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Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina,
Faculty Of Mathematics And Natural Sciences, University Of Tanjungpura, Jl. Prof. Dr. H. Hadari Nawawi, Pontianak 78124, Indonesia
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Anti-inflammatory Activity of Bajakah Stem (Spatholobus littoralis Hassk.) Ethanolic Extract in Carrageenan-Induced Paw Edema Mice Diah Wulandari Rousdy; Elvi Rusmiyanto Pancaning Wardoyo; Siti Ifadatin
Jurnal Biodjati Vol 7 No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.14126

Abstract

Bajakah tampala plant (Spatholobus littoralis Hassk.) has been used for traditional medicine by the Kalimantan Dayak tribe in the treatment of cancer. This study aimed to find out the potential of ethanol extract of the stem of Bajakah tampala (Spatholobus littoralis Hassk.) as an anti-inflammatory agent in carrageenan-induced mice. The method used was a Completely Randomized Design with five treatments and five replications. The treatments consisted of a water-treated mouse as a negative control, sodium diclofenac 30,8 mg kg-1 as a positive control, and an extract of bajakah dose 2.5; 250; 1250 mg kg-1 BW. The dose of bajakah extract was given orally one hour before carrageenan induction. The inflammation induction used the Winter method by injecting 0.15 ml of 2% carrageenan suspension into the soles of mice. The diameter of edema was measured for 210 minutes. The results showed that the diameter of the mice soles showed a significant increase in all groups after the carrageenan injection. The value of AUC (Area Under the Curve) of bajakah extract dose (2.5; 250; 1250 mg kg-1) from the 150th minute to the 210th minute did not show significant differences from one another. The sodium diclofenac as positive control gave the lowest total AUC value of 236 mm.minute, followed by bajakah extract at a dose of 2.5 mg kg-1 BW of 239.22 mm.minute. The calculation results of the percentage of the inflammation inhibition showed that the administration of ethanol extract of the stem of Bajakah, Spatholobus littoralis, at the lowest dose of 2.5 mg kg-1 BW provide the best inflammation inhibition with 19.21% inhibitory value, nearly approaching the positive control of diclofenac sodium with an inhibitory value of 21.53%.
Co-Authors Abraham Sambo Afandi Afandi Ahmad Yani Nelly Wahyuni Lia Destiarti Ali Djamhuri Amandus Yonatan Andhini Aprilia Anggraini, Wiwit Ara, Chilliany Ari Hepi Ari Hepi Yanti Ari Hepi Yanti Ari Hepi Yanti Ari Widiyantoro Arum Setiawan Arum Setiawan Ary Kusmawati Azkiya, Tiara Catur Wulandari Catur Wulandari Chilliany Ara Cucu Suhery Dede Suratman Desy Desy, Desy Devinda Ekarizky Diputri Diah Wulandari Rousdy Diah Wulandari Rousdy Diah Wulandari Rousdy Diah Wulandari Rousdy Diah Wulandari Rousdy Dian Purnama Sari Dwi Gusmalawati Endah Sayekti Ester Yulinda Evi Noviani Fadhlullah, Hafizh Rizqi Firman Saputra Firman Saputra Fransisko, Satria Fuza Amalia Gusrizal Gusrizal Haratua Tiur Maria Silitonga Harlia Harlia Hasan Ashari Oramahi Hildayati, Umi Ibnur Rusi Indri Kusharyanti Irtiawati, Irtiawati Irwan Lovadi Irwan Lovadi Junardi Junardi Kardina, Megawati Kustiati Kustiati Kustiati Laila Hanum Lena Dian Saputri Maryati Maryati Masnur Turnip Megawati - Muhammad Zaidi Zakaria Mukarlina -, Mukarlina Mukarlina, Mukarlina Nur Malinda Nurul Huda Oktavia, Vivi Pancaning Wardoyo Peli, Peli Perdana, Aurendyo Yuscel Rachmad Setijadi, Rachmad Rafdinal Rafdinal Rahmawati Rahmawati Rahmawati Rahmawati Rahmawati, Rahmawati Ratu Safitri Renny Puspita Sari Ribka Sinta Uli Panjaitan Rikhsan Kurniatuhadi, Rikhsan Rina agus setiawati Riyandi Riyandi Riyandi Riyandi Riza Linda Riza Linda Rizki Perdana Putri Rousdy, Diah setiawati, Rina agus Sholihin, Nur Siti Hodijah Siti Ifadatin Siti Ifadatin Siti Khotimah Siti Nur Hasanah, Siti Nur Sulistrioningsih, Sulistrioningsih Sumi, Sumi Tri Rima Setyawati Tsuyoshi Yoshimura Turnip, Masnur Unang Supratman Widya Anggraeni Widya Anggraeni Wiwit Anggraini Yudha Arman Zulfa Zakiah