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All Journal Jurnal Kesehatan Andalas Media Ilmu Kesehatan Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) SENTRI: Jurnal Riset Ilmiah JUKEJ: Jurnal Kesehatan Jompa Jurnal Riset Ilmiah Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Sains, Teknologi dan Kesehatan Proceeding International Health Conference
Yulia, Dwi
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Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Gambaran Faktor Koagulasi dan Jumlah Trombosit pada Pasien Diabetes Melitus Tipe 2: Sebuah Studi Potong Lintang Alfitri, Maura Salsabila; Decroli, Eva; Rofinda, Zelly Dia; Aprilia, Dinda; Yulia, Dwi; Lailani, Mutia
MEDIA ILMU KESEHATAN Vol 14 No 2 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i2.1314

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health threat, where chronic hyperglycemia and insulin resistance can affect coagulation profiles.Objective: This study aims to examine coagulation factor profiles and platelet counts in T2DM patients. Methods: A descriptive cross-sectional observational study using data from prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), and platelet counts of T2DM patients admitted to the Internal Medicine Ward of Dr. M. Djamil General Hospital, Padang, in October 2023. Data analysis was performed descriptively using SPSS v26 software. Results: Of the 39 patients analyzed, the distribution of characteristics showed a male predominance of 64.1%, with the largest age group being 45–59 years (48.7%). The most common complication associated with T2DM was chronic kidney disease, identified in 82.1% of the study population. Evaluation of hemostasis parameters showed that APTT was prolonged in 56.4% of patients. Conversely, PT (87.2%), INR (87.2%), and platelet count (66.7%) were within reference ranges. Conclusion: This study found most coagulation parameters normal, but a relatively high proportion had prolonged APTT, underscoring the need for individualized coagulation monitoring in T2DM, especially with renal complications
KORELASI INDEKS MASSA TUBUH DENGAN GLUKOSA DARAH PUASA DAN KOLESTEROL PADA SKRINING KESEHATAN TENAGA KEPENDIDIKAN FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Ramadhani, Jihan; Yulia, Dwi; Fasrini, Ulya Uti; Efrida, Efrida; Khaira, Fathiyyatul
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1758

Abstract

Introduction. Non-communicable diseases as a cause of death in Indonesia are increasing. Hyperglycemia, hyperlipidemia, and obesity are some of the factors that contribute to an increased risk of non-communicable diseases. Education workers are a group of office workers who are at risk of obesity and non-communicable diseases because they have low physical activity. The study aimed to determine a correlation between body mass index with fasting blood glucose levels and total cholesterol levels in the health screening of educational staff faculty of medicine of Andalas University.  Methods. This research was an analytical study with a cross-sectional design using secondary data for the faculty of medicine of Andalas University health screening that was held on September 08, 2021. The tools used in the study were a calibrated glucometer to measure fasting blood glucose and a calibrated auto-check for total cholesterol examination. 37 data met the inclusion and exclusion criteria. Data were processed and analyzed using univariate and bivariate analysis using the Pearson correlation test.  Results. The result showed that the educational staff of the medical faculty of Andalas University are mostly in the late adult category, most are female and most of them are obese. The mean of body mass index is 25.3 kg/m2, the mean of fasting blood glucose level is 126.57 mg/dL and the mean of total cholesterol level is 205, 14 mg/dL. The bivariate analysis results showed no correlation between body mass index and fasting glucose levels (r = 0.316; p = 0.057) and no correlation between body mass index and total cholesterol levels (r = 0.091; p = 0.591). Conclusions. This study concludes that there is no correlation between body mass index with fasting blood glucose levels and total cholesterol levels in the health screening of educational staff faculty of medicine of Andalas University.
PERBANDINGAN KADAR PROTHROMBINE TIME DAN ACTIVATED PARTIAL THROMBOPLASTINE TIME PADA PASIEN DM TIPE 2 KAKI DIABETIK DENGAN TANPA KAKI DIABETIK DI RSUP DR. M. DJAMIL PADANG TAHUN 2019 Decroli, Rezeki Penta; Yulia, Dwi; Miro, Saptino
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1846

