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All Journal Majalah Kedokteran Gigi Indonesia Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Padjadjaran Journal of Dentistry Dentin Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Ichrom Nahzi, Muhammad Yanuar
Bagian Konservasi Gigi, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat, Banjarmasin, Kalimantan Selatan, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Energy Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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PENGARUH EKSTRAK KULIT MANGGIS (GARCINIA MANGOSTANA L.) TERHADAP JUMLAH NEUTROFIL PADA INFLAMASI PULPA Studi In Vivo pada Tikus Wistar Jantan Lutfiyah Lutfiyah; Muhammad Yanuar Ichrom Nahzi; Suka Dwi Raharja
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.575

Abstract

ABSTRACK  Background:Indonesia has various numbers of plants with medicinal contents; one of them is mangosteen (Garcinia mangostana L.). Mangosteen pericarp which is regarded as waste turns out to have benefits to health. Mangosteen pericarp extract contains chemical substances such as saponin, tannin, flavonoid, steroid, quinon, and xanthone. These substances have many benefits, one of them is antiinflammatory properties.Purpose: The aim of this study was to assess the effect of mangosteen pericarp extract on neutrophils count in wistar rats’ pulp inflammation. Methods:This study was true experimental with post-test only with control design. Samples used were 39 male wistar rats divided into 3 treatment groups: no treatment group (negative control), mangosteen pericarp extract treatment group, and calcium hydroxide treatment group (positive control). Samples were analyzed histopathologically on day 1, 3, 5, and 7.Result: The result presented mean scoring of neutrophils in mangosteen pericarp extract treatment group as 13,33 on day 1, 10,00 on day 3, 4,33 on day 5 and 2,33 on day 7. Two way ANOVA and Post Hoc LSD tests indicated that there was a significant difference between mangosteen pericarp extract treatment group and no treatment group and calcium hydroxide treatment group with p value of < 0,05. Conclusion:There was a significant effect of mangosteen pericarp extract on neutrophils count in wistar rats’ pulp inflammation compared to calcium hydroxide in decreasing neutrophils count.  Keywords: mangosteen pericarp extract, Garciniamangostana L., anti-inflammatory, neutrophils, pulp inflammation,pulp capping.  ABSTRAK  Latar Belakang: Indonesia merupakan negara yang memiliki berbagai jenis tanaman yang berguna sebagai tanaman obat, salah satunya adalah buah manggis (Garcinia mangostana L.). Kulit buah manggis yang selama ini dibuang ternyata memiliki banyak manfaat bagi kesehatan. Kulit buah manggis mempunyai kandungan kimia berupa saponin, tanin, flavonoid, steroid, kuinon, dan xanthone. Kandungan tersebut memiliki banyak manfaat salah satunya sebagai antiinflamasi.Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis (Garcinia mangostana L.) terhadap jumlah neutrofil pada inflamasi pulpa gigi tikus wistar.Metode: Penelitian ini merupakan eksperimental murni dengan post-test only with control design. Sampel terdiri atas 39 tikus Wistar dengan jenis kelamin jantan yang dibagi menjadi 3 kelompok perlakuan yaitu kelompok tanpa obat (kontrol negatif), kelompok ekstrak kulit manggis (perlakuan) dan kelompok kalsium hidroksida (kontrol positif). Sampel dianalisis secara histologis pada hari ke-1, 3, 5 dan 7. Hasil penelitian menunjukan nilai rata-rata jumlah neutrofil ekstrak kulit manggis adalah 13,33 pada hari ke- 1, 10,00  pada hari ke-3, 4,33 pada hari ke-5 dan 2,33 pada hari ke 7.Hasil: Hasil two way ANOVA dan Post Hoc LSD menunjukan bahwa terdapat perbedaan bermakna antara kelompok ekstrak kulit manggis dengan kelompok tanpa obat dan kelompok kalsium hidroksida dengan nilai p<0,05.Kesimpulan: Terdapat pengaruh ekstrak kulit manggis (Garcinia mangostana L.) terhadap jumlah neutrofil pada inflamasi pulpa gigi tikus wistardibandingkan kalsium hidroksida yaitu terjadi penurunan jumlah neutrofil pada kelompok ekstrak kulit manggis dibanding kelompok kalsium hidroksida.Kata-kata kunci:  ekstrak kulit manggis, Garcinia mangostana L. antiinflamasi, neutrofil, inflamasi pulpa,pulp capping
KEBOCORAN MIKRO AKIBAT EFEK SUHU TERHADAP PENGERUTAN KOMPOSIT NANOHYBRID Gusti Gina Permata Sari; Muhammad Yanuar Ichrom Nahzi; Widodo Widodo
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.551

