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All Journal JURNAL GIZI INDONESIA Nexus Kedokteran Klinik Nexus Biomedika The Indonesian Biomedical Journal Jurnal Gizi dan Kesehatan Ilmu Gizi Indonesia Indonesian Journal of Medicine Abdimas Universal Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings Narra J Sehat Rakyat: Jurnal Kesehatan Masyarakat Journal of International Conference Proceedings Biocaster : Jurnal Kajian Biologi JAMAS: Jurnal Abdi Masyarakat Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Paramasari Dirgahayu
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The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
Dual Extracts of Star Fruit Leaves and Toddalia accuelata Leaves as Antiobesity in Rats Sundari, Isti; Indarto, Dono; Dirgahayu, Paramasari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.601 KB) | DOI: 10.30604/jika.v7i1.787

Abstract

The imbalance between food intake and energy expenditure can lead to obesity. Obesity is a major risk factor for chronic diseases such as cardiovascular disease and can cause premature death worldwide. This study is aimed to investigate the effect of Star Fruit Leaves Extract (SLE) and T. accumulate Leaves Extract (TLE) combination on Body Weight (BW), Body Mass Index (BMI), and Fat Content (FC) of obese rats. Male Wistar rats aged 5 weeks, with BW of 100-150 g were induced with a High Fat Diet (HFD) and 10% fructose solution for 30 days. A total of 18 rats were randomly divided into 3 groups, namely Negative Control (NC), Therapy (T), and Normal (N). After 35 days of treatment compared to the NC group, the mean BW of the T group was significantly lower (p=0.014) and the mean decrease was significantly higher (p less than 0.001).  Similarly, the mean BMI and FC of the T group were significantly lower and the decrease in the mean of both groups was significantly higher than that of the NC group (p less than 0.001). Therefore, the combination of SLE and TLE can be used as a treatment for obesity because it reduces BW, BMI, and FC better than only a low-calorie diet.Abstrak: Ketidakseimbangan antara asupan makanan dan pengeluaran energi dapat menyebabkan obesitas. Obesitas merupakan faktor risiko utama terjadinya penyakit kronis seperti penyakit kardiovaskular dan dapat menyebabkan kematian dini di seluruh dunia. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi Ekstrak Daun Belimbing (EDB)dan Ekstrak Daun T. accuelata (EDT) terhadap Berat Badan (BB), Indeks Massa Tubuh (IMT), dan kandungan lemak tikus obesitas. Tikus wistar jantan umur 5 minggu, BB 100-150 g diinduksi dengan pakan tinggi lemak dan larutan fruktosa 10% selama 30 hari. Sebanyak 18 ekor tikus dibagi secara acak menjadi 3 kelompok yaitu Kontrol Negatif (KN), Terapi (T), dan Normal (N). Setelah 35 hari perlakuan dibandingkan dengan kelompok KN, rata-rata BB kelompok T secara signifikan lebih rendah (p=0,014) dan rata-rata penurunannya lebih besar secara signifikan (p kurang dari 0,001). Demikian pula, rata-rata IMT dan kandungan lemak kelompok T secara signifikan lebih rendah dan penurunan rata-rata kedua kelompok tersebut secara signifikan lebih besar dibandingkan dengan kelompok KN (p kurang dari 0,001). Oleh karena itu, kombinasi EDB dan EDT dapat digunakan sebagai pengobatan obesitas karena dapat menurunkan BB, IMT, dan kandungan lemak lebih baik daripada diet rendah kalori saja.
Combination of Metformin and Magnesium Citrate Reduces TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 Expressions in Diabetic Model Rats Rahayu, Rachmi Fauziah; Prayitno, Adi; Purwanto, Bambang; Soewondo, Widiastuti; Nurwati, Ida; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3360

Abstract

BACKGROUND: Diabetes, which causes various complications, involves pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B p65 (NF-κB p65), interleukin-6 (IL-6), cluster of differentiation 4 (CD4), and matrix metalloproteinase-9 (MMP-9). Magnesium has demonstrated anti-diabetic properties, but its anti-inflammatory effects in preventing cardiovascular complications remain unclear. This study aimed to evaluate the anti-inflammatory effects of magnesium citrate, alone and in combination with metformin, by measuring TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 expression in diabetic model rats.METHODS: Thirty male Wistar rats were divided into five groups: normal control, diabetes control, metformin (treated with 9 mg/200 g/day metformin), magnesium citrate (treated with 3.6 mg/200 g/day magnesium citrate), and combination therapy (treated with 4.5 mg/200 g/day metformin + 1.8 mg/200 g/day magnesium citrate). Diabetes was induced in all groups except the normal control group using streptozotocin (STZ) and nicotinamide (NA). TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 expression levels were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: Significant differences in TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 expression levels were observed across all groups (p<0.001). The combination therapy group demonstrated the most significant reduction in all parameters compared to the diabetic control group (p<0.001) and other therapy groups. Both metformin and magnesium citrate monotherapies showed moderate reductions in cytokine levels but were less effective than combination therapy.CONCLUSION: Combination therapy with metformin and magnesium citrate exhibited the most potent anti-inflammatory effects, significantly reducing TNF-α, NF-κB p65, IL-6, CD4, and MMP-9 expressions in diabetic Wistar rats. This combination has potential as a therapeutic approach for managing diabetes and its complications.KEYWORDS: diabetes mellitus, inflammation, cytokines, metformin, magnesium citrate
ANALYSIS BIOACTIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXTRACT BEKUL FRUIT (Ziziphus jujuba Mill.) AS A POTENTIAL NUTRACEUTICAL Windayani, Komang; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 1 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i1.2350

