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All Journal JURNAL GIZI INDONESIA Nexus Kedokteran Klinik Nexus Biomedika The Indonesian Biomedical Journal Jurnal Gizi dan Kesehatan Ilmu Gizi Indonesia Indonesian Journal of Medicine Abdimas Universal Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings Narra J Sehat Rakyat: Jurnal Kesehatan Masyarakat Journal of International Conference Proceedings Biocaster : Jurnal Kajian Biologi JAMAS: Jurnal Abdi Masyarakat Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Paramasari Dirgahayu
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Soil-Transmitted Helminths (STH) Infection has no Relations with Anemia on Childrenin SDN Barengan, sub-district Teras, Boyolali Aryanda Widya Tazkagani Salsabila; Paramasari Dirgahayu; Amandha Boy Timor Randita
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: STH infections with prevalence degree of 28% become a problem in Indonesia societies, especially those who are trapped in low socio-economic level. The infection often affects children because children commonly lack of knowladge about personal sanitation, and their innate immune response has not well developed yet. STH infection can cause deficiencies of calories and protein, it also can cause anemia. An area with high humidity level like sub-district Teras in Boyolali is such a comfortable place for STH to grow rapidly. This study aimed to investigate whether there were any relation between STH infection and anemia on children in SDN Barengan, sub-district Teras, Boyolali. Method: This was an Observational analityc research with cross sectional approach. This research took place in SDN Barengan, sub-district Teras, Boyolali. Sampling technique for this research was undertaken with technique of purposive sampling. It took qualified students that met criterias, from first grade until fifth grade. The data were taken from feces examination by formol ether concentration method, hemoglobin examination by cyanmethemoglobin method, parents socio-economic demographic questionnaire, personal sanitation questionnaire, and foodrecall. The research was obtained as many as 74 research subjects, and analyzed by chi square. Result: The data showed 35 children (47.3%) were positively infected by STH disease and 11 children (14.9%) positively suffer anemia. The analysis of data showed that there was no significant relations between STH infection and anemia, p = 0.431. Analysis of most dominant factor that affects STH infection was bad habbit of barefooted with p = 0.000 (p < 0.05). Meanwhile, anemia disease was mostly caused by lack of protein intake with p = 0.048 (p < 0.05). Conclusion: STH infection has no significant relations for increasing the prevalence of anemia on children in SDN Barengan, sub-district Teras, Boyolali. Keywords: soil-transmitted helminth infection, anemia, primary school children
Hubungan antara Infeksi Protozoa Cryptosporidium Sp dengan Kejadian Diare Kronis pada Pasien HIV/AIDS di RSUD Dr. Moewardi Surakarta Surya Dewi Primawati; Paramasari Dirgahayu; Dani Redhono Haryoputro
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Cryptosporidium sp. is apicomplexan parasite that causes chronic diarrhea. This parasites infection can cause high mortality in immunocompromais individuals especially who are infected with HIV/AIDS. Although the HIV/AIDS infection is a concern in Indonesia, but there has been no study on the infection of chronic diarrhea in patients with HIV/AIDS. This study aimed to know the correlation between the Protozoan Cryptosporidium sp. infection and chronic diarrhea incident in patients with HIV/AIDS at Dr. Moewardi Hospital Surakarta. Methods: This was an observational analytic study using cross sectional approach conducted on May September 2013. Thirty six patients with HIV/AIDS at Dr. Moewardi Hospital that were appropriate with the criteria of restriction were taken for samples. The data about chronic diarrhea, age, gender, level of education were obtained from the questionnaire. Identification of Cryptosporidium sp. in stool was examined using modified acid fast stain techniques, while their consistency were obtained through macroscopic examination. Data about the status of patient's CD4 were obtained from the medical record. The correlation between chronic diarrhea, sex, level of education, consistency of the stool, CD4 status and Cryptosporidium sp. infection was analyzed by using Fisher Test (a=0.05). Results: Fisher test analysis showed there was no significant correlation between infection of Cryptosporidium sp. and incidence of chronic diarrhea (p = 1). Analysis of correlation between gender, level of education, consistency of the stool, CD4 status and Cryptosporidium sp. infection, the value of p > 0.05 was obtained. Conclusions: There was no significant correlation between Cryptosporidium sp. infection and chronic diarrhea incident in patients with HIV/AIDS at Dr. Moewardi Hospital Surakarta. Keyword : Cryptosporidium sp, chronic diarrhea, HIV/AIDS