Abstract

ABSTRACTBackground: Composite is broadly used by dental practitioners as restoration material to treat caries. Nanohybrid composite is a type of composite composed of nano-sized filler combined with larger filler. Polymerization shrinkage commonly occurs in every restoration using composite, resulting in a gap between cavity margin and teeth structure, which eventually leads to microleakage. Purpose: The purpose of this study was to assess and measure the rate of nanohybrid composite microleakage as a result of temperature change from 5ºC to 60ºC. Methods: This study was true experimental with post test-only with control design. Specimens used were 20 maxillary premolars, divided into 2 groups: 5ºC to 60ºC temperature change treatment group and control group (without temperature change, sitting idly at 37ºC).  Results: Mean scoring of treatment group was 3 and control group was 1,9. Conclusion: It can be concluded that independent samples T-test presented significant difference between treatment group and control group.  ABSTRAKLatar Belakang: Komposit merupakan suatu bahan restorasi yang biasa digunakan oleh dokter gigi untuk menumpat gigi yang karies. Komposit nanohybrid merupakan salah satu jenis komposit yang memiliki komposisi filler berukuran nano dan digabung dengan filler yang berukuran besar. Pengerutan polimerisasi merupakan hal yang selalu terjadi pada setiap penumpatan dengan bahan komposit. Akibat dari pengerutan adalah terbentuknya celah antara tepi kavitas dan struktur gigi, hal tersebut akan menyebabkan kebocoran mikro. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui adanya kebocoran mikro pada komposit nanohybrid akibat perubahan suhu 5ºC ke 60ºC serta mengukur besar kebocoran mikro yang terjadi. Metode: Jenis penelitian ini merupakan eksperimental murni dengan rancangan post test-only with control design. Penelitian ini menggunakan gigi premolar rahang atas sebanyak 20 buah yang dibagi menjadi 2 kelompok, yaitu kelompok perlakuan perubahan suhu 5ºC ke 60ºC, dan kontrol yang tidak dilakukan perubahan suhu atau didiamkan pada suhu 37ºC. Hasil: Rata-rata skor untuk kelompok perlakuan adalah 3 dan kelompok kontrol adalah 1,9. Kesimpulan: Dapat disimpulkan bahwa hasil uji T-test tidak berpasangan  menunjukkan perbedaan yang bermakna antara kelompok perlakuan dan kelompok kontrol.
KEBOCORAN TEPI RESTORASI RESIN KOMPOSIT NANOHYBRID SETELAH PERENDAMAN DALAM AIR SUNGAI DESA ANJIR PASAR Panji Kurniawan; Isyana Erlita; Muhammad Yanuar Ichrom Nahzi
Dentino : Jurnal Kedokteran Gigi Vol 2, No 1 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i1.2607

Abstract

ABSTRACTBackground: Composite resin is broadly used by dental practitioners as restoration material to treat caries. Nanohybrid composite resin is a type of composite resin composed of nano-size filler combined with larger filler. Composite resin has water absorption characteristic which tends to solute when it reacts with acid (low pH). Result from both of those characteristics is formation of a gap between restoration and cavity edge, which eventually leads to micro-leakage. Purpose: The aim of this study was to assess and measure the rate of nanohybrid composite resin micro-leakage as a result of submersion in water with acid characteristic (low pH). Methode: This study was a true experimental using posttest-only with control group design. Samples used were 20 maxillary premolars, divided into 2 groups: river water immersion which has acid characteristic (low pH) as treatment group, and sterile aquades immersion which has neutral characteristic (pH 7) as control group. Result: The result of Mann-Whitney showed a significant difference between the treatment group with the mean score of 4,00 and control group with the mean score of 3,00. Conclusion: Based on the study it can be concluded that there was a significant difference in micro-leakage effect of river water immersion and sterile aquades immersion on nanohybrid resin composite restorasion.Keywords: nanohybrid composite resin, acid pH, micro-leakage.
EFFECT OF DIAMETRAL TENSILE STRENGTH OF BULK FILL COMPOSITE RESIN WITH THE ADDITION OF SUGARCANE WASTE FIBER Isyana Erlita; Yusuf M. Hernandi; Muhammad Yanuar Ichrom Nahzi
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4599

