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All Journal E-Jurnal Medika Udayana Bulletin of Electrical Engineering and Informatics Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology Jurnal Berkala Epidemiologi Jurnal Biosains Pascasarjana Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Journal of Information Systems Engineering and Business Intelligence Journal of Tropical Biodiversity and Biotechnology Jurnal Kimia Riset The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Samudra Ekonomi dan Bisnis INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Berkala Ilmiah Kimia Farmasi Hang Tuah Medical Journal International Journal of Economics (IJEC)
Aryati Aryati
Dengue Study Group, Institute Of Tropical Disease, Universitas Airlangga, Mulyorejo Street, Mulyorejo 60115, Surabaya, East Java, Indonesia Clinical Pathology Department, Faculty Of Medicine, Universitas Airlangga, Prof.Dr.Moestopo Street, Tambaksari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pengaruh Perbedaan Konsentrasi Lactobacillus plantarum Terhadap Perubahan Kadar Kolesterol Total Pada Tikus Putih Widajati, Rahma; Aryati, Aryati; Notopuro, Harianto
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 6, No 1 (2020): JMK Yayasan RS.Dr.Soetomo, April 2020
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.163 KB) | DOI: 10.29241/jmk.v6i1.286

Abstract

Kebiasaan mengkonsumsi makanan yang mengandung lemak dan gula tinggi akan menyebabkan obesitas, yang pada akhirnya akan menimbulkan sindrom metabolik. Desain penelitian ini menggunakan rancangan penelitian post test only control group, dengan menggunakan sampel rattus norvegicus galur wistar berwarna putih, berjenis kelamin jantan, dewasa berusia 3-4 bulan, dengan berat badan 150-200 gram, dan dengan kondisi fisik sehat yang digunakan sebagai hewan model kolesterol tinggi dengan diberi pakan tinggi lemak, yang kemudian diberi bakteri probiotik Lactobacillus plantarum. Variabel bebas pada penelitian ini adalah Lactobacillus plantarum, sedangkan variabel tergantung adalah kadar kolesterol total dan kolesterol LDL. Pemeriksaan kadar kolesterol total dan kolesterol LDL dengan metode enzimatik kolorimetri dengan prinsip COD-PAP dilakukan pada akhir penelitian. Tujuan penelitian ini adalah untuk mengetahui dosis optimum probiotik yang dapat menurunkan kadar kolesterol tinggi dalam darah. Analisis data menggunakan one way Anova, dimana hasil yang didapat menunjukkan tidak adanya perbedaan yang signifikan pada pemberian bakteri Lactobacillus plantarum dengan konsentrasi 5x10⁸CFU dibandingkan konsentrasi 5x10⁹CFU. Oleh karena itu, pemberian Lactobacillus plantarum dengan konsentrasi sebesar 5x10⁸CFU merupakan dosis optimum yang dapat menurunkan kadar total kolesterol dan LDL kolesterol dalam darah.Kata kunci: Diet Tinggi Lemak, Tikus Putih, Kolesterol Tinggi, Lactobacillus plantarum; Kadar Kolesterol Total. 
Diagnostic accuracy of urinary cytokeratin fragment-19 (CYFRA21-1) for bladder cancer Setianingsih, Yennie A.; Djatisoesanto, Wahjoe; Laksita, Tetuka B.; Aryati, Aryati
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1142

