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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan Jurnal Farmasi Udayana Media Komunikasi FPIPS Majalah Kedokteran Bandung Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology JURNAL PENDIDIKAN KEPERAWATAN INDONESIA MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Keperawatan Padjadjaran JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSKK (Jurnal Sains Keolahragaan dan Kesehatan) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Farmasi Galenika
I Ketut Adnyana
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Journal of Mathematical and Fundamental Sciences

 1 
Mechanism of Action of Coumarin against Candida albicans by SEM/TEM Analysis Gunawan Pamudji Widodo; Elin Yulinah Sukandar; I Ketut Adnyana; Sukrasno Sukrasno
Journal of Mathematical and Fundamental Sciences Vol. 44 No. 2 (2012)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/itbj.sci.2012.44.2.4

Abstract

The aim of this study was to identify the antifungal activity of coumarin isolated from Ageratum conyzoides L. leaves and to observe its influence on Candida albicans cells by scanning electron microscope (SEM) and transmission electron microscope (TEM). Antifungal activity testing with the disk diffusion method showed coumarin was active toward pathogenic fungus Candida albicans with an MIC value of coumarin of 125 g mL-1. The results show that this compound damaged the cell by pores formation on the cell wall. Death of cells occurred due to leakage and necrosis of cytoplasmic content.
Anti-inflammatory Activities and Gastric Ulcer-inducing Properties of Tetraacetylquercetin and Tetrapivaloylquercetin Rina Herowati; Rahmana Emran Kartasasmita; I Ketut Adnyana; Tutus Gusdinar Kartawinata
Journal of Mathematical and Fundamental Sciences Vol. 48 No. 3 (2016)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2016.48.3.6

Abstract

Quercetin (3,3'4',5,7-pentahydroxyflavone) has been reported to show anti-inflammatory activity. However, its low oral bioavailability limits the application of quercetin in therapy. Ester derivatives of quercetin have been reported to have higher bioavailability than quercetin. This research aimed to study the anti-inflammatory activities and gastric ulcer-inducing properties of tetraacetylquercetinas well as tetrapivaloylquercetin. Synthesis of tetra-acyl derivatives of quercetin was conducted using acetic anhydride or pivaloyl chloride in the presence of pyridine and the structure was confirmed by 1H-NMR and 13C-NMR spectroscopy as well as elemental analysis. At a dose of 20 mg/kg bw, oral administration of quercetin only showed 20% inhibition activity on carragenan induced rat paw edema, while tetraacetyl and tetrapivaloyl derivatives at equimolar dose showed 11-33% and 5-15% inhibition activity respectively. Contrary to the gastric ulcer healing-promoting action of quercetin, tetraacetylquercetin caused mild gastric ulcers. However, no gastric ulcer was observed after administration of tetrapivaloylquercetin. It was concluded that acylation enhances the anti-inflammatory activity of quercetin but causes mild gastric ulcers in the case of tetraacetylation.
Particle Size Optimization of Melinjo (Gnetum gnemon L.) Seed Hardshell: A Potential Antioxidant Alternative Marlina Indriastuti; I Ketut Adnyana; Rika Hartati; Heni Rachmawati
Journal of Mathematical and Fundamental Sciences Vol. 56 No. 1 (2024): (In Progress)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2024.56.1.2

