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All Journal Indonesian Journal of Pharmaceutical Science and Technology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Sarwahita : Jurnal Pengabdian Kepada Masyarakat Kontribusia : Research Dissemination for Community Development Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Buana Farma ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) DedikasiMU: Journal of Community Service Community Medicine and Education Journal Jurnal Impresi Indonesia Journal of Social Research Empowerment: Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer International Journal of Health and Pharmaceutical (IJHP) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Salingka Abdimas Eduvest - Journal of Universal Studies PROSIDING SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT (SNPPM) UNIVERSITAS MUHAMMADIYAH METRO Jurnal Pandu Husada Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi Jurnal Implementa Husada (JIH)
Humairah Medina Liza Lubis
Dapartemen Patologi Anatomi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Sumatera Utara
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Hubungan Tingkat Pengetahuan Ibu dan Status Gizi Balita di Posyandu Melati Desa Sambirejo Kabupaten Langkat Raihana Zavira Ariani; Humairah Medina Liza Lubis; Nita Andrini
JURNAL IMPLEMENTA HUSADA Vol 6, No 4 (2025)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v6i4.24912

Abstract

Latar Belakang: Pengetahuan orang tua khususnya ibu merupakan hal yang penting dalam status gizi balita. Pengetahuan ibu yang kurang mengenai gizi dan asupan makanan yang diberikan kepada anaknya dapat mengakibatkan proses tumbuh kembang balita terhambat, terutama pada perkembangan area otak anak. Gizi anak sangat ditentukan oleh pengetahuan ibu mengenai makanan gizi yang perlu diberikan sesuai kebutuhan anaknya. Metode: Jenis penelitian ini adalah deskriptif dengan desain penelitian cross-sectional. Populasi dalam penelitian ini adalah ibu-ibu yang mempunyai balita usia 1-5 tahun di Posyandu Melati. Teknik pengambilan sampel menggunakan Purposive Sampling. Alat ukur dalam penelitian ini adalah kuesioner. Hasil: Analisis data menggunakan korelasi Somers'd Gamma menunjukkan nilai signifikan p=0,011 karena p=0,011 0,05. Kesimpulan: Terdapat hubungan antara tingkat pengetahuan ibu dengan status gizi balita di Posyandu Melati Desa Sambirejo Kabupaten Langkat.
Perbandingan Efektivitas Pemberian Silver Sulfadiazine dengan Gel Lidah Buaya (Aloe Vera) 99% pada Tikus Putih ( Rattus Norvegicus L.) Jantan Galur Wistar Sebagai Pengobatan Luka Bakar Atika Rahmi; Ratih Yulistika Utami; Hervina Hervina; Humairah Medina Liza Lubis
JURNAL IMPLEMENTA HUSADA Vol 1, No 1 (2020)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v1i1.4541

Abstract

Introduction: Burn injury is a common cause of morbidity and mortality. Outcomes of morbidity and disability for deep burns patients still not improved. Many modalities for wound bed preparation was not satisfied. Aloe vera gel have been used as an anti-inflammatory natural agent, for treatment many deseases. It has also been used in the traditional medicine of many cultures and said to be beneficial in the treatment of disorders such as burns Objective: To find out the comparison of the effectiveness of administration of silver sulfadiazine and aloe vera gel 99% as a treatment of burns in white rat (Rattus norvegicus L.) male Wistar strain. Methodology: The research used True Experiment method with "pretest-posttest with control group design" design Result: The results show that the P value for aloe vera number is 0.05, and the P value for Silver sulfadiazinee levels also showing 0.05. Conclusion: There is a difference in effectiveness of giving 99% aloe vera gel as a treatment for burns in white rats (Rattus norvegicus L.) male Wistar strain.Keywords: Burn Injury,Aloe Vera, Silver sulfadiazinee
In Silico Evaluation of Indole-3-Carbinol from Kale (Brassica oleracea L.) Against Cervical Cancer Through IGF2BP2 and MYCBP Targeting Farhan Abdullah Rizal; Humairah Medina Liza Lubis
JURNAL IMPLEMENTA HUSADA Vol 7, No 3 (2026)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v7i3.30306