Abstract

Backgrounds: Bulk fill composite resin is a composite resin type which can be polymerized as deep as 4 mm and is indicated for posterior tooth restoration. Most posterior tooth restorations become fractured because of the composite resins that are not able to withstand the tensile stress that happens. Efforts to increase diametral tensile strength is by adding fiber. The use of natural fibers can be an alternative because it is environmentally friendly and inexpensive. One of the natural fibers is fiber bagasse (Saccharum Officinarum L.). Purpose: To know the influence of composite resin diametral tensile strength value in bulk fill  with the addition of bagasse fiber. Methods: Experimental laboratory studies with post-test designs only with control group designs. The experiment of consist 36 samples which divided into 3 groups. Group I non-fiber bulk fill resin composite, group II filling composite with bagasse fibers and group III filling composite resins with glass fibers as a control group. The sample are immersed in saline solution and incubated for 24 hours at 37° C. Then sample tested its diametrically tensile strength using a Universal Testing Machine. Data analysis used One Way Anova test with significance value of 0,001 (p<0,05), followed by Post Hoc Bonferroni. Results: Post Hoc Bonfferoni test obtained p value= 0.001 (p<0.05), which means there are significant differences between the three groups where the group with the addition of glass fiber obtained the highest diametral tensile strength value. Conclusion: the addition of bagasse fiber affects the diametral tensile strength and can increase the diametral tensile strength of the bulk fill composite resin.
THE EFFECT OF AIR DRYING TIME ON BONDING (SELF ETCH) WITH ETHANOL AS A SOLVENT TO THE SHEAR BOND STRENGTH OF BIOACTIVE COMPOSITE RESIN Devi Rosalinda; Dewi Puspitasari; Muhammad Yanuar Ichrom Nahzi
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10643

Abstract

ABSTRACTBackground: Surface resistance between composite resin and dentin is currently one of the problems of restorative materials. Failure ofcomposite resin are still being reported in clinical studies with failure rates ranging between 5-45% based on observations for 5-17 years. Bioactive composite resin is a new type of composite resin that has mechanical and chemical properties similiar to teeth. The use of resins, bonding materials, drying time of the solvent, and type of solvent also affect the shear bond strength Purpose: The purpose of this study was to analyze the effect of air drying time bonding (self-etch) with ethanol as a solvent on the shear bond strength of bioactive composite resins. Methods: This study used 32 non-carious maxillary premolar teeth that were fixed using acrylic resin. Fiber glass with a diameter of 3 mm and thickness of 3 mm were fixed to dentin surface and applied using bioactive composite resin were divided into 4 treatment group, i.e. the group without air drying, 20 s, 40 s, and 60 s. Shear bond strength test using Universal Testing Machine. Results: One Way Anova and Post Hoc Bonferroni test showed significant differences with p=0,002 (p<0,05). The average shear bond strength value of the lowest bioactive composite resin in the group bonding without air drying with a value of 6.381 ± 2.818 MPa and the highest shear bond strength value of the bioactive composite resin in the 60 seconds bonding air drying group with a value of 11.873 ± 2.931 MPa. Conclusion: The air drying time of the bonding affects the shear bond strength of the bioactive composite resin.Keywords: Air drying time, bioactive composite resin, bonding, ethanol, shear bond strength.
THE EFFECT OF MAULI BANANA (Musa acuminata) STEM EXTRACT ON MACROPHAGE CELL NUMBER IN PULP INFLAMATION (In Vivo Study In Male Wistar Rat (Rattusnovergicus) Teeth) Nadia Dewi Astuti; Maharani Laillyza Apriasari; Muhammad Yanuar Ichrom Nahzi
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4616

