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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Forum Geografi IJoICT (International Journal on Information and Communication Technology) JOIN (Jurnal Online Informatika) Jurnal Teknologi dan Sistem Komputer Media Farmasi Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Forest and Society Jurnal Mandala Pharmacon Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Vokasi Jurnal Mandala Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Abdimas Madani PROFICIO: Jurnal Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Palawa Jurnal Pengabdian Kepada Masyarakat JI-KES (Jurnal Ilmu Kesehatan)
Ayu Shabrina
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Physical and SPF Value Stability Studies Avocado Oil Nano-emulgel with Carbopol 980 as A Gel Base Shabrina, Ayu; Pangestu, Diva Ma'arif; Amaliyah, Siska; Prihantini, Malinda; Heroweti, Junvidya; Prastiwi, Listyana Dewi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.100041

Abstract

Avocado oil (AVO) is a natural source of many unsaturated fatty acids that can help protect the skin from harmful UV radiation. The high content of unsaturated fatty acids in avocado oil can affect product stability. One way to overcome the stability of avocado oil for topical preparation is by formulating it into a gel base using Carbopol 980. The purpose of this study was to determine the physical stability and SPF value of avocado oil nano-emulgel (NE) with variations of Carbopol 980 as a gel base for 28 days of storage. AVONE was made with 5% AVO and Carbopol 980 base variation of 0.5% (NE1), 1.0% (NE2;), and 1.5% (NE3.) AVONE was stored in a climatic chamber at 30° ± 2°C with RH 65% ± 5%. The samples were tested for physical and SPF values before storage on days 7, 14, 21, and 28. The data obtained were analyzed statistically using one-way Anova. The AVONE on organoleptic parameters were stable; the resulting colour is broken-white with a distinctive oil aroma and thick and homogeneous texture. The pH value ranged from 6.21 ± 0.02 - 7.21 ± 0.02, with all formulas stable during storage. The viscosity value ranged from 13.28±0.23 - 47.22±0.89 dPa.s; the viscosity of NE3 was stable during storage. Adhesion and spreadability showed good ability to adhere to the skin. The SPF values ranged from 8.95±0.43 – 22.41±0.21, and NE3 was stable during storage. Avocado oil nano-emulgel with Carbopol 980 concentration of 1.5% was stable during storage.
Formulasi Tablet Asam Fenofibrat dengan Sistem Likuisolid Menggunakan Pelarut Propilenglikol dan Beberapa Adsorben Windriyati, Yulias Ninik; Shabrina, Ayu; Hasanah, Uswatun; Irmawati, Susiana; Haryati, Sri Febri; Fata, Surti Khayatul
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.59094

