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All Journal International Journal of Advances in Applied Sciences Ecotrophic, Journal of Environmental Science Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) CHEMICA Jurnal Teknik Kimia JITEK (Jurnal Ilmiah Teknosains) Science and Technology Indonesia Jurnal Fitofarmaka Indonesia JTERA (Jurnal Teknologi Rekayasa) Jurnal Biologi Tropis IJEMS (Indonesian Journal of Environmental Management and Sustainability) Media Farmasi Reka Buana : Jurnal Ilmiah Teknik Sipil dan Teknik Kimia Jurnal Pendidikan dan Konseling Jurnal Pengabdian Masyarakat Bumi Raflesia Jurnal Abdi Insani Current Research on Biosciences and Biotechnology Muhammadiyah Journal of Nutrition and Food Science (MJNF) Journal of Agri-Food Science and Technology (JAFoST) Jurnal Farmasi Sains dan Praktis Abdimas Indonesian Journal Journal of Halal Science and Research Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Masyarakat Bangsa Pelita: Jurnal Pengabdian kepada Masyarakat Journal of Industrial Process and Chemical Engineering (JOICHE) PROSIDING SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT (SNPPM) UNIVERSITAS MUHAMMADIYAH METRO Indonesian Journal of Chemical Engineering As-Sulthan Journal of Education International Journal of Multidisciplinary Reseach Biodiversitas Journal of Biological Diversity
Permadi, Adi
Department Of Chemical Engineering, Faculty Of Industrial Technology Universitas Ahmad Dahlan
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Identification and antioxidant activity test of β-tocopherol from Dompu corn oil as anti-aging Permadi, Adi; Budiastuti, Pramudita; Setyanto, Barry Nur; Wulandana, Rachmadian; Nuraisyah, Fatma; Novitasari, Putri Rachma; Syamsuddin, Arief; Ramadhan, Muhammad Kaisar Sutomo; Rosandy, Andi Rifki
International Journal of Advances in Applied Sciences Vol 14, No 1: March 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i1.pp175-184

Abstract

Corn is a well-cultivated food crop that is grown extensively worldwide. The used portion of corn is its seeds, which are rich in oil. The objective of this study is to separate and characterize tocopherol from corn oil in Dompu, Sumbawa by employing spectroscopic techniques such as ultraviolet (UV) spectrophotometry, ultra-performance liquid chromatography (UPLC), nuclear magnetic resonance (NMR), and liquid chromatography-mass spectrometry (LC-MS). Subsequently, the in-vitro antioxidant activity of the tocopherol was assessed. 1 kilogram of dry maize kernels subjected to 70% ethanol extraction yielded 30 grams (35 ml) of corn oil. The purified isolate obtained from the fractionated extract, using radial chromatography, demonstrated the presence of tocopherol. The isolated sample exhibited the presence of beta-tocopherol. Beta-tocopherol's anti-aging properties were assessed by conducting an in-vitro antioxidant activity test utilizing the tyrosinase enzyme. The IC50 value obtained was 83.954±2.849 ppm. The IC50 value indicates that beta-tocopherol possesses significant antioxidant activity, making it suitable for usage as a primary ingredient in cosmetics and pharmaceutical products.
Review : Exploration of Squalene from Natural Materials as its Potential in Health and Food Fields Permadi, Adi; Wilson, Mutiara
Indonesian Journal of Chemical Engineering Vol. 2 No. 2 (2024)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/ijce.v2i2.1423

Abstract

Squalene, a natural isoprenoid, plays a critical role in sterol biosynthesis and exhibits various health benefits, including antioxidant, anti-inflammatory, and antitumor properties. Found in sources such as shark liver oil, amaranth, olive oil, and microbial species, its demand has surged across pharmaceutical, cosmetic, and food industries. However, traditional extraction methods, predominantly from shark liver, raise sustainability concerns. This study explores alternative sources and production strategies, focusing on plant-based and microbial synthesis of squalene. Amaranth seeds and olive oil were highlighted as promising renewable sources due to their high squalene content. Advances in synthetic biology and metabolic engineering have enabled microbial platforms, such as genetically modified yeasts and microalgae, to produce pharmaceutical-grade squalene sustainably. Moreover, the development of innovative extraction techniques, such as supercritical CO₂ extraction, enhances yield and purity while minimizing environmental impact. The research further emphasizes squalene’s potential as a precursor for cholesterol, hormones, and vitamins, alongside its role in improving human health through applications in vaccines, cardiovascular protection, and cancer prevention. Future work should prioritize optimizing extraction methods, exploring untapped natural sources, and scaling microbial production to address the growing global demand sustainably.
Optimizing Hospital Waste Management Systems through Statistical Approaches: Evidence from a Central Java Hospital Adi Permadi; Viola Lulu Aulia; Aulia Audistia Rohmah; Tiara Eka Supriyanti; Ahmad Lupi
Indonesian Journal of Chemical Engineering Vol. 3 No. 1 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/ijce.v3i1.1425