Abstract

Background: Reversible pulpitis is a mild to moderate inflammatory condition of the pulp which often given pulp capping therapy as their treatments. Commonly used or "gold standard" material for pulp capping therapy is calcium hydroxide, but this material has side effect as an active therapeutic or chemical agent that can cause necrosis due to high pH. Mauli banana stem extract contains tannin and saponin compounds which have immunomodulatory properties that play a role in the pulp inflammatory process by increasing the number of macrophage. Objective: To prove the effect of mauli (Musa acuminata) banana extract gel concentration 37,5% upon macrophage cell count in pulp inflammation at day 3 and compare it with calcium hydroxide (Ca(OH₂)). Methods and Materials: This research was a pure experimental study with post-test only control group design. This research used 3 treatment groups, which were a group of mauli banana group of mauli banana extract gel 37,5% as treatment group, a group of calcium hydroxide as positive control group and a group of Hydroxypropyl Methyl Cellulose (HPMC) gel as negative control. Research Result: One Way Anova test results obtained p value = 0.0001 which means that there was a significant difference. Data analysis continued with Post Hoc Least Significant Difference (LSD) test which showed that there was significant difference between mauli banana extract gel concentration 37,5% with calcium hydroxide group with p value = 0,001 and with HPMC gel group p value = 0, 0001 (p <0,05), and there was no significant difference between the calcium hydroxide group and HPMC gel with p= 0,054 (p> 0,05). Conclusion: Provision of mauli banana extract gel 37,5% concentration can increase the number of macrophage cells on pulp inflammation on the 3rd day.
THE EFFECT OF KARAMUNTING (Rhodomyrtus Tomentosa) LEAF EXTRACT ON THE NUMBER OF MACROPHAGES IN PULP INFLAMMATION Indah Septiani; Muhammad Yanuar Ichrom Nahzi; Nolista Indah Rasyid
Dentino : Jurnal Kedokteran Gigi Vol 6, No 2 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i2.11994

Abstract

Background: Reversible pulpitis is an inflammation of dental pulp caused by the opening of the pulp due to cavities. One of the procedures in exposed pulp treatment is direct pulp capping using calcium hydroxide. However, this material has side effects, its high pH can cause necrosis, and due to that, a safer alternative material is needed. Karamunting leaf extract contains phenolic compounds, flavonoids, tannins, and saponins which have immunomodulatory properties that play an important role in healing exposed pulp. Objective: To determine the effect of karamunting leaf extract on the number of macrophages in pulp inflammation. Methods: This was a true experimental research with posttest-only group design, using simple random sampling that consist of 24 male Wistar rats which later be divided into 3 groups. The perforated rat dental pulp was then treated with karamunting leaf extract as a treatment group, calcium hydroxide as a positive control group, and not given any application (without drug) as a negative control group. The samples were analyzed histologically on the 3rd to 7th day after the application, inflammatory response occurred in all groups. Results: The two-way ANOVA results showed that there was a significant difference between the karamunting leaf extract group, the group that was not given drug, and the group given calcium hydroxide with a value p<0.05. Conclusion: Based on the research conducted, it is concluded that the administration of karamunting leaf extract can reduce the number of macrophages in pulp inflammation. Keywords: calcium hydroxid, exposed pulp, karamunting leaf, macrophages, pulp inflammation.
KEKASARAN PERMUKAAN RESIN-MODIFIED GLASS IONOMER CEMENT SETELAH PERENDAMAN DALAM AIR SUNGAI (Penelitian Menggunakan Air Sungai Desa Anjir Pasar, Barito Kuala, Kalimantan Selatan) Anindya Putri Permatasari; Muhammad Yanuar Ichrom Nahzi; Widodo Widodo
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.565