Abstract

Asam fenofibrat adalah antihiperlipidemia yang termasuk dalam kelas II Sistem Klasifikasi Biofarmasetik dengan kelarutan yang rendah dan permeabilitas dalam gastrointestinal yang tinggi. Disolusi asam fenofibrat berjalan lambat dan membatasi absorpsinya sehingga bioavailabilitasnya sulit diprediksi. Tujuan penelitian ini adalah mengembangkan formulasi tablet asam fenofibrat untuk meningkatkan disolusinya dengan sistem likuisolid. Metode penelitian dilakukan dengan mendispersikan asam fenofibrat dalam pelarut propilenglikol kemudian diadsorpsi menggunakan beberapa adsorben seperti Avicel PH 101, Avicel PH 102, Neusilin dan Starch 1500 sehingga terbentuk serbuk. Sistem likuisolid yang terbentuk dikompresi menjadi tablet dan dievaluasi karakteristiknya termasuk analisis dengan FTIR dan XRD untuk mengetahui adanya interaksi antar partikel dalam sistem likuisolid. Hasil pengembangan formula menunjukkan bahwa tablet likuisolid asam fenofibrat dengan berbagai adsorben yang digunakan memenuhi kriteria tablet yang tercantum dalam kompendia. Disolusi asam fenofibrat dari tablet likuisolid meningkat dibandingkan tablet konvensional yang dibuat tanpa pembentukan sistem likuisolid. Karakterisasi dengan XRD dan FTIR menunjukkan tidak terjadi perubahan kimia asam fenofibrat pada sistem likuisolid yang terbentuk.
Co-Authors Abiluzzihda, Abiluzzihda Adhi Gunawan Afifah Kumalasari Agnes Theresya Poerba Akhmad Pandhu Wijaya, Akhmad Pandhu AL Mamuda, Naila Amalia, Ayunda Tri Amaliyah, Siska Amirudin, Muhammad Subhan Angelita, Anastasya Annisa Rahayuning Pratiwi Apriliyani, Dwi Nur Anisa Arnida Lailatul Latifah Arsyada, Muhammad Farih Astri Risma Debi Auliasari, Dewi Wulandari Aza Zakiyatun Nida Aza Zakiyatun Nida Bambang Ari Wahyudi Daipadli Daipadli Dharmawan Dharmawan Dhimas Adhityasmara Diana Anisa Setyani Eka Sakti Wahyuningtyas Elya Zulfa Erik Firmansyah Erika Indah Safitri Faisal Bagus Setiawan Fata, Surti Khayatul Faza Putri_Maulina Hanik Firdausi, Zuhriya Muna Gunawan, Adhi Hafiz, Nur Haq, Stivenef Arinal Haryati, Sri Febri Heny Puspasari Heroweti, Junvidya Hidayati, Ishardina C. I Nyoman Sujana Ibrahim Arifin Ibrahim Arifin Ibrahim Arifin Icha Sabrina Milenia Khansa Ilma Nur Khafifa Inayati, Dian Inna Syafarina Intan Nuni Wahyuni Intan Pratiwi Irma Palupi Irmawati, Susiana Jalil, Ahmad Abdul Junvidya Heroweti Junvidya Herowety Kabur, Savio Ricardus Khoirul Anwar KHOIRUL ANWAR Kintoko Kintoko Kintoko, Kintoko Kusdi Latifah, Arnida L Latifah, Arnida L. Lobma, Fadhil M Fatchur Rochman M Fatchur Rochman MARIA ULFAH Mas’ud, Muhammad Maulana, Muhamad Amir Mimiek Muurukmihadi Misbahul Munir Muddiin, Muhammad Imaa Muhammad Fajar Kurniawan Muhammad Ikhsan M_Rifki Pratama_Kharisma Akbar Nalaratih, Novinda Niswatus Sholihah Nuni Wahyuni, Intan Nurjeha, Ismahani Batrisyia Nurkhasanah Nurkhasanah Nurkhayati, Nurkhayati Pangestu, Diva Ma'arif Poerba, Agnes Theresya Prastiwi, Listyana Dewi Pratama, Arvian Randitya Pratama, Fandy Indra Pratiwi, Nevy Prihantini, Malinda Puspasari, Heny Puspita, Weni Rabiatul Adawiyah Ratna Hapsari Ratna Hapsari Tri Mustika Dewi Ratu Nur’salsa Nadifah Rima Nofitasari Ririn Lispita Wulandari Risha Fillah Fithria risha fillah fithria Riyanti, Winanti Adi Rizky Adityo Saputro Rochman, M Fatchur Rossi Prabowo Rosyida, Salma Putri Saniya Alfa Salsabila Sapto Yuliani Setyani, Diana Anisa Siti Setianingsih Sofiyulloh, Muhammad Wahyu Sri Eka Rahmadany Sri Eka Rahmadany Sri Mastuti Sri Suwarni Sumantri Sumantri Sunanda, Hairudin Farid Urva Fresiva Uswatun Hasanah Vironica Rizky Fauziah Wahyu Kumala Sari Wahyu Setyo Wibowo Wahyuni, Intan N. Wahyuni, Intan Nuni Wibowo, Danang Novianto Wijayatri, Ratna Wirayudha, Halim Yulias Ninik Windriati Zuhriya Muna Zuhriya Muna Firdausi