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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin MEDISAINS Universa Medicina Syntax Literate: Jurnal Ilmiah Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Cahaya Mandalika Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of Social Research Jurnal Locus Penelitian dan Pengabdian MEDICINUS Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Plexus Medical Journal Indonesian Basic and Experimental Health Sciences
Ellistasari, Endra Yustin
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Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Hubungan Derajat Keparahan dengan Status Psikososial Pasien Melasma : Studi Cross-sectional Sambodo, Shelly Lavenia; Ellistasari, Endra Yustin; Kusumawardani, Arie; Irawanto, Muhammad Eko; Mulianto, Nurrachmat
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 12 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i12.4993

Abstract

Melasma tidak hanya berdampak pada aspek fisik berupa hiperpigmentasi, tetapi juga menimbulkan gangguan psikososial yang signifikan. Hubungan antara tingkat keparahan klinis melasma dengan derajat gangguan psikososial belum banyak diteliti di populasi Indonesia. Menganalisis hubungan antara tingkat keparahan melasma menggunakan Melasma Area and Severity Index (MASI) dengan derajat status psikososial menggunakan Melasma Quality of Life (MELASQOL). Studi cross-sectional dilakukan pada 15 pasien wanita dengan melasma di RSUD Dr. Moewardi Surakarta. Tingkat keparahan dinilai menggunakan skor MASI, sedangkan status psikososial dinilai menggunakan kuesioner skor MELASQOL. Analisis korelasi Pearson dan regresi linear sederhana digunakan untuk mengevaluasi hubungan antar variabel.  Rerata skor MASI adalah 5,95±1,15 dengan 53,3% pasien memiliki tingkat keparahan sedang dan 46,7% dengan tingkat derajat berat. Rerata skor MELASQOL adalah 40,33±6,22 dengan distribusi yang sama. Terdapat korelasi positif sangat kuat antara skor MASI dan MELASQOL (r=0,988; p<0,001; R²=0,977). Persamaan regresi menunjukkan MELASQOL = 8,62 + 5,33 × MASI. Terdapat hubungan positif yang sangat kuat antara tingkat keparahan melasma dengan derajat gangguan psikososial.
Evaluating the Serofast State in Syphilis: A Study of Clinical Characteristics, Immunological Markers, and HIV Status Lidjaja, Lifesia Natali; Ellistasari, Endra Yustin; Irawanto, Muhammad Eko; Kusumawardani, Arie; Mulianto, Nurrachmat
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3097

Abstract

Syphilis remains a significant global health burden, particularly among high-risk populations such as men who have sex with men (MSM). A major challenge in management is the serofast state, where patients fail to achieve serological cure despite adequate treatment. The immunological mechanisms driving this, especially in the context of HIV co-infection, remain unclear. This study aims to evaluate clinical and immunological factors associated with serofast status versus serological cure. A retrospective cohort study was conducted on 40 patients diagnosed with syphilis (early latent, late latent, or secondary). Data on demographics, HIV status, CD4/CD8 counts, and pre- and post-treatment VDRL titers were analyzed. Bivariate and multivariate logistic regression analyses were performed to identify predictors of the serofast outcome. The cohort was predominantly males (90.0%) and unmarried (80.0%). HIV co-infection was identified as the sole independent predictor of the serofast state (aOR = 10.94; 95% CI: 1.72-69.65; p=0.011). While post-treatment VDRL titers significantly decreased in the total cohort, the serofast group retained significantly higher antibody levels compared to the serological cure group (p<0.001). However, no statistically significant differences were found in CD4 counts, CD8 counts, or CD4/CD8 ratios between the two groups. HIV co-infection is a strong predictor of the serofast state in syphilis patients. The lack of significant differences in quantitative cellular immune markers suggests that the persistence of antibodies may be driven by functional immune dysregulation rather than absolute T-cell depletion. These findings emphasize the need for vigilant serological monitoring in HIV-syphilis co-infected individuals.
The Effect of Oral Bromelain on Interleukin-6 Levels in Tissue of Acne Vulgaris Model Rats noviani, Laura; Irawanto, Muhammad Eko; Ellistasari, Endra Yustin; Kusumawardani, Arie; Mulianto, Nurrachmat
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3102

