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All Journal JOPS (Journal Of Pharmacy and Science) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Current Research on Biosciences and Biotechnology Jurnal Buana Farma Narra J JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Jurnal Kesehatan Farmasi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal International Journal of Health, Engineering and Technology MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Roy Indrianto Bangar S
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Uji Aktivitas Ekstrak Etanol Daun Bandotan terhadap Penyembuhan Luka Sayat pada Tikus Putih Diabetes Melitus (Rattus norvegicus) Tya Bella Arthamarisi Simbolon; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5143

Abstract

The wound healing process in individuals with diabetes mellitus is generally slower due to disruption of the inflammatory, proliferation, and regeneration mechanisms. Diabetics experience chronic metabolic disorders that impact immune cell function, blood circulation, and the regenerative capacity of fibroblasts and keratinocytes. Consequently, the wound healing process in diabetic patients is often more complex and takes longer. One approach to accelerating the wound healing process in this condition is the use of natural ingredients with anti-inflammatory, antimicrobial, and regenerative properties. One potential plant in this regard is the bandotan leaf (Ageratum conyzoides), which is known to contain active compounds such as flavonoids, alkaloids, and tannins that play a role in the wound healing process. This study was conducted to assess the effectiveness of bandotan leaf extract in accelerating wound healing in an animal model of diabetes mellitus. A total of 30 male white rats (Rattus norvegicus) that had been induced to become diabetic with streptozotocin were divided into six groups of five rats each. The groups included: a normal control group (healthy mice without diabetes), a negative control group (diabetic mice without treatment), a positive control group (given Metcovazin ointment as a standard), and three treatment groups that received topical application of bandotan leaf extract at graded concentrations of 10%, 15%, and 20%. A circular wound with a diameter of approximately 6 mm was made aseptically using a punch biopsy tool on the back of each mouse after being given ketamine anesthesia. Treatment was given daily for twelve consecutive days. The main parameters observed included daily measurements of the wound area to determine the rate of wound contraction.
Formulasi dan Evaluasi Sediaan Tablet Effervescent dari Ekstrak daun Andaliman (Zanthoxylum acanthophodium Dc.) dengan Variasi Asam dan Basa Novrika Desclarita Naibaho; Roy Indrianto Bangar; Asyrun Alkhairi Lubis
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.206

Abstract

Andaliman leaves (Zanthoxylum acanthopodium) are a plant that has the potential to be used as a natural ingredient in the development of herbal preparations. Andaliman leaves are known to contain secondary metabolite compounds, including flavonoids, terpenoids, alkaloids, and tannins. This potential encourages the processing of Andaliman leaves into extracts which are then formulated in the form of effervescent tablets to increase practicality of use. This study aims to produce effervescent tablets of Andaliman leaf extract with good physical quality by making three formulas with varying concentrations of acid-base components. Extraction was carried out using 70% ethanol solvent, then an evaluation of the properties of the resulting granules and tablets was carried out. The test results showed that all formulas met the requirements for organoleptic tests, water content, flow time, and compressibility, but in the angle of repose test only F2 met the criteria. Tablet evaluation showed that all formulas met the organoleptic tests, hardness, friability, and dissolution time, while the uniformity and weight tests still showed discrepancies in some formulas. Overall, formula F2 is the best formula because it meets most of the evaluation parameters for granules and tablets, so it has the greatest potential to be developed as an effervescent tablet preparation from andaliman leaf extract.
Penentuan Kadar Total Fenol dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) dengan Metode DPPH Lampita Bellina Manullang; Razoki Razoki; Roy Indrianto Bangar
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.214