Abstract

Hospital wastewater contains various contaminants that can endanger both environmental and public health if not managed properly. This study investigates the optimization of a hospital wastewater treatment system in Purwokerto using descriptive statistical analysis. Data were collected for the year 2023 from one hospital and included parameters such as Total Suspended Solids (TSS), Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), ammonia, oils and grease, pH, total coliform, and several heavy metals including cadmium. Results indicate that most parameters met environmental quality standards set by the Ministry of Environment Regulation No. 68/2016, except for total coliform and cadmium, which occasionally exceeded the thresholds. The study suggests several optimization strategies including improved disinfection methods, regular monitoring, technological upgrades, and better staff training to enhance the treatment system's efficiency and ensure compliance with environmental regulations.
Comparative Efficacy of Wet Wipe Preservatives: Antimicrobial Performance to Inhibit Microbial Growth Hakim, M. Arif Lukman; Adi Permadi; Erna Astuti; Farahidah Mohamed
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9477

Abstract

The global market for wet wipes has seen significant growth in the past decade, establishing them as a popular product for personal care and household use. However, their high water and cellulose content makes them vulnerable to contamination by pathogenic microorganisms, which can cause changes in both their physical and chemical properties. This study aims to evaluate the efficacy of six preservative formulations in preventing microbial contamination in wet wipes. The formulas tested included: Formula 1 (F1) with phenoxyethanol and benzalkonium chloride; Formula 2 (F2) with phenoxyethanol, sodium benzoate, and potassium sorbate; Formula 3 (F3) with phenoxyethanol and caprylyl glycol; Formula 4 (F4) with polyaminopropyl biguanide and caprylyl glycol; Formula 5 (F5) with sodium benzoate, potassium sorbate, and cetylpyridinium chloride; and Formula 6 (F6) with propylene glycol and chlorphenesin. A 28-day challenge test was conducted using a multispecies inoculation technique, including bacteria, mould, and yeast. All formulas were initially sterile, as confirmed by sterility testing. The results showed that Formula F1 was the most effective, reducing microbial growth by over 6 log units within 14 days. Formulas F5 and F6 also demonstrated effectiveness, though microbial reduction in these formulas was slower, only reaching >6 log reduction by day 28. Formulas F2, F3, and F4 did not meet the required standards for mould and yeast reduction. These findings support the use of Formula F1 as the most reliable preservative combination, ensuring the safety and quality of wet wipes.
Pengaruh Berbagai Metode Ekstraksi dan Jenis Pelarutnya pada Kandungan Fitokimia dalam Minyak Jagung : Literature Review Sofiana, Nurani; Permadi, Adi; Jamilatun, Siti; Mufrodi, Zahrul
Muhammadiyah Journal of Nutrition and Food Science (MJNF) Vol. 5 No. 2 (2024): Muhammadiyah Journal of Nutrition and Food Science (MJNF)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Salah satu minyak nabati yang paling terkenal di Indonesia dan banyak negara lainnya adalah minyak jagung. Minyak jagung telah lama dianggap sebagai pilihan utama di antara minyak nabati karena rasanya yang netral, stabilitasnya yang baik, dan manfaat kesehatannya. Dalam hal produksi tahunan, minyak jagung berada di urutan kesepuluh di antara semua minyak nabati dan menyumbang sekitar 2% dari total minyak nabati yang diproduksi di seluruh dunia. Minyak jagung didapatkan melalui proses ekstraksi bubuk biji jagung menggunakan teknik refluks dan sokhletasi dengan berbagai pelarut, termasuk n-heksana, etanol, dan etil asetat, untuk menghasilkan minyak jagung. Selanjutnya, dilakukan analisis kandungan fenolik dan karotenoid dalam minyak jagung. Hasilnya menunjukkan bahwa ekstraksi dengan metode sokhletasi menggunakan pelarut etil asetat menghasilkan kandungan fenolik dan karotenoid tertinggi, yaitu mg/kg dan  mg/g. Sementara itu, metode sokhletasi dengan pelarut N-heksana menghasilkan kandungan fenolik terendah dan metode maserasi dengan pelarut etanol menghasilkan kadar karotenoid terendah. Sehingga, metode sokhletasi dapat digunakan dalam industri produksi minyak jagung untuk menghasilkan minyak jagung dengan kadar fitokimia lebih tinggi.
Therapeutic potential of alpha-linolenic acid from Sacha Inchi oil in cervical cancer: an in vitro study on HeLa cells Permadi, Adi; Putri, Mutiara Wilson; Akbar, Muhammad Ali
International Journal of Advances in Applied Sciences Vol 14, No 3: September 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijaas.v14.i3.pp966-974