Abstract

ABSTRACT  Background:Resin-modified glass ionomer cement is a hybrid form of glass ionomer cement and resin. Added resin (HEMA) in this material allows its characteristics to improve, especially its resistance of acid.The water of  Desa Anjir Pasar River has acidic nature with pH as low as 3-5.Purpose: The aim of this studywas to find surface roughness difference of resin modified glass ionomer cement after being soaked in the water of Anjir Pasar Village River compared to aquadest-soaked materials.Method:This study was true experimental used posttest only with control group design. Samples used resin-modified-glass ionomer cement specimenswhich were prepared in cylindrical-shaped with diameter of 10 mm and thickness of 2 mm. One groupwassoaked in aquadest (control) andanother group in river water with pH of 4,07for 4,5 days (equivalent to 3 years of exposure) before measuring the surface roughness of each group. Data was analyzed using parametric analysis Independent T-Test 95% (α = 0,05) which presented p value = 0,03 (p<0,05). Result:The result indicated that there was a significant difference of surface roughness between resin modified glass ionomer cement soaked in the water of Anjir Pasar Village River with pH of 4,07 for 4,5 daysand in the aquadest.Conclusion: Based on this study it was concluded that resin-modified glass ionomer cement which soaked with river water has higher surface roughness that resin-modified glass ionomer cement which soaked with sterile aquadest.   Keywords: Resin-Modified Glass Ionomer Cement, river water, surface roughness  ABSTRAK  Latar Belakang:Resin-modified glass ionomer cement merupakanhybrid dari glass ionomer cement dengan resin. Penambahan bahan resin (HEMA) memperbaiki sifatnya, yaitu ketahanan terhadap asam.Air Sungai Desa Anjir Pasar memiliki karakteristik asam dengan rentang pH 3-5.Tujuan:Tujuan penelitian ini untukmengetahuiperbedaan kekasaranpermukaanbahanresin-modified glass ionomer cement setelahdilakukanperendaman dalam air Sungai Desa Anjir Pasar dan akuades steril. Metode: Penelitian ini merupakan penelitian eksperimental murni dengan rancangan posttest only with control group design. Sampel penelitian ini menggunakan spesimen resin-modified glass ionomer cement dibuat berbentuk silindris dengan diameter 10 mm dan ketebalan 2 mm. Masing-masing kelompok direndam dalam akuades steril (kontrol) dan air sungai pH 4,07 selama 4,5 hari (sama dengan 3 tahun pemaparan), kemudian dihitung kekasaran permukaannya. Data diuji menggunakan analisis parametrik Independent T-Test 95% (α = 0,05) dan didapatkan p=0,03 (p<0,05). Hasil: Hasil penelitian menunjukkan bahwa terdapat perbedaan kekasaran permukaan yang bermakna pada resin-modified glass ionomer cement antara perendaman dalam air sungai pH 4,07 selama 4,5  dengan perendaman dalam akuades steril.Kesimpulan: terdapat perbedaan kekasaran yang lebih besar pada bahan resin-modified glass ionomer cement yang direndam dalam air sungai daripada yang direndam akuades steril.   Kata-kata kunci:  Resin-modified Glass Ionomer Cement, Air Sungai, Kekasaran Permukaan
TOXICITY TEST OF DAYAK ONION BULBS EXTRACT (Eleuthherine palmifolia (L) Merr) ON Artemia salina LEACH USING BSLT METHOD (Preface Study As Root Canal Irrigation Materials) Khairunnisa Khairunnisa; Muhammad Yanuar Ichrom Nahzi; Sherli Diana
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4609