Abstract

Diabetic Foot Ulcers are one of the most common, serious, and costly complications of type 2 diabetes mellitus. Diabetic Foot Ulcers have become more common in tandem with the rising prevalence of type 2 diabetes mellitus. Changes in many hematological parameters, such as Prothrombine Time and Activated Partial Thromboplastine Time, are influenced by the mechanism of diabetic ulcer occurrence. Understanding the various aspects of hematological parameters will help in the prevention and treatment of diabetic foot ulcers. This study aims to determine the comparison in the hematological profile in type 2 DM patients with and without diabetic foot ulcers at Dr. M. Djamil Padang hospital in 2019.  This type of research is an observational analytic study with a retrospective design using medical record data of patients at Dr. M. Jamil Padang hospital from August 2020 to March 2021. The sample consisted of the medical records of patients with type 2 diabetes mellitus with foot ulcers and without foot ulcers, respectively, as many as 60 subjects. Bivariate analysis using independent t-test or Mann Whitney test.  The results showed that the mean PT level of type 2 DM patients with diabetic foot ulcers was 12.8417 ± 2.36939, without diabetic foot ulcers 11.997 ± 1.8325 (p <0.001). The mean aPTT of patients with diabetic foot ulcers was 41.2733 ± 35.1686, without diabetic foot ulcers 32.912 ± 13.1263 (p <0.001).  This study concludes that there are significant in between type 2 DM patient with foot ulcer and without foot ulcers.
Perbedaan Rerata Indeks Fibrosis-4 Antara Manifestasi Klinis Berat Dan Kritis Pada Pasien COVID-19. Syarif, Umar; Nasrul, Ellyza; Yulia, Dwi
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p680-685.2023

Abstract

Latar Belakang: Coronavirus disease 2019 (COVID-19) adalah penyakit menular baru yang disebabkan SARS-CoV-2. Indeks Fibrosis-4 (FIB-4) saat ini digunakan sebagai prediktor awal menilai derajat berat dan perburukan COVID-19. Tujuan: Mengetahui perbedaan rerata indeks FIB-4 antara manifestasi klinis berat dan kritis pada pasien COVID-19. Metode: Penelitian analitik dengan rancangan potong lintang dilakukan terhadap 100 pasien COVID-19 dengan manifestasi klinis berat dan kritis di   RSUP Dr. M. Djamil Padang sejak Juli 2022 hingga Februari 2023. Indeks FIB-4  dihitung dengan rumus umur × SGOT dibagi jumlah trombosit × √SGPT. Data dianalisis dengan uji T tidak berpasangan, bermakna jika p <0,05. Hasil: Subjek penelitian sebagian besar laki-laki (62%). Rerata umur subjek penelitian 57 tahun, rentang 38-80 tahun. Rerata indeks FIB-4  seluruh subjek penelitian 4,24 (1,72-8,66). Rerata indeks FIB-4 dengan manifestasi klinis berat 2,83 dan manifestasi klinis kritis 5,65 bermakna (p=0,001). Pembahasan: Terdapat peningkatan indeks FIB-4 yang lebih tinggi pada pasien manifestasi klinis kritis dibandingkan dengan manifestasi klinis  berat, sehingga pasien dengan manifestasi klinis kritis sudah terjadi fibrosis hati. Keterbatasan pada penelitian ini adalah tidak dilakukannya fibroscan sebagai konfirmasi fibrosis hati. Simpulan:Terdapat peningkatan indeks FIB-4 yang lebih tinggi pada manifestasi klinis kritis dibandingkan dengan manifestasi klinis berat pada pasien COVID-19. 
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p125-137.2025

