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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Teknologi Informasi dan Ilmu Komputer Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB JURNAL WACANA KESEHATAN Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer Journal of Community Health and Preventive Medicine (JOCHAPM)
Djajalaksana, Susanthy
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Analysis of the Relationship between Neutrophils, Lymphocytes, and Comorbidities with Time to Death in COVID-19 Patients Tanuwijaya, Hendra; Djajalaksana, Susanthy; Tantular, Rezki
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.932

Abstract

BACKGROUND: COVID-19 caused 5.4 million deaths in 2021. Various parameters such as comorbidities and laboratory findings are known to be predictors of death in COVID-19, but these findings differ in each country, and their relationship to time of death has not been widely studied. This study was conducted to determine the relationship between levels of neutrophils, lymphocytes, neutrophil to lymphocyte ratio (NLR), and comorbidities with time to death in COVID-19. METHODS: A retrospective cohort study was conducted from April 2020 to September 2021 in the COVID-19 Inpatient Room at RSUD dr. Saiful Anwar Malang with 300 COVID-19 patient subjects aged 18 years and over. Data on comorbidities (hypertension, CAD, HF, obesity, COPD, CKD, cancer), time to death, and laboratory were taken from medical records. The Kolmogorov-Smirnov test, Chi square test and Mann Whitney test were carried out to analyze the data. RESULTS: There was a significant relationship between neutrophil levels and time to death, as well as a significant difference in neutrophil levels in the group with time to death >48 hours with comorbidities compared to <48 hours with and without comorbidities. There was a significant difference in lymphocyte levels and NLR in patients with comorbidities with time to death <48 hours and >48 hours (p < 0.05). CONCLUSION: There is a significant relationship between neutrophil levels and time to death, both in subjects with and without comorbidities showing the potential of neutrophil levels as a predictor of time to death in COVID-19.
Volatile Organic Compounds (VOC) and Serum Leukotriene B4 between COPD Patients and COPD with Lung Cancer Patients Djajalaksana, Susanthy; Listyoko, Aditya Sri; Prasetyo, Kevin Wahyudy; Wardoyo, Arinto Yudi Ponco
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.222-227

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is estimated to become the third leading cause of death worldwide in 2030. COPD can affect the lungs and cause chronic systemic inflammation. Leukotriene B4 (LTB4) is involved in COPD and lung cancer pathogenesis. There has been the development of non-invasive methods for detecting lung disease in the last few decades, such as the examination of volatile organic compounds (VOC). This study aimed to analyze the serum LTB4 and the difference of VOCs in exhaled breath of stable COPD patients and COPD with lung cancer patients. Methods: This case-control study recruited 20 stable COPD patients and 20 patients with COPD and lung cancer. An exhaled breath sample was collected in Tedlar bags and analyzed using an arrayed sensor breath analyzer to check the concentration of VOCs. Meanwhile, a venous blood sample was collected to examine the level of LTB4 using an ELISA kit. Independent t-test and Mann-Whitney test were used to analyze the data. Results: The carbon dioxide (CO2), nitrogen dioxide (NO2), carbon monoxide (CO), benzene (C6H6), and propane (C3H8) levels were significantly different (p <0.05) in COPD-only patients compared to COPD with lung cancer patients. Serum LTB4 increased in both groups. Conclusion: CO2, CO, and C3H8 levels increased, but the NO2 level decreased in COPD patients with lung cancer compared to COPD-only patients. Serum LTB4 increased in COPD with lung cancer patients.
Potential of Volatile Organic Compound (VOC) and Serum Interleukin-17 for Evaluation of Lung Cancer Therapy Based on Response Evaluation Criteria in Solid Tumors (RECIST) Permatasari, Adinda Pramitra; Setyawan, Ungky Agus; Rakhma, Sastia; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1127