Abstract

Bladder cancer is known for its high recurrence rate and requires constant patient monitoring. To confirm the diagnosis, a tissue sample from a cystoscopy is required, which the patient often avoids. Urine has the potential to be utilized as a diagnostic fluid because of its non-invasive nature and various biomarker contents. The aim of this study was to determine the diagnostic value of cytokeratin fragment-19 (CYFRA21-1) level in urine for diagnosing bladder cancer. This single-center cross-sectional study was performed with eligible inclusion were adults aged ≥18 years who presented with hematuria and suspected bladder cancer from imaging. Patients with a history of intravesical chemotherapy, radiotherapy and immunotherapy were excluded. Urine samples were collected prior to the cystoscopy. Detection of urinary CYFRA21-1 was carried out using the ELISA method. Of 154 patients included in the study, the diagnosis of bladder cancer was confirmed in 92 patients. Patients with bladder cancer had significantly higher urinary CYFRA21-1 levels compared to the non-bladder cancer group. The sensitivity, specificity, positive and negative predictive value, and positive likelihood ratio of the CYFRA21-1 were 80.4%, 43.5%, 67.9%, 60% and 1.425, respectively. The area under the curve for CYFRA21-1 was 0.608, computed from a receiver operating curve with a cut-off value of 13.3 ng/mL. In conclusion, urinary CYFRA21-1 levels have moderate diagnostic accuracy in determining bladder cancer among suspected individuals. Due to its high sensitivity, this biomarker could potentially be used alongside other screening tools for bladder cancer detection.
Comparison of PD-L1, CTR-1, VEGF, and p53 expression in sensitive and resistant epithelial ovarian cancer (EOC) patients to platinum-based chemotherapy Perbowo, Primandono; Tjokroprawiro, Brahmana A.; Aryati, Aryati; Kusumastuti, Etty H.; Ariani, Grace
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1419

Abstract

The current standard treatment for ovarian cancer is a combination of cytoreductive surgery and platinum-based chemotherapy; however, many patients develop resistance, leading to a high recurrence rate. The aim of this study was to analyze the expression of PD-L1, CTR-1, VEGF, and p53 in epithelial ovarian cancer (EOC) patients, comparing those sensitive and resistant to platinum-based chemotherapy. A cross-sectional study was conducted among EOC patients who underwent surgery and platinum-based chemotherapy between 2020 and 2023 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, with evaluations performed six months post-chemotherapy. The expression of PD-L1, CTR-1, VEGF, and p53 were measured using immunohistochemistry (IHC) and compared between chemotherapy-sensitive and resistant patients. A total of 65 patients were included: 31 resistant and 34 sensitive cases. The results showed higher PD-L1 expression in the resistant group compared to the sensitive group (mean combined positive score (CPS) of 0.46±0.29 vs 0.17±0.09, p<0.001). The CTR-1 expression was lower in the resistant group (immunoreactive score 2.90±1.30) compared to the sensitive group (immunoreactive score 6.82±2.68) with p<0.001. VEGF and p53 expression were also higher in the resistant group (6.68±2.59 vs 2.76±1.10 and 64.68±13.54% vs 30.15±13.06%, respectively) compared to the sensitive group, with both having p<0.001. The study suggests that increased expression of PD-L1, VEGF, and p53 and decreased CTR-1 expression are associated with platinum-based chemotherapy resistance among EOC patients. Therefore, these biomarkers might have the potential for predicting treatment responses and understanding resistance mechanisms.
Implementation of Good Corporate Governance and Sharia Bank Performance Aryati, Aryati
International Journal of Economics (IJEC) Vol. 4 No. 1 (2025): January-June
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijec.v4i1.1265

Abstract

Bank financial performance is the achievement of activities within a certain period, especially related to the collection, distribution of funds, and other bank operational activities. Good Corporate Governance (GCG) can improve bank performance. One of the important objectives of implementing GCG in Sharia banking is to improve bank performance. A number of important factors are used to measure the implementation of a bank's level, one of whicht is the implementation of GCG.  The level of Islamic banks is an important part of the efforts to increase the trust of shareholders, the public, and customers. The implementation of GCG can help and facilitate Sharia bank management in developing business strategies and making it easier to achieve goals. This study aims to determine the effect of GCG implementation on the level of Islamic banks in Indonesia.  Using the bank's internal respondents. The use of these respondents was expected to provide information related to the implementation of banks. This stud uses a quantitative discrete analysis approach. The research results show that the implementation of GCG has a significant effect on the level of sharia banking. Continuous efforts are needed to implement GCG in the future, especially to increase competitiveness.
The Predominance of the Synthesis Phase in Cell Cycles in Childhood Acute Lymphoblastic Leukemia Hernaningsih, Yetti; Aryati, Aryati; Ugrasena, I Dewa Gede; Nunki, Nastasya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2360

