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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Media Ilmu Kesehatan Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Poltekita : Jurnal Ilmu Kesehatan Health and Medical Journal Jurnal Ners Jurnal Dunia Gizi Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Jurnal Riset Ilmiah Neurona
Eva Decroli
Universitas Andalas
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Emerging Biomarkers for Prediabetes : A Review Dinda Aprilia; Eva Decroli; Alexander Kam; Putri Deas Hadilofyani
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.278

Abstract

Prediabetes is a global health concern marked by elevated blood glucose levels that do not yet meet the threshold for type 2 diabetes mellitus (T2DM). It is often underdiagnosed despite being associated with insulin resistance, beta-cell dysfunction, and increased cardiovascular risk. Improved strategies for early detection are crucial to prevent disease progression. This review aims to explore novel biomarkers associated with prediabetes and evaluate their potential clinical applications in early diagnosis and risk stratification. A literature search was conducted on English and Indonesian language publications, including original research, case reports, and expert guidelines, focusing on emerging molecular and metabolic biomarkers related to prediabetes. Several promising biomarkers have been identified, including adiponectin, microRNAs, fetuin A, alpha-hydroxybutyrate (α-HB), and Protein Z. Adiponectin demonstrates an inverse relationship with insulin resistance. Specific microRNAs, such as miR-192 and miR-193b, are implicated in glucose metabolism and beta-cell function. Elevated fetuin A levels are linked to hepatic insulin resistance, while increased α-HB levels reflect early metabolic shifts in glucose utilization. Additionally, altered Protein Z concentrations may contribute to prothrombotic states in individuals with prediabetes. In conclusion, these biomarkers offer valuable insight into the pathophysiology of prediabetes and hold potential for enhancing early detection and prevention strategies. However, further validation through large-scale studies is needed before their integration into clinical practice
The Role of Genomic Sequencing in Diabetes Mellitus Yanne Pradwi Efendi; Alexander Kam; Eva Decroli; Dinda Aprilia; Syafril Syahbuddin
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.279

Abstract

Diabetes Mellitus is a chronic metabolic disorder caused by impaired insulin secretion and/or insulin resistance. Genetic testing through genomic sequencing is one of the modalities available for diabetes mellitus. Genomic sequencing is the process of analysing DNA obtained from a blood sample (or alternatively from tissue samples). Broadly, genomic sequencing plays two major roles in diabetes mellitus: supporting diagnosis and guiding therapeutic approaches. In its development, genomic sequencing has proven valuable for diagnostic investigation in type 1 diabetes and maturity-onset diabetes of the young (MODY), as well as for assessing the polygenic risk score (PRS) in type 2 diabetes. Establishing a definitive diagnosis allows for the selection of individualised therapy. Several randomised controlled trials have demonstrated that the risk of developing diabetes can be reduced by up to half if detected at an earlier stage. Moreover, genomic sequencing can identify genetic variants that influence responsiveness to antidiabetic treatments. At present, several potential antidiabetic agents targeting novel pathways are under development and in various stages of clinical trials. The application of genomic sequencing thus facilitates the implementation of individualised therapy, ultimately contributing to the realisation of precision medicine.
Kadar Transthyretin Plasma pada Lanjut Usia Sarkopenia dan Non-Sarkopenia Fahrurozi, R. Ifan A.; Martini, Rose D; Mulyana, Roza; Murni, Arina W; Decroli, Eva; Miro, Saptino; Viotra, Deka; Yoga, Vesri
Jurnal Penyakit Dalam Indonesia Vol. 12, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Sarcopenia is a geriatric syndrome marked by an age-related decline in muscle mass, which is affected by protein intake. Transthyretin is a visceral protein used to evaluate nutritional status and acts as a positive regulator of muscle mass. This study aimed to assess the difference in plasma transthyretin levels between elderly groups with and without sarcopenia. Methods. This was an analytical observational study with a cross-sectional approach. Subjects were elderly patients who visited the Internal Medicine Polyclinic of Dr. M. Djamil Hospital Padang and met the inclusion and exclusion criteria from August to September 2024. Subjects were classified into sarcopenic and non-sarcopenic groups, followed by an examination of plasma transthyretin levels. Sarcopenia was diagnosed using bio-impedance analysis (BIA) measurement, handgrip strength with a Jamar hydraulic hand dynamometer, and physical performance with a walking speed test. Plasma transthyretin levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Comparative analysis was performed using the unpaired T-test using SPSS 29.0. Results. Among total of 46 subjects who participated in this study, the majority of elderly individuals with sarcopenia were predominantly female. The mean plasma transthyretin level in the sarcopenic elderly group was 10.9 (3.3) mg/dL, while in the non-sarcopenic elderly group was 20.3 (2.5) mg/dL. Comparative analysis demonstrated a significant difference in plasma transthyretin levels between sarcopenic and non-sarcopenic elderly individuals (p < 0.001). Plasma transthyretin levels in the sarcopenic elderly group were lower compared to the non-sarcopenic elderly group. Conclusion. There is a significant difference in plasma transthyretin levels between sarcopenic and non-sarcopenic elderly individuals.
Pengaruh Ekstrak Kemangi terhadap Ekspresi Gen Interleukin-1β pada Tikus Diabetes Melitus Gestasional Medison, Sultan Rafli Putra; Decroli, Eva; Ali, Hirowati
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1464