Abstract

Background: Lung cancer is the second leading cause of death in the world due to delays in diagnosis. Non-invasive Volatile Organic Compound (VOC) method to diagnose and monitor the progressivity of lung cancer. Interleukin-17 (IL-17) has an important role in the progression and treatment of lung cancer. Objective evaluation of chemotherapy using Response Evaluation Criteria in Solid Tumors (RECIST 1.1). This study aims to determine the relationship between VOC, IL-17, and lung cancer chemotherapy response based on RECIST at Saiful Anwar General Hospital, East Java.Methods: In a prospective cohort study, 47 lung cancer patients received first-line chemotherapy pre and post-three series of chemotherapy. Exhaled breath was collected with Tedlar Bags and then analyzed with µβreath for VOC. IL-17 in blood serum is determined by an enzyme-linked immunosorbent assay (ELISA). The data were analyzed using the Wilcoxon, Mann-Whitney, and Spearman tests.Results: There were significant in VOC Components (p 0.05) Formaldehyde (CH2O), Toluene (C7H8), Acetone (C3H6O), Hexane (C6H14), Methane (CH4), RECIST non-target lesions, and new lesions pre and post-three series of chemotherapy but not found in IL-17. Acetone (C3H6O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST Overall Response (OR) found significant. The analysis showed a positive correlation between Formaldehyde (CH2O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST OR, but a negative correlation between Acetone (C3H6O) pre-chemotherapy. Conclusions: There was a significant decrease in formaldehyde, toluene, hexane, methane and an increase in acetone in lung cancer patients pre and post-three series of chemotherapy. There was a significant relationship between formaldehyde, acetone pre-chemotherapy, and methane, IL-17 post-three series of chemotherapy based on the RECIST overall response
ANALISIS GENDER TERHADAP VITAL SIGN, BORG SCALE, DAN KADAR KARBON MONOKSIDA PADA PENGGUNAAN MASKER UNTUK SENAM PERNAPASAN DI ERA PANDEMI COVID-19 Triandani, Ni Komang Revina; Listyoko, Aditya Sri; Ratnaningrum, Safrina Dewi; Widodo, Edwin; Djajalaksana, Susanthy
Majalah Kesehatan Vol. 12 No. 1 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.01.6

Abstract

Senam pernapasan merupakan olah napas yang bermanfaat untuk meningkatkan kesehatan dengan mengefektifkan semua organ dalam tubuh secara optimal. Pada era pandemi COVID-19 penggunaan masker telah menjadi kebiasaan baru termasuk pada saat berolahraga. Salah satu faktor yang mempengaruhi penggunaan masker yaitu perbedaan gender dimana laki-laki dan perempuan memiliki kapasitas volume paru-paru yang berbeda. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan gender dan penggunaan masker terhadap tanda-tanda vital, Borg scale dan kadar CO peserta senam pernapasan di RSUD Dr. Saiful Anwar Malang.  Pengamatan dilakukan pada 3 (tiga) sesi yaitu sebelum senam, tahap inti, aerobic, dan setelah tahap pendinginan.  Penelitian menggunakan data sekunder dengan pendekatan metode analitik case control, kemudian dilakukan uji independent t test dan Mann Whitney. Hasil analisis tanda-tanda vital pada setiap sesi menunjukkan bahwa tidak terdapat perbedaan heart rate, respiratory rate, dan kadar CO yang signifikan antara kelompok yang bermasker dan tidak bermasker pada gender yang berbeda (p > 0,05). Sedangkan terdapat perbedaan saturasi oksigen yang nyata (p < 0,05) antara kedua kelompok tersebut pada tahap inti, aerobik, dan setelah pendinginan. Hasil analisis Borg scale menunjukkan berbeda (p < 0,05) pada tahap inti dan aerobik. Penelitian ini menunjukkan bahwa tidak ada perbedaan bermakna penggunaan masker pada senam pernapasan pada gender laki laki maupun perempuan untuk kelompok dewasa muda sehat sehingga penggunaan masker bedah mungkin dapat di pakai ketika melakukan senam pernapasan dalam era pandemi COVID-19.
Cohort Patient Evaluation of Lung Condition 9 Months after Severe Covid 19 Mahendra, Reza Aditya; Rakhma , Sastia; Sugiri, Yani Jane Rosihaningsih; Djajalaksana, Susanthy; Erawati, Dini Rachma
Malang Respiratory Journal Vol. 7 No. 1 (2025): March 2025 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.007.01.02