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
Hubungan Indeks Massa Tubuh dengan Kadar Glukosa Darah Puasa dan Tekanan Darah Pada Tenaga Kependidikan Fakultas Kedokteran Universitas Andalas Hasnah, Hidayatul; Yulia, Dwi; desmawati, Desmawati; fadrian, fadrian; alioes, yustini; arisanty, dessy
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i4.p371-382.2024

Abstract

Tujuan : mengetahui hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah pada tenaga kependidikan Fakultas Kedokteran Universitas Andalas. Metode : Jenis penelitian ini merupakan penelitian analitik dengan desain penelitian cross-sectional dengan subjek penelitian sebanyak 37 orang yang dilaksanakan di Fakultas Kedokteran Universitas Andalas pada tanggal 08 September 2021. Metode pengambilan sampel ini dengan total sampling, analisis data hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah menggunakan uji korelasi Spearman. Hasil: Nilai median indeks massa tubuh sebesar 24,22 Kg/, nilai rerata 24,94 Kg/, nilai minimum sebesar 16,23 Kg/ dan nilai maksimum 40,15 Kg/. Nilai median kadar glukosa darah puasa 127 mg/dL, nilai rerata 143,65 mg/dL, nilai minimum sebesar 93 mg/dL dan nilai maksimum 399 mg/dL. Nilai median dari tekanan darah 126 mmHg,nilai rerata 128,7 mmHg,  nilai minimum 94 mmHg, dan nilai maksimum 213 mmHg. Tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa (p=0,203) ataupun pada indeks massa tubuh dengan tekanan darah (p= 0,097) pada subjek penelitian. Kesimpulan: tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa dan antara indeks massa tubuh dengan tekanan darah pada tenaga kependidikan pada Fakultas Kedokteran Universitas Andalas.  
Platelet Large Cell Ratio as a Prothrombotic Biomarker to Predict the Severity of COVID-19 Rikarni, Rikarni; Najirman, Najirman; Yulia, Dwi; Burhan, Ida Rahmah; Amalina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2622

Abstract

 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the lungs causes alveolar cell inflammation and disruption, leading to increased levels of proinflammatory cytokines that stimulate platelet activation and consumption. In response, megakaryocytes will increase the production of large, immature platelets. Large platelets bind more to fibrinogen than small platelets, increasing the potential for thrombus formation. This study aims to analyze the platelet large cell ratio as a prothrombotic biomarker to predict the severity of thrombosis in patients. A prospective cohort study was conducted in May-November 2021 at M. Djamil Hospital involving 206 samples of confirmed coronavirus disease 2019 (COVID-19) patients. The examinations included platelet count, P-LCR, and D-dimer. Large platelet counts were calculated using the Platelet Large Cell Ratio (P-LCR) parameter with an automated hematology analyzer. Clinical manifestations of disease severity were monitored based on WHO criteria, grouped into non-severe and severe disease. The 3 results showed a mean age of 47.41 (SD = 17.82). Platelet count was 263,690 (116,995)/mm , P-LCR was 30.86 (6.63)%, and D-dimer value was 2,215.97 (2,590.86) ng/mL. The P-LCR in the severe group was 35.08 (8.21)%, and the non-severe group was 26.64 (6.81)%, with p <0.001. D-dimer in the severe group was 3,680.36 (3,006.23) ng/mL, and in the non-severe group, 869.12 (977.03) ng/mL, with p <0.001. The relative risk of a high P-LCR causing severe COVID-19 is 2.35 compared to a low P-LCR, with p <0.001. The relative risk of a high D-dimer value causing severe COVID-19 is 6.80 compared to a low D-dimer, with p <0.001. The conclusion is  that a greater increase in large platelet production occurs in severe COVID-19 disease. P-LCR is a crucial biomarker for evaluating platelet activity. A high P-LCR value is a risk factor for predicting the severity of COVID-19. Suggestions for the use of PLCR. Increased risk of thrombotic events in COVID-19 patients can be identified by P-LCR examination upon admission to the hospital, allowing for preventive treatment.
Korelasi Indeks Massa Tubuh dan Lingkar Perut dengan Kadar Glukosa Darah Sewaktu Assyura, Fazhladia; Firdawati, Firdawati; Asterina, Asterina; Yulia, Dwi; Mahata, Liganda Endo; Welan, Rahmani
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1078