Abstract

Background: Dayak onion (Eleutherine palmifolia (L) Merr) is a native plant from Central Kalimantan, which contains active compounds as anti-bacterials that can be used as an alternative material for root canal irrigation. High toxicity is one of the causes of root canal failure, so it takes a toxicity test to determine the toxic effects of the dayak onion bulbs extract. Purpose: To analyze the difference of toxic effects with various concentrations of dayak onion bulbs extract on Artemia salina Leach using BSLT method. Material and Methods: This study used true experimental research design, namely post-test only with control group design treated with 11 different treatments, which were dayak onion bulbs extract with concentrations 10 mg/ml, 20 mg/ml, 30 mg/ml, 40 mg/ml, 50 mg/ml, 60 mg/ml, 70 mg/ml, 80 mg/ml, 90 mg/ml, 100 mg/ml and sea water as its negative control, and done with 3 times repetitions. Result: The result of the probit analysis in the amount of LC50 was 70,371 mg/ml. The data analysis used Shapiro-Wilk and Levene’s Test results p > 0,05 means that all the data was normally distributed and homogenous. Further test with One Way Anova obtained result p < 0,05 which means there was a significant difference in the number of dead larvae between concentrations. Further test with Pos-hoc LSD obtained result that there was a significant difference at concentration 100 mg/ml with 10 mg/ml with value p=0,001. Conclusion: The highest toxic effect on dayak onion bulbs extract on Artemia salina Leach is at concentration of 100 mg/ml.
PENGARUH EKSTRAK KULIT MANGGIS (GARCINIA MANGOSTANA L.) TERHADAP JUMLAH SEL LIMFOSIT PADA INFLAMASI PULPA Studi In Vivo pada Gigi Molar Rahang Atas Tikus Putih Wistar Jantan Anis Belinda Zayyan; Muhammad Yanuar Ichrom Nahzi; Ika Kustiyah O.
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.559

