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Bagas Ardiyantoro
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Pegaruh Salep Ekstrak Kulit Kacang Tanah (Arachis Hypogaea L.) terhadap Penyembuhan Luka Sayat pada Kelinci Jantan New Zealand White Rahmawati; Septian Maulid Wicahyo; Bagas Ardiyantoro
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Bulan Oktober
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i2.297

Abstract

Latar belakang: Luka sayat merupakan salah satu jenis luka yang sering terjadi akibat benda tajam dan memerlukan penanganan tepat agar proses penyembuhan optimal. Kulit kacang tanah (Arachis hypogaea L.) mengandung flavonoid, tanin, saponin, alkaloid, dan terpenoid yang berpotensi sebagai antioksidan, antiinflamasi, dan antibakteri. Tujuan: Penelitian ini bertujuan mengetahui pengaruh salep ekstrak kulit kacang tanah terhadap penyembuhan luka sayat pada kelinci jantan, mengevaluasi mutu fisik sediaan, dan menentukan konsentrasi paling efektif. Metode: Penelitian eksperimental laboratorik dengan rancangan Posttest Only Group Design menggunakan kelinci jantan New Zealand White yang dibagi menjadi lima kelompok, yaitu kontrol negatif, kontrol positif (Betadine®), serta salep ekstrak konsentrasi 5%, 10%, dan 15%. Parameter meliputi mutu fisik, penyusutan panjang luka, persentase penyembuhan, dan Area Under Curve (AUC). Hasil: Seluruh formula memenuhi persyaratan mutu fisik. Salep ekstrak kulit kacang tanah berpengaruh terhadap penyembuhan luka, dengan konsentrasi 15% menunjukkan efektivitas terbaik berdasarkan nilai AUC dan persentase penyembuhan. Kesimpulan: Salep ekstrak kulit kacang tanah berpengaruh terhadap penyembuhan luka sayat dan memenuhi persyaratan mutu fisik. Variasi konsentrasi memengaruhi efektivitas penyembuhan luka.
Formulasi dan Uji Antibakteri Sediaan Sabun Padat Kombinasi Ekstrak Etanol Daun Pepaya Jepang (Cnidoscolus Aconitifolius) dan Minyak Serai Wangi (Cymbopogon Nardus L.) terhadap Bakteri Staphylococcus Aureus ATCC 25923 Chofifatun Mubarokah; Anna Fitriawati; Bagas Ardiyantoro
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Bulan Oktober
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i2.298

Abstract

Latar Belakang: Staphylococcus aureus merupakan bakteri penyebab infeksi kulit yang umum dijumpai. Bahan alam seperti minyak atsiri serai wangi (Cymbopogon nardus L.) dan ekstrak etanol daun pepaya Jepang (Cnidoscolus aconitifolius) berpotensi dikembangkan sebagai antibakteri dalam sediaan sabun padat. Tujuan: Penelitian ini bertujuan memformulasikan kombinasi ekstrak etanol daun pepaya Jepang dan minyak atsiri serai wangi dalam sediaan sabun padat, mengevaluasi mutu fisik, serta mengetahui aktivitas antibakterinya terhadap S. aureus ATCC 25923. Metode: Penelitian eksperimental laboratorium dilakukan dengan ekstraksi daun pepaya Jepang menggunakan metode maserasi etanol 70% dan perolehan minyak atsiri serai wangi melalui destilasi uap. Kombinasi bahan aktif diformulasikan menjadi tiga formula (F1, F2, dan F3). Evaluasi meliputi organoleptik, homogenitas, pH, tinggi busa, kadar air, asam lemak bebas, bahan tak larut etanol, lemak total, iritasi, dan hedonik. Aktivitas antibakteri diuji menggunakan metode difusi cakram. Hasil: Seluruh formula memenuhi persyaratan mutu fisik berdasarkan SNI dan menunjukkan aktivitas antibakteri. Formula dengan konsentrasi bahan aktif tertinggi menghasilkan daya hambat terbesar. Kesimpulan: Kombinasi kedua bahan aktif berhasil diformulasikan menjadi sabun padat yang memenuhi persyaratan mutu fisik dan memiliki aktivitas antibakteri terhadap S. aureus ATCC 25923.
Pengaruh Pemberian Fraksi Etil Asetat Daun Kelor (Moringa Oleifera Lamk.) terhadap Daya Ingat Mencit Jantan dengan Menggunakan Metode Labirin Y-Maze Bagas Ardiyantoro; Muhamad Farid Nurohman Krisnadi; Danang Raharjo
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8021