Correlation between Infection of Soil Transmitted Helminths (STH) and Peripheral Blood Eosinophil Levels amongElementary Student at Barengan Village, Teras Subdistrict, Boyolali. Aulia Nadhiasari; Bambang Sukilarso Sakiman; Paramasari Dirgahayu
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: The Parasitic infection, caused by intestinal helminths, accounts for significans burden of human disease in developing countries including Indonesia. In chronic infection, eosinophilia occurs as protection against helminth parasites. Increasing eosinophils is often associated with diseases, such as allergy, nephrotic syndromes, leoffler diseases, and also helminthiasis. However, there are little data to prove this unequivocally. This study aimed to determine the correlation between soil transmitted helminths infections and the levels of peripheral blood eosinophil among elementary students at Barengan Village, Teras Subdistrict, Boyolali Methods: This study was conducted by an observational analytic research in a cross sectional approach at Elementary School students in Barengan Village, Teras Subdistrict, Boyolali on periode of October-November 2014. We conducted on 74 samples according to the inclusion and exclusion criteria. The data were collected from stool, peripheral blood and questionnaires and then were statistically analyzed with Chi Square test to determine their correlation. Results: Our study showed that the prevalence of helminthiasis among student was 47.3% and Chi Square Analyzes between STH infection and eosinophilia had the value of p=0.041 with Odds Ratio= 2.695. Conclusions:Barengan Village, Teras Subdistrict, Boyolali is still an endemic area for helminthiasis (47.3%). This study shows correlation between soil transmitted helminthes infections and increasing the levels of peripheral blood eosinophil among elementary students at Barengan Village, Teras Subdistrict, Boyolali. Keywords: Soil transmitted helminths, eosinophil, elementarystudents of SD Barengan
Pengaruh Usia terhadap Cervical Intraepithelial Neoplasia (CIN) pada Wanita dengan Infeksi Saluran Reproduksi Berbasis Pemeriksaan Papsmear Dewi Okta Anggraini; Paramasari Dirgahayu; Brian Wasita
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Cervical Intraepithelial Neoplasia (CIN) is a dysplasia of cervical squamous cells posibbly turn into cervical cancer if not treated immediately. The established cause of CIN is Human Papillomavirus (HPV). Several studies showed correlation between Reproductive Tract Infection (RTI) with CIN. But, it is still controversial. Age is one of predicted factor which can influence CIN. Through some mechanisms, age can change the cervical cells. Methods: This study was cross-sectional approach. Samples were taken from medical record, papsmears form result and papsmear preparation in the Pathology Anatomy Laboratory, Faculty of Medicine, Sebelas Maret University from 2009-2012. Total of 410 samples were divided into two groups: control and case group. Control group contain sample without RTI while case group contain sample with RTI. Each group consisted of 205 women who subsequently divided into two subgroup, aged <40 years and ? 40 years. In this study, HPV infection is uncontrolled. Data were taken including name, age, clinical symptoms, ISR and CIN. These data are analyzed using Fisher test from SPSS version 19 for windows. Results: Total CIN were found: 5 samples (<40 years) and 3 samples (?40 years) from positive RTI; 20 samples (<40 years) and 53 samples (?40 years) from negative RTI. Fisher test results showed that age has correlation with CIN (p=0,001) and there is a significant difference risk between the age distribution with CIN [RD= -12.3%, 95%CI=(-19.8)-(-4798)]. In the negative RTI, there is a significant risk sample aged <40 years and aged ?40 years to get CIN [RD= -21.28%, 95% CI= (-33.91)- (-8.655)]. RTI does not have correlation with CIN (p = 0.06) Conclusion: Without HPV controlled, age distribution (<40 years and ?40 years) has an influence to the occurence of CIN and there is no correlation between RTI with CIN. Key words: Age, Cervical Intraepithelial Neoplasia (CIN), Reproduction Tract Infection (RTI)
Recent update on cerebral sparganosis: A bibliometric analysis and scientific mapping Dirgahayu, Paramasari; Ilyas, Muhana F.; Rahma, Annisa A.; Hanifa, Shafira N.; Wijayanto, Matthew A.; Triniputri, Winastari Y.; Lukas, Graciella A.; Wiyono, Nanang; Sari, Yulia; Mashuri, Yusuf A.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.982

