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All Journal Jurnal Keperawatan Jurnal Kedokteran Brawijaya Jurnal Kebijakan Kesehatan Indonesia JAM : Jurnal Aplikasi Manajemen Research Journal of Life Science Indonesian Journal of Human Nutrition MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Majalah Kesehatan FKUB Journal of Nursing Care and Biomolecular Journals of Ners Community Journal of Issues in Midwifery Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Jurnal Health Sains Narra J Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Ilmu Kedokteran Keluarga Konstruksi: Publikasi Ilmu Teknik, Perencanaan Tata Ruang dan Teknik Sipil Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) Media Penelitian dan Pengembangan Kesehatan
Sri Andarini
Departemen Kesehatan Masyarakat Fakultas Kedokteran Universitas Brawijaya Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Universa Medicina

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Bone metastases tend to increase in non-small cell lung cancer with epidermal growth factor receptor mutation Maleachi, Reginald; Erawati, Dini Rachma; Pratiwi, Suryanti Dwi; Andarini, Sri
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.4-10

Abstract

BackgroundIncreased understanding in molecular pathology of advanced non-small cell lung cancer (NSCLC) over the past decades has led to personalized treatment approaches being advocated. Epidermal growth factor receptor (EGFR) mutation that often occurs in NSCLC can be identified using immunohistochemical examinations. Moreover, clarifying the relationship between computed tomography (CT) and EGFR mutation of NSCLC might inform therapeutic decision-making. The purpose of this study was to determine the relationship between metastatic sites on primary chest CT-scan and EGFR mutation in NSCLC lung cancer patients. MethodsAn cross-sectional design using secondary data was conducted, involving 76 NSCLC patients. EGFR mutations were determined by immunohistochemical examination and metastatic sites by chest CT-scan with contrast. The collected metastatic sites comprised hilar and mediastinal lymphadenopathy, pulmonary nodules, and bone, liver, spleen and suprarenal metastases. A Chi square test was used to analyze the data. ResultsThis study revealed that the highest NSCLC stage was IVb, found in 39 samples (51.3%), while 34 (44.7%) subjects had EGFR mutation. There was no statistically significant difference between metastatic site and positive EGFR mutation, although positive bone metastases (54.8%) tend to have more numerous positive EGFR mutations compared to negative bone metastases (37.7%) (p=0.142). ConclusionsPatients with positive bone metastases tend to have higher positive EGFR mutation compared to negative bone metastases in NSCLC lung cancer patients. Prospective studies evaluating patients with EGFR mutation for bone metastases should be considered. This can provide information on therapeutic decision-making to obtain good clinical outcomes.
Co-Authors A.A. Ketut Agung Cahyawan W Afni, Anissa Cindy Nurul Anak Agung Gede Anom Aswin Annisa Rizky Maulidiana Aprilia, Nisa Aska, Andra Agnez Al Asmika Asmika Asti Melani Astari Bobby Christian, Samuel Catur Saptaning Wilujeng Dasa Novita, Khuznita Dewi Kartikawati Ningsih, Dewi Kartikawati Dewi Rachmawati Dian Handayani Diana Lyrawati Djanggan Sargowo Djanggan Sargowo Dwi Yogyo Suswinarto Dwi Yogyo Suswinarto, Dwi Yogyo Dyatmiko, Hendrian Eko Nofiyanto Erawati, Dini Rachma Erry Nur Rahmawati Fadhilah, Anita Fakhrizah Wildani , Safira Farida, Ery fatimah Fatimah Ferdina, Cucun Setya Frinny Sembiring Hanggara, Dian Sukma Hanifarizani, Rahma Dian Hastuti, Novianti Tri Herwendanasari, Deltania Hevy Purwaningtyas, Nuretha Hidayat Sujuti Hinisa, Fariha Nuzulul Holipah, Holipah I Made Subhawa Harsa I Wayan Agung Indrawan Iftinan, Yasmin Inggita Kusumastuty Intan, Dara Ismail, Dina Dewi Sartika Lestari Joys Karman Nike Palupi Kartikasari, Dhian Karyono Mintaroem Kuntadi, Muhammad Kuswantoro Rusca Putra Leny Budhi Harti Lestaluhu, Viqy Lestari, Retno Lilik Zuhriyah M. Halim Natsir M. Nooryanto Maleachi, Reginald Mira Mutiyani Mirnawati A Misbahuddin Azzuhri Mulyatim Koeswo Mulyatim Koeswo Nanik Setijowati Natasia, Nazvia Nazvia Natasia Nia Novita Wirawan, Nia Novita Nina Handayani Nindy Sabrina Nur Pratiwi Hartono, Nur Pratiwi Nur, Mangsur M Nurinnisa, Zarifa Praja, Dewangga Wahyu Pratiwi, Suryanti Dwi Pudji Lestari Putri, Dianita Setya Pradita Putri, Frilya Rachma Qomariyatus Sholihah Retty Ratnawati Retty Ratnawati Ridhoyanti Hidayah, Ridhoyanti Ririn Puji Rahayu Rismaina Putri Sasiarini, Laksmi Sasongko, Ardi Septi Dewi Rachmawati, Septi Dewi Seskoati Prayitnaningsih Shanti, Karina Muthia Simanjuntak, Roganda Siti Umi Ernawati, Siti Umi Suryana, Bagus Putu Putra Susanti, Fitria Dewi Tita Hariyanti Tri Anjaswarni Ulya, Zuhrotun Viera Wardhani Viera Wardhani Wahida Azis Wardani, Diadjeng Setya Wening Prastowo Widya Rahmawati Windarwati, Heni D. Wiradinata, Harsono Wuri, Kinanthi Yudhantara, Dearisa Surya