Abstract

Latar Belakang: Istilah Diabetes Melitus Gestasional (DMG) mengacu pada adanya intoleransi glukosa yang ditemukan pertama kali pada kehamilan, menyebabkan terjadinya inflamasi yang ditandai dengan peningkatan ekspresi gen Interleukin-1β (IL-1β) dan dapat memicu terjadi stres oksidatif. Kemangi (Ocimum basilicum) merupakan tanaman herbal dengan kandungan zat aktif yang mempunyai efek antidiabetes, antiinflamasi maupun antioksidan. Objektif: Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak daun kemangi (Ocimum basilicum) terhadap ekspresi gen IL-1β pada tikus model diabetes melitus gestasional. Metode: Penelitian ini adalah eksperimental dengan menggunakan metode post test only control group design. Penelitian ini dilakukan di Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas. Penelitian dilakukan selama bulan September 2023 sampai Januari 2024. Besar sampel yang digunakan ditentukan dengan rumus Federer. Jumlah sampel setiap kelompok adalah 6. Penelitian ini terdiri dari 4 kelompok yaitu 2 kontrol dan 2 perlakuan sehingga jumlah total sampel adalah sebanyak 24 serum. Hasil: Rerata hasil ekspresi gen IL-1β yang pada kelompok K- (kontrol negatif), K+ (kontrol positif), P1 (perlakuan 1), dan P2 (perlakuan 2) adalah masing masing 1,16, 1,24, 0,86, dan 0,81. Terdapat perbedaan bermakna pada setiap kelompok dengan nilai p = 0,000 (p<0,05). Hasil penelitian ini memperlihatkan  terdapat perbedaan bermakna penurunan ekspresi IL-1β antara K+ dengan P1 dan P2 (p<0,001) namun tidak terdapat perbedaan yang bermakna antara P1 dan P2. Kesimpulan: Pemberian ektrak kemangi dapat mempengaruhi ekspresi gen IL-1β pada tikus DMG.
Pendekatan Holistik (Fisik, Psikologis, Sosial, Spiritual) dalam Dukungan Keluarga pada Perawatan Ulkus Kaki Diabetik di Rumah T. Eltrikanawati; Rizanda Machmud; Eva Decroli; Rozi Sastra Purna
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.57822