Abstract

ABSTRACK  Background: Mangosteen is one of Indonesian’s favorite. Mangosteen pericarp extract contains saponin, tannin, flavonoid, xanthone and its derivatives, alpha-mangosteen, beta-mangosteen, and gamma-mangosteen, which have anti-inflammatory properties. Purpose: The aim of this study is to assess the effect of mangosteen pericarp extract on lymphocytes count in pulp inflammation and compare it to calcium hydroxide on day 1, 3, 5, and 7. Methods: This study was true experimental with pretest-posttest with control group design. Samples used were 39 white wistar (Rattus novergicus) rats divided into 3 groups of mangosteen pericarp extract treatment group, calcium hydroxide treatment group and no treatment group. Lymphocytes count was observed microscopically in zig zag fields of view. Result: The result presented mean scoring of lymphocytes in mangosteen pericarp extract treatment group as 3,67 on day 1, 6 on day 3, 11 on day 5, and 7,67 on day 7. Lymphocytes count reached its peak on day 5. Two way ANOVA and Post Hoc LSD tests indicated that there was significant difference between mangosteen pericarp extract treatment group and no treatment group, between mangosteen pericarp extract treatment group and calcium hydroxide treatment group, and between calcium hydroxide treatment group and no treatment group. Conclusion: There was a significant effect of mangosteen pericarp extract on lymphocytes count in wistar rats’ pulp inflammation compared to calcium hydroxide in decreasing lymphocytes count.  Keywords: pulp inflammation, lymphocytes, mangosteen pericarp extract, calcium hydroxide, antiinflammatory, pulp capping.  ABSTRAK  Latar Belakang: Manggis merupakan buah yang digemari oleh masyarakat Indonesia. Ekstrak kulit manggis mengandung saponin, tanin, flavonoid, xanthone dengan turunannya alpha-mangostin, beta-mangostin, dan gammamangostin, yang berfungsi sebagai anti-inflamasi. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis terhadap jumlah sel limfosit pada proses inflamasi pulpa dan membandingkannya dengan kalsium hidroksida pada hari 1, 3, 5 dan 7. Metode: Jenis penelitian ini merupakan eksperimental murni dengan rancangan pretest-posttest with control group. Penelitian ini menggunakan 39 tikus putih (Rattus norvegicus) wistar yang dibagi menjadi 3 kelompok, yaitu kelompok perlakuan ekstrak kulit manggis, kelompok kalsium hidroksida, dan kelompok tanpa obat. Jumlah limfosit dilihat secara mikroskopis dan dihitung secara zig-zag. Hasil: Hasil penelitian menunjukan skoring rata-rata jumlah sel limfosit perlakuan ekstrak kulit manggis hari 1 (3,67), hari 3 (6), hari 5 (11), dan hari 7 (7,67). Jumlah sel limfosit mencapai puncak pada hari ke-5. Hasil uji Two Way ANOVA dan uji Post hoc LSD menunjukkan bahwa terdapat perbedaan bermakna antara kelompok ekstrak kulit manggis dan tanpa obat, antara kelompok ekstrak kulit manggis dan kalsium hidroksida dan antara kalsium hidroksida dan tanpa obat. Kesimpulan: Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa pemberian ekstrak kulit manggis berpengaruh terhadap jumlah sel limfosit pada inflamasi pulpa gigi tikus wistar dibandingkan kalsium hidroksida dilihat dari penurunan jumlah sel limfosit pada kelompok ekstrak kulit manggis dibandingkan kelompok kalsium hidroksida.
Co-Authors A.M. Dewi Fathiya Julianti Aanisah Ramadamayati Agung Satria Wardhana Aida Yanti Aisya Nadhifa Ahmad Ajeng Zelline Ameriagitri Aldo Giovanni Amy Nindia Carabelly Andi Lukman Anindya Putri Permatasari Anindya Putri Permatasari, Anindya Putri Anis Belinda Zayyan Anis Belinda Zayyan, Anis Belinda Armanda, Ferdio Aspriyanto, Didit Astuti Noviyani Astuti, Nadia Dewi At-Thoyyar, Aila Aulia Rusmayati Aulia, Noor Rizki Basri, M. Hasriandy Candra Bayu Indra Sukmana Buyung Maglenda Cindy Dwintanandi Cindy Dwintanandi, Cindy Devi Rosalinda Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi, Renie Kumala Diana Wibowo Dinda Nur Rusyida Dini Permata Sari Dwi Raharja, Suka Endah Amalia Sari Eriwati, Yosi Kusuma Erni Marlina Fathiya Julianti, A.M. Dewi Ferdio Armanda Ferdy Rijaldi Furnama Winda Sari Ganesh, Rajendran Grina Adila Milawati Gusti Gina Permata Sari Gusti Gina Permata Sari, Gusti Gina Haliza, Ninda Andrea Hamdani, Riky Hanifah Mulyani Hasbullah, Irnamanda Dwipura Yakin Hatta, Isnur Hernandi, Yusuf M. Huldani Huldani I Made Yudha Dharmawan Ika Kustiyah O. Ika Kusuma Wardani Imanuella, Diandra Indah Septiani Juli Harnida Purwaningayu Khairunnisa Khairunnisa Khairunnisa Khairunnisa Kustiyah O., Ika Lia Yulia Budiarti Lukman, Andi Lutfiyah Lutfiyah Lutfiyah Lutfiyah Luthfie Haq M. Hasriandy Candra Basri Maharani Laillyza Apriasari Maria Tanumihardja, Maria Melisa Budipramana, Melisa Muhammad Muamar Khadafi Muhammad Nabiel Taqiyuddin Ham Muhammad Zainal Fikri Mustika Meisy Riyana Nadia Dewi Astuti Nida Amalia Nolista Indah Rasyid Noor Rizki Aulia Nor Azizatur Rosidah Nor Diane Razibi Nor Rahman Sugiarto Nor Rahmatika, Aniqah Nurrahman, Tri Panji Kurniawan Phradina Fili Septishelya Purwaningayu, Juli Harnida Raharja, Suka Dwi Rahmad Arifin Ratih Yusnita Razibi, Nor Diane Reisa Dahliani Rizki Fajar Fauzan Rosihan Adhani, Rosihan Rusmayati, Aulia Sadsyam, Titien Marwah Saiful Akhyar Lubis Sari, Galuh Dwinta Sarifah, Norlaila Selvia Shella Setyawardhana, Raden Harry Dharmawan Shella, Selvia Sherli Diana Sitepu, Alexander Siti Rohmah Suka Dwi Raharja Talitha Maghfira Ramadhinta Talitha Maghfira Ramadhinta, Talitha Maghfira Taqwa Handraji Manto Tomy Wira Wahyuda Tri Putri, Deby Kania Utami, Juliyatin Putri Virlia Putri Rachmayani Waty, Marsela Umbar Widodo Widodo Widodo Widodo Widyandini Aulia Arif Yusrinie Wasiaturrahmah Yusuf M. Hernandi