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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Media Ilmu Kesehatan Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Poltekita : Jurnal Ilmu Kesehatan Health and Medical Journal Jurnal Dunia Gizi Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Jurnal Riset Ilmiah Neurona Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Eva Decroli
Endocrinology And Metabolic Subdivision, Division Of Internal Medicine, Dr. M. Djamil General Hospital/ Medical Faculty Of Andalas University, Padang, West Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Gambaran Penyakit Penyerta pada Pasien Diabetes Mellitus Tipe-2 Lanjut Usia di RSUP Dr. M. Djamil Padang Periode Januari 2020 – Januari 2021 Aulia, Salsabila Syafna; Decroli, Eva; Nurhayati, Nurhayati
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1281

Abstract

Abstrak Latar Belakang: Proses menua menyebabkan terjadinya penurunan kualitas hidup sehingga membuat pasien diabetes mellitus tipe-2 lanjut usia berisiko lebih tinggi memiliki penyakit penyerta. Objektif: Tujuan penelitian ini untuk mengetahui gambaran penyakit penyerta pada pasien diabetes mellitus tipe-2 lanjut usia di RSUP Dr. M. Djamil Padang periode Januari 2020 – Januari 2021. Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan desain penelitian cross sectional. Penelitian ini menggunakan data sekunder berupa data rekam medis. Ada 65 data yang memenuhi kriteria sampel dan data tersebut diolah, kemudian dianalisis melalui analisis univariat. Hasil: Hasil penelitian menujukkan bahwa pasien diabetes mellitus tipe-2 lanjut usia paling banyak terdapat pada kelompok umur 60-69 tahun (86,2%) dan jenis kelamin perempuan (55,4%) dengan jumlah penyakit penyerta yang ditemukan pada masing-masing pasien sebanyak 6 penyakit, baik berdasarkan umur dan jenis kelamin. Jenis penyakit penyerta terbanyak yang ditemukan adalah jantung dan pembuluh darah (23,2%), terutama penyakit hipertensi. Kemudian diikuti dengan penyakit infeksi (20,1%), termasuk Covid-19 dan selanjutnya kelainan darah (13,1%). Kesimpulan: Jenis penyakit penyerta terbanyak yang ditemukan adalah jantung dan pembuluh darah, terutama penyakit hipertensi. Kata kunci: diabetes mellitus tipe-2, lansia, penyakit penyerta
In-hospital mortality and its determinant factors among patients with sepsis Fadrian, Fadrian; Decroli, Eva; Ahmad, Armen; Kam, Alexander; Muharramah, Disa Hijratul; Pradana, Genta; Putri, Vidola Yasena
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.3-15

Abstract

BACKGROUNDSepsis is a heterogeneous syndrome characterized by a variety of clinical features. Multiple studies have identified sepsis as the leading cause of death in hospitalized patients. A comprehensive report on the incidence, clinical characteristics, and predictors of sepsis is important. This study aimed to determine the relative importance of predictors of in-hospital mortality in sepsis. METHODSA retrospective cohort study at Dr. M. Djamil Central General Hospital focused on sepsis patients. A total of 200 participants, aged 18 and older, were included based on specific criteria and recruited through consecutive sampling. Data was gathered from medical records and laboratory results to identify factors influencing mortality in sepsis patients. These factors were classified into sociodemographic, intrinsic, and extrinsic categories. Statistical analysis utilized simple and multiple logistic regression. A p-value of less than 0.05 indicated statistical significance for predicting in-hospital mortality in sepsis. RESULTSThe sepsis patient mortality rate was 69.50%. Hospital-acquired pneumonia (HAP) emerged as the most common infectious diagnosis, impacting 47.50% of the patients. Type 2 diabetes mellitus (Type 2 DM) was identified as the most frequent comorbidity, present in 36.50% of cases. Multivariate analysis indicated that HAP (adjusted odds ratio [aOR] 2.32; 95% confidence interval [CI] 1.19–4.49; p=0.013) and hyperlactatemia (aOR 2.11; 95% CI 1.06–4.18; p=0.032) significantly increased the risk of mortality in sepsis patients. CONCLUSIONHospital-acquired pneumonia was the primary predictor of mortality in sepsis patients. Timely prediction and evaluation of sepsis outcomes are essential for developing strategies to reduce mortality rates.
Hiperparatiroid Primer Namanda Putri, Athari Fadhila; Decroli, Eva; Aprilia, Dinda; Kam, Alexander
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1499