Abstract

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit associated with Cutibacterium acnes colonization and activation of the Toll-like receptor–NF-?B pathway, which upregulates production of inflammatory mediators such as interleukin-6 (IL-6). Bromelain, a proteolytic enzyme derived from pineapple (Ananas comosus), is known to possess anti-inflammatory properties; however, experimental evidence regarding its effect on inflammatory cytokines in acne remains limited. This study aimed to evaluate the effect of oral bromelain administration on IL-6 levels in the tissue of acne vulgaris model rats. This in vivo laboratory experimental study employed a posttest-only control group design. Fifteen male Sprague-Dawley rats induced with C. acnes were divided into three groups: normal control (K1), negative control (K2), and treatment group (P) receiving oral bromelain at 88 mg/kgBW/day for 21 days. Tissue IL-6 levels were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using one-way ANOVA followed by a post hoc least significant difference (LSD) test. C. acnes induction significantly elevated tissue IL-6 levels compared to the normal control (p<0.001). One-way ANOVA revealed statistically significant differences in IL-6 levels between groups (p<0.001). The lowest IL-6 levels were observed in K1 (36.50±0.43) and the highest in K2 (94.01±0.57). The treatment group (P; 47.46±0.83) demonstrated significantly lower IL-6 levels than K2 and approximated K1 values. The post hoc LSD test confirmed statistically significant differences across all pairwise group comparisons (p<0.001). Oral bromelain administration effectively reduced IL-6 levels in the tissue of acne vulgaris model rats, demonstrating significant anti-inflammatory activity. These findings suggest that bromelain has potential as an adjunct therapy for inflammatory control in acne vulgaris.
Correlation Between Serum Il-24 Level in Acne Vulgaris Patients of Varying Clinical Severity Evanti, Annisa Marsha; Irawanto, Muhammad Eko; Mulianto, Nurrachmat; Kusumawardani, Arie; Ellistasari, Endra Yustin
Journal of Social Research Vol. 5 No. 4 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i4.3104

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit that significantly impacts patients' quality of life. The inflammatory process involves immune responses partially regulated by IL-24, suggesting its potential role in AV pathophysiology and clinical severity. However, data on serum IL-24 levels based on AV severity remain limited, particularly in Indonesia. This study aims to evaluate the relationship between serum IL-24 levels and acne vulgaris severity to further elucidate its molecular mechanisms. Methods: This observational analytical study with a cross-sectional design was conducted at Dr. Moewardi General Hospital, Surakarta, Indonesia, from November 2025 to January 2026, involving healthy individuals and acne vulgaris patients. AV severity was assessed using the Lehmann classification, and serum IL-24 levels were measured by ELISA. Results: A total of 60 subjects were involved, consisting of 15 healthy controls, 15 patients with mild AV, 15 with moderate AV, and 15 with severe AV. Pearson correlation analysis showed no significant relationship between serum IL-24 levels and AV severity (p = 0.186). However, there was a trend towards increasing serum IL-24 levels along with acne severity. In the healthy control group, IL-24 levels were lower than in the AV group. Conclusions: Serum IL-24 levels are not associated with acne vulgaris severity. This is likely due to its effect on local keratinocyte proliferation. Further research is needed to elucidate the pathophysiology using histopathological examination of skin tissue from patients with AV
Co-Authors Abas, Ervianti Aliwardani, Ambar Annisa Marsha Evanti Aulia Yasmin, Aulia Ayu, Ardelia Dyah Brian Wasita Cahyono, Aris Damayanti, Willa Dewi, Putti Fatiharani Dharmawan, Nugrohoaji Dita Eka Novriana Farida Mustifah, Etty Fatiharani, Putti Hidayatullah, Lalu Muh Syahrul Rio Ilona, Sri Esa Indah Julianto, Indah Irawanto, Muh. Eko Irawanto, Muhammad Eko Irfanti, Rakhma Tri Kamilah, Lian Kariosentono, Harijono Kariosentono, ⁠⁠Harijono Kasmitasari, Fitri Kusumawardani, Arie Lidjaja, Lifesia Natali Mardiana Mardiana Mochtar, Moerbono Monica, Pristia Widya Mulianto, ⁠Nurrachmat Nareswari, Adniana Novan Adi Setyawan Noviani, Laura Nurfaiqoh, Elok Nurrachmat Mulianto Octarica , Stella Gracia Octarica, Stella Gracia Poncorini, Eti Prasetyadi Mawardi Prasetyorini, Budi Eko Prihadi, Ihsany Arafiasetyanto Primisawitri, Pratiwi Prasetya Rahma, Alfina Rini Hastuti Rosita, Fiska Rosmarwati, Ervina Sesia Pradestine Shelly Lavenia Sambodo Suci Widhiati Sulistyo Sulistyo Triana, Agung Triasari Oktavriana Widhiati, Suci Widyastuti, Zilpa Wuri P, Adelia Yudhistira, Muhammad Yurizar Yuliarto, Danu