Abstract

Human sparganosis, a parasitic infection prevalent in Asia, can progress to cerebral sparganosis, a severe condition with significant neurological symptoms. Diagnosis and treatment are challenging due to its clinical similarity to other infections, highlighting the need for improved detection and management strategies. The aim of this study was to observe research trends, key contributors, gaps in the existing knowledge, diagnosis challenges, effective treatment options, and prevention strategies, providing recommendations for future research directions and clinical practice improvements on cerebral sparganosis. A bibliometric analysis was conducted by extracting 139 documents from the Scopus database in June 2024. The retrieved data were analyzed using the R package's Bibliometrix (Biblioshiny) and VOSviewer. Spanning 97 different sources, the research exhibited an annual growth rate of 2.5%. Annual scientific production revealed fluctuating research activity with peaks in 2010 and 2011 and notable citation peaks in 1996 and 2005, indicating pivotal studies that significantly influenced subsequent research. Early studies focused on diagnosis and specific parasites, while recent studies (2010–2024) have increasingly addressed clinical outcomes, treatment strategies, and advanced diagnostic techniques. Trends revealed a shift towards clinical and diagnostic advancements, with recent emphasis on diagnostic imaging, immunoassays, and the relationship between cerebral sparganosis and brain tumors. In conclusion, the studies on cerebral sparganosis underscore the potential for enhancing clinical practice by improving diagnostic accuracy, informing treatment decisions, and implementing targeted screening efforts based on epidemiology and risk factors. Recommendation to further study needs to notify the cerebral sparganosis in high-risk countries with similar socioeconomic and cultural characteristics to endemic regions, including Indonesia.
Scoping Review: Potential of Bekul Fruit (Ziziphus jujube Mill.) as an Antidiabetic Agent in Patients with Type 2 Diabetes Mellitus Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4301

Abstract

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (hyperglycemia) caused by damage or abnormalities in insulin production. Pharmacological therapy used as a treatment for diabetes mellitus in some patients has adverse side effects on the body, thus encouraging exploration to use natural ingredients as an alternative therapeutic source in reducing blood glucose. Therefore, a thorough review is needed to summarize scientific data and investigate the potential use of natural ingredients bekul fruit (Ziziphus jujube Mill.) in its role as an antidiabetic agent. This study used a scoping review with 4 databases: Pubmed, ScienceDirect, DOAJ and Google Scholar. The results of the scoping review of 5 scientific articles found that bekul fruit (Ziziphus jujube Mill.) is proven to have bioactive content that is rich in antioxidants such as phenolic/polyphenolic compounds (ferulic acid, caffeic acid, chlorogenic acid), flavonoids (quercetin, rutin, catechin), phytosterols, and inulin which have the potential as antidiabetic agents with different mechanisms of action in reducing blood glucose levels. Conclusion: bekul fruit (Ziziphus jujube Mill.) has the potential to be an alternative nutraceutical diet therapy in patients with diabetes mellitus.
Beetroot Powder (Beta vulgaris L.) Decrease Oxidative Stress by Reducing of Malondialdehyde (MDA) Levels in Hyperuricemia Wulandari, Anggraini; Dirgahayu, Paramasari; Wiboworini, Budiyanti
Journal of International Conference Proceedings Vol 4, No 1 (2021): Proceedings of the 9th International Conference of Project Management (ICPM) Mal
Publisher : AIBPM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32535/jicp.v4i1.1156

