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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Teknologi Informasi dan Ilmu Komputer Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB JURNAL WACANA KESEHATAN Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer Journal of Community Health and Preventive Medicine (JOCHAPM)

Djajalaksana, Susanthy

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Author-ID : 1230613

Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Wujudkan Generasi Bebas Rokok Djajalaksana, Susanthy
Jurnal Klinik dan Riset Kesehatan Vol 4 No 3 (2025): Volume 4 No 3, Juni 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.3.1

Rancang Bangun Aplikasi Pengukur Kesehatan Fungsi Paru Manusia Memanfaatkan Microphone Pada Smartphone Kusuma, Wahyu Teja; Pramukantoro, Eko Sakti; Djajalaksana, Susanthy
Jurnal Teknologi Informasi dan Ilmu Komputer Vol 3 No 2: Juni 2016
Publisher : Fakultas Ilmu Komputer, Universitas Brawijaya

ABSTRAKPenyakit Paru Obstruktif Kronik (PPOK) adalah penyakit yang ditandai dengan hambatan aliran udara di saluran nafas yang tidak sepenuhnya reversibel. Hambatan aliran udara ini bersifat progresif dan berhubungan degan respon inflamasi paru terhadap partikel gas beracun atau berbahaya [2][16]. Hasil penelitian pada bulan Januari-Desember 2010 menyebutkan bahwa PPOK menduduki urutan ke-3 dari penyakit paru terbanyak yang ada di RS Paru Batu Malang. Sedangkan di RSU Dr. Saiful Anwar Malang menduduki urutan ke-5. The Burden Of Disease Study dibawah naungan WHO menyatakan bahwa pada tahun 2030 PPOK akan menempati peringkat ke-3 penyebab kematian di dunia [5][15][16]. Sebagai solusi terhadap masalah tersebut yaitu dengan membangun sebuah aplikasi pengukur kesehatan fungsi paru manusia memanfaatkan microphone pada smartphone”. Guna mengetahui gangguan ventilasi paru, monitoring pengobatan, dan menilai perkembangan fungsi paru. Media smartphone dipilih karena memiliki teknologi Microphone API yang digunakan untuk menangkap input berupa rekaman suara hembusan napas pengguna. Dan mayoritas masyarakat telah melilikinya. Dari hasil pengujian validasi dapat disimpulkan bahwa aplikasi pengukur kesehatan paru manusia pada media smartphone berhasil diimplementasikan dengan memanfaatkan teknologi microphone. Dari hasil pengujian akurasi yang dilaksanakan di Rumah Sakit Saiful Anwar Kota Malang dapat disimpulkan bahwa ditemukan selisih akurasi Prediksi Nilai Acuan Normal sebesar FEV1 = 0,11 liter; FVC = 0,152432432 liter; FEV1/FVC = 4,742432432 %. Dan selisih akurasi Hasil Pengukuran sebesar FEV1 = -1,545945946 liter; FVC = -2,892432432 liter; FEV1/FVC = 11,52243243 %.Kata Kunci: Penyakit Paru Obstruktif Kronik, Microphone, Smartphone. ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is a disease characterized by air flow resistance in the airway that is not fully reversible. This air flow resistance is progressive and, relating to pulmonary inflammatory response to toxic gases or dangerous particles [2] [16]. The results of the study in January-December 2010 states that COPD ranks 3rd from most existing lung disease Pulmonary Hospital Batu Malang. Meanwhile, in Hospital Dr Saiful Anwar-5 ranks. The Burden Of Disease Study under the auspices of the WHO stated that by 2030 COPD will be ranked as the third leading cause of death in the world [5] [15] [16]. As a solution to these problems is to build an application measuring the health of human lung function utilizing a microphone on a smartphone ". In order to determine pulmonary ventilation disorders, treatment monitoring, and assessing the development of lung function. Media Smartphone Microphone technology chosen because it has an API that is used to capture the input of the user breath sound recordings. And the majority of people have melilikinya. From the results of the validation testing can be concluded that the application of measuring the health of the human lung on a smartphone media successfully implemented by utilizing the microphone. Accuracy of test results conducted at Saiful Anwar Hospital Malang can be concluded that the prediction accuracy differences were found Normal Reference Values for FEV 1 = 0.11 liters; FVC = 0.152432432 liters; FEV 1 / FVC = 4.742432432%. And the difference in the accuracy of measurement results for FEV1 = -1.545945946 liter; FVC = -2.892432432 liter; FEV 1 / FVC = 11.52243243%.Keyword: Chronic Obstructive Pulmonary Disease, Microphone, Smartphone.

