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All Journal Media Penelitian dan Pengembangan Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Respirologi Indonesia JFIOnline Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Abdi Insani Jurnal Cahaya Mandalika Pharmaceutical Sciences and Research (PSR) Cerdika: Jurnal Ilmiah Indonesia Jurnal Farmasi Indonesia Jurnal Kefarmasian Indonesia Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan
Retnosari Andrajati
Fakultas Farmasi UI
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Pengaruh Konseling dan Leaflet terhadap Efikasi Diri, Kepatuhan Minum Obat, dan Tekanan Darah Pasien Hipertensi di Dua Puskesmas Kota Depok Dewanti, Sri Wahyuni; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.3472

Abstract

Self-efficacy and low adherence was significant problem on using antihypertension drugs. The study purpose was to evaluate the effectiveness of counseling and provision of leaflets againts self-efficacy and adherence as well as the blood pressure of hypertensive patients at two community health centers in Depok City. The study desain is a quasi-experimental with 37 patients in counseling group and 36 patients in the leaflets group during March to June 2013. The instrument determine self-efficacy is MUSE scale, MMAS-8 scale for adherence and the tensimeter for blood pressure. Data were analyzed uses the Wilcoxon and Kolmogorov-Smirnov test. The results showed that the largest percentage of hypertension patients in community health centers have mild hypertension, has been suffering from hypertension between 1-5 years, received a single drug, mostly captopril, and did not feel any side effects. The counseling and provision of leaflets can increase self-efficacy and medication adherence, and lower systolic blood pressure significantly. Provision of leaflets to patients can increase self-efficacy and adherence, and lowering the systolic and diastolic pressure significantly. There is no significant difference between the effects of counseling and the provision of leaflets to increase self-efficacy and adherence, as well as a decrease in blood pressure in hypertensive patients in community health centers in Depok City
Perbandingan Penggunaan Kontrasepsi Suntik Zat Tunggal dan Kombinasinya terhadap Kejadian Reaksi Obat yang Tidak Dikehendaki di Satu Bidan Praktek Kota Depok Rahmawati, Ni Made Ayu; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 1, FEBRUARI 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i1.3477

Abstract

Injectable contraceptives raise health problems risk than oral or implan contraceptive. This study aimed to compare the incidence of adverse drug reactions (ADRs) single injectable contraceptive use (Depot medroxyprogesterone acetat/DMPA) with a combination of injectable contraceptive (CICs) use (DMPA and Estradiol cypionate/E2C). The study design was a cross-sectional two population comparison. The sample consisted of 88 acceptors in each group. The ADRs were analyzed using Chi Square and logistic regression multivariate. The largest side effect in single injectable contraceptive group were menstrual disorders (86,4%) and mood dischange, while the side effects in CICs group were mood (64,8%) and bone pain (51,1%). Menstrual disorders in single injectable contraceptives usage was 10.0 folds than CICs. Headache in injectable contraceptives usage was 1.9 folds than in the use of CICs. Menstrual disorders in overweight acceptor 3,8 folds than not overweight.As the ADR observation, the use of CICs is relatively safer than single injectable contraceptive
Risiko Penggunaan ACEi Terhadap Kejadian Batuk Kering pada Pasien Hipertensi di RSUD Cengkareng dan RSUD Tarakan DKI Jakarta Halim, Margareth Christina; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3694

Abstract

The use of angiotensin converting enzyme inhibitors (ACEi) as an antihypertensive agent can cause side effects such as dry cough. The aim of this study is to evaluate risk of ACEi administration on dry cough incidence with captopril as the standard against lisinopril and ramipril in hypertensive patients at RSUD Cengkareng and RSUD Tarakan Jakarta. The design of this study is prospective cohort. The inclusion criteria were patients who received ACEi as hypertension therapy for ≤ 3 months gathered from outpatient and willing to participate as sample in this study at RSUD Cengkareng and RSUD Tarakan. Subject of this study consist of 54 patients who received captopril and 54 patients received non captopril ACEi, taken by consecutive sampling from January-July 2014. Data was collected using structured interviews and medical record. Dry cough incidence due to ACEi was evaluated using Naranjo Algorithm and analyzed using Chi Square test. Dry cough incidence was found in 19,44% of sample. No significant relationship of age, gender, ethnic, comorbidity, body mass index (BMI), dosage, and duration of use with the dry cough incidence due to the use of ACEi. There is no difference on dry cough incidence between the use of captopril, lisinopril and ramipril.
Implementasi Penyesuaian Obat Diabetes pada Saat Puasa Ramadan dan Pengaruhnya Terhadap Nilai HbA1c Safyanty, Rahmi; Andrajati, Retnosari; Supardi, Sudibyo; Dewi Sartika, Ratu Ayu
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.126-134.2020

