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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

Antidiarrhea Activity of Ethanol Extract of Rambutan Leaves (Nephelium lappaceum L.) in Capsule Form on Male Mice Nurul Fadilah, Nitya; Ali Nofriyaldi; Ayu Rahmawati; Srie Rezeki Nur Endah; Widya Nurul Aini; Vincent O. Imieje
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.291-297

Abstract

Background: Diarrhea is characterized by changes in stool form to soft or liquid, with an intensity of bowel movements more than three times a day. One of the plants used as an alternative treatment for diarrhea is rambutan, particularly its leaves. Previous studies have shown that rambutan leaf extract can treat diarrhea. Objective: The purpose of this study was to determine the antidiarrhea activity of ethanol extracts of rambutan leaves containing tannins and flavonoids that inhibit intestinal motility. Methods: This study was conducted experimentally using the intestinal transit method, which measures the length of the intestine passed through a marker. The smaller the ratio between the length of the intestine and the marker, the greater the decrease in intestinal motility in the mice. Group 1: loperamide HCl at a dose of 4 mg/kg BW; Group 2:  placebo; Group 3: FI, FII, and FIII capsules at doses of 50 mg, 100 mg, and 150 mg. Results: The test results showed that Formulations 1, 2, and 3 had activities of 23.3%, 26.8%, and 32.3%, respectively. The capsule with the best results was formulation 3, at a dose of 150 mg. Compared with the positive control, the effectiveness of this capsule was 22% higher than that of loperamide. Conclusion: The results of this study showed that rambutan leaves extracted in capsule form effectively treats diarrhea. The one-way ANOVA test showed a significant difference between the FI, FII, and FIII groups (p <0.05).
Co-Authors Abdul Azis Ade Rizki Nurmayadi Afifah Avilani Afrah Hasna Fadhilah Agus Supriatman Aisyah Yaumul Furqan Alpin Maulana Amiruddin Yahya Apriyana Triwulan Arvyndho Derra Aulia Fitri, Windy Binti Nuriyatul Muthi’ah Cepi Rahmat Hidayat Chandra Rizky Noviandi Dede Syahrul Anwar Devi Sri Agustin Dewi Nurhaliza Diana Santi Edi Suhardiana Efilia Meirita Elysa Eka Endang Lestari Ermira Nilansari Putri Esa Mahesa Evi Dewi Sri Mulyani Fauziah Tazkia Nur Fitratul Wahyuni Fitri Pujiyanti Fitria, Sarah Galih Pambayun Gya Tri Lestari Hafizhah Nur Istiqomah Hanif Nur Fauzan Hari, Dewi Gulyla Hyasintha Aryanti I Made Suartika Ida Bagus Gede Manuaba Indah, Indah Kurniawati Jannah, Nurul Kamiel Roesman Bachtiar Lusi Indriani Maulida Nur Maya Rida Us Alifah Mestika, Diani Miftakhul Huda Muhammad Arif Muhammad Nur Zakia Mutiara Harkit Kamilatul Pu’adah N. Nurjanah Nabila Destiana Naufal Anasyi Nawwar Irfan Nevi Susianty Nggulam Zakia Nilama Wadnaty nisa, Annisa Nurul Maharani Nitya Nurul Fadilah Nofriyaldi, Ali Nola Fitri Noveri Rahmawati Novita Sari Novtafia Endri Nurbaiti Nurhasanah Nurjannah Nursyafni Nurul Fahida Oktavianus Sarno Prasiska Kholidya Prembayun Miji Lestari Rahmat Permana Reja Firman Saputra Rizky Nurul Melyani Rizky Subagya Rizva Alvina Rudi Hartono Shakynna Suandha Shinta Siti Sundari Siti Nabilah Hasna Sri Purnama Sari Srie Rezeki Nur Endah Sukarni Sunanih Teguh Ikhlas Ramadhan Teuku Mufizar Tsalitsatul Maulidah Ulfa Lailatul Vincent O. Imieje Wida Purwidianti Widhi Wicaksono Widya Nurul Aini Wilda Prasetya Winarti Wulandari, Tri Ayu YANTO Yulika Wati Zahra Aulia Nugraha