Abstract

Latar Belakang: Kesehatan lansia mempunyai pengaruh besar terhadap perkembangan Indonesia karena pertumbuhan penduduk Indonesia yang mempunyai struktur aging population. Salah satu usaha yang dapat dilakukan untuk menjaga kesehatan lansia dengan tujuan menciptakan lansia yang produktif dapat dilakukan dengan melakukan penilaian beberapa parameter kesehatan yang mudah dipahami seperti IMT, lingkar perut dan kadar glukosa darah.Objektif: Penelitian ini bertujuan untuk mengetahui korelasi antara IMT dan lingkar perut dengan hasil skrining kadar glukosa darah sewaktu pada pra lansia dan lansia di Nagari Sumanik tahun 2021.Metode: Penelitian ini merupakan penelitian analitik dengan desain penelitian cross sectional. Penelitian dilaksanakan pada Januari – Desember 2022. Data penelitian ini berasal dari data sekunder hasil pengabdian masyarakat pada bulan Oktober 2021 dengan besar sampel 40 orang pra lansia dan lansia. Analisis bivariat menggunakan uji Spearman Rank.Hasil: Hasil penelitian ini menunjukan rerata IMT adalah 26,93±5,168 kg/m2. Rerata lingkar perut yaitu 97±12,3. Rerata hasil skrining kadar glukosa darah sewaktu adalah 140±78,775 mg/dl. Hasil uji statistik ditemukan bahwa tidak terdapat hubungan antara IMT dengan hasil skrining kadar glukosa darah sewaktu (p = 0,738) dan r-correlation 0,054. Uji statistik lingkar perut dengan hasil skrining kadar glukosa darah sewaktu menunjukan tidak terdapat hubungan (p = 0,765) dan r-correlation 0,048.Kesimpulan: Tidak terdapat hubungan antara IMT dan lingkar perut dengan hasil skrining kadar glukosa darah sewaktu dengan korelasi sangat lemah. Kata Kunci: IMT, lingkar perut, kadar glukosa darah sewaktu, pra lansia, lansia
Overview of Bacterial Profile of Bloodstream Infections in the Intensive Care Unit (ICU): Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Rara Puspita Impelleren; Yulia, Dwi; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1055

Abstract

Background: Bloodstream infection (BSI) is a condition characterized by positive blood cultures in patients who have systemic infections. Bloodstream infections have developed into a threat to public health worldwide with high mortality rates in intensive care settings. This study aims to determine the bacterial profile of BSI in the intensive care unit (ICU) of Dr. M. Djamil General Hospital Padang. Methods: This study is a retrospective descriptive study with a cross-sectional design from secondary data at the Microbiology and Medical Records Installation Laboratory of Dr. M. Djamil General Hospital Padang. All blood samples from patients aged ≥18 years in the ICU who are suspected of being infected will be cultured and identified with VITEK 2 in 2022. Results: A total of 243 blood samples consisted of 126 men (52%) and 117 women (48%) with the largest age range being 41-60 years (48%). The diagnosis of BSI was found in 94% with the most common comorbidities being malignancy (42%) and stroke (15%). The most common bacterial bloodstream infections were found in the ICU of Dr. M. Djamil General Hospital Padang., namely Gram-positive bacteria (66%) and coccus (66%). The most common type of bacteria identified with the VITEK 2 automatic tool is Staphylococcus hominis. Multidrug-resistant organisms (MDRO) found in this study were 8% with the most common causes, namely extended spectrum B-lactamase (ESBL). Blood samples in this study found bacteria due to contamination by 38%. Conclusion: The BSI bacterial profile found was mostly in the ICU of Dr. M. Djamil General Hospital Padang is a Gram-positive bacterium, coccus-shaped, Staphylococcus hominis and ESBL. Blood cultures found bacteria contaminated by 38%.
Pengaruh Pemberian Kukis Kombinasi Tepung Ikan Tongkol (Euthynnus affinis) dan Tepung Bayam (Amaranthus tricolor) Dengan Penambahan Probiotik Dadih Terhadap Kadar Feritin Serum Pada Tikus Wistar Anemia Azahra, Azizah Firda; Lipoeto, Nur Indrawaty; Rofinda, Zelly Dia; Rita, Rauza Sukma; Desmawati, Desmawati; Yulia, Dwi; Fasrini, Ulya Uti
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 11 (2025): SENTRI : Jurnal Riset Ilmiah, November 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i11.4950

