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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Berkala Kedokteran Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kreativitas PKM WICAKSANA: Jurnal Lingkungan dan Pembangunan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Hang Tuah Medical Journal
Heny Arwati
DEPARTMENT OF MEDICAL PARASITOLOGY, FACULTY OF MEDICINE, UNIVERSITAS AIRLANGGA
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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SEQUESTRATION OF ERYTHROCYTE INFECTED BY Plasmodium berghei ANKA IN MICE LIVER TREATED WITH ETHANOL EXTRACT OF PEARL GRASS (Hedyotis corymbosa (L.) Lamk) Nabilla Feirizky Chairunnisa; Jelita Aprisano Putri; Heny Arwati
Journal of Vocational Health Studies Vol. 9 No. 2 (2025): November 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I2.2025.110-116

Abstract

Background: Malaria is a parasitic infection caused by the Plasmodium genus. Certain Plasmodium species can evade the immune system by sequestering internal organs, including the liver. The ethanolic extract of pearl grass (Hedyotis corymbosa (L.) Lamk) (EEPG) has been reported to have an antimalarial activity in reducing parasitemia and hepatomegaly in Plasmodium berghei ANKA-infected mice. Purpose: To analyze the effect of EEPG administration on the sequestration of P. berghei ANKA-infected erythrocytes in the livers of BALB/c mice. Method: P. berghei ANKA-infected mice were treated with EEPG at doses of 250, 300, and 350 mg/kg BW. The positive and negative control groups received dihydroartemisinin-piperaquine (DHP) 187.2 mg/kgBW and 1% CMCNa, respectively. The treatments were administered for four consecutive days, followed by observation of parasitemia on Giemsa-stained tail blood smears. On day five, mice were sacrificed for liver removal. Sequestrations were observed on HE-stained slides of mouse livers. The differences in sequestration between treatment groups were analyzed using One-way ANOVA and Games-howell post-hoc analysis. The correlation between parasitemia and sequestration was analyzed using the Pearson correlation test. Result: The percentage reduction of the number of infected erythrocyte sequestration in EEPG-treated groups was 81.74%, 77.72%, and 77.70%, respectively, while the positive control group was 91.14%. Parasitemia was correlated with the number of erythrocytes sequestration (p-value < 0.05). Conclusion: EEPG was able to decrease parasitemia along with the decrease in the number of infected erythrocytes sequestration in the liver. These results indicated that EEPG is
Co-Authors Amadeus Michel Goein Anak Agung Istri Sri Wiadnyani Apsari, Putu Indah Budi Apsari, Putu Indah Budi Aryati Aryati atika Awwaliyah Azmi Izzati Bagus Dwi Nugraha Budi Utomo Budi Utomo Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo, Callixte Denny Margono Denny P.N.H. Margono Denny P.N.H. Margono, Denny P.N.H. Dewi Hariyani Dinda Eka Putri Dusabimana Jean Damascene Dwi Susanti Dyah Ayu Febiyanti Eko Suhartono Fathmawati Fathmawati Florentina Sustini Frista Amalia Fuzianingsih, Eka Noviya Gabriel Zean Hartono Kahar, Hartono Hebert Adrianto Hidayat, Poppy Inas Hasna Azizah Indah S Tantular Indah Setyawati Tantular, Indah Setyawati INDAH TANTULAR Irene, Tuyishimire Jelita Aprisano Putri Jelita Aprisano Putri Juniastuti Juniastuti Kartika Arum Wardani KARTIKASARI, DWI PENI Khairul Bariyah, Khairul Kholida Nur Aini Kris Cahyo Mulyatno, Kris Cahyo Kusmartisnawati Kusmartisnawati Kusmartisnawati Kusmartisnawati, Kusmartisnawati Laily Nur Azizah Lelyana Sih Afgriyuspita Linda Dewanti Lindarto, Wira Widjaya Lucia Tri Suwanti, Lucia Tri M. Yasin Fitri Nugroho Majematang Mading Mardliyana Shalihah Marselaonety La’lang Meliance Bria Moses Tende Stephens Mufassirin Mufassirin Muhammad Kazwaini Muhammad Zulkifly Tasman Nabilla Feirizky Chairunnisa Nabilla Feirizky Chairunnisa Nathania Disa Ariesta Andriani Navisa, Claudia Clary Ni Wayan Winianti Nindya Tresiana Putri Nsanzimana Jean Baptiste Nurdianto, Arif Rahman Nurina Hasanatuludhhiyah Poppy Hidayat Priangga Adi Wiratama Puspa Wardhani Puspa Wardhani Puspa Wardhani Putri Rahayu putu indah budi apsari R. Heru Prasetyo Rahmatullah, Ivan Raudatul Jannah Rosalia Friska Ananda Rossyanti, Lynda Selviana Selviana Shoukat, Shahzad Sillehu, Sahrir Siti Munawaroh SRI HIDAJATI Sri Subekti Sriwijayanti Sulistyawati Stevani Florentia Bahi Subagyo Yotopranoto Subagyo Yotopranoto Subagyo Yotopranoto SUBAGYO YOTOPRANOTO Sudjajadi Keman Suhintam Pusarawati Sukmawati Basuki Suprapto Maat Supriyanto Supriyanto SUSANTI, DWI Syafarinah Nur Hidayah Akil Tantular, Indah Tanzilia, May Fanny Thomas Tandi Manu Willy Sandhika Windya Tri Hapsari Wiwied Ekasari Yetti Hernaningsih Yoes Prijatna Dachlan Yuniawan, Farah Shabrina Amazida Yuwono Marta Dinata