Abstract

This study aimed to determine the total phenolic content and evaluate the antioxidant activity of the ethanolic extract of Moringa oleifera L. Extraction was carried out using the maceration method with 96% ethanol. Total phenolic content was determined using the Folin–Ciocalteu method with gallic acid as the standard, while antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH. assay and expressed as IC₅₀ values. The results showed that the ethanolic extract of Moringa oleifera leaves contained an average total phenolic content of 69.126 mg gallic acid equivalents per gram of extract. The antioxidant activity test yielded an IC₅₀ value of 92.04 ppm, indicating strong antioxidant activity. The high phenolic content contributed to the extract’s ability to scavenge free radicals. These findings suggest that the ethanolic extract of Moringa oleifera leaves has potential as a natural antioxidant source.
Formulasi dan Evaluasi Sediaan Tablet Parasetamol dengan Pati Umbi Porang (Amorphophallus muelleri Blume) Sebagai Bahan Pengisi Hotma sarito Panjaitan; Roy Indrianto Bangar; Erida Novriani
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.215

Abstract

Paracetamol is a widely used analgesic–antipyretic drug; however, it exhibits poor flowability and compactibility, requiring suitable excipients in tablet formulation. This study aimed to formulate paracetamol tablets using porang tuber starch (Amorphophallus muelleri) as a filler and to evaluate the effect of its concentration on the physical properties of granules and tablets. Tablets were prepared by the wet granulation method using three concentrations of porang tuber starch: 10 mg (F1), 15 mg (F2), and 20 mg (F3). Granule evaluation showed moisture content ranging from 2.1–3.4%, flow time of 4.8–6.2 seconds, angle of repose of 25.6–30.4°, and compressibility index of 11.2–15.6%, indicating good flow and compressibility properties. Tablet evaluation demonstrated acceptable weight uniformity with deviations < 5%, hardness values of 5.1–7.8 kg, friability of 0.32–0.78%, and disintegration times of 3.4–6.8 minutes. The formulation containing 20 mg of porang tuber starch (F3) exhibited the most optimal characteristics, with the highest tablet hardness (7.8 kg) and the lowest friability (0.32%), while maintaining disintegration time within pharmacopeial limits. Therefore, porang tuber starch shows strong potential as a natural filler in paracetamol tablet formulations.
Profil Aktivitas Antioksidan Ekstrak Polar dan Non-Polar Umbi Porang (Amorphophallus muelleri Blume) Menggunakan Uji DPPH Nova Ria Ovelti Sihotang; Roy Indrianto Bangar; Hariyadi Dharmawan Syahputra
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.221

Abstract

Porang tuber (Amorphophallus muelleri Blume) is an Indonesian native commodity rich in glucomannan polysaccharides and potentially serves as a natural antioxidant source to counteract free radicals that trigger degenerative diseases. Objective of the researchv to map the antioxidant activity profile of non-polar, semi-polar, and polar extract s of porang tuber and determine the IC50 value using the DPPH method. Porang tuber powder was extracted through multilevel maceration using n-hexane, chloroform, ethyl acetate, and ethanol solvents. Antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with UV-Vis Spectrophotometry at 517 nm, utilizing Vitamin C and Quercetin as positive controls. Result: The results showed that all extract possessed extremely strong antioxidant activity. The lowest IC50 value was obtained from the ethyl acetate extract at 3.44 ppm, followed by the ethanol extract at 3.61 ppm and the n-hexane extract at 3.81 ppm. The activity of the ethyl acetate extract was stronger than the positive controls, Vitamin C (3.75 ppm) and Quercetin (4.52 ppm). Multilevel extraction is effective in separating the active compounds of porang tuber, with the semi-polar extract (ethyl acetate) exhibiting the most optimal and extremely strong antioxidant potential.
Hubungan Kejadian DRP dan Outcome Klinis Pasien Pediatri Vinando Vinando; Nerly Juli Pranita Simanjuntak; Roy Indrianto Bangar
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3741