Abstract

Anemia is a global health problem characterized by low hemoglobin and ferritin levels due to iron deficiency, which affects growth, cognition, and disease risk, particularly in children and women of reproductive age. Local food–based nutritional interventions such as skipjack tuna (heme iron), spinach (non-heme iron), and dadih (probiotics) have the potential to provide synergistic effects in improving iron status. This study aimed to determine the effect of cookies made from a combination of skipjack tuna flour and spinach with the addition of dadih probiotics on serum ferritin levels, as well as the effectiveness of Sodium Nitrite (NaNO₂) in decreasing ferritin and hemoglobin levels as indicators of anemia. The study used a Post-Test Only Control Group design with 36 female Wistar rats induced with anemia using NaNO₂ at a dose of 25 mg/200 g BW for 18 days, then divided into six treatment groups for 28 days. Ferritin levels were measured using the ELISA method. The results showed that administering cookies made from the combination of skipjack tuna flour and spinach with dadih probiotics significantly increased ferritin levels (P=0.000) compared to the control and single-ingredient groups. NaNO₂ was proven effective as an anemia-inducing agent. This combined cookie formulation has the potential to improve serum ferritin levels.
Co-Authors Alamsyah, Lucky Alfitri, Maura Salsabila Almurdi Almurdi Amalina Aprilia, Dinda Arifani, Adinda Rizky Assyura, Fazhladia Asta, Sri Wulanda Asterina, Asterina Astiena, Adila Kasni Azahra, Azizah Firda Cimi Ilmiawati, Cimi Decroli, Rezeki Penta Desmawati Desmawati Dessy Arisanty Desywar Efrida Efrida Elfira Yusri Ellyza Nasrul Em Yunir, Em Ermayanti, Sabrina Eva Decroli Fadrian, Fadrian Fathiyyatul Khaira, Fathiyyatul Febriyanti Fereshti Lailani Firdawati Firdawati Ghany, Firhan Fadlillah Hasnah, Hidayatul Hendra Permana Husni Husnil Kadri Ida Rahmah Burhan Indrapriyatna, Ahmad Syafruddin Mahata, Liganda Endo Masrul Djalal Mudjiran Nabila, Fathiya Sarah Najirman Najirman, Najirman Niawaty, Putri Nur Indrawaty Lipoeto Puja, Annisa Fitria Putra, Abdi Setia Ramadhani, Jihan Rara Puspita Impelleren Rashieka, Shaydi Amala Rauza Sukma Rita Rikarni Rikarni Rima Semiarty Rinal Effendi Rismawati Yaswir Rosfita Rasyid Roza Mulyana Rudy Afriant Saptino Miro, Saptino Satria Utomo Shinta Dewi, Viola Syandrez Prima Putra Syarif, Umar Ulya Uti Fasrini Warman, Fadil Ahmadhia Yoshie Anto Chicamy Yurniwati Yurniwati Yusri, Elfira Yustini Alioes Zelly Dia Rofinda