Abstract

Latar Belakang: Hiperparatiroid primer merupakan suatu kondisi klinis yang disebabkan peningkatan sintesis hormon paratiroid (HPT) akibat tumor paratiroid. Hiperparatiroid primer dapat mengganggu metabolisme kalsium. Dengan demikian, diagnosis hiperparatiroid primer secara umum dapat ditentukan melalui pemeriksaan kadar kalsium serum dan HPT serta ditemukannya tumor paratiroid melalui pemeriksaan pencitraan. Secara garis besar tatalaksana hiperparatiroid primer terdiri dari tatalaksana medikamentosa dan intervensi pembedahan. Tatalaksana medikamentosa meliputi pemberian suplementasi vitamin D, kalsimimetik dan bifosfonat. Intervensi pembedahan untuk mengangkat tumor paratiroid merupakan terapi definitif hiperparatiroid primer. Klinisi perlu meningkatkan pengetahuan dan keterampilan terhadap hiperparatiroid primer agar pelayanan pasien lebih komprehensif.  
Correlation Of Serum 25-Hydroxyvitamin D Levels With Glycemic Control In Type 2 Diabetes Mellitus Patients Putri, Septia Harma; Aprilia, Dinda; Decroli, Eva
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.18731

Abstract

ABSTRACT Background: Type 2 diabetes mellitus (T2DM) is caused by reduced insulin sensitivity, which can lead to insulin shortage. Several recent investigations have found that vitamin D is connected with insulin secretion and sensitivity. Vitamin D insufficiency is linked to poor glucose regulation. Aim: To determine the correlation between serum 25-hydroxyvitamin D levels and glycemic control in Type 2 DM patients. Method: T2DM patients' serum levels of 25-Hydroxyvitamin D, Fasting Blood Glucose (FBG), 2-hours postprandial blood glucose (2-h PBG), and HbA1c were examined in this cross-sectional analytical observational study. Statistical analysis was also performed. Result: From 49 samples included, the number of male subjects was almost the same as female, mean age was 58 years. There was a decrease in serum 25-Hydroxyvitamin D levels with a median of 27.87 ng/ml (12,626 -94,367). Glycemic control was found to be poor, the median of FBG levels was 134 mg/dl (61-339), 2-h PBG levels was 208 mg/dl (93-488) and HbA1c levels was 7.5% (5.6-12.8). Analysis using Spearman correlation between serum 25-Hydroxyvitamin D levels with levels of FBG, 2-h PBG and HbA1c showed values of r = -0.538 and p = 0.000, r = -0.354 and p 0.013, r = -0.501 and p 0.000. Conclusion: There was a statistically significant negative correlation between serum 25-Hydroxyvitamin D levels and levels of FBP, 2h-PBG and HbA1c in T2DM patients. Keywords: 25-Hydroxyvitamin D serum, glycemic control, fasting blood glucose, two-hour postprandial blood glucose, HbA1c.
Gambaran Faktor Koagulasi dan Jumlah Trombosit pada Pasien Diabetes Melitus Tipe 2: Sebuah Studi Potong Lintang Alfitri, Maura Salsabila; Decroli, Eva; Rofinda, Zelly Dia; Aprilia, Dinda; Yulia, Dwi; Lailani, Mutia
MEDIA ILMU KESEHATAN Vol 14 No 2 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i2.1314

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health threat, where chronic hyperglycemia and insulin resistance can affect coagulation profiles.Objective: This study aims to examine coagulation factor profiles and platelet counts in T2DM patients. Methods: A descriptive cross-sectional observational study using data from prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), and platelet counts of T2DM patients admitted to the Internal Medicine Ward of Dr. M. Djamil General Hospital, Padang, in October 2023. Data analysis was performed descriptively using SPSS v26 software. Results: Of the 39 patients analyzed, the distribution of characteristics showed a male predominance of 64.1%, with the largest age group being 45–59 years (48.7%). The most common complication associated with T2DM was chronic kidney disease, identified in 82.1% of the study population. Evaluation of hemostasis parameters showed that APTT was prolonged in 56.4% of patients. Conversely, PT (87.2%), INR (87.2%), and platelet count (66.7%) were within reference ranges. Conclusion: This study found most coagulation parameters normal, but a relatively high proportion had prolonged APTT, underscoring the need for individualized coagulation monitoring in T2DM, especially with renal complications
Tiroiditis Hashimoto dan Sindrom Gitelman Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Tamayo, Auliangi
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p772-775.2023