Abstract

This study aimed to evaluate the effect of diabetes medication adjustment during Ramadan fasting according to the recommendation of International Diabetes Federation-Diabetes and Ramadan International Alliance (IDF-DAR) to HbA1c values in type-2 diabetes mellitus patients. The study was conducted at a hospital in Jakarta, Indonesia with a cross-sectional study design involving 80 ambulatory patients with type-2 DM who fasted during Ramadan in 2016. About 60% of patients used oral antidiabetes drug (OAD), mostly the combination of biguanide + sulfonylurea drugs (27.5%). The adjustments were made in which 56.2% was in accordance with IDF-DAR recommendations. The study showed that the HbA1c values decreased insignificantly (p = 0.082) from 8.75 ± 1.90 to 8.63 ± 1.82 after the adjustment. The appropriate drug adjustment based on IDF-DAR had a significant effect on the HbA1c value of DM patient with p-value 0.030 (p < 0.05).The discrepancy of drug use based on IDF-DAR 3.222 times greater caused uncontrolled HbA1c. The most influential variable to HbA1c value was drug type with p-value 0.006 (p < 0.05). Improper adjustment of Insulin or combination insulin-OAD caused HbA1c value 5 times greater to be uncontrolled than OAD.
Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study Eliza, Delila; Syafhan, Nadia Farhanah; Andrajati, Retnosari; Fitriani, Sri Wulandah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.21-27.2023

Abstract

Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diabetes Mellitus (DM). Studies on the relationship between medication adherence and blood sugar control on the quality of life (QoL) in Type 2 DM patients are limited in Indonesia. This study aims to assess the relation between medication adherence with blood sugar control and the quality of life of Type 2 DM patients. This study used a cross-sectional design conducted at Universitas Indonesia Hospital. It used Medication Adherence questionnaires and EuroQoL 5D-5L questionnaires to assess patients’ medication adherence and quality of life. This study involved a total of 74 Type 2 DM patients with an average age of 57 ± 10.74 years. Medication adherence with good blood sugar control (HbA1c <7%) showed a significant relationship (p-value <0.05) with COR values of 3.74 (1.21 - 11.6) compared to non-adherent patients. But not on the QoL Index and VAS (Visual Analog Scale) values, where the value is lower in patients with high adherence and good blood sugar control. Factor asscociated with blood sugar controlled were comorbidites and medication adhrence while factor that associated with quality of life were comorbidities, ages, education and employment status
Pengaruh Faktor Risiko terhadap Kejadian Peningkatan Kadar Enzim Transaminase pada Pasien Covid-19 dengan Terapi Tocilizumab Nasution, Izza Aulia Rizqika; Andrajati, Retnosari; Syafhan, Nadia Farhanah; Imaniar, Rania
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.476 KB) | DOI: 10.35617/jfionline.v15i1.137

Abstract

Abstract: Tocilizumab is an anti-IL-6 which is recommended as cytokine release syndrome therapy in the treatment of Covid-19. One of the side effects of tocilizumab that can occur is hepatotoxicity, from mild elevated transaminases to severe drug-induced liver injury (DILI). Currently, research related to tocilizumab hepatotoxicity and the risk factors affecting Covid-19 patients is limited and still needs to conduct. This research is an observational study with cross-sectional design. Data collection was carried out retrospectively using secondary data obtained from medical records department, patients with Covid-19 at Universitas Indonesia Hospital in 2020-2021. Patients confirmed with positive Covid-19 receiving Tocilizumab therapy in medical record were included in this study. Patient demographics, clinical diagnoses, laboratory examinations, history of others medication were also reviewed. Patients with less than 18 years old, incomplete medical record data, and referred to other hospitals were excluded. The sampling technique used was total sampling, namely all patients who met the inclusion criteria were taken as subject in this research. Chi-square test was used to analyze the relationship between each risk factors and the incidence of elevated transaminases. The results of Chi-square test showed that several risk factors significantly increased the incidence of elevated transaminases in patients given tocilizumab therapy, including age, obesity, diabetes mellitus, and ceftriaxone as antibiotic therapy.
EFFECTIVENESS OF AMLODIPINE WITH CONCOMITANT HERBAL THERAPY (BAY LEAVES, CELERY, CUCUMBER) IN HYPERTENSIVE PATIENTS IN SURAKARTA Mahmuda, Nur Amalia; Andrajati, Retnosari; Elya, Berna
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2939