Abstract

Pemanfaatan bahan alami sebagai terapi diet atau nutrisi dalam mengobati atau mencegah suatu penyakit berkembang sangat pesat. Salah satu bahan alami yang memiliki potensi sebagai agen nutraceutical adalah buah bekul Bali (Ziziphus jujuba Mill.). Saat ini belum banyak bukti empiris terkait potensi nutraceutical yang terdapat pada buah bekul (Ziziphus jujuba Mill.) varietas Bali. Penelitian ini bertujuan untuk mengetahui kandungan senyawa bioaktif dan aktivitas antioksidan yang terdapat dalam ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali. Metode yang digunakan pada penelitian ini yaitu eksploratorik desain dengan sampel menggunakan buah bekul Bali (Ziziphus jujuba Mill.). Penelitian ini dilaksanakan di Laboratorium Penelitian dan Pengujian Terpadu (LPPT) Universitas Gajah Mada pada bulan April 2024. Proses ekstrasi menggunakan metode maserasi dan uji aktivitas antioksidan dilakukan dengan metode DPPH. Penentuan kadar total flavonoid, fenolik dan saponin menggunakan metode spektrofotometer UV-Vis, sedangkan penentuan kadar quercetin menggunakan metode HPLC. Hasil uji aktivitas antioksidan berdasarkan nilai IC50 tergolong kuat yaitu sebesar 78,57%, kandungan senyawa total flavonoid (114,85 mg QE/g), quercetin (60,00 µg/g), fenolik (109,34 mg GAE/g) dan saponin (9,90 mg/g). Dapat disimpulkan bahwa ekstrak etanol buah bekul (Ziziphus jujuba Mill.) varietas Bali diketahui memiliki kandungan senyawa bioaktif yaitu fenolik, flavonoid dan turunannya seperti quercetin, dan saponin serta memiliki aktivitas antioksidan tergolong kuat yang dapat dimanfaatkan sebagai agen nutraceutical.
Systematic Review: Peran Sel, Jaringan, dan Kolagen dalam Penyembuhan Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 4 No. 4 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v4i4.5771

Abstract

Tympanic membrane perforation is a significant clinical concern that can lead to hearing impairment and recurrent ear infections. This study aims to review the roles of Interleukin-1 beta (IL-1β), Fibroblast Growth Factor (FGF), fibroblasts, keratinocytes, granulation tissue, and collagen density during the wound-healing phases of the tympanic membrane.A Systematic Journal Review was conducted by analyzing studies retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar databases published between 2020 and 2025. Of the 400 records screened,, 10 studies met the inclusion criteria. The findings revealed that IL-1β plays a key role in the inflammatory phase by modulating immune responses and recruiting healing cells. FGF stimulates fibroblast and keratinocyte proliferation, which are essential for extracellular matrix (ECM) remodeling and re-epithelialization. Moreover, granulation tissue formation and collagen deposition are critical determinants of structural integrity and healing quality. Overall, tympanic membrane repair requires synergistic interactions among molecular mediators, cellular components, and biomaterial support to optimize tissue regeneration. These findings provide a scientific basis for developing more effective regenerative and tissue-engineering strategies for middle ear therapy.
Co-Authors Adi Magna Patriadi Nuhriawangsa Adi Prayitno Adi Prayitno Amandha Boy Timor Randita Annang Giri Moelyo Annang Giri Moelyo Antonius Christanto Aryanda Widya Tazkagani Salsabila Aulia Nadhiasari Bambang Purwanto Bambang Sukilarso Sakiman Betty Saptiwi Brian Wasita Brian Wasita Budiyanti Wiboworini Christanto, Antonius Dani Redhono Haryoputro Dewi Okta Anggraini Dhani Redhono, Dhani Dono Indarto Dwi Surya Supriyana Endang Listyaningsih Suparyanti Eti Poncorini Pamungkasari Fadila, F Hanifa, Shafira N. Hartono Hartono Ida Nurwati Ilyas, Muhana F. Irma Suryani Lilik Wijayanti Lukas, Graciella A. Ma'rufah, Siti Made Setiamika Mashuri, Yusuf Ari Muchsin Doewes Nabila Adib Sungkar Nabila Adib Sungkar Nanang Wiyono Negara, Khesara Sastrin Prasita Pamungkasari, Eti P. pasa, chusairil Pradipto Subiyantoro Putri, Mahendri Deayu Rachmi Fauziah Rahayu Rahma, Annisa A. Ratih Dewi Yudhani Ratih Puspita Febrinasari Risya Cilmiaty Risya Cilmiaty, AR Risya Cilmiaty, Risya Setiamika, Made Slamet Riyadi Soewondo, Widiastuti Sri Haryati Sundari, Isti Surya Dewi Primawati Sutartinah Tamaulina Br Sembiring Triniputri, Winastari Y. Umi Mahmudah Widia Susanti Wijayanto, Matthew A. Windayani, Komang Wulandari, Anggraini Yanita Listianasari Yudhani, Ratih Dewi