Abstract

Ulkus Kaki Diabetik (UKD) merupakan komplikasi serius dari Diabetes Melitus yang memerlukan perawatan jangka panjang, khususnya di lingkungan rumah. Anggota keluarga memainkan peran krusial sebagai pengasuh utama; namun, bentuk dukungan keluarga holistik masih belum cukup disintesis dari perspektif pendidikan kesehatan. Penelitian ini bertujuan untuk mengidentifikasi dan menyintesis bentuk dukungan keluarga holistik dalam perawatan di rumah bagi pasien dengan ulkus kaki diabetik. Tinjauan dilakukan menggunakan metode state-of-the-art dengan pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Artikel diambil dari basis data terindeks Scopus, termasuk PubMed, ScienceDirect, dan Scopus, yang diterbitkan antara tahun 2020 dan 2026. Kriteria inklusi mencakup studi berbahasa Inggris yang berfokus pada dukungan keluarga dalam perawatan UKD. Data dianalisis menggunakan sintesis tematik. Sebanyak 15 artikel memenuhi kriteria inklusi. Empat tema utama dukungan keluarga diidentifikasi: dukungan fisik, dukungan psikologis, dukungan sosial, dan dukungan spiritual. Keluarga berkontribusi secara aktif dalam perawatan luka, dukungan emosional, pengambilan keputusan, dan mekanisme koping pasien. Temuan ini menunjukkan bahwa perawat, pendidik, dan praktisi kesehatan masyarakat harus mengintegrasikan pendidikan kesehatan berbasis keluarga yang terstruktur ke dalam program manajemen ulkus kaki diabetik. Pendekatan semacam ini dapat meningkatkan kualitas perawatan luka di rumah, mengurangi komplikasi, serta meningkatkan hasil klinis pasien dan keluarga dalam manajemen penyakit kronis.
Profil Risiko Diabetes dan Sindrom Metabolik Berdasarkan Indeks Massa Tubuh dan Glukosa Darah Sewaktu di Bukik Batabuah Dinda Aprilia; Eva Decroli; Alexander Kam; Yanne Pradwi Efendi; Athari Fadhila Namanda Putri
Abdika Sciena Vol 3 No 2 (2025): JURABDIKES Volume 3 No 2, Desember 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v3i2.328

Abstract

Latar Belakang: Diabetes melitus (DM) dan sindrom metabolik merupakan masalah kesehatan global dengan peningkatan prevalensi setiap tahun. Indeks massa tubuh (IMT) dan kadar glukosa darah merupakan indikator penting dalam menilai risiko DM dan sindrom metabolik pada populasi komunitas. Tujuan: Mengetahui karakteristik indikator risiko DM dan sindrom metabolik berdasarkan IMT, GDS dan demografis masyarakat Bukik Batabuah tahun 2024. Metode: Penelitian deskriptif observasional terhadap 69 responden. Data yang dikumpulkan meliputi usia, jenis kelamin, IMT, kategori IMT, dan GDS. Analisis dilakukan secara deskriptif. Hasil: Rerata usia responden 50,93 tahun, dengan mayoritas perempuan (76,81%). Rerata IMT 23,23 kg/m² dengan 24,64% responden tergolong overweight–obesitas. Rerata GDS 130,59 mg/dL dengan nilai maksimum 337 mg/dL menunjukkan adanya risiko gangguan glukosa. Kesimpulan: Populasi Bukik Batabuah menunjukkan risiko metabolik yang ditandai dengan IMT di atas normal. Skrining komunitas dan intervensi promotif-preventif diperlukan  
Pituitary macroadenoma with optic chiasm compression and hypopituitarism: a case report Alexander Kam; Dinda Aprilia; Eva Decroli
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.81-87