Abstract

Uncontrolled proliferation and resistance to apoptosis should be controlled to kill the cancer cells, as the goal of treatment in acute leukemia. It is therefore important to know, which characteristic dominates the proliferative phase because, to be more effective, new drugs that will be developed should be targeted at that phase. This study aimed to find the dominant phase in the proliferative phase of the cell cycle in childhood Acute Lymphoblastic Leukemia (ALL). This study was conducted on 63 patients, comprising 33 patients with specimens of Bone Marrow Mononuclear Cells (BMMC), 30 patients with specimens of Peripheral Blood Mononuclear Cells (PBMC), and 10 children as controls with specimens of PBMC. Cell cycle examinations were performed with PI/RNase, run on BD FACS Calibur, and analyzed with modfit LT 4.1 software to determine the phases of G0/G1, synthesis (S), and mitosis (G2/M). Regarded the S and G2/M phases as the proliferation phase. Statistical analyses used one-way ANOVA and Kruskal-Wallis to compare S and G2/M phases within groups,and an Independent T-test and Mann-Whitney to compare the same phases between groups. Among the proliferation phases, the synthesis phase had significantly higher domination than the mitotic phase in both the BMMC (10.18±7.81% vs. 5.41±3.77%; p = 0.010) and PBMC (4.33±2.15% vs 2.30±1.56%; p=0.000) groups. A similar result was found in the control group (1.01±0.51% vs 0.36±0.38%; p=0.011). The synthesis phase in BMMC had significantly higher domination than PBMC groups (p=0.024) and control (p 0.002). The synthesis phase predominates among the proliferation phases of the cell cycle in childhood ALL.
Comparative Analysis of Anti-Müllerian Hormone Assessment Methods in Low Prognosis Females Undergoing In-Vitro Fertilization Susanti, Indah; Mardiyah, Nikmatul; Lumban Toruan, Anggia Augustasia; Aryati, Aryati; Royland Marpaung, Ferdy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2632

Abstract

ABSTRACT Prognosis in individuals undergoing in-vitro fertilization (IVF) is often assessed using anti-other commonly employed laboratory methods. Blood samples from 120 low-prognosis females undergoing IVF treatment at the ASHA Infertility Clinic, Primasatya Husada Citra Hospital, Surabaya, Indonesia, were analyzed using both Cobas e411 (Roche) and Maglumi X3 (SNIBE) platforms. The Cobas employs electrochemiluminescence immunoassays (ECLIA), while Maglumi X3 utilizes CLIA labelled with N-(4-aminobutyl)-N-ethylisoluminol (ABEI). The concordance of the tests was evaluated using Spearman's rank correlation, Passing-Bablok regression, and Bland-Altman statistical analyses. The median AMH value was 2.55 ng/dL for Cobas e411 and 2.54 ng/dL for Maglumi X3. The Passing-Bablok regression analysis yielded an intercept of -0.0064 (95% CI: -0.0400 to 0.0296) and a slope of 0.9869 (95% CI: 0.9689 to 1.0000), indicating no significant bias. The Spearman correlation analysis between the two methods stated a strongly positive correlation (p=0.985, p<0.0001). The Bland-Altman analysis indicated an average bias of -0.05, implying that the Maglumi X3 measures AMH levels lower than the Cobas e411, with the limits of agreement (LoA) spanning from -1.1 to 1.0. The AMH test performed using the Maglumi X3 (SNIBE) demonstrates a strong correlation and consistency with the current laboratory test (Cobas e411), making it a reliable alternative for measuring AMH levels. However, the results should be interpreted alongside other clinical parameters and observations.
Correlation between IL-1beta and IL-18 Levels with Dengue Virus Infection Severity Sari, Arabella Vonia; Aryati, Aryati; Budhy, Theresia Indah; Ma`ruf, Anwar; Husada, Dominicus; Palupi, Retno; Sunari, I Gusti Agung Ayu Eka Putri; Indrasari, Yulia Nadar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2682

