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The Effect of Vitamin D Supplementation on Sputum Conversion, Erythrocyte Sedimentation Rate and Neutrophil-Lymphocyte Ratio in Pulmonary Tuberculosis Patients – A Randomized Controlled Trial Sonjaya, Muchamad Regi; Isa, Mohamad; Yasmina, Alfi; Ansori, Isa; Nurrasyidah, Ira; Kusumawardhani , Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 1 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i1.1290

Abstract

BACKGROUND : The health issue of pulmonary tuberculosis (TB) remains a concern in Indonesia. Vitamin D supplementation is one way to manage tuberculosis, which is a crucial case control metric. It is anticipated that vitamin D's anti-inflammatory properties will lower erythrocyte sedimentation rate (ESR) and inflammatory indicators, hence speeding up sputum conversion. AIMS :  To analyze the effect of vitamin D supplementation on sputum conversion, ESR and neutrophil-lymphocyte ratio (NLR) among pulmonary tuberculosis patients METHOD : Patients with pulmonary tuberculosis who were treated as outpatients at Ulin Banjarmasin Hospital and Pekauman Health Centre between May-July 2024 and who satisfied the study's inclusion requirements were included in the randomised controlled trial. Subjects were randomly divided into 2 groups (19 subjects in the treatment group and 19 subjects in the control group) using random selection with sealed envelopes. The treatment group received antituberculosis drugs (ATD) and vitamin D supplementation at a dose of 10,000 IU/day for eight weeks after the initiation of TB therapy, while the control group received ATD and a placebo. ESR and NLR examinations were performed prior to treatment, in weeks 4 and 8, whereas sputum evaluations were conducted at weeks 2, 4, 6, and 8. Statistical Product and Service Solutions (SPSS) was used for data analysis. P-value <0,05 was significant statistically. RESULT :  The study subjects were 38 pulmonary TB patients, most of whom were women (65.0%) with an average age of 50.42 ± 18.61 years. Overall, during the 8 weeks of intervention, there was a significant effect of vitamin D supplementation on sputum conversion (OR = 1.61, 95%CI = 0.030-0.931, p = 0.037). There was no significant effect of vitamin D supplementation on NLR (regression coefficient = 0.549, 95%CI = -1.769-2.858, p = 0.641) and ESR (regression coefficient = -5.529, 95%CI = -20.658-9.599, p = 0.474). CONCLUSION : Vitamin D supplementation significantly affects sputum conversion. In the 8th week, almost all subjects who initially had positive BTA became negative. But does not significantly affect ESR and NLR.
PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO ANIMASI BERBASIS APLIKASI CANVA UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MUATAN PELAJARAN PENDIDIKAN PANCASILA KELAS IV SDN PAKINTELAN 02 Rosyada, Hafizh Amrina; Ansori, Isa
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 9 No. 2 (2024): Volume 09 No. 2 Juni 2024
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v9i2.14311

Abstract

Pancasila education as one of the subject contents in elementary schools plays a crucial role in shaping the character and morals of the Indonesian nation. Through teaching the values contained in Pancasila, students are taught to understand and apply basic principles such as divinity, humanity, unity, populism, and social justice in everyday life. In learning Pancasila education, a teacher is also required to innovate in the use of learning media. Animated video media was chosen as a teaching aid with the hope of improving student learning outcomes. Canva, an easy-to-use online graphic design platform, allows teachers to create attractive and interactive animated videos without requiring in-depth technical skills. This research uses a quantitative approach with a Research and Development (R&D) research type adapted from Borg and Gall. The research results were obtained from processing data, questionnaires, and tests. The results showed that the canva application-based animated video learning media was very feasible to use in learning pancaila education seen from the percentage of material expert and media expert scores which showed a percentage of 91.6% and 79.16%. The results of the student pretest and posttest showed an increase in the average score where in the small group test the pretest average score was 43.3 while the posttest average score was 90.