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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Of Nursing Practice Jurnal Surya Masyarakat Jurnal Kesehatan Islam : Islamic Health Journal Medical Technology and Public Health Journal Medical and Health Science Journal Community Development Journal Biomolecular and Health Science Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang REMIK : Riset dan E-Jurnal Manajemen Informatika Komputer Community Development Journal: Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat Indonesia Berdaya Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat International Islamic Medical Journal Jurnal Kesehatan Tambusai Prominentia Medical Journal Journal for Quality in Public Health
Salim, Hotimah Masdan
Universitas Nahdlatul Ulama Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medical and Health Science Journal

 1 
REVIEW ARTICLE: AMEBIASIS MOLECULAR PATHOGENESIS DEVELOPMENT Muliani, Nurlina; Salim, Hotimah Masdan
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1195

Abstract

Amebiasis is one of the gastrointestinal tract infection disease caused by Entamoeba histolytica ,a parasitic protozoan. Amebiasis is the second disease, caused by parasite, that leading cause of death after malaria. Infection occurs through faecal-oral route and after ingestion a contaminated food and beverages by human faeces. The pathogenesis of E. histolytica can be classified into 3 processes, i.e: death of host cell, inflammation, and parasitic invasion. The recent years, a molecularly amebiasis pathogenesis has been developed, i.e: adherence, phagocytosis, tropogocytosis of host cell and how the parasites can survive and attack host cells so it can cause an infection in humans. Molecular development is an important thing to be considered in the selection of amebiasis therapy.
REVIEW ARTICLE: AMEBIASIS MOLECULAR PATHOGENESIS DEVELOPMENT Muliani, Nurlina; Salim, Hotimah Masdan
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1195

Abstract

Amebiasis is one of the gastrointestinal tract infection disease caused by Entamoeba histolytica ,a parasitic protozoan. Amebiasis is the second disease, caused by parasite, that leading cause of death after malaria. Infection occurs through faecal-oral route and after ingestion a contaminated food and beverages by human faeces. The pathogenesis of E. histolytica can be classified into 3 processes, i.e: death of host cell, inflammation, and parasitic invasion. The recent years, a molecularly amebiasis pathogenesis has been developed, i.e: adherence, phagocytosis, tropogocytosis of host cell and how the parasites can survive and attack host cells so it can cause an infection in humans. Molecular development is an important thing to be considered in the selection of amebiasis therapy.
NEUROPROTECTIVE ACTIVITY OF EXTRACT OF CELERY (APIUM GRAVEOLENS) IN INSILICO STUDY Mahendra, Reza; Rofik, Ainul; Salim, Hotimah Masdan; Ulfa, Maria; Awwaliyah, Evy Silvia
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 2 (2021): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i2.2362

Abstract

Backround: Celery (Apium graveolens L., Apiaceae) is one of the medicinal plants with secondary metabolite components that have pharmacological effects such as vitamin (choline) content. This study aims to evaluate the mechanism and interaction of choline contained in celery on its effectiveness as a neuroprotective. Methods: This research is an experimental research using the in silico study. Results: The insilico search found that the choline content in celery binds to Slc5a7, Chat and Ache. Which has a function in the process of neurotransmitter biosynthesis, neurotransmitter metabolic processes and neurotransmitter secretion processes Conclusion: The celery (Apium graveolens L., Apiaceae)  have pharmacological activity as neuroprotective through the interaction of Slc5a7, Chat and Ache
Antidepressant Effects of Mitragyna Speciosa Korth Extract on Diabetic Rats Putra, Reza Hery Mahendra; Awwaliyah, Evi Sylvia; Salim, Hotimah Masdan; Alam, Ilham Putera; Rofiq, Ainul
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.5919

Abstract

Background: Diabetes mellitus is most common associated with neurological complications, including depressive symptoms, so this study investigated whether mitragyna may provide benefits in reducing depressive symptoms in animal models of diabetes. This study aims to evaluate the effect of mitragyna as a potential antidepressant agent in animal models of diabetes mellitus using the Force Swimming Test (FST). Methods: In this study, diabetes mellitus rats were induced by administering streptozotocin and then divided into four groups: control group (Control), Group Diabetes (DM), Mitragyna treatment group (DM+EMS 15mg) and (DM+EMS 30mg). After the treatment period, the rats were then tested with the FST, which is used to measure immobility behavior which can be used as an indicator of depressive symptoms. Results: The results showed that the treatment group that received mitragyna showed shorter immobility times compared to the control group (P<0.01), indicating an increased active response in facing FST stressors. Conclusion: These results indicate that mitragyna has potential as an antidepressant agent in reducing depressive symptoms in rats models of diabetes mellitus.
Atypical Presentation of Multiple Myeloma: From Heart Failure to Multiple Myeloma Sohaimi, Ainur Elliana; Jamhuri, Nur Syazwani; Ibrahim, Ismail; Salim, Hotimah Masdan
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.6068