Abstract

Introduction: COVID-19 is an infection caused by novel coronavirus Serious Acute Respiratory Syndrome (SARS)-CoV-2. About 20% patients with severe symptoms could become critically ill. In this case report, we present a case with severe COVID-19 infection. Case report: Mr. SA, a 54-year-old patient came to the hospital with chief complaint of dry cough. Patient had fever for 2 days and myalgia. Patient had a history of well-controlled hypertension. X-ray examination showed worsening consolidation and CT-scan showed pleural effusion. Patient was treated with convalescent plasma therapy, IVIG, and symptomatic drugs. The patient was diagnosed with confirmed case of severe COVID-19, stage I hypertension, hypercoagulable state, CCS, and grade I obesity. The Evaluation of this patient consist of CT Scan, Lung Function using a Body Plethysmograph that will followed for 9 month after the patient discharged. Conclusion: There had been a few therapeutic options for COVID-19 but no definitive treatment yet. IVIG and convalescent plasma had been used for the treatment of SARS-CoV and MERS-CoV. As such, these treatments were also used in COVID-19 treatment with promising results. Keywords: COVID-19, IVIG, convalescent plasma
Tingkat Pengetahuan Masyarakat Di Kota Malang Tentang Obstructive Sleep Apnea Djajalaksana, Susanthy; Afif, Zamroni; Muhammad, Iqbal; Dini, Zata; Pratiwi, Eka
JURNAL WACANA KESEHATAN Vol 10, No 1 (2025): Juli
Publisher : AKPER Dharma Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52822/jwk.v10i1.678

Abstract

Obstructive Sleep Apnea Syndrome (OSA) merupakan masalah kesehatan masyarakat yang sering terjadi dan dapat menimbulkan berbagai masalah kesehatan jangka panjang. Oleh karena itu, perlu dilakukan penelitian tentang tingkat pengetahuan masyarakat di puskesmas Kota Malang tentang OSA sebagai upaya preventif untuk deteksi dini dan penatalaksanaan dini OSA. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional. Penelitian ini menggunakan teknik quota sampling dengan jumlah subjek sebanyak 100 subjek. Tingkat pengetahuan masyarakat diukur menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya kemudian dibagi menjadi baik, sedang dan buruk. Analisis statistik menggunakan korelasi Pearson dengan tingkat signifikansi p<0,05. subjek berjumlah 100 orang yang terdiri dari 52% laki-laki dan 48% perempuan. Sebagian besar subjek berusia < 50 tahun (80%) dengan tingkat pendidikan sarjana (76%). Tingkat pengetahuan tidak berkorelasi dengan jenis kelamin (r = -0,041, p = 0,682), usia (r = 0,144, p = 0,151), dan tingkat pendidikan (r = 0,109, p = 0,282). Pada penelitian ini didapatkan sebagian besar tingkat pengetahuan subjek baik dan tidak berkorelasi dengan jenis kelamin, usia, dan tingkat pendidikan.Kata Kunci: Tingkat Pengetahuan, Obstructive Sleep Apnea, Masyarakat Kota Malang.
PROFILE OF PATIENTS AT RISK FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) BASED ON PUMA SCORE IN SIX COMMUNITY HEALTH CENTERS IN MALANG CITY Djajalaksana, Susanthy; Wardoyo, Arinto; Muarif, Husnul; Sari, Fitri; Listyoko, Aditya; Lyono, Albert; Pratiwi, Eka; Fahmi, Kristia; Muhammad, Iqbal; Falyani, Silvy; Prasetyo, Kevin; Christanto, Anthony
Journal of Community Health and Preventive Medicine Vol. 5 No. 1 (2025): JOCHAPM Vol. 5 No. 1 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jochapm.2025.005.01.3

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a growing global health problem. Early screening and a deeper understanding of the risk patient profile are critical for effective management. This study aims to analyze the profiles of patients at risk for COPD based on PUMA scores and FEV1/FVC results from six public health centers in Malang City. This study used an analytical-observational design with a cross-sectional approach. Samples were purposefully selected from patients at risk of COPD in six public health centers in Malang. PUMA scores were measured using a questionnaire. Data was collected from November 2022 to April 2023 at six public health centers in Malang City. A total of 117 research subjects participated, comprising 58.97% male and 41.02% female, with an average age of 47 years. Most subjects were active smokers (43.50%). Based on PUMA scores (cutoff >6), 22.03% were at risk of COPD, while 77.97% were not at risk. FEV1/FVC results were >0.7 in 71 subjects (60.68%) and <0.7 in 46 subjects (39.31%). Among subjects at risk of COPD, 92% had FEV1/FVC < 0.7. There were 117 subjects screened for the early detection of COPD. The results of the PUMA* score can help health practitioners in identifying patients at risk of COPD.
Path Analysis in PLS for Assessing the Impact of Metabolic Syndrome on Pulmonary Fibrosis in a Rat Model Yaman, Muli; Djajalaksana, Susanthy; Putra, Ngakan Putu Parsama; Yudhanto, Hendy Setyo
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.889

Abstract

Background: Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, and insulin resistance, which are associated with increased risk for pulmonary fibrosis. This study investigates the impact of MetS on pulmonary fibrosis in a rat model using Partial Least Squares (PLS) path analysis. Methods: Sprague Dawley rats were fed a high-fat, high-fructose diet for 37 weeks to induce MetS. Key metabolic parameters, including body weight, lipid profiles, fasting blood glucose, fibrosis markers and Aschroft scores, were assessed. PLS path analysis was conducted to explore the relationships between these variables and their influence on pulmonary fibrosis. Results: PLS path analysis identified a strong correlation between increased body weight and MetS development (path coefficient=0.977). Dyslipidemia, characterized by elevated triglycerides and reduced HDL cholesterol, was also associated with MetS. A novel association was found between glucose dysregulation and pulmonary fibrosis (R2=0.908; path coefficient=0.947), suggesting that hyperglycemia contributes to lung fibrosis. Reduced PPARγ expression was associated with insulin resistance and inflammation, implicating it in fibrotic processes. Conclusion: This study highlights the role of metabolic disturbances in promoting pulmonary fibrosis in MetS. PLS path analysis effectively identified key metabolic pathways, suggesting potential targets for therapeutic intervention to mitigate MetS effects and prevent fibrosis. Further research is warranted to explore these pathways and develop targeted therapies.
Significance Level of Pleural Fluid Tissue Inhibitor Metalloproteinase-1 (TIMP-1) and Glucose Levels as Biomarkers of Malignant Pleural Effusion Michaela, Cleine; Putra, Ngakan Putu Parsama; Djajalaksana, Susanthy; Setijowati, Nanik; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.208-215

Abstract

Introduction: Distinguishing between malignant and non-malignant pleural effusions is often challenging due to overlapping biochemical profiles. Conventional diagnostic methods, including cytology and biopsy, are limited by their invasive nature, high costs, and potential complications. Emerging biomarkers, such as tissue inhibitor of metalloproteinase-1 (TIMP-1) and pleural fluid glucose levels, show promise as alternative diagnostic tools, but their clinical utility requires further validation. This study investigated the diagnostic value of TIMP-1 and pleural fluid glucose levels in differentiating malignant from non-malignant pleural effusions and explored their correlation in malignant cases. Methods: This cross-sectional analytical study included patients with exudative pleural effusion, categorized as malignant or non-malignant based on cytology and/or biopsy results. Biomarker levels of TIMP-1 and pleural fluid glucose were measured using enzyme-linked immunosorbent assay (ELISA) and biochemical analysis. Diagnostic thresholds for both biomarkers were determined using receiver operating characteristic (ROC) curve analysis. Results: Among 88 patients studied (33 malignant, 55 non-malignant), pleural fluid glucose levels were significantly lower in malignant cases (55.97 vs. 93.71 mg/dL; p=0.001), while TIMP-1 levels were notably higher (13.88 vs. 13.34 pg/mL; p<0.001). Tissue inhibitor of metalloproteinase-1 demonstrated superior diagnostic accuracy (86.5%) compared to glucose (70.6%) and the combined biomarker model (76.5%), with the sensitivity and specificity of 84.8% and 83.6%, respectively. Conclusion: Elevated TIMP-1 levels and reduced pleural fluid glucose levels are promising diagnostic biomarkers for malignant pleural effusion (MPE). Tissue inhibitor of metalloproteinase-1 exhibited the highest diagnostic accuracy, highlighting its potential as a non-invasive diagnostic tool in clinical practice.
Analysis of Urinary Midkine and Volatile Organic Compound (VOC) Levels Using a Breath Analyzer for Screening and Early Diagnosis of Lung Cancer Mafisah, Saidah; Setyawan, Ungky Agus; Tantular, Rezki; Permana, Deden; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.223-231