Abstract

Memory decline is an early symptom of neurodegenerative disorders such as dementia, often caused by oxidative stress due to an imbalance between the production of Reactive Oxygen Species (ROS) and the body’s antioxidant defense system. Moringa leaves (Moringa oleifera Lamk.) are known to contain flavonoids, particularly quercetin, which exhibit antioxidant activity and are potentially beneficial for cognitive function. This study aimed to evaluate the effect of the ethyl acetate fraction of Moringa leaves on memory improvement in male mice induced with 10% ethanol. The ethyl acetate fraction was obtained through maceration using 70% ethanol, followed by fractionation with ethyl acetate. A total of 25 male mice were divided into five groups: negative control (1% CMC Na), positive control (Ginkgo biloba 60 mg/kgBW), and three treatment groups receiving the ethyl acetate fraction of Moringa leaves at doses of 50, 100, and 150 mg/kgBW. Memory performance was assessed using the Y-Maze method, consisting of three phases: acclimatization (T0), induction (T1), and treatment (T2). Data were analyzed using one-way ANOVA followed by Duncan’s post hoc test.The results showed that the ethyl acetate fraction of Moringa leaves significantly (p value < 0.05) reduced error counts and latency time, with the most optimal effect observed at a dose of 150 mg/kgBW. This dose led to a significant improvement in memory performance compared to the control groups, including the positive control. These findings suggest that the ethyl acetate fraction of Moringa leaves has a more effective potential to enhance memory compared to the positive control, with a time difference of 40 seconds and an error rate difference of 11.67%.
Efektivitas Ekstrak Etanol Daun Maja (Aegle Marmelos (l.) corr.) terhadap Laju Penyembuhan Luka Insisi pada Kelinci Jantan New Zealand (Oryctolagus Cuniculus) Model Diabetes Anita Dwi Septiarini; Rahma Fitri Lestari; Bagas Ardiyantoro
JIKES : Jurnal Ilmu Kesehatan Vol. 5 No. 1 (2026): Juli-Desember 2026
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/jik.v5i1.2785

Abstract

Diabetes Mellitus (DM) adalah gangguan metabolik yang ditandai tingginya kadar glukosa darah akibat kegagalan pankreas memproduksi insulin atau terjadinya resistensi insulin. International Diabetes Federation (IDF) mencatat prevalensi DM global mencapai 537 juta jiwa pada rentang usia 20-79 tahun (10,5%), dengan Indonesia menempati peringkat kelima dunia, yaitu 19,5 juta kasus pada 2021 dan diproyeksikan meningkat menjadi 28,6 juta pada 2045. Salah satu komplikasi utama DM adalah ulkus diabetikum, yang timbul akibat kerusakan saraf dan pembuluh darah akibat hiperglikemia kronis yang tidak terkendali. Daun maja diketahui mengandung metabolit sekunder seperti flavonoid, tanin, saponin, alkaloid, dan terpenoid yang berpotensi mendukung proses penyembuhan luka diabetes. Penelitian ini bertujuan menguji efektivitas ekstrak etanol daun maja (Aegle marmelos (L.) Corr.) terhadap penyembuhan luka insisi pada kelinci yang diinduksi aloksan, menggunakan desain eksperimental Post-test Only Control Group Design. Sebanyak empat ekor kelinci diinduksi aloksan intravena untuk menciptakan kondisi hiperglikemia melalui kerusakan sel beta pankreas, kemudian dibagi menjadi enam kelompok perlakuan: netral, kontrol negatif (Na-CMC 0,5%), kontrol positif (Povidone iodine 10%), serta ekstrak konsentrasi 15%, 25%, dan 35%. Hasil menunjukkan ketiga konsentrasi ekstrak memberikan efek penyembuhan luka bermakna (p<0,05), dengan konsentrasi 35% terbukti paling efektif dan hasilnya paling mendekati kontrol positif.
Cost-Effectiveness Analysis of the Use of the Antihypertensive Drugs Candesartan and Ramipril in Hospitalized Patients with Heart Failure and Hypertension Dinda Herawati; Niken Luthfiyanti; Bagas Ardiyantoro
Jurnal Pharmacopoeia Vol 5 No 2 (2026): September 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i2.1447