Abstract

INTRODUCTIONPituitary macroadenomas are benign pituitary tumors measuring more than 1 cm in diameter that constitute a substantial proportion of intracranial neoplasms. Despite their benign histology, these tumors may lead to significant morbidity due to local mass effects and endocrine dysfunction. Compression of the optic chiasm can result in progressive visual impairment and irreversible blindness if not promptly treated. Additionally, pituitary hormonal deficiencies may cause life-threatening metabolic and systemic complications. Early recognition and multidisciplinary management are therefore essential to prevent permanent sequelae and optimize functional recovery. Case DescriptionA 40-year-old woman presented with a one-year history of recurrent headaches accompanied by progressive blurring of vision, diplopia, and visual field defects. She also reported irregular menstruation and unintended weight loss. Brain magnetic resonance imaging demonstrated a 2.13 × 2.28 × 3.05 cm pituitary macroadenoma with a characteristic “snowman appearance” compressing the optic chiasm. Hormonal evaluation revealed secondary adrenal insufficiency, hypogonadotropic hypogonadism, suppressed thyroid-stimulating hormone (TSH) with elevated free thyroxine (T4), and hyperprolactinemia attributed to the stalk effect, consistent with hypopituitarism and thyroid dysfunction. Initial stabilization with hydrocortisone and methimazole was performed prior to definitive management. The patient subsequently underwent transsphenoidal tumor resection with appropriate perioperative glucocorticoid coverage. Postoperatively, she remained clinically stable with improvement in headache and visual symptoms, and continued hormonal therapy under close endocrinological supervision. ConclusionsThis case underscores the importance of comprehensive hormonal assessment, timely neurosurgical intervention, and coordinated multidisciplinary care in managing pituitary macroadenomas complicated by optic chiasm compression and hypopituitarism to achieve favorable clinical outcomes.
Glucocorticoid-induced adrenal insufficiency after receiving intravenous methylprednisolone for Graves' ophthalmopathy: a case report Yanne Pradwi Efendi; Dinda Aprilia; Eva Decroli
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.76-80

Abstract

BACKGROUNDGraves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease and can significantly impair visual function and quality of life. High-dose intravenous methylprednisolone (IVMP) is recommended as first-line therapy for moderate-to-severe active GO due to its superior efficacy and tolerability compared with oral glucocorticoids. However, IVMP therapy may be associated with rare but potentially serious adverse effects, including suppression of the hypothalamic–pituitary–adrenal (HPA) axis leading to GI adrenal insufficiency (GI-AI). Case descriptionWe report the case of a 38-year-old man with Graves’ disease who developed AI following IVMP therapy for moderate-to-severe GO. The patient received five weekly doses of IVMP 500 mg (cumulative dose 2.5 g) for progressive ocular symptoms. He subsequently presented with fatigue, weight gain, moon face, and buffalo hump. Laboratory evaluation revealed a markedly low morning serum cortisol level of 1 mcg/dL, confirming adrenal insufficiency. Patient was diagnosed with GI-AI accompanied by features of iatrogenic Cushing’s syndrome. Management consisted of hydrocortisone replacement therapy at a dose of 20 mg/day along with ongoing antithyroid treatment using methimazole. Serial monitoring of cortisol levels demonstrated gradual recovery of HPA axis function, accompanied by clinical improvement. ConclusionThis case highlights that glucocorticoid-induced adrenal insufficiency can occur on IVMP used for GO. Clinicians should maintain a high index of suspicion and perform appropriate adrenal function monitoring during and after IVMP therapy to ensure early detection and safe management of this potentially life-threatening complication.
Profil Metabolik pada Masyarakat Sijunjung: Studi Cross-Sectional Dinda Aprilia; Eva Decroli; Alexander Kam; Yanne Pradwi Efendi; Athari Fadhila Namanda Putri
Abdika Sciena Vol 4 No 1 (2026): JURABDIKES Volume 4 No 1, Juni 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v4i1.376

