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All Journal JOPS (Journal Of Pharmacy and Science) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Current Research on Biosciences and Biotechnology Jurnal Buana Farma Narra J JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Jurnal Kesehatan Farmasi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal International Journal of Health, Engineering and Technology MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Roy Indrianto Bangar S
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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FORMULASI SEDIAAN HAND BODY GEL DENGAN SARI BUAH RAMBUTAN (Nephelium lappaceum L.) Nailan Azizah; Nerly Juli Pranita Simanjuntak; Roy Indrianto Bangar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1673

Abstract

Rambutan fruit (Nephelium lappaceum L.) contains vitamins A, B, and C, which act as antioxidants and are beneficial for skin health. The utilization of rambutan fruit juice in a hand body gel formulation aims to produce a natural moisturizing product that is safe for use. This study was conducted experimentally by formulating rambutan fruit juice into hand body gel at concentrations of 3%, 5%, and 7%, along with a blank formulation. Each formulation was evaluated for its physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, and viscosity. In addition, skin irritation testing and skin moisture testing using a skin analyzer were performed over three weeks of use. The results showed that all formulations had good physical quality, pH values suitable for the skin, and did not cause irritation. Skin moisture testing indicated an increase in skin moisture in all formulations, with the 7% concentration showing the highest improvement. In conclusion, rambutan fruit juice can be formulated into a hand body gel that is safe and effective as a skin moisturizer, with the 7% concentration being the best formulation.
Hubungan Tingkat Pengetahuan Pasien Hipertansi Terhadap Kepatuhan Minum Obat Pada Pasien Rawat Jalan Di Rumah Sakit Royal Prima Adelia Pratiwi; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3416

Abstract

Hypertension s a chronic condition with a high prevalence that can lead to cardiovascular complications if patients do not adhere to medication regimens and the medication adherence is on of the primary key to therapeutic success. However, low adherence rates remain a significant challenge, often linked to insufficient patient understanding. This study aimed to analyze the relationship between the level of knowledge of hypertensive patients and their medication adherence at Royal Prima Hospital. This research method employed a quantitative correlational design with a cross-sectional approach involving 78 outpatient respondents selected through purposive sampling. Demographic data were analyzed using the Chi-Square Test, while the relationship between the main variables was tested with Spearman Correlation. The results showed that the majority of respondents had a sufficient level of knowledge (52.6%) and moderate adherence (48.7%). The Spearman Correlation test yielded a coefficient value (rₛ) of 0.803 with p < 0.001, indicating a very strong and significant positive relationship between the level of knowledge and medication adherence. Conversely, the Chi-Square Test results showed no significant association between demographic characteristics and adherence. It is concluded that knowledge is a crucial determinant influencing treatment adherence among hypertensive patients.
Perbandingan Pelarut Etanol dan Gliserin pada Ekstrak Etanol Buah Bit (Beta vulgaris L.) terhadap Pertumbuhan Bakteri Staphylococcus aureus Tiani Nduru; Astriani Natalia Br Ginting; Roy Indrianto Bangar
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 1 (2026): Januari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i1.7167

Abstract

Infectious diseases caused by Staphylococcus aureus remain a significant health concern globally, with increasing antibiotic resistance necessitating alternative antimicrobial agents. Beetroot (Beta vulgaris L.) contains bioactive compounds with potential antibacterial properties. This study investigated the antibacterial activity of beetroot ethanol extract against Staphylococcus aureus and compared the effects of ethanol and aqueous solvents in the extraction process. Beetroot simplicia was prepared and characterized according to standard protocols. Extraction was performed using 70% ethanol maceration method, yielding 20.29% extract. Phytochemical screening and thin-layer chromatography identified secondary metabolites. Antibacterial activity was evaluated using the Kirby-Bauer disc diffusion method at concentrations of 5%, 10%, and 15%, both with and without glycerin addition. Simplicia characterization met quality standards with moisture content of 0.25%. TLC analysis revealed alkaloids, flavonoids, terpenoids, steroids, saponins, and tannins. Beetroot ethanol extract demonstrated concentration-dependent antibacterial activity with inhibition zones of 8.1±0.87 mm (5%), 10.2±0.71 mm (10%), and 13.9±0.79 mm (15%). Glycerin-supplemented extracts showed comparable activity. Beetroot ethanol extract exhibits significant antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent for pharmaceutical applications.
Evaluasi Aktivitas Antidiabetes In Vivo dari Fraksi Etil Asetat dan n-Heksana Ekstrak Kulit Kayu Raru (Cotylelobium melanoxylon) pada Model Tikus Diabetes yang Diinduksi Aloksan Rio Sinar Parsaoran Simanullang; Roy Indrianto Bangar; Astriani Natalia Br. Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1358