Abstract

Heart failure is a complex syndrome that prevents the ventricles from pumping blood effectively. The high prevalence of heart failure in patients with hypertension and the need for long-term therapy increase healthcare costs, making clinical and economic evaluation necessary. This study aims to determine the cost-effectiveness of in hospital antihypertensive therapy at Dr. Moewardi General Hospital in Surakarta. This study is a non-experimental study with an analytical observational design and a retrospective approach. Data were obtained from medical records and cost data for inpatients with heart failure and hypertension admitted between January 2025 and December 2025. The data obtained were analyzed using descriptive analysis, therapeutic efficacy analysis, cost-effectiveness analysis, statistical analysis, and sensitivity analysis. The study results showed that the average reduction in Mean Arterial Pressure (ΔMAP) with ramipril therapy was 20.45 mmHg, which was higher than the 17.42 mmHg reduction observed with candesartan. The ACER value for ramipril was IDR 941,574/mmHg from the hospital’s perspective and IDR 968,730/mmHg from the Health Social Security Administering Agency perspective, which were lower than those for candesartan, at IDR 1,241,209/mmHg and IDR 1,323,003/mmHg, respectively. The ICER values of −IDR 781,079/mmHg from the hospital’s perspective and −IDR 1,068,045/mmHg from the Health Social Security Administering Agency perspective indicate that ramipril is dominant. The differences in effectiveness and total cost were not statistically significant (p > 0.05). Sensitivity analysis shows that the costs of medical devices and medical procedures have the greatest impact on total costs. It can be concluded that, based on the results of the cost-effectiveness analysis, ramipril therapy is more cost-effective than candesartan from both perspectives.
Pharmacoeconomic Study Using Cost-Effectiveness Analysis to Examine Antibiotic Use in Patients with Pneumonia Hospitalized at Dr. Moewardi Regional General Hospital in Surakart Sahra fasa Nur Rohmah; Niken Luthfiyanti; Bagas Ardiyantoro
Jurnal Pharmacopoeia Vol 5 No 2 (2026): September 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i2.1462

Abstract

Pneumonia is an acute infection that affects lung tissue. The disease affects all age groups. Pneumonia is classified into three categories: community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP). Antibiotics are used to treat pneumonia. Given the wide range of antibiotic options, an analysis is needed to determine which antibiotics are most effective. This study aims to determine which antibiotic Levofloxacin or Ampicillin-Sulbactam plus Azithromycin is the most cost-effective for the treatment of pneumonia among inpatients at Dr. Moewardi General Hospital in Surakarta from January through December 2025. This was a descriptive observational study with retrospective data collection. A total of 100 patients were selected using purposive sampling; these were inpatients with pneumonia aged ≥ 18 years who had complete medical records and therapy cost data. This study used the Cost-Effectiveness Analysis (CEA) method from two perspectives the hospital’s and the National Health Insurance Agency’s to determine the degree of effectiveness and the Average Cost-Effectiveness Ratio (ACER). The use of antibiotics may be considered, specifically Levofloxacin (80%) and Ampicillin-Sulbactam + Azithromycin (20%). Levofloxacin has a higher therapeutic efficacy (86.25%) compared to Ampicillin-Sulbactam + Azithromycin (65%). From the perspective of hospitals and Social Security Administration Agency, the ACER values for Levofloxacin are both lower Rp 120,509 and Rp 232,286, respectively while those for Ampicillin Sulbactam + Azithromycin are higher Rp 457,989 and Rp 628,926, respectively. Levofloxacin is more cost-effective than ampicillin-sulbactam plus azithromycin, based on its lower ACER score.
Prediktor Keberhasilan Terapi Obat Anti Tuberkulosis (OAT) Pada Pasien TBC di Puskesmas Masaran 2 Vanesha Aida Rahma Viona; Niken Luthfiyanti; Bagas Ardiyantoro
KOLONI Vol. 5 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i3.1352