Abstract

Activated monocytes/macrophages and T lymphocytes that generate a cytokine storm are thought to play a critical role in the development of dengue. Cytokine storms, characterized by the excessive production of proinflammatory cytokines, can result in cellular dysfunction and organ failure, often contributing to the severity of dengue in affected patients. Interleukin-18 (IL-18), like IL-1beta, is a proinflammatory cytokine released during inflammation triggered by inflammasome activation. Increased IL-1beta and IL-18 during dengue virus infection (DVI) are known to worsen the host's vascular permeability, increasing hemostasis disorders and potentially, all of which are important elements in the pathophysiology of dengue fever. This study investigates the association between IL-1beta levels, IL-18 levels, age, dengue virus serotype, and the severity of dengue virus infection, aiming to understand how these factors interact and influence disease outcomes. This study is an observational cross-sectional design from 59 DVI patients in Dr. Soetomo General Hospital, Surabaya with positive dengue PCR results. Both IL-1beta and IL-18 levels reveal no significant relationship with the patient's age, infection status, and dengue virus serotype. A weak negative significant relationship between IL-1beta levels and the severity of DVI, indicating an inverse relationship between IL-1beta levels and the severity. Further studies are required to investigate the function of these cytokines in severe dengue.
Classification and Counting of Mycobacterium Tuberculosis using YOLOv5 Saurina, Nia; Chamidah, Nur; Rulaningtyas, Riries; Aryati, Aryati
Journal of Information Systems Engineering and Business Intelligence Vol. 11 No. 2 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jisebi.11.2.267-278

Abstract

Background: Indonesia is a nation with the third-highest number of tuberculosis (TB) cases worldwide, after China and India. TB detection has been facilitated using YOLOv5 deep learning framework despite previous studies not having incorporated assessment metrics recommended by International Union Against Tuberculosis and Lung Disease (IUATLD).   Objective: This study aims to present a method for classifying and enumerating Mycobacterium tuberculosis by using YOLOv5 architecture with IUATLD evaluation standards. Sputum samples served as the primary medium for identifying the presence of Mycobacterium tuberculosis. In addition, the method showed precise delineation of bacterial boundaries to minimize classification inaccuracies and improve edge clarity through YOLOv5.  Methods: Following the acquisition of microscopic images of TB, the data were resized from 1632x1442 to 640x480 pixels. Annotation was performed using YOLOv5 bounding boxes, and the model was subsequently trained as well as tested according to IUATLD guidelines.  Results: During the analysis, YOLOv5-based classification system produced optimal performance. The model achieved 84.74% accuracy, 87.31% precision, and Mean Average Precision (mAP) score of 84.98%. These metrics showed high reliability in identifying Mycobacterium tuberculosis in the image dataset.  Conclusion: The classification and quantification of Mycobacterium tuberculosis using YOLOv5 framework shows high precision, with mAP score of 84.98%, signifying strong model performance. Additionally, the counting process achieves a MAPE (Mean Absolute Percentage Error) of 0.15%, reflecting excellent prediction accuracy.  Keywords: IUATLD, Tuberculosis, YOLOv5.
Blood Q Creatinine Based on Sex and Age in Healthy Indonesian Geriatrics Marpaung, Ferdy Royland; Santoso, Djoko; Cavalier, Etienne; Aryati, Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2726

Abstract

Median blood creatinine (Qcr) is necessary for an accurate evaluation of geriatric renal function. Nonetheless, there is a significant void in existing literature concerning creatinine reference data unique to the elderly. To improve diagnostic precision and clinical decision making in this susceptible group, this study developed a corresponding Q model for serum creatinine in geriatric patients stratified by age and sex. To determine the Qcr serum and reference range creatinine concentrations, 913 healthy elderly patients (452 males and 461 females) undergoing routine examinations at clinical laboratories were studied. Creatinine concentration reference intervals were divided into 3 age groups, namely: 60-69 years, 70-79 years, and >80 years. The median and percentiles p2.5 (lower reference limit/LRL) and p97.5 (upper reference limit/URL) were determined by the study. The study determined the Qcr serum creatinine and reference values for the elderly, stratified by age and sex. There were no significant differences observed in creatinine level across the age group, either in males or females. Males exhibited higher creatinine compared to females (p <0.05). These recently developed, age and sex stratified Qcr values are an invaluable tool for clinical laboratories, enabling more precise, tailored care for elderly patients with renal issues and enabling clinicians to more accurately assess geriatric renal function.
RF AND ANTI-CCP POSITIF IN ANKYLOSING SPONDYLITIS(AS) PATIENT WITH RHEUMATOID ARTHRITIS(RA): TRUE OR FALSE POSITIVE? TRUE OR FALSE POSITIVE? Margalin, Brilliant; Aryati, Aryati; Yuliasih, Yuliasih; R Raharjo, Paulus
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2765

