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All Journal JOPS (Journal Of Pharmacy and Science) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Current Research on Biosciences and Biotechnology Jurnal Buana Farma Narra J JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Jurnal Kesehatan Farmasi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal International Journal of Health, Engineering and Technology MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Roy Indrianto Bangar S
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Uji Aktivitas Formulasi Mikrokapsul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria Rosc) Sebagai Antidislipedemia terhadapTikus Putih (Rattus Norvegicus) Kevin Wijaya; Razoki Razoki; Roy Indrianto Bangar
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 4 (2025): Oktober : Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i4.2275

Abstract

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  
POTENSI ANTIBAKTERI PAREM KARO UNTUK MENANGANI INFEKSI Staphylococcocus aureus PADA PENDERITA DIABETIC FOOT Br Tarigan, Jenny Alfa Dilla; Sembiring, Novitaria Br; Bangar S, Roy Idrianto
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2411

Abstract

One of the cronic and serious complications of diabetes mellitus is diabetic foot. Staphyloccocus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. Testing the antibacterial activity of Karo hot parem against staphylococcus aureus bacteria using disc diffusion method with 255, 50% and 75% concentration of Karo hot parem extract, positive control Ciprofloxacin Disks (5µg) and negative control DMSO 10%. This disc diffusion method was carried out to determine the diameter of the inhibition formed by Karo hot parem extract in inhibiting the growth of Staphyloccocus aureus bacteria. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes Astriani Natalia Br Ginting; Vera Estefania Kaban; Roy Indrianto Bangar; Daimah W. S. Harahap
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 1 (2025): Februari 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i1.4844

Abstract

Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.
Efek Pemberian Fraksi Etil Asetat Ekstrak Etanol Kulit Buah Jeruk Bali (Citrus Maxima Merr) terhadap Kadar Glukosa Darah Tikus Hiperglikemia Desita, Maya; Roy Indrianto Bangar Siagian; Astriani Natalia Br Ginting
JOURNAL SAINS STUDENT RESEARCH Vol. 3 No. 6 (2025): Jurnal Sains Student Research (JSSR) Desember
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jssr.v3i6.7120

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels (hyperglycemia). Herbal medicine is often used as an alternative treatment, and pomelo peel (Citrus maximaMerr) is believed to have potential as an antihyperglycemic agent due to its content of bioactive compounds such as flavonoids and vitamin C. This study aimed to examine the antihyperglycemic effect of the ethyl acetate fraction of the ethanol extract of pomelo peel (Citrus maxima Merr) in alloxan-induced Wistar rats. Hyperglycemic rats were divided into 6 groups (Normal Control, Negative Control, Positive Control/Metformin, and Fraction Doses of 125, 250, 500 mg/kgBW). The treatment was administered for 14 days. The results showed that the pomelo peel ethyl acetate fraction significantly reduced the blood glucose levels of the hyperglycemic rats, with the effect becoming clearly visible by Day 9. This reduction effect was dose-dependent, where the 500 mg/kgBW dose provided the most optimal antihyperglycemic effect, closely approaching the effect of Metformin and the normal group. The ethyl acetate fraction ofpomelo peelis effective in lowering the blood glucose levels of hyperglycemic rats. This activity is strongly suspected to originate from the content of active compounds such as flavonoids, saponins, and alkaloids.
Antihyperuricemia Effectiveness Test of Ethanol Extract of Kedondong Pagar Leaves (Lannea coromandelica (Houtt.) Merr.) Against Male White Rats (Ratus norvegicus) Nasution, Irma Suryani; Siregar, Anggie Patrisia; Br Ginting, Astriani Natalia; Kaban, Vera Estefania; Siagian, Roy Indrianto Bangar
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.137

Abstract

Hyperuricemia is a metabolic disorder caused by elevated serum uric acid levels that may progress to gout and other complications. Although synthetic drugs such as allopurinol are effective, their long-term use may cause adverse effects, thus alternative therapies derived from natural products are needed. This study aimed to evaluate the antihyperuricemic activity of the ethanol extract of kedondong pagar leaves (Lannea coromandelica (Houtt.) Merr.) in male white rats (Rattus norvegicus). An in vivo experimental study was conducted using potassium oxonate–induced hyperuricemic rats. The animals were divided into five groups: negative control (0.5% CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving the ethanol extract at doses of 100, 200, and 300 mg/kgBW. Serum uric acid levels were measured before induction, after induction, and hourly up to six hours following treatment. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides in the extract. The results demonstrated that the ethanol extract of Lannea coromandelica leaves significantly reduced serum uric acid levels in a dose-dependent manner, with the 300 mg/kgBW dose showing the greatest effect and approaching the efficacy of allopurinol. In conclusion, the ethanol extract of kedondong pagar leaves has potential as a natural antihyperuricemic agent.
Formulasi dan Evaluasi Sediaan Sabun Cair dari Umbi Porang (Amorphophallus muelleri Blume): Novia Agustini Irmasyari Siregar; Roy Indrianto Bangar; Erida Novriani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7530

