagai Kandidat Bahan Tabir Surya Nur, Syamsu; Nursamsiar, Nursamsiar; Aswad, Muhammad; Tumigolung, Aprilia Ester Eunike; Risfah Yulianti; Burhan, Asril
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15257

Abstract

Kersen (Muntingia calabura L) fruits have the potential to be used as an active ingredient in sunscreens because of phenolic and flavonoid content that can absorb UV rays. This study aims to determine the percentage of erythema/pigmentation transmission and SPF value as parameters for sunscreen activity. Kersen fruits were extracted by maceration using 96% ethanol. The ethanol extract of Kersen Fruits was also fractionated to separate the components of the active compounds based on the polarity level using n-hexane, ethyl acetate, and ethanol as solvents. The test was carried out using the in vitro method by measuring the ability of the material to absorb ultraviolet light at a wavelength of 292.5-372.5 nm. This research was conducted at concentrations of 100, 200, 400, 600, and 800 µg/mL for ethanol, lyophilisate, n-hexane, and ethanol fractions, while the ethyl acetate fraction concentrations are 50, 100, 150, 200, 250 µg/mL. The results showed the best value at the ethyl acetate fraction concentration of 250 µg/mL with % Te of 5.28 and % Tp of 28.65 and the SPF value of 16.54. Based on the % Te and Tp, the ethyl acetate fraction exhibited protection against erythema and pigmentation with the category of extra protection and based on the SPF value with the category of ultra protection.
Pemberdayaan Masyarakat Desa Sukajaya Sumedang Selatan dalam Produksi Minuman Kesehatan dan Bumbu Rempah berbasis Teknologi Farmasi: Empowering the Sukajaya Village Community South Sumedang in the Production of Health Drinks and Spices based on Pharmaceutical Technology Elya, Berna; Forestrania, Roshamur Cahya; Rahmasari, Ratika; Ariestanti, Donna Maretta; Nur, Syamsu
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i2.5888

Abstract

As a result of observations and joint discussions with the Village Community, information was obtained that there are agricultural products in the form of spices with high annual production quantities. However, the selling value of these spices still needs to be improved. Technology has not touched them and has yet to be managed optimally. Therefore, the team empowers the community to process herbs into food products, namely health drinks and spices based on pharmaceutical technology. This activity aims to improve community welfare and mutual elements of human resources in the region. This activity was attended by 28 community members who are Partners and Village Officials. Social empowerment of the society involved in the downstream activities of agricultural products in Sukajaya Village will be carried out through socialization stages, FGD with society and village officials, establishing a micro business plan for downstream health drink products and spices building production facilities, and assistance. This activity produces products in spices, health drinks, and herbal candy. At least 80-90% of the community understands each stage of the activity so that it can become a provision for self-development. The output of this activity is in the form of innovative products, such as health drinks and spice products, which can increase partner empowerment.
Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

Abstract

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.
Effect of Solvent Polarity on Antioxidant and Antidiabetic Activity of Kesambi Leaf Extract (Schleichera oleosa L.) Nursamsiar, Nursamsiar; Marwati, Marwati; Sami, Fitriyanti J.; Nur, Syamsu; Kasmawati, Henny; Asnawi, Aiyi
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9439