The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer Tjahyadi, Rizal Muldani; Setyawan, Ungky Agus; Astuti, Tri Wahju; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp171-180

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.

D-Dimer and Brixia Score to Mortality in COVID-19 Patients Falyani, Silvy Amalia; Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Erawati, Dini Rachma; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.99-106

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious severe and acute respiratory syndrome caused by the SARS-CoV-2 virus. A variety of factors can increase a patient's risk of death, including coagulopathy characterized by increased D-dimer levels. Brixia scores could be one of the determinants of COVID-19 severity, as assessed by chest radiographs. This study aimed to analyze chest radiographic severity based on the Brixia score at the degree of coagulation based on D-dimer in mortality of COVID-19 patients who were hospitalized. Methods: This cohort retrospective study was conducted at Dr. Saiful Anwar General Hospital, Malang, using an observational cross-sectional design. The study included 300 medical records of COVID-19 patients who passed away while hospitalized. The data were analyzed using the Wilcoxon test, and the results were also tested for Spearman correlation to determine the relationship between variables. Results: Significance results of median D-dimer were found by age and severity of COVID-19 (p-values 0.015 and 0.002), and median Brixia scores by age, gender, severity of COVID-19, and length of treatment (p-values 0.001, 0.001, 0.001, and 0.005). The results were also compared with normal values, which were significant (p = 0.000). Spearman correlation test results between the final D-dimer and the initial Brixia score (p = 0.005). Conclusion: The research results display a retrospective study of the correlation between D-dimer and Brixia score values "‹"‹and outcomes in COVID-19 patients. Higher D-dimer values"‹ "‹and Brixia scores on admission were shown to be associated with mortality.

Myastehenia Gravis is Caused by the Thymoma in Anterosuperior Mediastinum Sinistra and Posteroinferior Sinistra Irfan, Ferdy Syah; Djajalaksana, Susanthy
Malang Respiratory Journal Vol. 1 No. 1 (2019): The Many Faces of Respiratory Disease
Publisher : Universitaas Brawijaya

Background: Thymoma is the most common thymus tumor; it covers 30% of the anterior mediastinum mass in adult. Almost half of thymoma does not present with any symptom and is found by accident. In 40% of patients have symptom of myasthenia gravis; other symptoms include chest pain, symptoms of bleeding and compression to other mediastinumâ€™s structures. Ninety percent of thymoma is located in anterior mediastinum.Case: A 42-year-old woman came to Saiful Anwar Hospital with a complaint of difficulty in swallowing since three months before admission. We performed physical examination and chest X-ray APâ€™ and the result was within normal limit. In USG examination, there was no abnormality. From the laboratory examination, we found leucocytosis and from the CT-scan imaging, we found pocketed pleural effusion sinistra at the postero-inferior part.Based on these findings, we diagnosed (pre-operation diagnosis) this patient as anterosuperior mediastinum tumor: suspect thymoma. The pulmonologist consulted to Surgical Department for surgery. The surgeon performed sternotomy-tumor excision. The result from the vries coup and histopathogical examination was thymoma. FOB after the surgery showed an edema at the right vocal cord (post-extubation). Post-operative chest X-ray showed no mass in antero-superior mediastinum.

Successful Therapy on Patients with Yolksac and Embrional Carcinoma by Surgery and Chemotherapy Prasetya, Fahmi Adhi; Djajalaksana, Susanthy; Retnani, Diah Prabawati; Isharanto, Artono; Normahayu, Indrastuti; Okta, Shinta
Malang Respiratory Journal Vol. 2 No. 01 (2020): Shape the Curves
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2020.002.01.5

Background: Malignant mixed germ cell tumors account for 13-25% of all non seminoma germ cell tumors, almost all cases were found in males (85%), increased in the third decade, and had an average survival rate of 40-45%. With modern management the average 5-year survival rate can be over 80%.Case Report: We reported a case report in Saiful Anwar Malang Hospital, Indonesia, a young man, 26 years old with an malignant epithelial tumor derived from mediastinal or lung. The CT scan of the chest showed an lobulated solid mass of iso-hipodens on the anterior superior mediastinum, mass encompassing the aortic arch, left pulmonalis artery, subclavian artery. The result from transthoracic FNAB with USG guidance showed an malignant epithelial tumor derived from mediastinal or lung, impression of an adeno squamous carcinoma. The AFP, LDH, and NSE serum level was elevated. Patient underwent a surgical sternotomy and tumor debulking. The biopsy showed an malignant mixed germ cell tumor (yolksac and embrional carcinoma). These were confirming the diagnosis of malignant mixed germ cell mediastinal tumor (yolksac and embrinonal carcinoma). Patient received a combination bleomycin, etoposid, cisplatin 3 series chemoteraphy Â and evaluated.Conclusion: Some procedures like biopsy, tumor marker, could differentiate the subtype of mediastinal germ cell tumor. The multimodality treatment by combining surgical therapy (surgical sternotomy and tumor debulking) with chemotherapy could increase the survival rate of patients.