Abstract

Tuberculosis (TB) remains a major public health problem in Indonesia, with Central Java among the five provinces with the highest case burden. The success of TB treatment is influenced by various predictive factors, both sociodemographic and clinical, which need to be identified to optimize therapeutic outcomes. This study aimed to determine the predictors associated with the success of Anti-Tuberculosis Drug (ATD) therapy in TB patients at Puskesmas Masaran II and to identify the most influential factor. This was a non-experimental study using a cross-sectional approach, with data collected retrospectively from the medical records of TB patients during the period of May 2023–May 2026. The sample was determined using the Slovin formula with a purposive sampling technique, resulting in 71 patients who met the inclusion and exclusion criteria. Data were analyzed univariately and bivariately using the Chi-Square test (α = 0.05), with associations expressed as Odds Ratios (OR) and 95% confidence intervals. A total of 45 patients (63.4%) achieved negative sputum smear conversion by the fifth month, while 26 patients (36.6%) failed to convert. Of the 14 variables tested, six were significantly associated (p < 0.001) with treatment success: drug side effects, nutritional status, treatment regimen, patient category, drug resistance, and comorbidities. Drug side effects showed the strongest association (OR = 23.062; 95% CI: 6.148–86.507). These six factors are important predictors of ATD therapy success in TB patients at Puskesmas Masaran II.
Physical Quality Characterization and Total Flavonoid Content of Neem Leaf Kombucha (Azadirachta indica A. Juss) as a Nutraceutical Candidate Tiara Ajeng Listyani; Bagas Ardiyantoro; Anna Fitriawati; Jihannaz Firdamaya
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2026: Proceeding of the 7th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/fqwagj16

Abstract

Neem leaves (Azadirachta indica A. Juss) contain secondary metabolites with potential health benefits. Fermentation using a SCOBY may modify the phytochemical profile and enhance their potential as functional beverages; however, the strong bitterness of neem leaves remains a challenge for nutraceutical development. This study aimed to characterize the physical quality and initial total flavonoid content (TFC) of neem leaf kombucha at various concentrations and fermentation times. Four formulas (0.3%, 1%, 3%, and 1% with clay pretreatment) were evaluated on days 8, 12, and 14. Physical quality was assessed by measuring pH and alcohol content (refractometry), while TFC was determined using UV-Vis spectrophotometry. On day 14, pH ranged from 2.54 to 3.21 in undiluted samples and from 2.97 to 3.44 after 21-fold dilution, with alcohol contents of 4.3–6.3% and 0.3–0.5%, respectively. TFC values in undiluted samples were 0.02862, 0.03388, 0.03695, and 0.03016 mg QE/mL for the 0.3%, 1%, 3%, and clay-pretreated 1% formulas, respectively, while diluted samples contained 0.01416, 0.02094, 0.02440, and 0.01990 mg QE/mL. Fermentation for 14 days produced the highest flavonoid response, with the 3% concentration showing the highest TFC. The clay-pretreated 1% kombucha retained a substantial flavonoid content and may improve palatability.
Uji Stabilitas dan Penentuan Nilai Spf Emulgel Kombinasi Ekstrak Daun Pucuk Merah (Syzygium Myrtifolium Walp.) dan Lidah Buaya (Aloe Vera) Tria Yuni Asih; Anna Fitriawati; Bagas Ardiyantoro
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2544

Abstract

Excessive exposure to ultraviolet (UV) radiation can adversely affect skin health, causing erythema, hyperpigmentation, premature aging, and increasing the risk of skin cancer. Natural-based sunscreen products have gained attention because plant-derived compounds possess antioxidant properties and the ability to absorb UV radiation. Red shoot leaves (Syzygium myrtifolium Walp.) contain flavonoids, phenolic compounds, and tannins that potentially contribute to photoprotective activity, whereas Aloe vera is known for its moisturizing and soothing properties. This study aimed to develop an emulgel containing a combination of purified red shoot leaf extract and Aloe vera extract, evaluate its physical characteristics and stability, and determine its Sun Protection Factor (SPF) value. The study was conducted experimentally in the laboratory using six formulations, consisting of a blank formulation (F0) and five formulations containing different concentrations of the extracts (F1–F5). Physical evaluations included organoleptic characteristics, homogeneity, pH, spreadability, adhesiveness, and viscosity. Stability testing was performed using a cycling test for six cycles, while SPF was measured in vitro using UV-Vis spectrophotometry based on the Mansur method. All formulations demonstrated acceptable physical properties, with pH values ranging from 6.54 to 6.96, spreadability from 46.4 to 64.0 mm, adhesiveness from 2.01 to 3.18 seconds, and viscosity from 2,377 to 5,380 cPs. The highest SPF value was 6.98 at 500 ppm, classified as moderate protection.
Nootropic Effect of Galinsoga parviflora Leaf Extract Using The Novel Object Recognition Test in Mice Annie Rahmatillah; Bagas Ardiyantoro; Anita Dwi Septiarini; Suci Rhoma Vetiana; Restu Handoyo Aji Cahyopo Putro
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3855