Abstract

Kesambi (Schleichera Oleosa (L.) is one of the beneficial plants in Indonesia which contains fenolic and flavonoids that exhibit antioxidant properties. The presence of antioxidants in plants could be associated with antidiabetic activity of these plants. This research was conducted to determine the antioxidant and antidiabetic activities of n-hexane, ethyl acetate, acetone and methanol extracts from Kesambi leaves. Extraction was carried out by the ultrasonic assisted extraction (UAE) method. The antioxidant activity was determined quantitatively by DPPH and ABTS method, while the antidiabetic activity was evaluated by using α-glukosidase inhibition method. The IC50 values from the determination of antioxidant and antidiabetic activities were obtained by using Microplate reader at the maximum wavelength. Results of the antioxidant determination DPPH method showed that IC50 values of n-hexane, ethyl acetate, acetone and methanol extracts were 414.1993; 57.7862; 6.33 dan 13.4558 µg/mL, respectively. And for ABTS method showed 162.679; 22.6684; 10.7975; dan 146.869 µg/mL. This indicates the acetone and methanol extracts give the best results in antioxidant activity. Meanwhile, IC50 values of in vitro antidiabetic activity of n-hexane, ethyl acetate, acetone and methanol extracts were 99.3235; 272.8723; 1.6799; dan 24.4653 µg/mL, respectively. Acetone and methanol extracts of kesambi leaf give the best results in antidiabetic activity.
Cytotoxic Effect, Antibacterial Activity, and in Silico Evaluation of Berberine Compound from Methanolic Extract of Arcangelisia flava Merr Stems Sami, Fitriyanti Jumaetri; Nur, Syamsu
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Menispermaceae family has 72 genera and more than 400 species, geographically distributed in Asia, Africa, America, and Oceania. The plants of this family are known to have high alkaloid content. One genus of this family is Arcangelisia, with only one species known as Arcangelisia flava Merr. This plant is used as traditional medicine for ailments such as diarrhea, jaundice, and malaria. Therefore, this study was to isolate the alkaloid compounds and test the antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as their toxicity to the shrimp larvae. The isolated compound was confirmed for in silico activity against the target proteins 1UAG (E. coli) and 7RM7 (S. aureus). Based on the analysis of spectroscopic data, UV VIS, FT IR, and NMR, one alkaloid compound was successfully isolated and determined to be a berberine compound. Methanol extract and berberine test against Artemia salina shrimp larvae exhibit active toxicities with LC50 values of 89.13 µg/mL and 75.86 µg/mL, respectively. Antibacterial test result shows that methanol extract and berberine are more active against E. coli than S. aureus. The in-silico activity of the berberine compound supports the result of in vitro antibacterial evaluation. A. flava plant extract has biological capabilities as an anti-microbial and cytotoxic effect, so further development can be carried out in utilizing A. flava plant extract as an effective natural medicine candidate.
Co-Authors Adjara, Syafia Mustika Afsari, Mutiara Indah Ayu Agustina Aisyah, Andi Nur Aiyi Asnawi Amrullah, Akhmad Andi Ardiansyah Arifin Ariestanti, Donna Maretta Astuti Amin Awaluddin, Akbar Azizah, Suhaimi Berna Elya Biring, Frans Syukur Burhan, Asril Djamaluddin, Suci F Elly Wahyudin Endang Lukitaningsih Erma Yunita Fadilah Qonitah Fajriati, Annisa Firzan Nainu Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami, Fitriyanti Jumaetri Forestrania, Roshamur Cahya Gemini Alam Hardiyanti, Widya Hayun Hayun, Hayun Herlina Rante Indradewa, Rhian Irwana, Rina Ivone P., Velyostri Kasmawati, Henny Keyzia, Kurnia Khairi, Nur Khairuddin - Kharismatul Khasanah Kusmardi Kusmardi Latada, Nadila P. Latifah Rahman Lumi, Stefanus Agustinus Mamada, Sukamto S. Marianti A Manggau Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Matandung, Friska Nissa Maulita Indrisari, Maulita Megawati Megawati - Mistriyani, Mistriyani Muhammad Aswad Munawarah Munawarah, Munawarah Mus, Suwahyuni Muslimin, Lukman Novi Fajar Utami Nurjannah Nursamsiar Nursamsiar Nursamsiar Nurul Jannah paluseri, Andi Payung, Deslin Pratama, Nofran Putra Putri Indah Sayakti Rahim, Kurnia Rahman, Annisa Amirah Rahmasari, Ratika Reny Syahruni Risfah Yulianti Risfah Yulianty Rosyid, Sujud Z Rumiyati, Rumiyati Salampe, Mirnawati Sami, Fitriyanti Sami, Fitriyanti J. Sari, Rifta SEPTI WULANDARI Shelina, Vivi Sitti Rahimah, Sitti Solly Aryza Sukriani Kursia, Sukriani Tonapa, Novianti Triana Hertiani Tumigolung, Aprilia Ester Eunike Umar, Abdul H. Utami, Novi F. Wahyuddin, Nurzadrina Yusnita Rifai, Yusnita Zulbayu, L.M. Andi