Abstract

Hipertensi merupakan penyakit kronis yang memerlukan pengelolaan jangka panjang. Penggunaan tanaman obat sebagai terapi komplementer mulai banyak dilirik, namun bukti ilmiahnya masih terbatas. Penelitian ini bertujuan untuk mengevaluasi efektivitas amlodipin dengan terapi penyerta tanaman obat (daun salam, seledri, dan/atau timun) dibandingkan dengan monoterapi amlodipin pada pasien hipertensi. Desain penelitian adalah kohort retrospektif dengan menggunakan data dari rekam medis dan kuesioner pada pasien di tiga puskesmas Kota Surakarta. Efektivitas terapi diukur dari pencapaian target tekanan darah selama tiga bulan. Analisis dilakukan menggunakan uji bivariat dan regresi logistik multivariat. Hasil menunjukkan efektivitas klinis lebih tinggi pada kelompok amlodipin dengan terapi penyerta tanaman obat berupa daun salam, seledri, dan/atau mentimun (78,4%) dibandingkan monoterapi amlodipin (68,8%), meskipun tidak signifikan secara statistik (p=0,160). Faktor yang berhubungan signifikan dengan efektivitas adalah kepatuhan terapi (p<0,001), tekanan darah sistolik awal (p<0,001), dan tingkat pendidikan (p=0,047). Penggunaan tanaman obat sebagai terapi penyerta pada pasien yang menjalani terapi amlodipin menunjukkan potensi tambahan dalam menurunkan tekanan darah, namun belum terbukti signifikan. Penelitian prospektif atau uji klinis diperlukan untuk menilai manfaat dan keamanannya lebih mendalam.
Faktor Yang Mempengaruhi Penurunan Fraksi Ejeksi Ventrikel Kiri Pada Pasien Kanker Yang Mendapatkan Kemoterapi Doksorubisin Di Rumah Sakit Kanker Dharmais Maifitrianti, Maifitrianti; Sutandyo, Noorwati; Andrajati, Retnosari
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 2: September 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i2.3761

Abstract

Doksorubisin masih sering digunakan dalam pengobatan kanker. Efek samping doksorubisin terhadap jantung perlu mendapatkan perhatian khusus. Penelitian ini bertujuan untuk memperoleh gambaran penurunan fraksi ejeksi ventrikel kiri dan faktor risiko yang mempengaruhinya pada pasien kanker yang mendapatkan kemoterapi doksorubisin di Rumah Sakit Kanker Dharmais (RSKD). Desain penelitian yang digunakan adalah cross sectional. Data diperoleh dari rekam medis pasien. Populasi adalah pasien kanker yang mendapatkan kemoterapi doksorubisin minimal 4 siklus periode Oktober 2011-Oktober 2013. Penilaian fungsi jantung didapatkan dari data Echocardiography jantung yaitu fraksi ejeksi ventrikel kiri sebelum kemoterapi dan setelah siklus terakhir kemoterapi. Penurunan fraksi ejeksi ventrikel kiri ≥10% pada penelitian dinilai sebagai penurunan yang bermakna. Analisis statistik menggunakan software Statistical Products Social Science (SPSS) versi 18. Sebanyak 77 pasien memenuhi kriteria inklusi dan eklusi. Sebanyak 37 pasien (48,05%)  mengalami penurunan fraksi ejeksi ventrikel kiri <10% dan sebanyak  28  pasien  (36,36%) mengalami penurunan fraksi ejeksi ventrikel kiri ≥10%. Hipertensi berpengaruh terhadap penurunan fraksi ejeksi ventrikel kiri ≥10% secara bermakna (p=0,032). Jenis kelamin laki-laki dan radiasi dada kiri menunjukkan adanya kecenderungan berhubungan dengan penurunan fraksi ejeksi ventrikel kiri ≥10% (p=0,095 dan p=0,051). Doksorubisin dapat menyebabkan penurunan fraksi ejeksi ventrikel kiri ≥10% pada lebih dari sepertiga pasien kanker di RSKD dan faktor yang paling mempengaruhinya adalah komorbiditas hipertensi. Kata Kunci: doksorubisin; faktor risiko; penurunan fraksi ejeksi ventrikel kiri 
PENGARUH PENYULUHAN DAN PEMBERIAN LEAFLET PADA IBU TERHADAP PENGETAHUAN, PERSEPSI DAN PENYIMPANAN ANTIBIOTIK DI KELURAHAN BEJI DAN PANCORAN MAS KOTA DEPOK Zainuddin, Fuad; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 2 (2023)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i2.1455