Abstract

Latar Belakang: Penyakit tidak menular (PTM) seperti obesitas, diabetes melitus (DM), dislipidemia, dan hiperurisemia merupakan permasalahan kesehatan yang semakin meningkat prevalensinya di Indonesia, termasuk di daerah pedesaan. Desa Lansek Manih kabupaten Sijunjung sebagai salah satu daerah di Sumatera Barat memiliki akses terbatas terhadap fasilitas kesehatan sehingga deteksi dini terhadap faktor risiko metabolik menjadi sangat penting. Tujuan: Penelitian ini bertujuan untuk menggambarkan profil indeks massa tubuh (IMT), prevalensi diabetes melitus, kadar kolesterol, dan kadar asam urat pada masyarakat Desa Lansek Manih, Sijunjung. Metode: Penelitian ini merupakan studi deskriptif observasional dengan desain cross-sectional. Sebanyak 74 responden yang direkrut secara consecutive sampling dari kegiatan pengabdian masyarakat di desa Lansek Manih Sijunjung. Data yang dikumpulkan meliputi usia, jenis kelamin, indeks massa tubuh (IMT), status diabetes melitus, kadar kolesterol total, dan kadar asam urat. Hasil: Rerata usia responden adalah 49,62 tahun (18–70 tahun) dengan lebih banyak berjenis kelamin perempuan (57,97%). Rerata IMT sebesar 26,25 kg/m², dengan 62,16% responden termasuk kategori overweight dan obesitas. Sebanyak 12,16% responden terdiagnosis diabetes melitus. Rerata kadar kolesterol adalah 237 mg/dL dan rerata kadar asam urat adalah 6,12 mg/dL. Kesimpulan: Prevalensi overweight/obesitas, dislipidemia, dan diabetes melitus yang tinggi pada masyarakat desa Lansek Manih Sijunjung mengindikasikan perlunya program skrining dan intervensi dini terhadap faktor risiko metabolik di tingkat komunitas.
Co-Authors Adang Bachtiar Ade Chandra Afriwardi Afriwardi Ahmad, Armen Al Hafiz Alexander Kam Alfitri, Maura Salsabila Andi Fadilah Yusran Putri Antoni, Adi Aprilia, Dinda Asman Manaf Athari Fadhila Namanda Putri Athari Fadhila Namanda Putri Aulia, Salsabila Syafna Auliangi Tamayo Brian Sri Prahastuti Darwin Amir, Darwin Deddy Saputra Deka Viotra Delmi Sulastri Dessy Arisanty Dinda Aprilia Dwitya Elvira, Dwitya Efendi, Nursyirwan Ellyza Nasrul Eryati Darwin Eti Yerizel Fadella, Annesa Fadrian, Fadrian Fahrurozi, R. Ifan A. Fauzar Fauzar Fereshti Lailani Finisia Noviyanti Firdawati Firdawati Garri Prima Decroli Genta Pradana, Genta Hafni Bachtiar Hardisman Harie Satria ES Hirowati Ali, Hirowati Husna Yetti Jannah, Lidya Raudhatul Jonggara Oktaviandra Siahaan Kam, Alexander Linosefa Linosefa Martini, Rose D Medison, Sultan Rafli Putra Meliza Wahyuni Mudjiran Muhammad Luthfi Muharramah, Disa Hijratul Murni, Arina W Mustafa Noer Muthia Faurin Nada Utami Prahastiwi Nadila Andam Astari Namanda Putri, Athari Fadhila Nining Kurniawati Nur Indrawati Lipoeto Nurhayati Nurhayati Prayitno, Irwan Putri Deas Hadilofyani Putri Sri Lasmini Putri, Biomechy Oktomalio Putri, Septia Harma Putri, Vidola Yasena Rahayuningsih, Sri Puji Restu Susanti Risviani, Darayani Ritonga, Sukhri Herianto Rizanda Machmud Robby Satria Putra Roza Kurniati Roza Mulyana Rozi Sastra Purna Saptino Miro Saptino Miro, Saptino Sheila Jihan Safira Sofiani, Dinda Putri Suci Berlian Hemilton Sukri Rahman Susila Sastri Syafril Syahbuddin Syafril Syahbuddin T. Eltrikanawati Tamayo, Auliangi Try Rahmi Lussii Karsuita Ulvyana, Vyora Vesri Yoga Yanne Pradwi Efendi Yanne Pradwi Efendi Yanne Pradwi Efendi Yanne Pradwi Efendi Yulia, Dwi Yuliarni Syafrita Yusrawati Yusrawati Yustini Alioes Zelly Dia Rofinda