Elderly Male Patient with Fibrotic Non Spesific Instertitial Pneumonia from Lung Biopsy by Video Assisted Thoracoscopy santony, Santony; Djajalaksana, Susanthy; Chozin, Iin Nur; Erawati, Dini Rachma; Yudhanto, Hendy Setyo
Malang Respiratory Journal Vol. 2 No. 02 (2020)
Publisher : Universitaas Brawijaya

Background: NSIP is a rare disease, the incidence rate ranges from 1 to 9 per 100,000 population, where most cases of NSIP are idiopathic. NSIP definitive diagnosis is very difficult because it must be with a multidisciplinary approach and confirm from a pulmonary biopsy. On the course of his illnesses the possibility of Connective tissue diseases (CTDs) arising in NSIP during follow up period was about 10% of cases.Case Report: We reported one case at RS Dr. Saiful Anwar, an old adult male smoker, age 64 with fibrotic type Non Spesific Instertitial Pneumonia (NSIP). From clinical patients including anamnesis, physical examination and laboratory results and X-Ray chest, ILD suspicion was found. Bodypletstimography results show a corresponding decrease in DLCO with ILD. CT-Scan results obtained by crazy paving with pulmonary bronchiectasis traction in accordance with ILD susp Sussection NSIP and enforced from VATS biopsy results with conclusions according to NSIP description. Patients received corticosteroid therapy for 4 weeks and showed clinical improvement.Conclusion: In these patients the diagnosis of fibrotic NSIP has gone through a multidisciplinary approach including the pulmonology, radiologist and pathologist sections. Corticosteroid therapy in these patients gives good results and the patient is in stable condition. Periodic monitoring is necessary because of the risk of exacerbations and the incidence of CTD complications..

A Young Women with Infected Polycystic Lung Disease That Affects the Quality of Life Suwandi, Gede Sasmika; Djajalaksana, Susanthy
Malang Respiratory Journal Vol. 3 No. 2 (2021): Vol. 3 No. 2
Publisher : Universitaas Brawijaya

Introduction: Polycystic lung disease (PLD) is a group of diseases with heterogeneous pathophysiological processes. The demographics and clinical symptoms vary widely. The etiology of PLD is related to neoplasms, genetics, lymphoproliferative disorders, infections, interstitial diseases, smoking, and developmental disorders. In HRCT, cystic, nodular, ground glass opacities and pneumothorax can be found. Tissue biopsy and immunohistochemistry are needed to determine the type of PLD. Age is very influential towards the survival rates, rapid decline in lung function often occurs at a young age, thus, causing long-term complications in the cardiovascular systemCase Description: A 14-years-old woman complained of shortness of breath and cough was diagnosed with Poly cystic lung disease with Lung TB as secondary infection. CT Scan Thorax showed multiple cavities with consolidation, abdominal ultrasound of the ovary found a simple cystic lesion. The patient underwent TB treatment. After evaluation, clinical symptoms improved, but the patient is often absent from school, thus, indicating disruption in quality of life. Spirometry data showed decreased pulmonary function ad modum restriction, and moderate obstruction. The patient is planned to undergo several examinations such as Bodypletysmography, Bronchoscopy, and VATS to obtain tissue samples, so a diagnosis can be made. Considering the age of the patientâ€”who is still youngâ€”definitive therapy as a continuation is expected to improve the patient's quality of life.Conclusion: The diagnosis of PLD in the patient still requires further examination. Other tests, such as biopsy followed by immunohistochemical examination, can be used to confirm the type of PLD. Currently, the patient is undergoing TB treatment and routine control to the clinic. Ater treatment, the clinical symptoms alleviated, but shortness of breath is still present, especially felt after walking fast and carrying heavy loads. Spirometry was done as an evaluation of pulmonary function, showing moderate restriction and obstruction. It is clear that PLD affects the quality of life in this patient.