Abstract

Introduction: Cervical cancer remains one of the leading causes of morbidity and mortality worldwide, including in Indonesia, involving metabolic reprogramming such as the Warburg effect in tumorigenesis. The proteins IGF2BP2 and MYCBP are known to play important roles in promoting cancer cell proliferation through the regulation of cellular metabolism. Objective: This study aimed to investigate the anticancer potential of Indole-3-Carbinol against cervical cancer by targeting IGF2BP2 and MYCBP using an in silico approach. Method: The study employed molecular docking analysis targeting IGF2BP2 and MYCBP proteins, using 5-fluorouracil and doxorubicin as comparator compounds. Result: The results showed that Indole-3-Carbinol exhibited binding energy (∆G) values of -3.20 kcal/mol for IGF2BP2 and -5.75 kcal/mol for MYCBP, with better binding affinity than 5-fluorouracil but lower than doxorubicin. Interaction analysis revealed that Indole-3-Carbinol interacted with both IGF2BP2 and MYCBP proteins, with IGF2BP2 showing a higher number of interacting amino acid residues. Further studies are required to confirm its preferential molecular target. Furthermore, Indole-3-Carbinol fulfilled Lipinski’s criteria, demonstrated high gastrointestinal absorption, the ability to penetrate the blood-brain barrier, and a favorable toxicity profile without carcinogenic effects. Conclusion: Indole-3-Carbinol shows preliminary in silico potential as a cervical anticancer candidate targeting the IGF2BP2 pathway and modulating the Warburg effect, with the advantage of being a relatively safe natural compound.
The Role of Cherry Coffee Ethanol Extract in Repairing Liver Damage in Type 2 Diabetic Rats Tengku Soraya Putri; Nurfadly Nurfadly; Humairah Medina Liza Lubis
JURNAL IMPLEMENTA HUSADA Vol 7, No 1 (2026)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v7i1.25430

Abstract

Abstract:Background. Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia due to insulin resistance and pancreatic β-cell dysfunction. Chronic hyperglycemia triggers oxidative stress and increases inflammation, thereby contributing to liver damage. The potential of coffee cherry ethanol extract as an antioxidant and anti-inflammatory agent could serve as a therapeutic option for improving liver damage. Objective. This study aims to evaluate the effects of coffee cherry ethanol extract on liver histopathology in a T2DM mouse model. Methods. This study used 28 male Wistar rats, divided into 7 groups with 4 rats in each group, administered coffee cherry ethanol extract at doses of 100 mg/kg body weight and 200 mg/kg body weight/day/oral. Results. The results showed that administration of coffee cherry ethanol extract improved hepatocyte structure, reduced inflammatory infiltration, and decreased fat accumulation in liver tissue compared to the untreated DMT2 group (p0.05). Conclusion. Coffee cherry ethanol extract has potential as an adjunct therapy to slow the progression of DMT2 complications in the liver. Further studies are needed to confirm its efficacy, mechanism of action, and long-term effects in humans. Keywords: ethanol extract, liver histopathology, oxidative stress, type 2 diabetes mellitus. 
Hubungan Tingkat Pengetahuan Ibu tentang Makanan Pendamping ASI (MPASI) terhadap Status Gizi Anak di Posyandu Balita Puskesmas Sambirejo, Kecamatan Binjai, Kabupaten Langkat Rahmah Filzah; Humairah Medina Liza Lubis
Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi Vol. 4 No. 3 (2026): Agustus: Antigen: Jurnal Kesehatan Masyarakat dan Ilmu Gizi
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/antigen.v4i3.1125