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disease with continuously increasing global prevalence, driving the search for safer and more effective alternative therapies based on natural ingredients. Raru bark (Cotylelobium melanoxylon) has been traditionally used as an antidiabetic agent, yet scientific evidence supporting the efficacy of its specific fractions remains limited. Methods: This laboratory experimental study evaluated the antidiabetic activity of ethyl acetate and n-hexane fractions of raru bark ethanol extract in alloxan-induced male Wistar rats (n=3 per group). Extraction was performed using maceration method with 96% ethanol, followed by sequential liquid-liquid fractionation. Simplicia characterization included determination of water content, total ash content, acid-insoluble ash content, as well as water-soluble and ethanol-soluble extractive values. Phytochemical screening was conducted qualitatively, while blood glucose levels were measured periodically over 14 days and analyzed using one-way ANOVA (p<0.05). Results: Simplicia characterization met the requirements of the Indonesian Herbal Pharmacopoeia with water content of 9.99%, total ash content of 1.78%, and acid-insoluble ash content of 0.19%. Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins. The ethyl acetate fraction demonstrated more significant blood glucose reduction (318→95 mg/dL) compared to the n-hexane fraction (312→160 mg/dL) over the 14-day observation period, with a final mean value approaching that of the positive control (80.00±11.66 mg/dL). Statistical analysis revealed significant differences among treatment groups (p<0.05). Conclusion: The ethyl acetate fraction of raru bark extract exhibited superior in vivo antidiabetic activity compared to the n-hexane fraction in alloxan-induced diabetic rat models, correlating with the content of semi-polar compounds such as flavonoids and phenolics. The ethyl acetate fraction shows potential for development as a natural-based antidiabetic agent.
Evaluasi Aktivitas Antidiabetes In Vivo dari Fraksi Etil Asetat dan n-Heksana Ekstrak Kulit Kayu Raru (Cotylelobium melanoxylon) pada Model Tikus Diabetes yang Diinduksi Aloksan Rio Sinar Parsaoran Simanullang; Roy Indrianto Bangar; Astriani Natalia Br. Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1358

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disease with continuously increasing global prevalence, driving the search for safer and more effective alternative therapies based on natural ingredients. Raru bark (Cotylelobium melanoxylon) has been traditionally used as an antidiabetic agent, yet scientific evidence supporting the efficacy of its specific fractions remains limited. Methods: This laboratory experimental study evaluated the antidiabetic activity of ethyl acetate and n-hexane fractions of raru bark ethanol extract in alloxan-induced male Wistar rats (n=3 per group). Extraction was performed using maceration method with 96% ethanol, followed by sequential liquid-liquid fractionation. Simplicia characterization included determination of water content, total ash content, acid-insoluble ash content, as well as water-soluble and ethanol-soluble extractive values. Phytochemical screening was conducted qualitatively, while blood glucose levels were measured periodically over 14 days and analyzed using one-way ANOVA (p<0.05). Results: Simplicia characterization met the requirements of the Indonesian Herbal Pharmacopoeia with water content of 9.99%, total ash content of 1.78%, and acid-insoluble ash content of 0.19%. Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins. The ethyl acetate fraction demonstrated more significant blood glucose reduction (318→95 mg/dL) compared to the n-hexane fraction (312→160 mg/dL) over the 14-day observation period, with a final mean value approaching that of the positive control (80.00±11.66 mg/dL). Statistical analysis revealed significant differences among treatment groups (p<0.05). Conclusion: The ethyl acetate fraction of raru bark extract exhibited superior in vivo antidiabetic activity compared to the n-hexane fraction in alloxan-induced diabetic rat models, correlating with the content of semi-polar compounds such as flavonoids and phenolics. The ethyl acetate fraction shows potential for development as a natural-based antidiabetic agent.
Co-Authors Adelia Pratiwi Ain Naia Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br. Ginting Astriani Natalia Br. Ginting Astyka, Ririn Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Br Ginting, Astriani Natalia Br Pinem, Elys Dayanty Br Sembiring, Novitaria Br Tarigan, Jenny Alfa Dilla Cut Rahil Sofia Daimah W. S. Harahap Daimah Wirdatus Sanaun Harahap Daulay, Wardiyah Desita, Maya Desmina Nur Cahaya Simanjuntak Edy Fachrial Erida Novriani Erida Novriani Ginting, Astriani Natalia Br Hardivia Kaur Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hotma sarito Panjaitan IKHTIARI, REFI Inesha Viata Melika Purba Josita Jenny Haryanti Hutagulung Kaban, Vera E. Kevin Wijaya Khairatunawa, Tisa Kinanti Maharani Lampita Bellina Manullang Lubis, Muhammad F. Lumban Gaol, Irma Yohana Michelle Veronica Gulo gulo Muhamad Insanu Muhammad Yunus Muhammad Yunus Muhammad Yunus Muhtamilatur Rahma Nailan Azizah Nasution, Haris M. Nasution, Irma Suryani Nerly Juli Pranita Simanjuntak Nerly Juli Pranita Simanjuntak Ningsih, Kurnia Nastira Ningsih, Wulan Seppia Nova Ria Ovelti Sihotang Novelia Zwi Dwinayanti Silaban Novia Agustini Irmasyari Siregar Novrika Desclarita Naibaho Nurhadijah Sibagariang Pasti Marito Samosir Permata Gulo, Elastis Rachel Adriany Br Sinaga Rahmana Emran Kartasasmita Razoki Razoki Razoki Razoki Razoki Razoki Razoki, Razoki Refi Ikhtiari Sembiring , Novitaria Br Sembiring, Novitaria Br Shintjia Dewi Agustan Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Tasyah Helgiera Tiani Nduru Tya Bella Arthamarisi Simbolon Utama, Rezza F. Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban vina andriani Vinando Vinando Waruwu, Loice Desy Krisna Yanti Wilson Kanggaran Yerly Ramadani Lubis Yulyana, Ana