Abstract

Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA) are different autoimmune arthritis diseases but have overlapping clinical manifestations. Rheumatoid Factor (RF) and Anti-Cyclic-Citrulinated-Peptide (anti-CCP) serological examinations have an important role because they are seropositive in RA and seronegative in AS. This case report is interesting because it discusses a patient with AS who was unexpectedly negative for HLA-B27, positive for RF and anti-CCP, raising doubts about clinical and laboratory discrepancies. Patients with AS and RA disease can occur simultaneously, although it is very rare. This case report analyzes the diagnostic role of RF and Anti-CCP examinations, whether they are true positive or false positive.
Co-Authors Agus Santosa Agus Sulistyono Agustin Iskandar Aksono HP., Eduardus Bimo Alida Roswita Harahap Anak Agung Wiradewi Lestari Andina Putri Aulia Andyanita Hanif Hermawati Anniwati, Leonita Aprilia, Andrea AR, M. Yazid Ariani, Grace Arifoel Hajat Bastiana Bastiana Budi Utomo Cavalier, Etienne Darto Saharso Desak Gde Ushadi Bulan Dewata Dewi Wulandari Djoko Santoso Doddy M. Soebadi Dominicus Husada Dwiyanti Puspitasari, Dwiyanti Eko Sulistijono Erawati Erawati Erni Juwita Nelwan, Erni Juwita Erwin Astha Triyono Fahimah Martak Ferdy Royland Marpaung Gondo Mastutik Handayani, Cut Fitri Harianto Notopuro Harsasi Setyawati Haryanto, Isnaeni Yudi Hebert Adrianto Heny Arwati Herdiman Theodorus Pohan Hermawati, Andayanita Hanif Hermina Novida, Hermina I A Putri Wirawati I Dewa Gede Ugrasena Ilham Harlan Amarullah Indah Susanti Iris Rengganis Isnaeni Isnaeni Yudi Haryanto Isnin Anang Marhana Jusak Nugraha Kris Cahyo Mulyatno, Kris Cahyo Kuntaman Kuntaman Kusmiati, Tutik Kusumastuti, Etty H. Laksita, Tetuka B. Lulut Kusumawati Lumban Toruan, Anggia Augustasia M. Andriady S. Nasution Maharani, Anisa Mardiyah, Nikmatul Margalin, Brilliant Marpaung, Ferdy Royland Masanori Kameoka, Masanori Masyeni, Sri Ma`ruf, Anwar Merylin Ranoko Mohammad Guritno Suryokusumo Mufasirin Muhammad Nazarudin Muhammad Rivai Mustika Amri Nabil Salim Ambar Nia Saurina Niluh Suwasanti Norwahyuni, Yuyun Nunki, Nastasya Nur Chamidah Nurdianto, Arif Rahman Patria Dewi, Pande Putu Ayu Perbowo, Primandono Pranidya, Nada Putri Purnomo, Windu Puspa Wardhani R Raharjo, Paulus R. Tedjo Sasmono Rahmawati, Lita Diah Retno Palupi Riries Rulaningtyas Rizaliansyah, Ferdian Rizqidhana Juliana Putri Rony, Zahara Tussoleha Royland Marpaung, Ferdy Rusli, Musofa Saptawati Bardosono Saraswati Dewi Sari, Arabella Vonia Sasmono, R. Tedjo Setianingsih, Yennie A. Shifa Fauziyah Shuhai Ueda Siti Churrotin, Siti Soegeng Soegijanto Sofro, Muchlis AU Sri Subekti Sri Sumarsih Suci Andriani Suhendro Suhendro SUKACITA TEHUPURING Sunari, I Gusti Agung Ayu Eka Putri Sunaryo Hardjowijoto Suprapto Maat Teguh Hari Sucipto, Teguh Hari Theresia Indah Budhy Sulisetyawati Thomas Tandi Manu Tjokroprawiro, Brahmana A. Tomohiro Kotaki, Tomohiro Trieva Verawaty Butarbutar Ueda, Shuhai Usman Hadi wahjoe djatisoesanto Wardhani, Puspa Wibrianto, Aswandi Widajati, Rahma Widodo J Pujiraharjo Yetti Hernaningsih Yohan, Benediktus Yovilianda Maulitiva Untoro Yulia Iriani, Yulia Yulia Nadar Indrasari Yuliasih