Abstract

This study investigated the potential of alpha-linolenic acid (ALA) from Sacha Inchi oil as a therapeutic agent for cervical cancer through an in vitro study on HeLa cells. Cervical cancer is one of the most common types of cancer in women, which is often caused by human papillomavirus (HPV) infection. Although chemotherapy therapy is one of the main methods in cancer treatment, this approach often causes side effects and drug resistance. ALA, which is one of the main components of Sacha Inchi oil, is known to have antioxidant and anti-cancer activities. In this study, Sacha Inchi oil was analyzed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) for identification of its active components. Cytotoxic assays were performed using the MTT method on HeLa cells, which showed that ALA significantly inhibited cancer cell viability at low concentrations, with low IC50 values compared to the positive control compound cisplatin. These results suggest that ALA has potential as an effective anti-cancer agent against cervical cancer cells. This study concludes that ALA from Sacha Inchi oil can be a strong candidate in the development of safer and more effective cervical cancer therapy.
Phytochemical Test of Sacha Inchi Oil from Central Java Hadi, Mulyono; Permadi, Adi; Suharto, Totok Eka; Putri, Mutiara Wilson; Gulo, Herbert Alessandro Panias; Maema, Nadin Okta; Halimathusyakhdyah, Halimathusyakhdyah; Lupi, Ahmad
Journal of Agri-Food Science and Technology Vol. 6 No. 3 (2025): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jafost.v6i3.12885

Abstract

Sacha inchi oil is a seed-derived oil from the Amazon Rainforest, known for its high nutritional value and bioactive compounds. It contains essential fatty acids such as omega-3 and omega-6, along with tocopherols, polyphenols, carotenoids, and phytosterols, making it beneficial for health applications. Due to its nutritional and therapeutic properties, sacha inchi oil has gained significant attention in the food, cosmetic, and pharmaceutical industries. This study contributed to identify and analyze the bioactive compounds in sacha inchi oil extracted from seeds obtained in Central Java, Indonesia. The extraction process was carried out using a hot pressing method, followed by qualitative phytochemical analysis and LC-HRMS identification. The phytochemical tests confirmed the presence of flavonoids, alkaloids, tannins, phenolics, saponins, steroids, and terpenoids, all of which contribute to antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, LC-HRMS analysis did not detect flavonoids, tannins, and saponins, possibly due to their low concentration, matrix effects, or degradation during analysis. These findings highlight sacha inchi oil’s potential in nutraceutical, pharmaceutical, and cosmetic industries. Its bioactive compounds suggest its potential use in functional foods, dietary supplements, and therapeutic applications, particularly in preventing oxidative stress-related diseases. Further research is recommended to optimize extraction techniques, improve compound stability, and evaluate its bioavailability and long-term health benefits. The presence of bioactive compounds indicates that sacha inchi oil can be a valuable functional ingredient for health and medical applications, contributing to sustainable and natural health solutions.
Optimization of thin layers of coated turmeric extract (Curcuma longa L) tablets using a dipping method Permadi, Adi; Yuliani, Sapto; Wahyuningsih, Iis; Satar, Ibdal
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i1.20130

Abstract

Turmeric extracts have many benefits, such as an anti-oxidant, anti-inflammatory, and neuro-protector for dementia. The turmeric extracts can be prepared in the form of a thin layer of coated tablets through a dipping method using the dip coating and Simplex lattice design (SLD) methods. The quality of the thin layers of coated tablets is much related to the formulation in the coating process. This research aims to formulate and optimize the coating composition of HPMC, PEG-400, and dip time. Consequently, the TSLT meets the standard requirements. The core tablets were made by using the wet granulation method with the formulation of turmeric extract, erosol, lactose, gelatin, and aquades. Before the core tablets had been produced, the eligibility of granules was initially evaluated based on the standard requirements. Subsequently, the core tablets that meet the standard requirements were printed and replicated. The coating processes on core tablets were performed by dipping into the coating solution in the various duration of dipping times: 5, 30, and 60 seconds. The coating solution consists of HPMC, PEG-400, glycerine, sunset yellow, and distillate water. Then, produced TSLTs were evaluated based on the hardness, friability, and disintegration time. The best optimization process for the mixture of HPMC and PEG-400 indicates a more positive value of R (R = 0.2024).
Qualitative and Quantitative Analysis of Lecithin Content and Bioactive Chemical Compenents of Corn Oil From Dompu District Ramadhan, M. Kaisar Sutomo; Permadi, Adi; Sulistiawati, Endah
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7494