Abstract

Introduction: Hyperuricemia is a metabolic disease associated with lifestyle habits, age, sex, and inherited factors. High uric acid levels in a hyperuricemia state cause oxidative stress that can lead to increased malondialdehyde (MDA) levels. Beetroot powder has the potential as a functional food rich in antioxidants that can reduce MDA levels. This study aims to determine the beetroot powder effect on MDA level reduction in hyperuricemia rat models. Methods: This research was an experimental study with fifteen hyperuricemia rats were divided into three groups by randomized pre-post control group design. They were divided into three groups: P1 were healthy rats + standard feed (comfeed), P2 were hyperuricemia rat models + standard feed (comfeed) and P3 were hyperuricemia rat models + beetroot powder 3,12 g/kg/bw for 14 days. The MDA level examinations were conducted on day 0 and day 14. Results: After 14 days of treatment, the P3 group has a significant decrease in MDA levels compared to day 0 (p = 0.042). Groups P1 and P2 have a significant increase in MDA levels (p = 0.043). MDA levels between groups were significantly different (p = 0.002) on day 14. Conclusion: Giving beetroot powder for 14 days with dose 3,12 g/kg/bw for 14 days significantly reduced MDA levels in hyperuricemia.
Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial Pasa, Chusairil; Pamungkasari, Eti P.; Doewes, Muchsin; Purwanto, Bambang; Hartono, Hartono; Cilmiaty, Risya; Dirgahayu, Paramasari
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1321

Abstract

Osteoporosis increases fracture risk and reduces quality of life in menopausal women. Although physical activity, such as walking and bone joint exercise, is known to help maintain bone health, its effectiveness needs further examination. The aim of this study was to analyze the effects of physical activity, in particular walking and bone joint exercise, on enhancing bone remodeling in menopausal women. A randomized controlled trial was conducted among menopausal women and allocated into three groups: walking, bone joint exercise, and control groups. The intervention was provided for eight weeks, with the outcomes measured before and after the intervention. The study assessed five bone remodeling biomarkers: estrogen, parathyroid hormone (PTH), receptor activator of nuclear factor kappa-β ligand (RANKL), tumor necrosis factor-alpha (TNF-α), and bone mineral density (BMD). The paired sample student t-test and ANOVA were used to assess the effects of the interventions. The results indicated that, compared to pre-intervention, both walking and bone joint exercise significantly increased the estrogen (p=0.026 and p=0.023, respectively), decreased RANKL (p=0.019 and p=0.002, respectively), decreased PTH levels (p=0.022 and p=0.048, respectively) and increased the BMD scores (p=0.001 and p<0.001, respectively). In the control group, none of the remodeling biomarkers significantly changed except the mean level of TNF-α, which was increased significantly (p=0.001). This study highlights that structured exercise, such as walking and bone joint exercise, can significantly enhance bone remodeling markers in menopausal women. Therefore, implementing such physical activities into management may provide benefits to menopausal women.
OLAHRAGA DAN KONSUMSI BUAH SEBAGAI NUTRISI MEDIS PADA PENYAKIT TIDAK MENULAR (PTM): Exercise and Fruit Consumption as Medical Nutrition for Non Communicable Diseases (NCDs) Wijayanti, Lilik; Haryati, Sri; Dirgahayu, Paramasari; Suparyanti, Endang Listyaningsih; Negara, Khesara Sastrin Prasita; Riyadi, Slamet; Supriyana, Dwi Surya; Ma'rufah, Siti; Setyawan, Sigit
JAMAS : Jurnal Abdi Masyarakat Vol. 3 No. 1 (2025)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/jms.v3i1.174

