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All Journal International Journal of Public Health Science (IJPHS) JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Althea Medical Journal Jurnal Keolahragaan Journal of Biomedicine and Translational Research Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) IJEMS (Indonesian Journal of Environmental Management and Sustainability) JOURNAL SPORT AREA Journal of Dedicators Community PREPOTIF : Jurnal Kesehatan Masyarakat Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Eduvest - Journal of Universal Studies Jurnal Keperawatan Indonesian Journal of Biomedicine and Clinical Sciences
Muniroh, Muflihatul
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Sorghum Tempeh Enteral Formula Reduces Inflammatory (IL-6) and Thrombotic (PAI-1) Markers in Atherogenic Diet-Induced Rats Bintang, Francisca Natalia; Resti, Nina; Lestari, Endang Sri; Muniroh, Muflihatul; Anjani, Gemala; Syauqy, Ahmad; Djamiatun, Kis; Afifah, Diana Nur
Media Gizi Indonesia Vol. 21 No. 2 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i2.185-195

Abstract

Atherosclerosis is predominantly an inflammatory process that is the key pathophysiological cause of ischemic coronary heart disease (CHD). Some studies suggest that sorghum can reduce atherosclerotic parameters through many biological activities, such as antioxidant, anti-inflammation, and anti-thrombotic properties. The primary objective was to evaluate the effect of an enteral sorghum tempeh formula on the levels of Plasminogen Activator Inhibitor-1 (PAI-1) and Interleukin-6 (IL-6) in an atherosclerotic rat model. A total of 24 male rats were utilized, with the experiment structured into an 8-week atherogenic diet induction period, followed by a 4-week intervention phase. The rats were divided into four groups: a healthy control, an atherogenic control, and two treatment groups supplemented with the formula at 0.75g/200 g and 1.50g/200 g body weight (BW), respectively. IL-6 and PAI-1 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA). The atherogenic diet successfully induced a significant elevation in both IL-6 and PAI-1 levels compared to the healthy control group (p=0.000), indicating a heightened inflammatory and thrombotic state in the atherosclerotic group. Conversely, the groups receiving the sorghum tempeh-based formula exhibited a significant reduction in both IL-6 and PAI-1 levels compared to the atherogenic control group (p=0.000), suggesting potent anti-inflammatory and antithrombotic properties of the sorghum tempeh.
Co-Authors - Anggorowati Adengganan, Yogi Adriyan Pramono Afriana, Rizky Dyas Ahmad Syauqy Ani Margawati Anjani, Gemala Annastasia Ediati Annisa Pratiwi, Annisa Apoina Kartini Ardyarini, Hikmatunnisa Tri Ariani, Mahayu D. Ariosta Ariosta Awal Prasetyo Besari Adi Pramono Bintang, Francisca Natalia Budiono, Bernadus Parish Diana Nur Afifah, Diana Nur Djuara P Lubis Elsa Naviati Endang Sri Lestari Etika Ratna Noer Fitry, Febriana Ramadhani Hadiprajitno, Peter I. Halleyantoro, Ryan Hardhono Susanto Hermawan Istiadi Ignatius Riwanto, Ignatius Julian Dewantiningrum Juniarto, Achmad Z. Karlowee, Vega Kesumayadi, Irfan Kis Djamiatun Mambaya, Helvi Desi Mohammad Sulchan Muhammad Nur Muhammad Sulchan Nani Maharani Neni Susilaningsih Nugraha, Eka Djatnika Nur, Muhammad Hasbi Nyoman Suci Widyastiti Partiwi, Rina Perdanawati, Mia Prabowo, Erik Qolby, Qonita Nur Renni Yuniati Resti, Nina Retnoningrum, Dwi Sadana, Aqsa Aufa Syauqi Sekartaji, Anindhita Dyah Selamat Budijitno Septiani, Bernadeta Novita Sigit Adi Prasetyo, Sigit Adi Siti Fatimah Muis Sri Achadi Nugraheni Untung Sujianto Utami, Arini Veni, Rizka Widyastuti, Trioni Yan Wisnu Prajoko Yetty Movieta Nency, Yetty Movieta Yora Nindita Zetta, Adelia Paradya