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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Jurnal Teknologi Informasi dan Ilmu Komputer Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB JURNAL WACANA KESEHATAN Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Journal of Multidisciplinary Applied Natural Science Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer Journal of Community Health and Preventive Medicine (JOCHAPM)
Djajalaksana, Susanthy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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A Case Report : Thymoma Mimicking Teratoma Clinically and Radiographic Appearance Eka Pratiwi; Djajalaksana, Susanthy; Pratiwi, Suryanti; Isharanto, Artono; Erawati, Dini; Yudhanto, Hendy
Malang Respiratory Journal Vol. 6 No. 1 (2024): March 2024 Edition
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.01.03

Abstract

Background: Thymoma is a rare tumor of thymic epithelial cells in anterior mediastinum. The etiology of thymoma is not known with certainty. Thymomas are difficult to distinguish from teratomas or other mediastinal tumors. Diagnosis of thymoma or teratoma is based on clinical symptoms, CXR, Thorax CT Scan, biopsy for definite diagnosis, and requires IHC examinations to be able to differentiate it from other mediastinal tumors. Case Presentation: A 62-year-old female, came with complaints of shortness of breath since 5 months when walking long distances accompanied by a dry cough for 1 week, and weight loss of 4 kgs in 10 months. Patient came from Lawang Hospital with results of AFP 1.59, B-HCG 3.8, CXR showed mediastinal mass, CT Scan Thorax showed solid mass with fat component and calcification in the right side of anterior mediastinum, suspected of a mature teratoma. Patient then underwent Tumor Excision Per Median Sternotomy by Cardiothoracic Surgeon on October 19, 2022, sampled a round tissue sized 7.5x7x6 cm with smooth surface, intact capsule likes teratoma. Discussion: PA examination was performed, with result of Germ Cell Tumor, we continued with Calretinin, CD99, SMA, S100, and Melan A IHC examinations. The results of the last IHC examination found, Type A Thymoma Cells. Patient is currently stable and recommended for radiotherapy. Conclusion: A patient with a thymoma mimicking a mature teratoma macroscopically and radiographically is an interesting case based on the results of thymoma type A from Immunohistochemistry examination but perform macroscopic likes teratoma. Keywords: Thymoma, Teratoma, Clinically, Radiographic
Management of Pneumomediastinum Patients in COVID-19: Rare Cases Santosa, Andrew; Djajalaksana, Susanthy; Listyoko, Aditya; Erawati, Dini
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.04

Abstract

Background: Spontaneous pneumomediastinum in patients with confirmed cases of Covid-19 is a very rare clinical finding in the world, especially in Indonesia. This is considered an indication of concern for a more serious medical problem. Aim: This case report discusses the management of COVID-19 patients with pneumomediastinum. Case: A 30 year old man came to the hospital with the main complaint of shortness of breath and cough. The patient was diagnosed with a confirmed case of Covid-19 and received therapy using High Flow Nasal Cannula (HFNC) as a therapeutic modality. After 5 days in the hospital, the patient's shortness of breath felt increasingly severe, and he began to feel chest pain and swelling around the chest area which spread to both sides of his neck. A thorax x-ray examination showed pneumomediastinum and subcutaneous emphysema, then a chest CT scan was performed and the results showed pneumomediastinum which was thought to be caused by esophageal rupture. After we communicated with the Thoracic Surgery Department, conservative therapy was recommended. Conclusion: Covid-19 infection can cause hypoxaemic respiratory failure and acute respiratory distress syndrome, both of which can be deadly. Supplementation of high-flow nasal cannula (HFNC) oxygen therapy can be very beneficial for patients, but can cause dangerous side effects such as pneumomediastinum. Pneumomediastinum (PM) is the presence of open air in the mediastinal cavity. In this case, we suspect that the pneumomediastinum was the result of Covid-19-related alveolar damage and esophageal rupture, and not due to the use of HFNC. Pneumomediastinum complications need to be detected early, so that management can reduce associated morbidity and mortality. Keywords: Pneumomediastinum; COVID-19, HFNC
Risk Factors Analysis for Rapid In-Hospital Mortality among Covid-19 Patients in a Tertiary Care Hospital in Indonesia Febriawati, Juwita; Putra, Ngakan Putu Parsama; Listyoko, Aditya Sri; Djajalaksana, Susanthy
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.15