Abstract

Latar Belakang: Salah satu penyakit kompleks yang sering dialami oleh anak-anak adalah penyakit saluran pernafasan. Tenaga kesehatan sering mengalami masalah dalam pelayanan kesehatan seperti pemberian dosis obat yang tepat, sediaan obat yang tepat, dan lain sebagainya. Sehingga menyebabkan suatu kejadian yang mengganggu hasil kesehatan penyakit saluran napas yang berhubungan dengan pengobatan yang diberikan sering dikaitkan dengan masalah terkait obat atau dikenal dengan Drug Related Problems (DRP). Drug Related Problems (DRP) mempunyai pengaruh terhadap outcome klinis terapi pasien. Sehingga peneliti ingin meninjau lebih lanjut kemungkinan kejadian DRP yang dapat terjadi serta melakukan evaluasi hubungan kejadian DRP dengan hasil klinis pada pasien pediatric yang menderita penyakit saluran pernafasan pada instalasi rawat inap. Metode: Penelitian ini dilakukan secara observasional analitik dan dilakukan teknik total sampling dalam pengambilan sampe dimana sampel yang diambil hanya memenuhi kriteria inklusi. Setelah dilakukan pengambilan sampel dianalisis DRP berdasarkan pedoman American Society of Health Pharmacist (ASHP). Jumlah DRP yang didapatkan dikorelasikan dengan hasil klinis pasien menggunakan uji statistic. Uji statistic yang digunakan adalah metode chi-square dan didapatkan nilai p-value untuk mengetahui signifikansi kedua hubungan tersebut. Hasil: Pada penelitian ini didapatkan jumlah kasus yang sesuai dengan syarat inklusi adalah 114 kasus. Jumlah kejadian DRP adalah 445 dari keseluruhan dimana setiap DRP yang ada terhitung satu. Uji chi-square didapatkan nilai p-value dengan hasil 0.000 yang menandakan bahwa terdapat hubungan yang signifikan antara kenaikan jumlah DRP dengan penurunan outcome klinis yang diterima pasien. Kesimpulan: Terdapat hubungan yang signifikan antara kenaikan jumlah DRP dengan penurunan hasil klinis ehingga perlu dilakukan peninjauan kembali oleh tenaga kefarmasian untuk mendapatkan outcome klinis yang baik oleh pasien.
STUDI FORMULASI GEL EKSTRAK KULIT RARU (COTYLELOBIUM MELANOXYLON PIERRE) SEBAGAI AGEN ANTIBAKTERI Michelle Veronica Gulo gulo; Roy Indrianto Bangar; Refi Ikhtiari
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3748

Abstract

Acne is a skin condition affecting adolescents and young adults, characterized by an imbalance in the skin microbiome, excessive sebum production, and the accumulation of keratin, triggered by the bacteria Propionibacterium acnes, a significant pathogenic factor. Acne can be treated with antibiotics, but long-term antibiotic use can have side effects if used incorrectly. Raru wood has pharmacological potential due to its content of secondary metabolites such as flavonoids, tannins, saponins, and triterpenoids. Raru bark extract was developed into a gel dosage form to optimize its treatment effectiveness. The purpose of this study was to determine the gel formulation and antibacterial effectiveness of raru bark extract in the gel preparation. The research method was experimental, involving the formulation and evaluation of the gel, as well as testing its antibacterial activity using the disc method at a concentration of 3%, negative controls, and positive controls.
MOLECULER DOCKING SENYAWA BIOAKTIF KULIT RARU (Cotylelobium melanoxylon) TERHADAP TARGET α-GLUKOSIDASE DAN α-AMILASE Josita Jenny Haryanti Hutagulung; Roy Indrianto Bangar
Jurnal Kesehatan Farmasi Vol 8 No 1 (2026): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v8i1.3749

Abstract

Diabetes mellitus is a metabolic disease that affects the body’s ability to control blood glucose levels, making effective treatments necessary to reduce postprandial glucose increases. Flavonoid compounds from raru bark (Cotylelobium melanoxylon) have shown potential as inhibitors of carbohydrate-digesting enzymes, especially α-amylase and α-glucosidase. This study aimed to evaluate the antidiabetic potential of flavonoid compounds from raru bark using an in silico approach with molecular docking. Five flavonoid compounds—rutin, isoquercetin, quercetin, quercitrin, and isoquercitrin—were tested to examine their binding ability to the target enzymes. The results showed that rutin and isoquercetin had lower binding energy values than the standard ligand, indicating more stable interactions and stronger enzyme inhibition. These findings suggest that flavonoid compounds from raru bark may be developed as natural antidiabetic agents; however, further in vitro and in vivo studies are needed to confirm their safety and effectiveness.
PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT KAYU RARU (Cotylelobium melanoxylon (Hook.f) Pierre) MELALUI UJI DPPH Nurhadijah Sibagariang; Roy Indrianto Bangar; Refi Ikhtiari
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2181