Abstract

Seorang perempuan usia 34 tahun datang dengan keluhan lemah pada kedua tangan dan kaki, benjolan di leher, riwayat berdebar-debar, penurunan berat badan dan siklus menstruasi yang tidak teratur. Pasien didiagnosis dengan tiroiditis Hashimoto dan sindrom Gitelman. Pasien diterapi dengan levotiroksin dan koreksi elektrolit. Pasien kemudian pulang dalam keadaan perbaikan klinis.
Two-Year Follow-Up of Parathyroid Hormone, Calcium, and Vitamin D Serum Levels in a Patient after Parathyroidectomy Alexander Kam; Dinda Aprilia; Eva Decroli; Syafril Syahbuddin
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 1 (2025): InaJEMD Vol. 2, No. 1
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Parathyroidectomy is the definitive treatment for primary hyperparathyroidism. Because of the hungry bone syndrome and prolonged hypocalcemia risk, we must follow up on a patient's parathyroid hormone, calcium, and vitamin D serum after parathyroidectomy. In this case report, we reported on a parathyroidectomy patient whom we followed for two years and who, interestingly, had elevated parathyroid hormone levels. A 35-year-old male patient diagnosed with a left parathyroid tumor underwent parathyroidectomy and isthmolobectomy. The patient was treated with calcium, vitamin D, and levothyroxine supplementation. We diagnosed the patient with hungry bone syndrome on the fourth day of post-parathyroidectomy. Then, we documented calcium, vitamin D, and PTH levels in the next two years. The calcium levels are 7.2 (June 2022), 8.2 (July 2022), 8.5 (September 2022), 7.8 (October 2022), 8.1 (June 2023), 9.7 (June 2024). The PTH levels are 244.2 (June 2022), 328.3 (July 2022), 306.5 (September 2022), 457.2 (October 2022), 163.3 (June 2023), 34.4 (June 2024). The Vitamin D levels are 34.4 (July 2022), 13.4 (March 2023), 35.2 (September 2023), 50.4 (April 2024). We increased the dose of calcium and vitamin D supplementation. The patient is in good condition and has reached a normal level of these laboratory parameters in the second year post-parathyroidectomy. PTH, calcium, and vitamin D serum are needed for follow-up in patients after parathyroidectomy. Normalizing calcium and vitamin D serum is essential to maintaining a normal PTH level. Normal PTH, calcium, and vitamin D serum are the cure indications in this patient.
Pituitary Macroadenoma with Hypogonadism in 30 year old Liver Cirrhosis Patient: A Case Report Alexander Kam; Dinda Aprilia; Eva Decroli; Syafril Syahbuddin
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 1 (2025): InaJEMD Vol. 2, No. 1
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pituitary macroadenomas can suppress pituitary hormone secretion, one of which is the gonadotropin hormone, causing hypogonadism. The condition of hypogonadism can increase the risk of NAFLD, which can then become liver cirrhosis. A 30-year-old man came to the hospital with decreased consciousness and hematemesis melena. From physical examination, laboratory, and pituitary MRI, the patient was diagnosed with pituitary macroadenoma, hypogonadotropic hypogonadism, primary hypothyroidism, acute adrenal insufficiency, and liver cirrhosis. The patient was given hydrocortisone therapy, correction of electrolyte levels, hypoglycemia protocol, levothyroxine 100 mg/day, and management of hematemesis melena. After that, Sustanon 250 mg was given every two weeks intramuscularly. The patient went home in good condition and was planned for neurosurgery consultation for transsphenoidal resection. After the injection of Sustanon, the patient experienced increased penile length and testicular volume. The condition of hypogonadism in patients with pituitary macroadenoma can be a risk factor for NAFLD, which can then progress to liver cirrhosis. NAFLD and liver cirrhosis also can cause hypogonadism in men by several mechanisms. The patient has been well-managed and experienced clinical improvement.
Aspek Imunologi pada Diagnosis dan Tatalaksana Graves’ Disease Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Rahayuningsih, Sri Puji
Health and Medical Journal Vol 7, No 3 (2025): HEME September 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i3.1722

Abstract

Graves’ Disease (GD) adalah penyebab hipertiroidisme paling umum yang mengenai kelenjar tiroid. Penyakit ini merupakan salah satu bagian dari Autoimmune Thyroid Disease (AITD) yang bersifat spesifik organ (tiroid), yang ditandai dengan adanya autoantibodi yang menstimulasi Thyroid Stimulating Hormone Receptor (TSHR) pada kelenjar tiroid yang akan menyebabkan hiperplasia tiroid atau struma serta peningkatan produksi dan sekresi hormon tiroid. Graves’ disease merupakan interaksi yang kompleks antara mekanisme imunologi dan disfungsi tiroid. Penyakit ini berdampak negatif pada kualitas hidup dan dapat menimbulkan risiko psikosis, takiaritmia, dan gagal jantung. Sifat autoimunitas GD menyebabkan penyakit ini dapat kambuh kembali, sehingga pengelolaannya memerlukan waktu yang lebih lama, sama seperti pada penyakit autoimun lainnya. Pada penyakit ini, target pengobatan terbaru yaitu dengan memerhatikan mekanisme imunopatogenesis dasar terjadinya penyakit. Oleh karena itu, pemahaman yang mendalam tentang aspek imunologis GD, dapat memfasilitasi pengembangan terapi yang lebih baik, yaitu terapi yang berfokus pada modulasi respons imun yang menjadi fokus utama dalam upaya untuk mengendalikan aktivitas penyakit dan mencegah komplikasi jangka panjang.
Manajemen Pasien Diabetes Melitus Tipe 2 pada Puasa Ramadan Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Ulvyana, Vyora
Health and Medical Journal Vol 7, No 3 (2025): HEME September 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i3.1723