Abstract

Penyakit Tidak Menular (PTM) atau biasa juga disebut sebagai penyakit degeneratif  adalah merupakan jenis penyakit yang tidak bisa ditularkan oleh penderita ke orang lain, jenis penyakit ini berkembang secara perlahan dan terjadi dalam waktu yang panjang. Beberapa penyakit yang termasuk PTM adalah diabetes mellitus (DM) dan hipertensi. Kegiatan  ini  untuk menambah  pengetahuan tentang  olah raga dan  konsumsi buah sebagai nutrisi medis pada pasien PTM. Pengabdian kepada masyarakat (PkM) dilakukan terhadap 36 orang pasien yaitu  15 orang pasien DM dan 21 orang penderita hipertensi di kelompok prolanis K – Nisa. Pasien yang datang dilakukan pengukuran tekanan darah, penghitungan nadi latihan, penyuluhan tentang DM, hipertensi dan penghitungan nadi latihan, olah raga dan pengisian kuosioner sambil dilakukan focus group discussion. Hasil pengisian kuosiner sudah beberapa pengetahuan yang memberikan hasil yang baik dan beberapa yang masih memerlukan peningkatan. Pengetahuan yang sudah baik yaitu pengetahuan tentang olah raga, nadi latihan, komplikasi PTM, definisi tekanan darah tinggi, manfaat olah raga dan durasi waktu olah raga dan jumlah konsumsi buah. Pengetahuan yang masih perlu ditingkatkan adalah gejala awal penyakit DM dan hasil pemeriksaan gula darah pada pasien DM. Dari hasil kegiatan ini diperlukan adanya sosialisasi yang terus menerus kepada masyarakat tentang gejala awal penyakit DM dan perlunya pemeriksaan gula darah. Pengetahuan pasien PTM sudah baik tentang olah raga dan konsumsi buah sebagai nutrisi medis.
EFEKTIFITAS PEMBERIAN JUS LABU SIAM (Sechium edule) TERHADAP PROFIL LIPID TIKUS (Rattus novergicus) MODEL HIPERLIPIDEMIA Yanita Listianasari; Paramasari Dirgahayu; Brian Wasita; Adi Magna Patriadi Nuhriawangsa
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 40 No. 1 (2017)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v40i1.6046.