Abstract

Systemic inflammation plays an important role in pathogenesis of Covid-19, especially in development of ARDS which is characterized by decrease of PaO2/FiO2 ratio. CRP and procalcitonin are inflammatory markers that are closely associated with severity and mortality of Covid-19. Although several studies have addressed benefit of CRP and procalcitonin as markers on Covid-19 severity, the benefit of these inflammatory markers for in-hospital mortality remain inadequately understood. The aim of this study was to analyze PaO2/FiO2 ratio,comorbidity,CRP,and procalcitonin as risk factors that affect time of in-hospital mortality Covid-19 patient. This was a retrospective observational cohort study of 250 Covid-19 patients who died during hospitalization and data was retrieved from medical record. Laboratory data was collected from three different times, including at time of admission,third day of hospital care,and before patient’s death. Data were analyzed using Chi square test,Mann Whitney test,Wilcoxon test, Friedman test, and binary logistic regresion. There were significant differences between CRP and procalcitonin at admission and time of in-hospital mortality (p<0.001; p=0.007). Binary logistic regression  analysis revealed significant relationship between CRP and time of in-hospital mortality with p=0.007. ROC curve showed optimal threshold of 11.75mg/L with sensitivity 72.3%; specificity 59.6%, RR 3.24(95% CI: 1.84-5.70). Significant changes were observed regarding PaO2/FiO2 ratio,CRP,and procalcitonin at admission as compared to before patient’s death with p<0.001;p=0.017;p<0.001 respectively. This study showed significant decrease of PaO2/FiO2 ratio, elevated CRP and procalcitonin at admission as compared to before patient’s death. The increase of CRP could serve as predictor for time of in-hospital mortality for Covid-19 patient.
Persistent Pneumothorax in Neurofibromatosis Type-1 Simamora, Hustorio Aliongko; Djajalaksana, Susanthy; Chozin, Iin Noor; Erawati, Dini Rachma; Yudhanto, Hendy Setyo; Damanik, Gracelia Ruth Elisabeth; Dani, Adinda Amalia; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.64-70

Abstract

Introduction: Neurofibromatosis type 1 (NF-1) is a rare autosomal dominant disorder. While typically recognized by its cutaneous features, pulmonary involvement, including apical cysts and basal interstitial fibrosis consistent with interstitial lung disease (ILD), can occur in up to 20% of patients. These manifestations create a predisposition to complications such as spontaneous pneumothorax. While this is relatively uncommon, occurring in approximately 1.5% of patients with NF-1, it represents a serious and potentially life-threatening complication when it does occur. Case: A 52-year-old male with a 20-pack-year smoking history and active pulmonary tuberculosis (TB) presented with acute chest pain and dyspnea. Dermatological examination and skin biopsy confirmed the diagnosis of NF-1. A high-resolution computed tomography (HRCT) scan of the chest revealed multiple subpleural pulmonary cysts consistent with NF-1-related ILD, alongside findings suggestive of active TB. The patient was diagnosed with a secondary spontaneous pneumothorax (SSP), which proved to be persistent despite initial chest tube drainage, ultimately requiring surgical intervention. Conclusion: This case highlights that NF-1 is a significant underlying risk factor for persistent pneumothorax, particularly when co-existing with other conditions like active TB and a history of smoking. The chronic inflammation and parenchymal destruction associated with these comorbidities can exacerbate the inherent structural lung abnormalities in NF-1, leading to complex, difficult-to-manage clinical scenarios. Early recognition of pulmonary manifestations in patients with NF-1 is crucial for anticipating and managing severe complications.
Furosemide Increases GABAA Receptor Activity via Antagonism to Sodium-Potassium-Chloride Cotransporter 1 In Silico and In Vivo Siregar, Marsintauli Hasudungan; Nurdiana, Nurdiana; Bal’afif, Farhad; Djajalaksana, Susanthy; Setiawansyah, Arif
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.365