Abstract

Complementary feeding (MPASI) refers to food or beverages given to infants after six months of age to meet nutritional needs and support growth and development. Mothers’ knowledge of complementary feeding is an important factor in food selection and feeding practices that may influence the nutritional status of toddlers. This study aims to determine the relationship between mothers’ knowledge of complementary feeding and the nutritional status of toddlers at the Toddler Integrated Health Post (Posyandu) of Sambirejo Public Health Center, Binjai District, Langkat Regency. This study employed a descriptive design with a cross-sectional approach and was conducted from June to December 2024. The sample consisted of 45 mothers with toddlers selected using total sampling. Data on mothers’ knowledge were collected through questionnaires, while toddlers’ nutritional status was assessed through anthropometric measurements. Data were analyzed using univariate and bivariate analyses with the Spearman correlation test. The results showed that 24 mothers (53.3%) had good knowledge, 14 (31.1%) had moderate knowledge, and 7 (15.6%) had poor knowledge. Regarding nutritional status, 23 toddlers (51.1%) had good nutritional status, 14 (31.1%) were undernourished, and 8 (17.8%) were severely undernourished. A significant relationship was found between mothers’ knowledge and toddlers’ nutritional status (p<0.001; r=0.523). Better maternal knowledge was associated with better nutritional status. Complementary feeding education through Posyandu is needed to optimize toddlers’ nutritional status.
Neuroprotective Potential of Oleic Acid and Alpha Tocopherol on Memory Function: In-Silico Docking and ADMETox Regita Herlianda Cahyani; Emni Purwoningsih; Luhu Avianto Tapiheru; Humairah Medina Liza Lubis
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i2.10263

Abstract

Decreased levels of brain-derived neurotrophic factor (BDNF) are closely related to neurodegenerative diseases such as Alzheimer's. This causes a decrease in cognitive function, memory and behavior due to a decrease in the BDNF protein which has the main function of protecting nerve growth, plasticity, nerve resilience, as well as being an important shield against nerve degeneration. Objective: of this research is to analyze the interaction between the oleic acid and alpha tocopherol ligands with the BDNF protein by molecular docking, as well as to analyze the ADMETox compounds of oleic acid and alpha tocopherol. Methods: This research is descriptive analytical. Molecular docking uses the Autodock tools, LigandScout, Discovery Studio, and Marvin Sketch applications. ADMETox analysis uses the SwissADME, ADMETlab 2.0, and ProTox-II sites. Results: the binding energy of oleic acid compounds to BDNF, TrkB, and CREB is -3.13 kcal/mol, -6.13 kcal/mol, and -3.70 kcal/mol. The binding energy results for alpha tocopherol compounds on BDNF, TrkB, and CREB are -5.67 kcal/mol, -8.04 kcal/mol, and -7.04 kcal/mol. ADMETox found that alpha tocopherol and oleic acid compounds fulfill Lipinski's rule of five and do not inhibit cytochrome P450 enzymes. Conclusion: Oleic acid and alpha tocopherol bind to BDNF, TrkB and CREB proteins and are safe for oral consumption.
Co-Authors Abdul Gafar Parinduri Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Aini, Rahma Ainur Rofiq Ainur Rofiq Aisyah Salsabila Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Anriani, Dwi Arifin, Salsalina Dwi Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Emni Purwoningsih Fadillah, Akram Fadlina, Shofiah Dina Farhan Abdullah Rizal Farisha Firzana Fayyaza, Nesya Alya Febryandani, Silvy Claresta Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Harahap, Azra Wifa Ilham Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad Hutabarat, Siti Rahmah IBNU AFIF ARMADI Ilham Hariaji Imanda Jasmine Siregar Imas Putri Munthe Indra, Kirana Arum Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Khairunisa, Zafira Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah Luhu Avianto Tapiheru M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Wal Ikraam Wilyandra Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Nita Andrini Noviardy, Arya Nurcahaya Sinaga Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Parinduri, Saskya Nabila Prayoga, M. Iqbal Purnama, Bena Melinda Purwiningsih, Emni Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Raihana Zavira Ariani Ramadhan, Galang Ramadhan, Reza Mukti Rasyid, Teuku Rifqi Harun Al Ratih Yulistika Utami Refangga Sudi Wardana Regita Herlianda Cahyani Riaulina, Nasha RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Sabian Bintang Ramadhan Salsabila, Aisyah Salsabila, Asya Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Shaik Hussain, Basrah Bee Binte Sianipar, Tasya Amanda SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih Tania Mulia Utami Tegar Alamsyah Tengku Soraya Putri Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Widya Yustika Yulhan, Oche Axena Yuliansyah, Putri Ridha Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani