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Profil Indeks Larva pada Delapan Wilayah Puskesmas di Surabaya LYNDA ROSSYANTI; DWI SUSANTI; IVAN RAHMATULLAH; DWI PENI KARTIKASARI; SUKMAWATI BASUKI; HENY ARWATI; INDAH TANTULAR; SUHINTAM PUSARAWATI; HERU PRASETYO; SRI HIDAJATI; SUBAGYO YOTOPRANOTO; SRI WIJAYANTI SULISTYAWATI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract

ABSTRACT Background : Dengue virus infection is still a health problem in Surabaya. On 2015 Insidence Rate (IR) for Surabaya is 22.50 and the Case Fatality Rate (CFR) is 2%. This figure has decreased compared to 2014, but has not met the target achievement indicator for the P2DBD target CFR <1%. Method : The study was conducted in the rainy season, May 2015 in several Puskesmas areas in Surabaya. Samples were randomly selected as many as 378 houses spread in eight health centers (Pegirian, Krembangan Selatan, Hamlet Wall, Tambak Rejo, Putat Jaya, Simomulyo, Sawahan and Tanahkali Kedinding). The larvae survey was conducted using the single larva method. Larvae were taken from breeding sites and stored in specimen bottles for species identification at the Parasitology Laboratory Faculty of Medicine Universitas Airlangga. Result : The highest House Index (HI) was obtained (60.46%) or the 39.54% larvae free rate in Simomulyo and the lowest HI (33.33%) or 66.67% ABJ in Pegirian Puskesmas. Larvae species identification showed 100% was Aedes aegypti. The high HI value at the Simomulyo Health Center is not in line with the number of cases of dengue virus infection in 2015 which was 4 cases. Whereas in Pegirian Health Center with the lowest HI value found 11 cases. Discussion : These results could be due to the possibility because the study did not calculate larval density and high population mobility in the area.
Microscopic-Based Trend in Imported Malaria among Workers of Trenggalek District Returning from Kalimantan Island, Indonesia During 2012 – 2016 Heny Arwati; Kusmartisnawati Kusmartisnawati; Subagyo Yotopranoto; Poppy Hidayat; Yoes Prijatna Dachlan
Journal of Tropical Life Science Vol. 9 No. 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.01.14

Abstract

Malaria in Indonesia remains a significant health problem. Trenggalek District is one of the receptive malaria areas in East Java Province, Indonesia, with mainly imported malaria from outside Java Island. The people of this district accustomed to traveling to outside Java where malaria is endemic for temporary working purposes. Usually, they have acquired malaria infection in the areas where they worked and brought to their homeland during their return to the district. The number of imported malaria cases depend on the returning season of the workers. When no workers return from outside Java malaria case is zero. During the year of 2012-2016 microscopic examination of Microscopic examination of Giemsa-stained thick blood films of the workers have been done in the working activity of Pandean Primary Health Center on their arrival from Kalimantan Island either by active or passive case detection. Microscopically positive data were reported herein to describe the trend of imported malaria in the studied areas. A total number of malaria-infected workers were 118 cases. The trend towards increasing case number yearly between 2012 and 2013 being 1.35%, then decreasing between 2013 and 2016 to only 4 cases in 2016. Different patterns of imported malaria by month were seen in each year but no specific pattern throughout the year. The Plasmodium vivax infection was predominant every year and followed by Plasmodium falciparum and mixed infection of those two species. Trends of imported malaria cases in Trenggalek district were decreased and increased irregularly in each month yearly. However, the number of cases declined annually during 2013 – 2016. Antimalarial prophylaxis and insecticides prevent the workers from malaria infection.
The differences of parasitemia in Plasmodium berghei infected mice treated with extract of mango parasite leaves with Artemisinin combination Muhammad Zulkifly Tasman; Heny Arwati; Nurina Hasanatuludhhiyah; Puspa Wardhani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.13882

Abstract

Malaria is a disease transmitted through the bite of a female Anopheles mosquito caused by the Plasmodium parasite. Plasmodium has been reported to become resistant to artemisinin. Thus, the study on the ethanol extract of mango parasite leaves/Dendrophthoe pentandra (MP) on P. berghei-infected BALB/c mice with and without artemisinin combination (MP+A) was conducted. This study is experimental laboratory research with a post-test only design. The percent parasitemia in mice treated with ethanol extract of MP and MP+A leaves decreased. There was no difference in the spleen index in mice given ethanol extract of MP, and MP+A leaves with p = 0.203 and the spleen weight of mice with p = 0.134 (significance: p <0.005). Pearson Correlation test showed a correlation between spleen index with parasitemia and spleen weight with parasitemia; however, there was no correlation between body weight and parasitemia. The ethanol extracts of MP and MP+A leaves had significant antimalarial activity, and the difference in the percent parasitemia between groups was significant but not so far. The spleen index value was not affected by the ethanol extract of MP and MP+A leaves, but the percent parasitemia was affected.
Effect of ethanol extract of Hedyotis corymbosa (L.) Lamk against parasitemia and hepatomegaly in Plasmodium berghei ANKA-infected mice Jelita Aprisano Putri; Nabilla Feirizky Chairunnisa; Heny Arwati; Hartono Kahar
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.15903

Abstract

Malaria is a parasitic infectious disease that remains one of the focuses of world health problems. The ethanol extract of Hedyotis corymbosa has biochemical compounds potentially become a new antimalarial drug. This study aimed to analyze the effect of this extract on parasitemia and hepatomegaly in mice infected with Plasmodium berghei ANKA. Twentyfive BALB/c mice were infected with P. berghei ANKA and grouped into 5 groups. Group 1-3 were treated with 250 mg/Kg BW (HC250), 300 mg/Kg BW (HC300), and 350 mg/Kg BW (HC350) of ethanol extract of H. corymbosa (EEHC), respectively. Group 4 was a positive control (POS) which was given dihydroartemisisnin-piperaquin (DHP) and Group 5 was a negative control (NEG) which was only given CMC Na 1%. Treatments were given orally once a day for four consecutive days. Parasitemia was observed daily on Giemsa-stained tail blood smear. On day 5 the mice were sacrificed, blood were collected by cardiac punctured, the livers were removed and the length, width, and weight were measured. There was no significant difference on parasitemia between Group 1, 2, 3 and NEG. However, the highest inhibition of parasite s growth was found in Group 3 (61.4%. Observation on hepatomegaly, showed that a significant difference on the length of the liver was found between Group 3 and NEG.
Correlation of Parasitaemia and Anemia in Mice Infected with Plasmodium berghei ANKA Inas Hasna Azizah; Stevani Florentia Bahi; Heny Arwati; Mufassirin Mufassirin
Medical Laboratory Technology Journal Vol. 9 No. 1 (2023): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v8i2.494

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Malaria is an infectious disease caused by protozoa of the genus Plasmodium and transmitted through the bite of a female Anopheles mosquito. Plasmodium berghei ANKA is a species of rodent malaria parasite that is commonly used to study malaria pathology and the immune system against infections. Parasitaemia in malaria is the figure of malaria pathology due to some numbers of parasite-infected erythrocytes present in the peripheral blood. Hemoglobin (HGB) and hematocrit (HCT) levels are the parameters of anemia and some hematological changes caused by malaria infection. This study aimed to determine the correlation between parasitemia and anemia in BABL/c mice infected with Plasmodium berghei ANKA. Two uninfected and infected mice groups were compared for parasitemia, HGB, and HCT levels. Analysis statistics showed a significant difference in HGB and HCT between uninfected and infected groups. Pearson correlation analysis showed no significant correlation between parasitemia and HGB and HCT levels in infected mice. Anemia in mice infected with Plasmodium berghei ANKA can occur when parasitemia is even low; the higher parasitemia worsens the hamatological condition. Parasitemia plays a role independently in the severity of anemia. Plasmodium berghei infection in mice is useful for studying malaria anemia.
Genetic Diversity of Plasmodium falciparum Glutamate Rich Protein in Patients Attending the Merauke Hospital in Papua Province, Indonesia Thomas Tandi Manu; Puspa Wardhani; Heny Arwati; Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1662

Abstract

Malaria remains an important health problem in Indonesia with the highest transmission in Papua Province, an eastern part of this country. The genetic diversity of malaria parasites is the main problem in understanding several aspects of malaria infections and the dynamics of their transmission, which also play a role in the development of a vaccine. Plasmodium falciparum is the deadliest of the human malaria parasites. Plasmodium falciparum glutamate-rich protein (Pfglurp) is one of the many erythrocytic stages antigens currently under development for a vaccine. The Pfglurp gene hasbeen extensively used as a marker to investigate the genetic diversity, Multiplicity of Infection (MOI), the level of malaria transmission, immunity against malaria, as well as a discriminatory instrument to distinguish new from recrudescent infections of the field parasite population. Thus, this genotyping study aimed to find out the genetic population of P.falciparum at the Merauke District, Province of Papua, Indonesia. DNA samples were isolated from Dried Blood Spots (DBS) obtained from P.falciparum infected patients in the Regional Public Hospital of Merauke, Province of Papua, Indonesiaduring May 2019-July 2019. The isolated DNAs were then amplified for nested Polymerase Chain Reaction (PCR) prior to Pfglurp genotyping. The glurp gene was identified in all 51 DBS samples of P.falciparum-infected patients, and 18 variants of allele were found. Among them, 45.10% were found to bear multigenotype infections. The size of the dominant allele (12.5%) was 701-750 bp. The MOI was 1.58. The genetic population of P.falciparum in Merauke Hospital has contained a higher percentage of multigenotypes compared with monogenotypes indicating the high transmission of malaria in the studied area.
The Fluctuation of Aedes Aegypti in Endemic Area of Dengue Hemorrhagic Fever in Surabaya City, Indonesia Yotopranoto, Subagyo; Kusmartisnawati, Kusmartisnawati; Mulyatno, Kris Cahyo; Arwati, Heny
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.971 KB) | DOI: 10.20473/ijtid.v1i2.2163

Abstract

This research was aimed to describe the density pattern and the fluctuation of Aedes aegypti larval based on the season in dengue haemorrhagic fever (DHF) endemic area in Surabaya city. The population of the research was the house of people together with its breeding sites either inside and outside the house. The 55 houses were randomly chosen in 11 RWs in Nginden Subdistrict. The sample of this research was Aedes aegypti larva obtained from its breeding sites. The sample sizes were all of the larval in the containers existed in the chosen houses. The samples of the larval were taken and carried for identification and documentation of the species. This research was applied in the same houses in January, March, and May 2008 in rainy season. The results indicated that the highest larval index occurred in January with House Index (HI) 76.8%, Container Index (CI) 40.5%, and Breteau Index (BI) 137.5%. There was a decrease in March with HI 63.3%, CI 31.3%, and BI 92.7%. It continued to decrease in May with HI 42.6%, CI 21.1%, and BI 57.4%. All of those larval indices in the three observed months showed a high percentage of larval which was much higher than the safe limit or the critical threshold (5%) as defined by WHO. It implied that people in Nginden Subdistrict were threaten by the infection of DHF. The three indices achieved the peak in January, which was also the peak of the rainy season. It gradually decreased in March and May as the rainy season decreased its intensity of rain. Larval Density Index (LDI) also showed a high value. There were 173 larval/house in January, 187 larval/house in March, and 84.8 larval/house in May. The containers or breeding sites of Aedes were mostly found in January then their existences gradually decreased in March and May. Traditional bath tub was the most productive container inside the house, while drum and bucket were the most productive containers outside the house. Other containers which contributed abundance of larval were refrigerator, flower pot, well, and PDAM meter box.
Characteristics Environmental and Anopheles Larva Species In High And Low Clinical Malaria Cases In The Landak District of West Kalimantan Province Bariyah, Khairul; Utomo, Budi; Subekti, Sri; Sustini, Florentina; Juniastuti, Juniastuti; Fathmawati, Fathmawati; Arwati, Heny
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.10419

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Malaria remains a health problem in Indonesia. West Kalimantan is a malaria endemic area with high and lowincidence. Landak District is one of the malaria endemic area. Malaria cases were found in the areas around illegalgold mining and oil palm plantations. The aims of this study were to describe the characteristics of the breeding sitesand species of Anopheles larvae found in high malaria cases area, namely Amboyo Utara Village and low clinicalmalaria cases, area namely Mandor Village. This research is a descriptive research with cross sectional design. Thesamples were Anopheles larvae collected with Accidental sampling technique in the breeding sites. Environmentalcharacterization of breeding sites were physical characteristic including water temperature and sun exposure,chemical characteristic including water pH and salinity, and biological characteristics including water biota. Theresults of this study ware environmental characteristics that have the potential to breed Anopheles mosquitoes inAmboyo Utara Village, including water temperature 26-30ï‚°C, shandy, water pH 5.0-7.6, salinity 0.2-1.0 ppt, biotaswater hyacinth, grass and tadpole. The Mandor village, water temperature 29-30 ºC, shandy, pH of 6.9-8.0, salinity of0.5 ppt, water biota grass. Anopheles species found in Amboyo Utara village were larvae of An. vagus (94.30%), An.tessellatus (3.42%), An. subpictus (1.62%), An. indefinitus (0.81%) and An. maculatus (0.81%). Characteristics ofbreeding sites in Mandor village were larvae of An. maculatus (11.11%), An. subpictus (3.70%), and An. vagus(85.18%). The conclusion of this study was that di erent species found at breeding sites with di erent environmentalcharacteristics in both high and low malaria areas in Landak District, West Kalimantan Province.
Correlation of Total IgE Level and Intensity of Infection among Soil Transmitted Helminthiasis Farmers in Klungkung Regency, Bali, Indonesia Apsari, Putu Indah Budi; Arwati, Heny; Dachlan, Yoes Prijatna
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.551 KB) | DOI: 10.20473/fmi.v55i2.24562

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The phenomena of increasing total IgE level in Soil Transmitted Helminthiasis and its protective role in resistance of infection remains unclear. The purpose of this study was to determine the correlation between total IgE and the intensity of Soil transmitted helminthiasis among farmers in these area. Total 162 farmer, age ranged 25-80 years participated in this cross sectional analytic study. Kato-Katz method was used to diagnose Soil Transmitted Helminthiasis and to determined infection intensity based on egg per gram (EPG). Total IgE levels were measured by enzyme linked flourescent assay (ELFA). The results of this study showed that 13,56% farmer positive  for Soil Transmitted Helminthiasis, with single infection of Ascaris lumbricoides were 1,85%, 9,26% for Trichuris trichiura, 0,61% for Hookworm and mixed infection that were 1,23% for A.lumbricoides+T.trichiura 0,61%  for A.lumbricoides+Hookworm. The intensity of infection were in mild category. Total IgE level in Soil transmitted Helminthiasis group was significantly different compared with noninfected group (p<0.05, t-test). There was significant correlation between EPG and total IgE level (r=0.667, p=0.001, Spearman test). As a conclusion total IgE level was significantly correlated with EPG, this fact can be used to develop management of Soil Transmitted Helminthiasis theraphy.
Association Between Patients Behavior, Housing Conditions and Malaria Severity in the Fourteen Military Hospital, Margibi County, Liberia Gabriel Zean; Heny Arwati; Linda Dewanti; Atika; Moses Tende Stephens
JURNAL KESEHATAN LINGKUNGAN Vol. 17 No. 4 (2025): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v17i4.2025.361-368

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Introduction: Malaria has been a significant public health issue in Liberia, with behavioural and environmental factors influencing transmission and consequences. This study evaluated the association between patient behavior and housing condition with malaria status and severity in a military hospital in Margibi County, Liberia, in 2024. Methods: A cross-sectional study utilising 54 patients infected with P. Falciparum, where 53.7% were male, aged 20 to 49, and 46.3% were female, examining the association between patients' behaviour, housing condition and malaria severity in the Fourteenth Military Hospital in 2024. The association between variables was analysed using Chi-square and Fisher's exact tests. Results and Discussion: The association between patient behavior and housing conditions with malaria case status was statistically insignificant, as was the association between these factors and malaria severity. Small sample sizes and unmeasured confounders may not have provided sufficient statistical power to detect significant differences between groups, even though stronger associations between certain variables might exist but were undetected due to limited data. Further research with a more controlled design and larger sample sizes will be necessary to investigate the association between these variables further. Conclusion: There was no significant association between patient behavior and housing conditions with malaria case status or severity. A more systematic approach to data collection, incorporating factors related to malaria status and severity, could provide a clearer understanding of the contributors to P. falciparum infection status and disease, which can be correlated with patient behavior.
Co-Authors Amadeus Michel Goein Anak Agung Istri Sri Wiadnyani Apsari, Putu Indah Budi Apsari, Putu Indah Budi Aryati Aryati atika Awwaliyah Azmi Izzati Bagus Dwi Nugraha Budi Utomo Budi Utomo Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo, Callixte Denny Margono Denny P.N.H. Margono Denny P.N.H. Margono, Denny P.N.H. Dewi Hariyani Dinda Eka Putri Dusabimana Jean Damascene Dwi Susanti Dyah Ayu Febiyanti Eko Suhartono Fathmawati Fathmawati Florentina Sustini Frista Amalia Fuzianingsih, Eka Noviya Gabriel Zean Hartono Kahar, Hartono Hebert Adrianto Hidayat, Poppy Inas Hasna Azizah Indah S Tantular Indah Setyawati Tantular, Indah Setyawati INDAH TANTULAR Irene, Tuyishimire Jelita Aprisano Putri Jelita Aprisano Putri Juniastuti Juniastuti Kartika Arum Wardani KARTIKASARI, DWI PENI Khairul Bariyah, Khairul Kholida Nur Aini Kris Cahyo Mulyatno, Kris Cahyo Kusmartisnawati Kusmartisnawati Kusmartisnawati Kusmartisnawati, Kusmartisnawati Laily Nur Azizah Lelyana Sih Afgriyuspita Linda Dewanti Lindarto, Wira Widjaya Lucia Tri Suwanti, Lucia Tri M. Yasin Fitri Nugroho Majematang Mading Mardliyana Shalihah Marselaonety La’lang Meliance Bria Moses Tende Stephens Mufassirin Mufassirin Muhammad Kazwaini Muhammad Zulkifly Tasman Nabilla Feirizky Chairunnisa Nabilla Feirizky Chairunnisa Nathania Disa Ariesta Andriani Navisa, Claudia Clary Ni Wayan Winianti Nindya Tresiana Putri Nsanzimana Jean Baptiste Nurdianto, Arif Rahman Nurina Hasanatuludhhiyah Poppy Hidayat Priangga Adi Wiratama Puspa Wardhani Puspa Wardhani Puspa Wardhani Putri Rahayu putu indah budi apsari R. Heru Prasetyo Rahmatullah, Ivan Raudatul Jannah Rosalia Friska Ananda Rossyanti, Lynda Selviana Selviana Shoukat, Shahzad Sillehu, Sahrir Siti Munawaroh SRI HIDAJATI Sri Subekti Sriwijayanti Sulistyawati Stevani Florentia Bahi Subagyo Yotopranoto Subagyo Yotopranoto Subagyo Yotopranoto SUBAGYO YOTOPRANOTO Sudjajadi Keman Suhintam Pusarawati Sukmawati Basuki Suprapto Maat Supriyanto Supriyanto SUSANTI, DWI Syafarinah Nur Hidayah Akil Tantular, Indah Tanzilia, May Fanny Thomas Tandi Manu Willy Sandhika Windya Tri Hapsari Wiwied Ekasari Yetti Hernaningsih Yoes Prijatna Dachlan Yuniawan, Farah Shabrina Amazida Yuwono Marta Dinata