Abstract

GABAA receptor dysfunction and altered chloride homeostasis significantly contribute to seizure pathophysiology, with the sodium-potassium-chloride cotransporter 1 (NKCC1) playing a crucial role in regulating neuronal excitability. This study investigated furosemide's capacity to enhance GABAA receptor activity through NKCC1 antagonism and evaluated its therapeutic profile in combination with diazepam for seizure management. Comprehensive molecular docking analyses were conducted to assess binding affinities of furosemide and diazepam to NKCC1, followed by in vivo experiments using pentylenetetrazol-induced seizure models to evaluate GABAA receptor expression, seizure duration, and multiple pathophysiological biomarkers. Molecular analysis revealed that furosemide demonstrated measurable NKCC1 binding capacity (binding energy: -7.09 kcal/mol; Ki: 6.34 µM), though significantly lower affinity compared to diazepam (binding energy: -7.83 kcal/mol; Ki: 1.81 µM). The furosemide-diazepam combination exhibited complex competitive binding interactions, with furosemide substantially reducing diazepam's NKCC1 binding affinity. NKCC1 antagonism by furosemide effectively enhanced GABAA receptor expression by 29.8 ± 1.60% when used alone and 37.60 ± 2.0% in combination with diazepam. However, combination therapies resulted in significantly longer seizure durations (80 ± 3.0 s) compared to diazepam monotherapy (42.5 ± 2.10 s), suggesting antagonistic interactions on acute seizure suppression that may reflect altered chloride gradients or competitive pharmacokinetic effects. Despite reduced efficacy in seizure termination, combination therapy demonstrated selective advantages in other pathophysiological domains, including superior blood-brain barrier protection (reduced albumin level to 90.90 ± 2.70 µg/mL) and reduced excitotoxic damage. These findings indicate that furosemide-diazepam combination therapy presents a complex therapeutic profile characterized by trade-offs between acute seizure control and neuroprotective mechanisms. The data suggest potential utility in maintenance therapy or prevention of seizure-related complications rather than acute seizure termination, warranting further investigation into temporal optimization strategies and dose modifications.
Kemajuan Pemeriksaan Penunjang dalam Meningkatkan Ketepatan dan Kecepatan Diagnosis Penyakit di Era Digitalisasi Djajalaksana, Susanthy
Jurnal Klinik dan Riset Kesehatan Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.2.1

Abstract

Co-Authors Afif, Zamroni Arif Setiawansyah Arinto Wardoyo Arinto Yudi Ponco Wardoyo Bal’afif, Farhad Bayuadi, Imam Cendani, Wulan Chen, Chung-Yu Chozin, Iin Chozin, Iin Noor Chozin, Iin Nur Christanto, Anthony Damanik, Gracelia Ruth Elisabeth Dani, Adinda Amalia Dini, Zata Djajalakasana, Susanthy Edwin Widodo Eka Pratiwi Eka Pratiwi Eko Sakti Pramukantoro, Eko Sakti Erawati, Dini Erawati, Dini Rachma Fahmi, Kristia Falyani , Silvy Falyani, Silvy Falyani, Silvy Amalia Febriawati, Juwita Fitri Sari, Fitri Harun Al Rasyid Indah Sari, Fitri Indrastuti Normahayu, Indrastuti Iqbal Muhammad Irfan, Ferdy Syah Isharanto, Artono Kevin Wahyudy Prasetyo Kristiani, Maria Kusuma Wardhana, Koernia Listyoko, Aditya Listyoko, Aditya Sri Lyono, Albert Mafisah, Saidah Mahendra, Reza Aditya Matabei, Shannon Conversia Pdabo Michaela, Cleine Muarif, Husnul Nanik Setijowati Nurdiana Nurdiana Okta, Shinta Permana, Deden Permatasari, Adinda Pramitra Prasetya, Fahmi Adhi Prasetyo, Kevin Pratiwi, Suryanti Pratiwi, Suryanti Dwi Putra, Ngakan Putra, Ngakan Putu Parsama Rachma Erawati, Dini Rahman, Perdana Rakhma , Sastia Rakhma, Sastia Ramadhan, Fitratul Retnani, Diah Prabawati Safrina Dewi Ratnaningrum, Safrina Dewi santony, Santony Santosa, Andrew Santosa, I Setyawan, Ungky Setyawan, Ungky Agus Setyo Yudhanto, Hendy Simamora, Hustorio Aliongko Siregar, Marsintauli Hasudungan Sugiri, Yani Jane Sugiri, Yani Jane Rosihaningsih Suprapta, Aloysius Suryaman, Rachmat Susanti, Lia Suwandi, Gede Sasmika Tantular, Rezki Tanuwijaya, Hendra Timuda, Caesar Ensang Tjahyadi, Rizal Muldani Tri Wahju Astuti, Tri Wahju triandani, Ni Komang Revina Triwahju Astuti Wahyu Tejakusuma, Wahyu Wardhana, Koernia Yaman, Muli Yudhanto, Hendy Yudhanto, Hendy Setyo Yusdianto, Adrian