Abstract

FORMULASI MASKER GEL DENGAN EKSTRAK DAUN MANGGA ARUMANIS (Mangifera Indica L.) SEBAGAI BAHAN AKTIF Tasyah Helgiera; Astriani Natalia Br Ginting; Roy Indrianto Bangar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1626

Abstract

Exposure to ultraviolet (UV) radiation and environmental pollution can generate free radicals that contribute to skin damage and accelerate premature aging. One approach to protect the skin from these effects is the use of antioxidants derived from natural sources. Arumanis mango leaves (Mangifera indica L.) contain secondary metabolites such as flavonoids, tannins, and saponins which have potential antioxidant activity and can be utilized as active ingredients in cosmetic formulations. This study aimed to formulate a gel mask containing ethanol extract of arumanis mango leaves and to evaluate the physical quality of the preparation. The extract was obtained using the maceration method with 96% ethanol as the solvent. The gel mask was formulated into three different extract concentrations, namely 0%, 4%, and 6%. The physical evaluation included organoleptic test, homogeneity, pH, spreadability, and drying time tests. The results showed that the gel mask preparations exhibited good physical characteristics, with homogeneous appearance, pH values ranging from 5.16–6.26, spreadability of 5.5–6.8 cm, and drying time of 17–20 minutes. The variation in extract concentration affected the color of the preparation but did not significantly influence the overall physical stability of the gel. Therefore, ethanol extract of arumanis mango leaves can be formulated into a gel mask preparation that meets the physical quality requirements for skincare products.
Co-Authors Adelia Pratiwi Ain Naia Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br. Ginting Astriani Natalia Br. Ginting Astyka, Ririn Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Br Ginting, Astriani Natalia Br Pinem, Elys Dayanty Br Sembiring, Novitaria Br Tarigan, Jenny Alfa Dilla Cut Rahil Sofia Daimah W. S. Harahap Daulay, Wardiyah Desita, Maya Desmina Nur Cahaya Simanjuntak Edy Fachrial Erida Novriani Erida Novriani Ginting, Astriani Natalia Br Harahap, Daimah Wirdatus Sanaun Hardivia Kaur Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hotma sarito Panjaitan IKHTIARI, REFI Inesha Viata Melika Purba Josita Jenny Haryanti Hutagulung Kaban, Vera E. Kevin Wijaya Khairatunawa, Tisa Kinanti Maharani Lampita Bellina Manullang Lubis, Muhammad F. Lumban Gaol, Irma Yohana Michelle Veronica Gulo gulo Muhamad Insanu Muhammad Yunus Muhammad Yunus Muhammad Yunus Muhtamilatur Rahma Nailan Azizah Nasution, Haris M. Nasution, Irma Suryani Nerly Juli Pranita Simanjuntak Nerly Juli Pranita Simanjuntak Ningsih, Kurnia Nastira Ningsih, Wulan Seppia Nova Ria Ovelti Sihotang Novelia Zwi Dwinayanti Silaban Novia Agustini Irmasyari Siregar Novrika Desclarita Naibaho Nurhadijah Sibagariang Pasti Marito Samosir Permata Gulo, Elastis Rachel Adriany Br Sinaga Rahmana Emran Kartasasmita Razoki Razoki Razoki Razoki Razoki Razoki Razoki, Razoki Refi Ikhtiari Rio Sinar Parsaoran Simanullang Sembiring , Novitaria Br Sembiring, Novitaria Br Shintjia Dewi Agustan Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Tasyah Helgiera Tiani Nduru Tya Bella Arthamarisi Simbolon Utama, Rezza F. Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban vina andriani Vinando Vinando Waruwu, Loice Desy Krisna Yanti Wilson Kanggaran Yerly Ramadani Lubis Yulyana, Ana