Abstract

Porang tuber (Amorphophallus muelleri Blume) is a potential natural resource that can be developed as an active ingredient in cosmetic preparations, particularly liquid soap. This study aimed to formulate and evaluate liquid soap containing porang tuber extract and to determine its physical quality characteristics. The tubers were extracted by maceration using 70% ethanol. Prior to extraction, simplicia characterization was performed, including determination of moisture content, water-soluble extractive, ethanol-soluble extractive, total ash, and acid-insoluble ash. Phytochemical screening was carried out to identify secondary metabolites. The extract was formulated into liquid soap preparations with concentrations of 3%, 5%, and 8%. The evaluation included organoleptic tests, pH measurement, foam height test, irritation test, and hedonic test. The results of simplicia characterization showed that all parameters met the requirements of the Herbal Pharmacopeia. Phytochemical screening indicated the presence of alkaloids, flavonoids, saponins, tannins, and triterpenoids. The formulated liquid soaps showed acceptable physical characteristics, pH values within the Indonesian National Standard range (8–11), adequate foam formation, and no skin irritation. Hedonic testing demonstrated that all formulations were acceptable to panelists. It can be concluded that porang tuber extract has potential as a natural active ingredient in liquid soap formulations.
Formulasi dan Evaluasi Sediaan Roll on Aromaterapi Minyak Atsiri Buah Andaliman (Zanthoxylum Acanthopodium Dc.) Novelia Zwi Dwinayanti Silaban; Roy Indrianto Bangar; Asyrun Alkhairi Lubis
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7535

Abstract

Andaliman (Zanthoxylum acanthopodium DC.) is an endemic spice from North Sumatra with significant therapeutic potential derived from its essential oils. Terpenoid compounds such as geranyl acetate, limonene, and citronellol in andaliman are recognized for their efficacy in aromatherapy to alleviate nausea and vomiting. This study aims to construct an aromatherapy roll-on formulation using andaliman fruit essential oil and to evaluate its physical characteristics and safety profile. The research employed a laboratory experimental method, utilizing the Stahl steam distillation technique for essential oil isolation. The preparations were formulated into three concentration variations: F0 (0%), F1 (5%), and F2 (10%). Evaluation parameters included organoleptic properties, homogeneity, viscosity, pH value, dermal irritation tests, and hedonic (preference) tests. The results demonstrated that all formulas maintained excellent physical stability and homogeneity. The pH values ranged from 5.52 to 6.06, which is considered safe as it aligns with the physiological pH of human skin (4.5–6.5). Irritation tests confirmed that the formulations did not trigger adverse skin reactions in respondents. According to the hedonic test, panelists showed high preference for aroma, texture, and comfort, although the scent longevity requires further optimization due to the volatile nature of the essential oil. Overall, the andaliman essential oil aromatherapy roll-on meets the physical quality and safety standards for topical preparations.
Perbandingan Ektrak Konvensional dengan Green Ektraksi Umbi Porang (Amorphophallus Muelleri) terhadap Aktivitas Antioksidan Pasti Marito Samosir; Roy Indrianto Bangar; Vera Estefania Kaban
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7536

Abstract

Porang tuber (Amorphophallus muelleri) contains various bioactive compounds with potential antioxidant activity, while extraction efficiency is strongly influenced by the applied method. This study aimed to compare conventional and environmentally friendly extraction techniques, including maceration, Soxhlet extraction, Microwave-Assisted Extraction (MAE), and Ultrasonic-Assisted Extraction (UAE), using 70% ethanol as the solvent. Antioxidant activity was evaluated using the DPPH radical scavenging assay and expressed as IC₅₀ values. The results showed that differences in extraction methods significantly affected antioxidant activity. Soxhlet extraction exhibited the highest antioxidant activity with the lowest IC₅₀ value (0.1788 µg/mL), followed by MAE (0.4312 µg/mL), maceration (0.6315 µg/mL), and UAE (0.6574 µg/mL). The superiority of the Soxhlet method is related to continuous solvent reflux and heat-assisted mass transfer, which enhance the release of antioxidant compounds. These findings confirm that porang tuber is a promising natural antioxidant source, with Soxhlet extraction identified as the most effective method under the applied experimental conditions for future development of functional food, nutraceutical, and pharmaceutical applications.
Kajian Potensi Etil Asetat Ekstrak Daun Andaliman : Total Fenol Flavonoid dan Aktivitas Uji Antioksidan Muhtamilatur Rahma; Roy Indrianto Bangar; Muhammad Yunus
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7537