Abstract

Swamedikasi antibiotik dapat meningkatkan terjadinya resistensi dan risiko penggunaan antibiotik yang tidak tepat. Salah satunya disebabkan kurangnya pengetahuan masyarakat terhadap bahaya menyimpan antibiotik dirumah. Penelitian ini bertujuan untuk menilai pengaruh penyuluhan dan pemberian leaflet pada ibu terhadap pengetahuan, persepsi dan penyimpanan antibiotik. Penelitian ini menggunakan rancangan penelitian Quasi Experiment non randomized pre post control group. Intervensi berupa penyuluhan dan pembagian leaflet pada ibu. Penelitian dilakukan di Kota Depok pada bulan Januari-Oktober 2014. Wilayah kerja kelurahan Pancoran Mas sebagai lokasi intervensi dan kelurahan Beji sebagai kontrol. Subjek penelitian adalah ibu rumah tangga usia 18-65 tahun. Jumlah subjek untuk kelompok intervensi 52 dan kontrol 52 ibu rumah tangga. Analisis data dilakukan dengan menggunakan uji beda dan analisis multivariat. Hasil penelitian menunjukkan pengetahuan awal ibu didapatkan informasi sebesar 81,7% tidak tahu bahwa membeli antibiotik harus menggunakan resep, persepsi awal ibu didapatkan informasi sebesar 42,3 % menganggap antibiotik bukan obat keras dan sebesar 51% diketahui ibu menyimpan antibiotik dirumah. Perbedaan bermakna pengetahuan dan persepsi ibu pada kelompok penyuluhan dan pemberian leaflet lebih tinggi dibanding sebelum penyuluhan. Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Penyuluhan dan pemberian leaflet memberikan pengaruh secara bermakna terhadap peningkatan pengetahuan dan persepsi. Ada hubungan yang bermakna antara pengetahuan, persepsi dan penyimpanan antibiotik ditunjukan dengan nilai p < 0,05.
The Implementation of Telepharmacy in Bangka Belitung Islands Province Djuria, Rachmawati Felani; Andrajati, Retnosari; Syafhan, Nadia Farhanah; Wispriyono, Bambang
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1059

Abstract

Telepharmacy is a telemedicine health service in the pharmaceutical sector that uses telecommunications to assist patients located far away during the Covid-19 pandemic. Furthermore, professional organizations are responsible for continuously providing information to pharmacists, ensuring they stay updated with the latest developments in the field. Mobile applications have emerged as the primary medium through which information can be accessed. Therefore, this research aimed to determine the implementation of telepharmacy in the Bangka Belitung Islands Province using observational research with a qualitative approach. The participants comprised a total of 11 individuals and the technique employed was purposive sampling. Subsequently, the collected data were subjected to analysis using the Miles and Huberman model. The results showed that the utilization of telepharmacy commenced within Bangka Belitung Islands Province and the community pharmacy service implemented the concept in the form of Drug Information Services, drug consultation or patient counseling, and prescription services through e-prescribing. Additionally, field observations highlighted the presence of services such as home delivery of medicines, patient education, and online non-cash payments. The implementation of telepharmacy within hospitals remains absent, despite the widespread adoption of digital services facilitated by the SIMRAS application. Pharmacists also ensured the administrative compliance of their colleagues through the utilization of the SIAP application. The preliminary stages of the implementation commenced in the Bangka Belitung Islands Province.  
Co-Authors . Widiarti Abdul Munim Ai Yeni Herlinawati Yeni Anton Bahtiar Ardiansyah Kahuripan Ardiansyah Kahuripan, Ardiansyah Arry Yanuar Atika Wahyu Puspitasari Bambang Wispriyono Berna Elya Daimah Wirdatus Sanaun Harahap Diah Handayani Djuria, Rachmawati Felani Forestrania, Roshamur Cahyan Fuad Zainuddin Harianto Harianto Hasanah, Kurniatul Heni Susilowati Heni Susilowati Husnawati Husnawati Ika Puspitasari Indriani, Lusi Iwan Wahyudin Jiři Vlček Juheini Amin Juheini Amin Mahdi Jufri Mahmuda, Nur Amalia Maifitrianti Maifitrianti, Maifitrianti Maifitrianti, Maifitrianti Makhdalena Makhdalena, Makhdalena Margareth Christina Halim, Margareth Christina Masyrifah, Mas Merry Christianie Merry Christianie, Merry Mun‘im, Abdul Nadia Farhanah Syafhan Nasution, Izza Aulia Rizqika Noorwati Sutandyo Putri, Risani Andalusia Raden Rara Diah Handayani Rahmawati, Ni Made Ayu Rais, Yulia Rais, Yulia Rania Imaniar Ratika Rahmasari Ratu Ayu Dewi Sartika Rizka Andalusia Rizka Andalusia Safyanty, Rahmi Santi Purna Sari Santi Purnasari Sinabutar, Reniati Siti Setiati Sri Wahyuni Dewanti Sri Wulandah Fitriani, Sri Wulandah Sudibyo Supardi Syamsu Nur Tetty Syafridani Tetty Syafridani, Tetty Toksisitas Hematologi Regimen, Toksisitas Hematologi Vernissa, Venni Vitri Agustiarni Widiarti Widiarti Widya Kardela Wulandari, Nora Yona Harianti Putri Yudhorini, Linda Triana Yulia Trisna Yulia Trisna, Yulia Yulian Rahmadini Yulian Rahmadini, Yulian Zainudin, Fuad