Abstract

Hyperlipidemia is a lipid profile (TC, TG, HDL, LDL) metabolism disorder becoming the leading cause of cardiovascular disease. Flavonoid, phenol, vitamin C contained in squash have strong cardioprotective effect but its optimal dose has not been known yet. The objective of this research was to analyze the effectiveness of squash juice administration with varying doses on the lipid profile of hyperlipidemia model-rat with High Fat Diet induced. This research was done in laboratory experimental research with pre and posttest control group design.The experimental animals were consisted of 36 rats and divided into negative control, positive control, treatment I (drug), treatment II, III, IV (squash juice dose 1 ml, 2 ml, 4 ml/ 100 g BW rat/day) with treatment for 38 days. The rat’s blood was taken before and after treatment for lipid profile. TC, HDL, LDL levels were measured using spectrophotometer Microlab 300 with CHOD-PAP. TG level was measured using Microlab 300 with GPO-PAP. Considering the statistic analysis, squash juice at doses 1 ml, 2 ml and 4 ml / 100 g BW rat/day, could reduce significantly (p < 0.05) TC, TG, LDL levels of rats. HDL level of rat could increase significantly (p < 0.05) with squash juice at dose 1 ml/100 g BW rat/day. There was no significant difference between the three doses of squash juice, so that squash juice at dose 1 ml/100 g BW rat/day is the best dose to reduce the lipid profile of hyperlipidemia model-rat. Hiperlipidemia merupakan gangguan metabolisme profil lipid (kolesterol total, trigliserida, HDL, LDL) yang menjadi penyebab utama timbulnya penyakit kardiovaskular. Flavonoid, fenol, vitamin C yang terkandung dalam buah labu siam mempunyai efek kardioprotektif yang kuat akan tetapi belum diketahui dosis optimal. Tujuan penelitian ini adalah untuk menganalisis efektifitas pemberian jus labu siam dengan variasi dosis terhadap profil lipid tikus model hiperlipidemia. Metode yang digunakan adalah eksperimental laboratorik dengan rancangan pre and posttest control group design. Sebanyak 36 tikus putih Strain Wistar jantan dibagi menjadi 6 kelompok dengan 6 ekor tiap kelompok, yaitu kontrol negatif, kontrol positif (diinduksi High Fat Diet), perlakuan 1 (diinduksi High Fat Diet dan obat), perlakuan 2, 3, 4 (diinduksi High Fat Diet dan jus labu siam) dosis 1 ml, 2 ml, 4 ml/100 g BB tikus/hari) dengan perlakuan selama 38 hari. Pengambilan darah tikus dilakukan sebelum dan sesudah perlakuan untuk analisis profil lipid. Kadar kolesterol total, HDL, LDL diukur menggunakan spektrofotometer Microlab 300 dengan metode CHOD-PAP. Kadar trigliserida diukur menggunakan spektrofotometer Microlab 300 dengan metode GPO-PAP. Data dianalisis menggunakan uji Paired T-Test dan menunjukkan jus labu siam ketiga dosis dapat menurunkan secara bermakna (p<0,05) kadar kolesterol total, trigliserida dan LDL tikus. Kadar HDL tikus dapat naik secara bermakna (p<0,05) dengan jus labu siam dosis 1 ml/100 g BB tikus/hari. Pemberian jus labu siam dosis 1 ml/100 g BB tikus/hari merupakan dosis yang paling efektif dalam menurunkan kadar kolesterol total, trigliserida dan LDL serta menaikkan kadar HDL.
Co-Authors Adi Magna Patriadi Nuhriawangsa Adi Prayitno Adi Prayitno Amandha Boy Timor Randita Annang Giri Moelyo Annang Giri Moelyo Antonius Christanto Aryanda Widya Tazkagani Salsabila Aulia Nadhiasari Bambang Purwanto Bambang Sukilarso Sakiman Betty Saptiwi Brian Wasita Brian Wasita Budiyanti Wiboworini Christanto, Antonius Dani Redhono Haryoputro Dewi Okta Anggraini Dhani Redhono, Dhani Dono Indarto Dwi Surya Supriyana Endang Listyaningsih Suparyanti Eti Poncorini Pamungkasari Fadila, F Hanifa, Shafira N. Hartono Hartono Ida Nurwati Ilyas, Muhana F. Irma Suryani Lilik Wijayanti Lukas, Graciella A. Ma'rufah, Siti Made Setiamika Mashuri, Yusuf Ari Muchsin Doewes Nabila Adib Sungkar Nabila Adib Sungkar Nanang Wiyono Negara, Khesara Sastrin Prasita Pamungkasari, Eti P. pasa, chusairil Pradipto Subiyantoro Putri, Mahendri Deayu Rachmi Fauziah Rahayu Rahma, Annisa A. Ratih Dewi Yudhani Ratih Puspita Febrinasari Risya Cilmiaty Risya Cilmiaty, AR Risya Cilmiaty, Risya Setiamika, Made Slamet Riyadi Soewondo, Widiastuti Sri Haryati Sundari, Isti Surya Dewi Primawati Sutartinah Tamaulina Br Sembiring Triniputri, Winastari Y. Umi Mahmudah Widia Susanti Wijayanto, Matthew A. Windayani, Komang Wulandari, Anggraini Yanita Listianasari Yudhani, Ratih Dewi