Abstract

Jumlah penyandang diabetes melitus (DM) tipe 2 di kalangan muslim global diperkirakan mencapai 148 juta, dengan sekitar 116 juta di antaranya melaksanakan ibadah puasa Ramadan. Sebanyak 45% populasi muslim dunia berada di kawasan Asia Tenggara, termasuk Indonesia sebagai negara dengan populasi muslim terbesar. Kondisi ini menimbulkan tantangan klinis karena banyak penyandang DM tipe 2 tetap berpuasa meskipun berisiko mengalami komplikasi akibat perubahan pola makan dan pengobatan. Tujuan penelitian ini adalah untuk mengevaluasi keamanan dan efektivitas manajemen diabetes tipe 2 selama puasa Ramadan serta menyusun rekomendasi berbasis bukti bagi penyandang diabetes. Penelitian ini merupakan tinjauan literatur sistematis terhadap studi-studi yang membahas manajemen DM tipe 2 selama Ramadan, dengan pencarian artikel dari database PubMed, Scopus, dan Google Scholar menggunakan kata kunci “diabetes tipe 2”, dan “puasa ramadhan”. Hasil tinjauan menunjukkan bahwa dengan perencanaan yang baik, termasuk edukasi pra-Ramadan, penyesuaian terapi farmakologis, dan pemantauan glukosa yang adekuat, sebagian besar penyandang DM tipe 2 dapat menjalankan puasa dengan aman. Namun, komplikasi seperti hipoglikemia, hiperglikemia, ketoasidosis diabetikum (KAD), dan dehidrasi tetap menjadi risiko utama bagi mereka yang berpuasa tanpa panduan medis. Terdapat kebutuhan mendesak akan pedoman praktis dan individualisasi manajemen DM tipe 2 selama Ramadan untuk meminimalkan risiko komplikasi dan meningkatkan keamanan beribadah bagi penyandang diabetes.
Co-Authors Adang Bachtiar Ade Chandra Afriwardi Afriwardi Ahmad, Armen Al Hafiz Alexander Kam Alexander Kam Alfitri, Maura Salsabila Andi Fadilah Yusran Putri Antoni, Adi Aprilia, Dinda Asman Manaf Aulia, Salsabila Syafna Auliangi Tamayo Brian Sri Prahastuti Darwin Amir, Darwin Deddy Saputra Delmi Sulastri Dessy Arisanty Dinda Aprilia Dinda Aprilia Dwitya Elvira, Dwitya Efendi, Nursyirwan Efendi, Yanne Pradwi Ellyza Nasrul Eryati Darwin Eti Yerizel Fadella, Annesa Fadrian, Fadrian Fahrurozi, R. Ifan A. Fauzar Fauzar Finisia Noviyanti Firdawati Firdawati Garri Prima Decroli Genta Pradana, Genta Hafni Bachtiar Hardisman Harie Satria ES Husna Yetti Jannah, Lidya Raudhatul Kam, Alexander Linosefa Linosefa Martini, Rose D Meliza Wahyuni Mudjiran Muhammad Luthfi Muharramah, Disa Hijratul Murni, Arina W Mustafa Noer Muthia Faurin Mutia Lailani Nada Utami Prahastiwi Nadila Andam Astari Namanda Putri, Athari Fadhila Nining Kurniawati Nur Indrawati Lipoeto Nurhayati Nurhayati Prayitno, Irwan Putri Sri Lasmini Putri, Biomechy Oktomalio Putri, Septia Harma Putri, Vidola Yasena Rahayuningsih, Sri Puji Restu Susanti Risviani, Darayani Ritonga, Sukhri Herianto Robby Satria Putra Roza Kurniati Roza Mulyana Saptino Miro Saptino Miro, Saptino Sheila Jihan Safira Sofiani, Dinda Putri Sukri Rahman Susila Sastri Syafril Syahbuddin Syafril Syahbuddin Tamayo, Auliangi Try Rahmi Lussii Karsuita Ulvyana, Vyora Viotra, Deka Yanne Pradwi Efendi Yoga, Vesri Yulia, Dwi Yuliarni Syafrita Yusrawati Yusrawati Yustini Alioes Zelly Dia Rofinda