A Confirmed Case of Idiopathic Pulmonary Fibrosis - Probable Usual Interstitial Pneumonia Pattern through Lung Biopsy Kristiani, Maria; Djajalaksana, Susanthy; Erawati, Dini; Yudhanto, Hendy; Bayuadi, Imam
Malang Respiratory Journal Vol. 4 No. 1 (2022): Vol. 4 No. 1
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2022.004.01.2

Background: Although classified as a rare disease, the global burden of disease study reports showed that interstitial lung disease is ranked 40th in the diseases with high mortality, and its prevalence had increased by 86% since 1990. The most common interstitial lung disease”idiopathic pulmonary fibrosis (IPF)”has low survival rates”2-3 years after diagnosis”and is irreversible. Establishing a definite diagnosis of IPF is very difficult because it needs a multidisciplinary approach, as an establishment based on the description of HRCT and lung biopsy is needed. The goal of therapy is to prevent the progression of fibrosis. Case: We report a case of an adult woman, 46 years old with idiopathic pulmonary fibrosis (IPF) with Probable Usual Interstitial Pneumonia (UIP) pattern at dr. Saiful Anwar Hospital. History taking, physical examination and laboratory and chest Xray examination of the patient found a suspicion of ILD. CT-scan showed fibrosis in both lungs, honeycomb appearance with pulmonary bronchiectasis traction, which fit the description of IPF, and thus suspended the diagnosis of ILD. VATS pulmonary biopsy confirmed the diagnosis of IPF. The patient experienced a decrease in clinical conditions, as her complaint was worsening in the last month, in accordance to the state of acute exacerbations. Conclusion: In this patient, the diagnosis of IPF with Probable UIP pattern was made through a multidisciplinary approach, including the pulmonology, radiology and anatomical pathology department. Keywords: IPF, IPF, Probable UIP Pattern, IPF Diagnosis

A Thymoma (Case Report): Importance of Comorbidity, Lifestyle, and Thymoma Size in Treatment Success Suryaman, Rachmat; Djajalaksana, Susanthy; Setyawan, Ungky; Wardhana, Koernia; Erawati, Dini; Yudhanto, Hendy
Malang Respiratory Journal Vol. 4 No. 2 (2022): September 2022
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2022.004.02.4

Thymoma is a rare malignancy with an incidence of 0,15 case per 100.000 population and is the most commonly diagnosed anterior mediastinal malignancy. With 12,5% 15-year survival rate, and is often accompanied by autoimmune disease such as myasthenia gravis, pure red blood cell aplasia, and hypogammaglobulinemia, better understanding of factors affecting prognosis is needed to improve patient quality of life and survival.

Co-Authors Afif, Zamroni Arinto Wardoyo Arinto Yudi Ponco Wardoyo Bayuadi, Imam Cendani, Wulan Chen, Chung-Yu Chozin, Iin Chozin, Iin Nur Christanto, Anthony Dini, Zata Djajalakasana, Susanthy Edwin Widodo Eka Pratiwi Eka Pratiwi Eko Sakti Pramukantoro, Eko Sakti Erawati, Dini Erawati, Dini Rachma Fahmi, Kristia Falyani , Silvy Falyani, Silvy Falyani, Silvy Amalia Febriawati, Juwita Fitri Sari, Fitri Harun Al Rasyid Indah Sari, Fitri Indrastuti Normahayu, Indrastuti Iqbal Muhammad Irfan, Ferdy Syah Isharanto, Artono Kevin Wahyudy Prasetyo Kristiani, Maria Kusuma Wardhana, Koernia Listyoko, Aditya Listyoko, Aditya Sri Lyono, Albert Mafisah, Saidah Mahendra, Reza Aditya Matabei, Shannon Conversia Pdabo Michaela, Cleine Muarif, Husnul Nanik Setijowati Okta, Shinta Permana, Deden Permatasari, Adinda Pramitra Prasetya, Fahmi Adhi Prasetyo, Kevin Pratiwi, Suryanti Pratiwi, Suryanti Dwi Putra, Ngakan Putra, Ngakan Putu Parsama Rachma Erawati, Dini Rahman, Perdana Rakhma , Sastia Rakhma, Sastia Ramadhan, Fitratul Retnani, Diah Prabawati Safrina Dewi Ratnaningrum, Safrina Dewi santony, Santony Santosa, Andrew Santosa, I Setyawan, Ungky Setyawan, Ungky Agus Setyo Yudhanto, Hendy Sugiri, Yani Jane Sugiri, Yani Jane Rosihaningsih Suprapta, Aloysius Suryaman, Rachmat Susanti, Lia Suwandi, Gede Sasmika Tantular, Rezki Tanuwijaya, Hendra Timuda, Caesar Ensang Tjahyadi, Rizal Muldani Tri Wahju Astuti, Tri Wahju triandani, Ni Komang Revina Triwahju Astuti Wahyu Tejakusuma, Wahyu Wardhana, Koernia Yaman, Muli Yudhanto, Hendy Yudhanto, Hendy Setyo Yusdianto, Adrian

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