Abstract

Background: The global prevalence of Alzheimer's disease and cognitive impairments continues to rise, yet current pharmacological options offer limited efficacy and notable side effects. Galinsoga parviflora leaves contain neuroprotective flavonoids and phenolics, but their impact on recognition memory remains insufficiently explored. Objective: This study evaluated the nootropic activity of an ethanolic extract of Galinsoga parviflora leaves in scopolamine-induced memory-impaired mice using the Novel Object Recognition Test (NORT). Methods: Twenty-five male BALB/c mice were assigned to five groups: negative control (CMC-Na), positive control (donepezil 0.5 mg/kg bw), and three extract treatments (10%, 20%, 30%). Memory deficits were induced via intraperitoneal scopolamine (1 mg/kg bw). NORT evaluated recognition memory by recording exploration times for familiar (T1) and novel (T2) objects to derive the Discrimination Index (DI). Data were analyzed using one-way ANOVA with Tukey’s post-hoc test. Results: The extract produced a dose-dependent increase in DI: 0.001 ± 0.039 (negative control), 0.11 ± 0.02 (10%), 0.28 ± 0.02 (20%), and 0.38 ± 0.01 (30%), compared to 0.46 ± 0.03 for donepezil. ANOVA revealed significant overall differences (p = 0.000). Post-hoc testing confirmed that the 30% extract significantly outperformed the negative control (p = 0.004) and approached donepezil efficacy. Conclusion: Galinsoga parviflora leaf extract mitigates scopolamine-induced recognition memory deficits in a dose-dependent manner. The 30% concentration exhibited the strongest effect, comparable to donepezil. Further studies on cholinergic biomarkers and histopathology are required to elucidate its neuroprotective pathways.
Co-Authors Abdul Wahab Sabrina, Azimah Adliah Suci Rahmadani Alya Atla Lidya Anita Dwi Septiarini Anita Dwi Septiarini Anita dwi setiarini Anna Fitriawati Annie Rahmatillah apriliyanti, laela intan arniwati mat daud, Noor Ason Merari P Bangkit Riska Permata Chofifatun Mubarokah Danang Raharjo Della Puspita Ningrum Dinda Herawati Dwi Nurul Khotimah Dwi S, Anita Erick Nur Sulistyawan Erina Yuliyanti Erlangga Dito Wahyu Ardhana Fadila, Vera Nurhidayatul Fika Riyanti Fitriana, Mona Haikal Zanki Hery Widijanto Inna Risky Setyawati Intan Oktaviani Iqbal Sirajudin Maulidinawan Jayak Pratama, Kharisma Jihannaz Firdamaya Karim Karim, Karim Listyani, Tiara Ajeng Lutfiyanti, Niken Mardiyono Mardiyono Meyliawati, Ika Muhamad Farid Nurohman Krisnadi Nabila Melyi Aryani Nafiah, Azidatun Netty Dea Sosiantini Niken Luthfiyanti Nissa Syahraningtyas Putri Permata, Bangkit Riska Putri, Anisa Fadilah Kumala Putri, Fera Adila Rahma Fitri Lestari Rahmad Adji, Alenda Rahmat Hidayat Rahmat Hidayat Rahmatillah, Annie Rahmawati Restu Handoyo Aji Cahyopo Putro Retno Kurnia Dewi Rohmana, Vivin Marwiyati Sahra fasa Nur Rohmah Salsabila Khoerunniyssa Sari, Silvia Mega Kusuma Septian Maulid Wicahyo Septian Maulid Wicahyo Siwi Hastuti Suci Rhoma Vetiana Suharjaya, Feby Nuranawati Tasya Aurelia Thoha Irfan Darojat Tria Yuni Asih Triana Triana Trianita Septiana uswatun hasanah, alfiana Uswatun Khasanah Vanesha Aida Rahma Viona Wali Jati, Ilham Wardani, Tatiana Siska Wiwin Novitasari Zainul ‘Arifah