Abstract

Natural ingredients can have extraordinary potential as alternative medicines due to their accessibility and cost-effectiveness. Application of these ingredients should consider solubility and permeability, which determine the success of pharmaceutical characteristics formulation and biological activity indication. In this context, physical manipulation, specifically particle size reduction, is an effective strategy to address these issues. Previous research has explored active compounds in the stilbenoid group, found in the outer skin, hard shell, and endosperm of melinjo (Gnetum gnemon L.) seeds, functioning as antioxidant. Based on the potential as antioxidant, stilbenoid compounds, including resveratrol, contained in melinjo seed hardshell have shown significant pharmacological effects. Therefore, this research aimed to investigate the potential of melinjo seed hardshell extract as a natural antioxidant alternative by modifying the particle size through a grinding process to obtain nanoparticles. The analysis was carried out using ball milling to enhance the solubility of melinjo seed hardshell extract by increasing the saturated solubility and surface area of the particles. The results showed that the total phenol content and the antioxidant power increased significantly (p < 0.05) after ball milling. Melinjo seed hardshell nanoextract is reported herein as a promising source of natural antioxidant from local Indonesian plants.
Co-Authors - Liandhajani - Sukrasno . Patonah Afifa, Alia Tri Afifa, Alia Tri Agung Dwi Juniarsyah Agung Dwi Juniarsyah Alia Tri Afifa Ame Suciati Setiawan Andayani, Desak Gede Sri Andreanus A. Soemardji Apriantono, Tommy Armina, Tjokorde Istri Cempaka Kuning Christanti, Yohanna Dadan Resmana Dangin, I Gede Rama Andika Yuda Daryono Hadi Tjahjono Desak Gede Sri Andayani Desak Gede Sri Andayani Dewi Safitri Dewi Safitri DEWI SAFITRI Dwi Hadi Setya Palupi Eka Fitri Susiani Elin Y. Sukandar Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elis Susilawati Elis Susilawati Finna Setiawan Fisheri, Neng Gunawan Pamudji Widodo Gusdinar, Tutus Hannan, Hannan Hasan, Muhamad Fahmi HENI RACHMAWATI Hikmat Permana I Gusti Agung Ayu Kartika I Made Agus Gelgel Wirasuta Irda Fidrianny Irianti Bahana Maulida Reyaan Irvani Rakhmawati Iwo, Maria Immaculata Juniarsyah, Agung Dwi Kartasasmita, R. E. Kogilavani Ramasamy Kuning, Cempaka Kusnaedi Kusnaedi Kusnandar Anggadiredja Leni Herliani Afrianti Leonny Yulita Hartiadi Lia Amalia Liandhajani, - Linda Amalia Lisna Anisa Fitriana, Lisna Anisa Maria Immaculata Iwo Mariani, Ria Marlina Indriastuti Mukti Priastomo Nawawi, As’ari Nazhifa Ufamy Neng Fisheri Ni Kadek Warditiani Niken Indriyanti Niken Indriyanti Nisrina Dita Arlinda Nisrina Dita Arlinda, Nisrina Dita Nugrahani, Retta Poety Prawestyi Pratiwi Wikaningtyas Prawestyi, Poety Primal Sudjana Purwanti, Sandra Jati Rahmana Emran Kartasasmita Rahmatullah, Satrio Wibowo Rahmawati, Siti Farah Rakhmawati, Irvani Ramasamy, Kogilavani Ray, Hamidie Ronald Daniel Readi, Septa Reyaan, Irianti Bahana Maulida Rika Hartati Rini Syafriani Rini Syafriani Rizki Mulyawan Rizki Mulyawan Rosmadi, Arief Samsul Bahri Sandi, Dita Ayulia Dwi Sansan Candra Setiawan . Setiawan Setiawan Setiawan, Finna Sigit, Joseph Iskendiarso Slamet Ibrahim Soemardji, Andreanus A. Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Ukan Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno, Sukrasno Suryani Suryani Susiani, Eka Fitri Susilawati, Elis Suwendar Suwendar Tommy Apriantono Tutus Gusdinar Kartawinata Ufamy, Nazhifa Ukan Sukandar Ukan Sukandar Wikaningtyas, Pratiwi Wirasutisna, Komar Ruslan Wiyasa, Komang Ngurah Yani Mulyani Yani Mulyani Yedy Purwandi Sukmawan Yohanna Christanti Yuliet Yuliet Yuniarto, Ari Zazuli, Zulfan Zulfan Zazuli