Abstract

Indonesia is one of the Asian nations that has an abundance of vegetation that can be utilized as food yields and medication. One of the plants that can be utilized as neighborhood food is the Corn plant (Zea mays L.), corn is one kind of food crop that has for some time been known and developed. Dompu Regency, located in the province of West Nusa Tenggara,  is one of the largest corn producers in Indonesia. From this statement, a revolution is needed for the development of the food industry sector, namely the development of processed products from corn raw materials, namely corn oil. Corn oil extraction is carried out by the Maceration Method, a simple extraction process carried out by soaking the simplicia in a solvent for a certain time at room temperature and protected from light. Development in finding the percentage level (%) of lecithin LC-HRMS (Liquid Choromatography High-Resulution Mass Spectrometry), Among the Compounds: Percentage level (%) of bioactive lecithin compounds from major (main) components: 1-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine (C26H52NO7P) = 8.882%, 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC (C26H50NO7P) = 6.874%, 1 Palmitoy-Phospadicholine (C24H50NO7P) = 1.898%, 1-Oleoyl-2-hydroxy-sn-glycero-3-PE (C23H46NO7P) = 1.161%, 2-monolinolenin (C21H36O4) = 0.577, (2R)-2-Hydroxy-3-(phosphonooxy)propyl (11Z,14E)-11,14-icosadienoate (C23H43O7P) = 0.386 %, 1-Stearoylglycerol (C21H42O4) = 0.072.
Biokonjugasi AmineQDs untuk Penargetan Spesifik Sel Kanker Permadi, Adi
Journal of Industrial Process and Chemical Engineering (JOICHE) Vol 3, No 1 (2023)
Publisher : Institut Teknologi Adhi Tama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31284/j.joiche.2023.v3i1.7536