Abstract

Multiple myeloma (MM) is a hematological malignancy commonly associated with bone pain, hypercalcemia, and renal failure. However, its presentation can occasionally mimic other medical conditions, which may delay diagnosis. This case report describes a patient who was initially diagnosed and treated for heart failure but was later found to have MM, highlighting the importance of considering MM in the differential diagnosis of heart failure. A 56-year-old lady presented with recurrent episodes of shortness of breath, orthopnea, paroxysmal nocturnal dypsnea and bilateral lower limb swelling which she had been treated for decompensated heart failure with optimal therapy. She denied any family history of cardiovascular disease personal history of underlying medical condition and was a nonsmoker. This patient was diagnosed with multiple myeloma and probability of concomitant cardiac amyloidosis and commenced on bortezomib, thalidomide and dexamethasone (VTD) regime and standard optimal therapy of heart failure but her condition deteriorated. After a few days of starting chemotherapy, patient demised despite all the resuscitative effort. Multiple myeloma is common hematological malignancy with its distinct clinical features of “CRAB”, however, more attention and alertness should also be exercised by clinicians as to be able to diagnose it early.
The Role Of Mitragyna speciosa (Korth) As An Anti-Inflammatory Agent In Wound Healing In Living Cells Ferdinan Hanafi, Eka Satria Akbar; Pramesti, Rosandhy Alfiyah; Jazuli, Muhammad Aqil Siroj; Rihhadatulays, Khuzaimah Nur Juhanifah; Salim, Hotimah Masdan; Savitri, Ardyarini Dyah
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 1 (2025): FEBRUARY : Fragmentation In Modern Healthcare Approaches Amid Rising Chronic And
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i1.7994

Abstract

Background: Wound is a condition in which the integrity of body tissue is disrupted, leading to the activation of a complex biological process known as wound healing. This process aims to restore the protective skin barrier, prevent infection, and minimize fluid loss. It involves sequential phases of hemostasis, inflammation, proliferation, and remodeling. While inflammation is essential for initiating repair, prolonged or excessive inflammation may delay the healing process. Mitragyna speciosa (Korth) is a medicinal plant traditionally used in various cultures and has been reported to exhibit multiple pharmacological properties, including anti-inflammatory, antioxidant, antibacterial, analgesic, and wound-healing activities. Methods: The present systematic review was conducted to identify and synthesize scientific evidence regarding the potential of Mitragyna speciosa extract as a therapeutic agent in wound healing through anti-inflammatory and other biological pathways. Literature searches were performed in ScienceDirect, PubMed, MDPI, DOAJ, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results :A total of 1,176 studies were screened, and five experimental studies fulfilled the inclusion criteria. The findings consistently demonstrated that Mitragyna speciosa extract suppressed pro-inflammatory mediators such as nitric oxide, reactive oxygen species, tumor necrosis factor-alpha, interleukin-6, and enzymatic pathways including cyclooxygenase-2 and 5-lipoxygenase. In addition, the extract stimulated cell migration, endothelial migration, and angiogenesis, thereby supporting tissue regeneration. Toxicity profiles suggest that the extract is safe at effective concentrations, although responses remain dose-dependent. Conclusions: Overall, Mitragyna speciosa shows promise as a plant-based therapeutic option for wound healing. Nevertheless, current evidence is limited and largely derived from in vitro studies, indicating the need for more extensive in vivo and clinical investigations.
Effects of Kratom (Mitragyna speciosa) Hydrogel Application on Pancreatic Histopathology in Type 2 Diabetic Mice Muhammad Aqil Siroj Jazuli; Ismail, Zainul Hadi Wildan; Rihhadatulays, Khuzaimah Nur Juhanifah; Hanafi, Eka Satria Akbar Ferdinan; Jinan, Puspita Rahmatul; Pramesti, Rosandhy Alifyah; Salim, Hotimah Masdan; Bintarti, Tri Wahyuni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8018