Abstract

Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Midkine, a heparin-binding growth factor, promotes proliferation, angiogenesis, and metastasis. Volatile organic compounds (VOCs) reflect cellular and molecular changes, aiding in cancer diagnosis. This study explored urinary midkine and VOC profiles as biomarkers for lung cancer screening and early diagnosis. Methods: A case-control, cross-sectional study was conducted on 20 controls (family members of lung cancer patients) and 20 lung cancer patients who had not received therapy. Volatile organic compounds breath analysis and urinary midkine measurements were performed. Volatile organic compounds, including total volatile organic compounds (TVOCs), ethanol (C2H5OH), formaldehyde (CH2O), toluene (C7H8), acetone (C3H6O), hexane (C6H14), and methane (CH4), were collected from exhaled breath using Tedlar bags and measured with a µβreath analyzer. Meanwhile, urinary midkine levels were determined using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. Statistical analyses included an independent t-test, Mann-Whitney U test, Spearman correlation, and diagnostic testing with receiver operating characteristic (ROC) analysis. Results: Urinary midkine levels were higher in lung cancer patients than in controls (330.56±120.50 vs. 282.18±146.28 pg/mL), although not significant (p>0.05). The independent t-test revealed that ethanol levels were significantly elevated in lung cancer patients (p < 0.001), whereas methane levels were not (p > 0.50). Receiver operating characteristic analysis demonstrated sensitivity and specificity: urinary midkine (60%, 60%), ethanol (75%, 75%), and methane (45%, 45%). Conclusion: Ethanol VOC appears to be a promising non-invasive biomarker for the early detection of lung cancer, whereas elevated urinary midkine levels did not demonstrate significant diagnostic value.
Co-Authors Afif, Zamroni Arinto Wardoyo Arinto Yudi Ponco Wardoyo Bayuadi, Imam Cendani, Wulan Chen, Chung-Yu Chozin, Iin Chozin, Iin Nur Christanto, Anthony Dini, Zata Djajalakasana, Susanthy Edwin Widodo Eka Pratiwi Eka Pratiwi Eko Sakti Pramukantoro, Eko Sakti Erawati, Dini Erawati, Dini Rachma Fahmi, Kristia Falyani , Silvy Falyani, Silvy Falyani, Silvy Amalia Febriawati, Juwita Fitri Sari, Fitri Harun Al Rasyid Indah Sari, Fitri Indrastuti Normahayu, Indrastuti Iqbal Muhammad Irfan, Ferdy Syah Isharanto, Artono Kevin Wahyudy Prasetyo Kristiani, Maria Kusuma Wardhana, Koernia Listyoko, Aditya Listyoko, Aditya Sri Lyono, Albert Mafisah, Saidah Mahendra, Reza Aditya Matabei, Shannon Conversia Pdabo Michaela, Cleine Muarif, Husnul Nanik Setijowati Okta, Shinta Permana, Deden Permatasari, Adinda Pramitra Prasetya, Fahmi Adhi Prasetyo, Kevin Pratiwi, Suryanti Pratiwi, Suryanti Dwi Putra, Ngakan Putra, Ngakan Putu Parsama Rachma Erawati, Dini Rahman, Perdana Rakhma , Sastia Rakhma, Sastia Ramadhan, Fitratul Retnani, Diah Prabawati Safrina Dewi Ratnaningrum, Safrina Dewi santony, Santony Santosa, Andrew Santosa, I Setyawan, Ungky Setyawan, Ungky Agus Setyo Yudhanto, Hendy Sugiri, Yani Jane Sugiri, Yani Jane Rosihaningsih Suprapta, Aloysius Suryaman, Rachmat Susanti, Lia Suwandi, Gede Sasmika Tantular, Rezki Tanuwijaya, Hendra Timuda, Caesar Ensang Tjahyadi, Rizal Muldani Tri Wahju Astuti, Tri Wahju triandani, Ni Komang Revina Triwahju Astuti Wahyu Tejakusuma, Wahyu Wardhana, Koernia Yaman, Muli Yudhanto, Hendy Yudhanto, Hendy Setyo Yusdianto, Adrian