Abstract

This study aims to develop an AmineQDs bioconjugation technique to enhance specific cancer cell targeting. AmineQDs were synthesized using a solvothermal method, modified with amine groups, and conjugated with folic acid via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide- N-hydroxysuccinimide(EDC-NHS) carbodiimide activation. This bioconjugation process aims to improve the selectivity of QDs toward cancer cells, enabling more effective detection and therapy. Characterization results indicated successful bioconjugation, but the fluorescence of QDs was quenched after conjugation, likely due to electronic structure changes or self-quenching. Further evaluation of reaction conditions, including pH and buffer types, is needed to maintain optical stability. With proper optimization, AmineQDs have the potential to serve as highly accurate and efficient nanotechnology-based cancer diagnostic and therapeutic agents.
Co-Authors Abdul Aziz ABM Helal Uddin Afwiyah, Fadhilah Agung Kurniawan Ahmad Fatwa Zufar Ahmad Lupi Al Haq, Permata Aulia Alamsyah, Tegar Ali, Fitra Mara Ananda Ranu Bachtiar Andi Rifki Rosandy Anton Yudhana Anugrah, Nawang Aprilla, Annisa Hera Aprillia Syahputri, Arina Ardina Fitri Sugianti Arwini, Arwini Aulia Audistia Rohmah Aulia Nur Rahma Azhar, Sella Angelina Aziz , Abdul Baswara, Ahmad Raditya Cahya Budiastuti, Pramudita Chang, Jia-Yaw Chasanah, Alfi Dewi, Kartika Tunggal Dimas, Doni Djamaluddin Perawironegoro Djamaluddinn Perawironegoro Efiana, Nuri Ari Elza Naura Syafitri Endah Sulistiawati Erna Astuti Evitasari, Rachma Tia Fadilah, Haqi Miftah Farahidah Mohamed Fatma Nuraisyah, Fatma Fatwa Zufar , Ahmad Fatwa Zufar, Ahmad Fausta, Ahnaf Zaki Febian, Muhammad Izzul Firdaus, Stradivary Firdaus, Stradivary Maulida Gita Indah Budiarti Gulo, Herbert Alessandro Panias Hadi, Mulyono Hakim, M. Arif Lukman Hakim, Muhammad Arif Lukman Halimathusyakhdyah, Halimathusyakhdyah Hapsari, Intan Tri Hasnaeni hasnaeni, Hasnaeni Hayuningtyas, Ratih Heavena, Indana Azza Hendry Pangestu Ibdal Ibdal Ibdal Satar Ibdal Satar Ibdal Satar Iis Wahyuningsih Iis Wahyuningsih Ika Dyah Kumalasari INDRO PRASTOWO Iqbal Ramadhan, Iqbal Irawan, Ichsanul Fikri Umar Joko Pitoyo Khairi, Amalya Nurul Khalif Fathan Muzakki Khasanah, Fitri Nur Latifatunnajib, Sukma Lubnah, Ifa Lukhi Mulia Shitophyta Lupi, Ahmad Maema, Nadin Okta Mahendra, Abang Muhammad Wahyu Mariska, Novia Martomo Setyawan Maryudi Maryudi Maryudi Maryudi Maryudi Masila, Maya Laffayza Daeng Masyfiyah, Salsabila Fariha Maulida Firdaus , Stradivary Ma’arif, Sandhy Aulia MUCH FUAD SAIFUDDIN Mufti Khakim, Mufti Muhamed, Farahidah Muhammad Ali Akbar, Muhammad Ali Muhammad Aufakumara Sucipto Munawaroh, Annisa Luthfiana Mustaqim, Luthfi Mustofa Ahda Mutiara Wilson Putri Mutiara Wilson Putri Nafi’, Zahrotun Nanik Trijayati Nazira Mahmud Nazzal, Sami Nisya Silvani Sembiring Nisya Slivani Sembiring Noor Syahdan Fitrianto Nor Adila Mhd Omar NOVI FEBRIANTI Novia Rahmawati Novitasari, Putri Rachma Nur Halimah NURUL HIDAYAH Oemardy, Zalfadhia Luthfia Paramita, Lathifah Aurora Pariz, Ananda Rizky Al Pawenang, Denta Kesdik Prastiwi, Salma Maulidya Pratiwi Apridamayanti, Pratiwi Pratiwi, Margaretha Herlin Pratomo, Zaki PURWANTI PURWANTI Putri, Aninda Cahaya Putri, Mutiara Wilson Rahayu, Wahidah Mahanani Rahman, Zulfan Hanif Rahmawati, Daniar Ramadani, Noorpani Ramadhan, M. Kaisar Sutomo Ramadhan, Muhammad Kaisar Sutomo Ramadhan, Rafli Ratna Wijayatri Renangga Yudianto Retnosyari Septiyani Riani Ayu Lestari Rosyidah, Ummy Rumaisha, Sanda Safitri, Harminah Sapsuha, Nurkhalisah Sapto Yuliani Sapto Yuliani Sapto Yuliani Saputri, Rully Indah Satar, Ibdal Satria, Rizky Adi Septiyani, Retnosyari Setyanto, Barry Nur Shofa-ulhusna, Fatihah Sholihah, Laila Melati Nur Sinaga, Alexander Maruli Tua Sinaga, Alexander MT Sirajuddin, Muhammad Mar’ie Siti Jamilatun Siti Nur Azizah, Siti Nur Sofiana, Nurani Sofyan Hadi Suhendra Suhendra Sukma Latifatunnajib Sumardani, Wahyu Bintoro Suyadi Suyitno Suyitno Syaeful Akbar Padya Syamsuddin, Arief Syaputri, Dhayu Carista Tiara Eka Supriyanti Totok Eka Suharto Totok Eka Suharto TRIANIK WIDYANINGRUM Trianik Widyaningrum Trias Pramedikawati Vania Insani Syita Harmony Viola Lulu Aulia W, Hamizagha Nur Abid Wahidah Mahanani Rahayu Wahyu Dewi Hapsari Wahyuni, Denik Putri Wantini Wardana, Mikael Dia Wibisono, Ilham Kukuh Widyasmoko, Hamizagha Nur Abid Wilson, Mutiara Winarni Winarni Wulandana, Rachmadian Wulandari, Annisa Desna Yanti, Dinda Putri Dwi Yatus Widiana Hanizatul Ardila Yeni Triwidyastuti Yolanda Waldatul Marwa Zahrul Mufrodi Zahrul Mufrodi, Zahrul