Abstract

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by elevated blood glucose caused by insulin resistance and impaired insulin production by pancreatic β-cells due to oxidative stress. Kratom (Mitragyna speciosa) has been widely investigated for its antidiabetic, anti-inflammatory, and antioxidant effects, attributed to its alkaloid, flavonoid, phenolic, and saponin contents. This study aimed to evaluate the potential of topical kratom hydrogel as an innovative approach to improving pancreatic histology in type 2 diabetic mice, which has not been previously reported. Methods: Fifteen mice were divided into three groups: untreated diabetic group (DM), diabetic group treated with 5% kratom hydrogel (K5), and diabetic group treated with 15% kratom hydrogel (K15). Treatments were administered for two weeks. Parameters assessed included the percentage of healthy β-cells and acinar cells, as well as histological scoring of islet damage. Data were analyzed using parametric or non-parametric tests according to the normality distribution of each parameter. Results: Administration of 5% kratom hydrogel significantly increased the percentage of healthy β-cells (p<0.05) compared with 15% kratom hydrogel, which unexpectedly showed a lower proportion of healthy cells than the untreated group. Interestingly, the higher dose appeared to exert more toxic effects, whereas the lower dose provided better protective effects. No significant differences were observed in acinar cell parameters or islet damage scores, possibly due to the limited sample size. Conclusion: These findings provide preliminary evidence supporting the systemic therapeutic potential of topical kratom hydrogel, particularly in determining the effective dose and the need for larger sample sizes to obtain more consistent outcomes.
Co-Authors A., Ratna Ariesta Dwi Abdul Muhith Achmad Hilman Fahmy Aditya Bhayusakti Adyan Donastin Afiyah, R. Khairiyatul Aisyah Aisyah Aji, Audi Ikhfina Tanra Akas Yekti Pulih Asih Alam, Ilham Putera Alam, Ilham Putra Algristian, Hafid Andi Roesbiantoro Andreas Putro Ragil Santoso, Andreas Putro Ragil Anggraini, Yasi Ardianti, Ami Awwaliya, Evi Awwaliyah, Evi Sylvia Awwaliyah, Evy Silvia Bagas Setiawan Ihsan Zaini Bagas Setiawan Ihsan Zaini Bariyah, Khadijah Khairul Bermawi, Bastiana Bintarti, Tri Wahyuni Bintarti, Tri Wahyuni Choiriya, Dian Dakwatul Choirotussanijah Choirotussanijah Choirotussanijjah Danny Irawan David Sajid Muhammad Dayu Satriya Wibawa Deny Febriwijaya Romadhani Desi Irawati, Adinda Devyana Dyah Wulandari Dwi Arman Prasetya Dwimantoro EBISINTEI, PRECIOUS Edza Aria Wikurendra Endah Budi Permana Putri Erfina Miftakhul Zannah Evi Octavia Djamaludin Faraadies, Rangga Azhaar Fariska Zata Amani Fatmawati, Ulik Ferdinan Hanafi, Eka Satria Akbar Fifi Khoirul Fitriyah Garfansa, Marchel Putra Hanafi, Eka Satria Akbar Ferdinan Handayani Handayani Handayani, Nanik HAQUE, ZAMIRAH MABARROH EL Ika Mardiyanti Ilham Putera Alam Ilham Putra Alam Ima Kurniastuti Ismail Ibrahim Ismail, Zainul Hadi Wildan ISWAHYUDI ISWAHYUDI Iswahyudi Iswahyudi Izki Masyaqqoni Pujiana Jamhuri, Nur Syazwani Jazuli, Muhammad Aqil Siroj Jessica Puspa Kencana Jinan, Puspita Rahmatul Karina Dwiyanti Kencana, Jessica Puspa Lea Maera Shanty Lintan Farizqi Kurnia Lysa Veterini Machmudah, Machmudah Maria Ulfa Marinda Dwi Puspitarini Marselli Widya Lestari Michio Shimabukuro Muhammad Aqil Siroj Jazuli Muhammad, Akbar Reza Muhammad, David Sajid Muhammada, Davida Sajid Mukhtar Adi Nugroho Muliani, Nurlina Mulyadi Mulyadi Nadia Nisaussholihah Nahdatien, Ima Nanda Fadhilah Witris Salamy Nanik Handayani Nisaussholihah, Nadia Novera Herdiani, Novera Nur Azizah AS Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Puspitasari, Mia Puspitasari, Renny Novi Putra, Reza Hery Mahendra R.A. Hani Faradis Ratna Ariesta Dwi Andriani Reza Mahendra Rihhadatulays, Khuzaimah Nur Juhanifah Rofik, Ainul rofiq, ainul Romadhani, Deny Febriwijaya Rosda Rodhiyana Savitri, Ardyarini Dyah Siti Nur Hasina Siti Robi’atus Sholiha Sohaimi, Ainur Elliana Sonny Edbert Syafiuddin, Achmad Tri Deviasari Wulan Tri Wahyu Bintarti Ubaidillah Zuhdi Widya Dio Kharisma Wiratama, Rahardyan Dika Yanti, Alfiyah Indah Yasi Anggraini Yenni Arista Cipta Ekalaturrahmah Yuani Setiwati Zannah, Erfina Miftakhul