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Journal : Pharmacy Reports

The neuroprotective effects of Robusta coffee (Coffea canephora) on neurodegenerative diseases Warman, Ressalia Shoumadani; Iqbal, Muhammad; Triyandi, Ramadhan
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.83

Abstract

Neurodegenerative diseases represent a growing global health challenge, particularly in aging populations. This review examines the neuroprotective potential of Robusta coffee (Coffea canephora) and its bioactive compounds in neurodegenerative conditions. Robusta coffee contains a rich profile of bioactive compounds, including caffeine, chlorogenic acids, and other polyphenols, which demonstrate significant antioxidant, anti-inflammatory, and neuroprotective properties. Evidence from preclinical and epidemiological studies suggests that these compounds can modulate multiple pathways involved in neurodegenerative processes, including oxidative stress, neuroinflammation, and protein aggregation. This review synthesizes current findings on the molecular mechanisms underlying the neuroprotective effects of Robusta coffee components in conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Recent advances in delivery systems, such as nanoparticle formulations, are also discussed as potential approaches to enhance the bioavailability and efficacy of coffee bioactives. By identifying the therapeutic potential of Robusta coffee components and highlighting gaps in current knowledge, this review provides a foundation for developing novel preventive and therapeutic interventions for neurodegenerative diseases based on these naturally occurring compounds.
Co-Authors A.P, Afna Nur AA Sudharmawan, AA Abda Abda Afriyana, Regi Afriyani Agustine Sesunan, Dyah Surya Akbar, Muhamad Farhan Akbar, Muhammad Farhan Andrifianie, Femmy Anggraini K, Dea Anggraini T, Salsabila Ariyati, Retno Desy Asep Sukohar Atri Sri Ulandari Ayu Larasati, Nikken B, Agaphe Suluh Baehaqi Bayu Anggileo Pramesona Betta Kurniawan, Betta Cantika, Diana Helen Damayanti, Ervina Defri, Carisa Nabila Dwita Oktaria Elisa, Syavira Elisabeth Elva Monika Fadila, Riska Intan Farhan Akbar, Muhamad Fasha, Anugrah Fredison, Fredison H, Fitri Nur H, Siti Nur Hakim, Fatiyah Kamilah Hartanti, Lani Hasmal, Aditia Leo Hasyimi, Meifia Ihsanti Dwi Rahayu J, Zayatri Nurul Junando, Mirza L.P, Eka Ananda Larrassati, Vanesya Naya Leo Hasmal, Aditia LP, Eka Ananda Mallarangeng, Andi Nafisah Tendri Adjeng Michelle S, Natalia Muhamad Iqbal Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Mutiara Hati, Nadia Novriana, Dina NUR AFRIYANI Nur Hidayah, Fitri Nurmasuri, Nurmasuri Nurwijayanti Nuryanti, Eva Oktoba, Zulpakor P, Cindy Ivana P, Citra Yuliyanda P, Cutra Yuliyanda Pardilawati, Citra Yuliyanda Pasaribu, Risma Kristina Uli Pawarti, Nungky Pramesona, Bayu Anggelio Puteri, Vadiyani Fricillya Putik Titian Citra Hening Putri, Ida Ayu Gede Bintang Widia Putri, Yessa Rahmadini R, Diah Puspita R, Dwi Aulia R, P Neysha Romantika Rahayu, Anis Dwi Rahayu, Anisa Dwi Rahmadhita, Elmira Ramadhana Komala Ramdini, Dwi Aulia Rasmi Zakiah Oktarlina Ronalda Budyantara S, Natalia Michelle S, Nova Antika S, Suci Ainu Safitri, Nara Salsabila, Lyansaputri Sari, Merry Indah Sari, Ni Putu Ayudya Satria, Dzakiyyah Shoofina Jasmine Sayoeti, Muhammad Fitra Wardana Sormin, Merris Hartati Suci Ainu Sella Suharmanto Sukohar, Asep. Suri, Nurma Syazili Mustofa T, Salsabila Anggraini Tri Umiana Soleha Utami, Diana Mulia Virginia, Jesica Wardana, Muhammad Fitra Wardhana S, Muhammad Fitra Wardhana, M. Fitra Warman, Ressalia Shoumadani Widianto, Ardi Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono WS, Muhammad Fitra Yuviana, Yuviana Zeta, Nathasya Karren Zulfikar