Abstract

Andaliman leaves (Zanthoxylum acanthopodium DC.) are a traditional plant native to North Sumatra with potential as a natural antioxidant source due to their phenolic and flavonoid compounds. This study aimed to evaluate the antioxidant potential of the ethyl acetate extract of andaliman leaves based on total phenolic content, total flavonoid content, and antioxidant activity. Extraction was carried out using the maceration method with ethyl acetate as the solvent. Total flavonoid content was determined using the AlCl₃ method with quercetin as the standard, while total phenolic content was analyzed using the Folin– Ciocalteu method with gallic acid as the standard. Antioxidant activity was evaluated using the DPPH radical scavenging assay. The results showed that the ethyl acetate extract of andaliman leaves contained 73.40 mg QE/g extract of total flavonoids (7.3%) and 148.48 mg GAE/g extract of total phenolics. The antioxidant activity test yielded an IC₅₀ value of 4,2485 µg/mL, indicating that the extract exhibits very strong antioxidant activity. The high levels of phenolic and flavonoid compounds are believed to play an important role in the radical scavenging activity observed. Based on these findings, it can be concluded that the ethyl acetate extract of andaliman leaves has strong potential to be developed as a natural antioxidant source for applications in the pharmaceutical and health fields.
Therapeutic Efficacy of Topical Bay Leaf (Syzygium polyanthum) Extract Gel on Macroscopic Ulcer Healing in Alloxan-Induced Diabetic Rats Permata Gulo, Elastis; Yunus, Muhammad; Bangar, Roy Indrianto
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 02 (2026): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v4i02.182

Abstract

Diabetes mellitus is a chronic disease that impairs wound healing due to oxidative stress and prolonged inflammation. Bay leaf (Syzygium polyanthum) contains bioactive compounds with potential therapeutic effects in promoting tissue repair. This study aimed to evaluate the effectiveness of topical bay leaf extract gel on macroscopic wound healing in alloxan-induced diabetic rats. This experimental in vivo study used 30 male rats divided into six groups: normal control, negative control, positive control (Bioplacenton), and treatment groups receiving extract gel at concentrations of 2.5%, 5%, and 10%. Diabetes was induced using alloxan, followed by burn wound creation and topical treatment for 14 days. The results showed that treatment groups exhibited faster wound healing compared to the negative control. The 2.5% and 10% extract gel groups demonstrated more optimal wound closure, comparable to the positive control by day 14. These findings indicate that flavonoid and phenolic compounds in bay leaf contribute to antioxidant and anti-inflammatory activities, supporting tissue regeneration. In conclusion, bay leaf extract gel is effective in accelerating wound healing in diabetic conditions. Further studies are recommended to investigate histopathological changes and molecular mechanisms.
Co-Authors Adelia Pratiwi Ain Naia Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br. Ginting Astriani Natalia Br. Ginting Astyka, Ririn Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Br Ginting, Astriani Natalia Br Pinem, Elys Dayanty Br Sembiring, Novitaria Br Tarigan, Jenny Alfa Dilla Cut Rahil Sofia Daimah W. S. Harahap Daulay, Wardiyah Desita, Maya Desmina Nur Cahaya Simanjuntak Edy Fachrial Erida Novriani Erida Novriani Ginting, Astriani Natalia Br Harahap, Daimah Wirdatus Sanaun Hardivia Kaur Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hotma sarito Panjaitan IKHTIARI, REFI Inesha Viata Melika Purba Josita Jenny Haryanti Hutagulung Kaban, Vera E. Kevin Wijaya Khairatunawa, Tisa Kinanti Maharani Lampita Bellina Manullang Lubis, Muhammad F. Lumban Gaol, Irma Yohana Michelle Veronica Gulo gulo Muhamad Insanu Muhammad Yunus Muhammad Yunus Muhammad Yunus Muhtamilatur Rahma Nailan Azizah Nasution, Haris M. Nasution, Irma Suryani Nerly Juli Pranita Simanjuntak Nerly Juli Pranita Simanjuntak Ningsih, Kurnia Nastira Ningsih, Wulan Seppia Nova Ria Ovelti Sihotang Novelia Zwi Dwinayanti Silaban Novia Agustini Irmasyari Siregar Novrika Desclarita Naibaho Nurhadijah Sibagariang Pasti Marito Samosir Permata Gulo, Elastis Rachel Adriany Br Sinaga Rahmana Emran Kartasasmita Razoki Razoki Razoki Razoki Razoki Razoki Razoki, Razoki Refi Ikhtiari Rio Sinar Parsaoran Simanullang Sembiring , Novitaria Br Sembiring, Novitaria Br Shintjia Dewi Agustan Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Tasyah Helgiera Tiani Nduru Tya Bella Arthamarisi Simbolon Utama, Rezza F. Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban vina andriani Vinando Vinando Waruwu, Loice Desy Krisna Yanti Wilson Kanggaran Yerly Ramadani Lubis Yulyana, Ana