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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Cendekia Journal of Pharmacy Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Inovasi Farmasi Indonesia Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal farmasi UIN Alauddin Makassar Jurnal Ilmiah Medicamento Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Pengabdian Masyarakat (ABDIRA) Sasambo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Empiris Jurnal Pengabdian Pada Masyarakat (EJPPM) Jurnal Pelayanan dan Pengabdian Kesehatan untuk Masyarakat Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Farmasi dan Sains Jurnal Sains dan Kesehatan Journal of Pharmascience
Okta Muthia Sari
Program Studi Farmasi, FMIPA, Universitas Lambung Mangkurat
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Uji Aktivitas Antidiabetes Ekstrak Etanol 96% Daun Bungur (Lagerstroemia speciosa) Secara In Vivo Ega Rezkyan Khalid; Aditya Maulana Perdana Putra; Dita Ayulia Dwi Sandi; Nabila Hadiah Akbar; Khoirunnisa Muslimawati; Okta Muthia Sari
Journal of Pharmascience Vol. 12 No. 1 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.21737

Abstract

Diabetes Melitus (DM) telah menjadi permasalahan global dan termasuk ke dalam penyakit yang paling umum di dunia. Pengobatan menggunakan herbal merupakan salah satu solusi untuk mengatasi diabetes dan tumbuhan bungur (Lagerstroemia speciosa) merupakan herbal yang dapat mengatasi hal tersebut. Penelitian ini bertujuan untuk mengidentifikasi adanya aktivitas antidiabetes dan menentukan dosis yang memiliki efek antidiabetes terbesar pada ekstrak etanol 96% L. speciosa secara in vivo menggunakan metode Tes Toleransi Glukosa Oral (TTGO). Mencit diambil darahnya pada menit ke-0 dan diberikan larutan uji sesuai kelompoknya, yaitu kontrol negatif (Na-CMC), kontrol positif (metformin), dan kelompok dosis terpilih (75 mg/kgBB, 100 mg/kgBB, dan 125 mg/kgBB). Setelah 30 menit, diberikan larutan dekstrosa dan diambil darah mencit untuk diuji menggunakan pada menit ke-10, 20, 30, 45, 60, 90, dan 120 setelah pemberian dekstrosa. Hasil menunjukkan penurunan glukosa darah pada menit ke-20-30 pada seluruh kelompok perlakuan ekstrak dan kontrol positif, dimana kelompok dosis 125 mg/kgBB ekstrak L. Speciosa (159 ± 35,46) menghasilkan penurunan kadar glukosa yang tidak jauh berbeda dengan penurunan yang terjadi pada kelompok metformin (150,4 ± 46,42). Hasil uji statistik menunjukkan bahwa kadar glukosa darah kelompok perlakuan pada menit ke-30 terdapat perbedaan bermakna dengan kontrol negatif (Sig. <0,05) dan tidak berbeda bermakna dengan kontrol positif (Sig. ≥0,05). Kesimpulan penelitian ini adalah Hasil uji Tes Toleransi Glukosa Oral (TTGO) menunjukkan adanya aktivitas antidiabetes oleh ekstrak etanol 96% daun L. speciosa yang ditandai dengan adanya penurunan kadar glukosa darah pada mencit, efek antidiabetes terbesar pada ekstrak etanol 96% daun L. speciosa dengan dosis 125 mg/kgBB.
In Silico Evaluation of Kaempferol, Gallic Acid, and Stigmasterol from Lagerstroemia speciosa as Multi-Target Antidiabetic Agents: Molecular Docking and Dynamics Simulation Study Aditya Maulana Perdana Putra; Catherina Adeline Kurniawan; Anna Khumaira Sari; Nabila Hadiah Akbar; Khoirunnisa Muslimawati; Okta Muthia Sari; Dita Ayulia Dwi Sandi; Normaidah Normaidah; Putri Helena Junjung Buih; Ariranur Haniffadli
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.9720

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that leads to severe complications and continues to increase in prevalence worldwide. Although Lagerstroemia speciosa is a well-recognized antidiabetic medicinal plant, most in silico studies have focused exclusively on its major constituent, leaving the antidiabetic potential of its other phytochemicals largely unexplored. This study investigated the multi-target antidiabetic potential of phytochemicals derived from L. speciosa leaves using an in silico approach targeting three key enzymes: aldose reductase, glucokinase, and glycogen synthase kinase 3-beta (GSK3-β). A total of 62 compounds were screened by molecular docking with AutoDock Vina, followed by toxicity predictions using ProTox-II and ToxTree. The top ligand for each target, kaempferol (aldose reductase), gallic acid (glucokinase), and stigmasterol (GSK3-β), was selected for further evaluation through molecular dynamics simulations using GROMACS 2016.3 for 100 ns. Structural and interaction stability were assessed through RMSD, RMSF, SASA, Rg, and RDF analyses. Binding free energies were calculated using the MM/PBSA method via g_mmpbsa. The results indicated that stigmasterol exhibited the most favorable MM/PBSA binding free energy (–133.377 kJ/mol), followed by kaempferol (–65.714 kJ/mol) and gallic acid (–45.629 kJ/mol). However, this favorable energy was dominated by nonspecific van der Waals contributions, consistent with the diffuse interaction patterns and low hydrogen-bond occupancy (4.24%) for stigmasterol. Kaempferol exhibited the highest hydrogen-bond occupancy (64.38%), indicating a stable, consistent interaction with its target enzyme. Rg and RDF analyses confirmed the compactness and specific atomic interactions of the kaempferol and gallic acid complexes.
Optimalisasi Pengabdian Kepada Masyarakat di wilayah Banjarbaru sebagai Upaya Meningkatkan Kesadaran Deteksi Dini Penyakit Okta Muthia Sari; Putri Helena Junjung Buih; Nanda Hesti Rahmawati; Siti Najwa; Firdarima Salsabila; Indah Maharati Zoan; Luthfia Azzahra; Syahrul Yaiis Abdul Rahman
Empiris Jurnal Pengabdian Pada Masyarakat Vol. 4 No. 1 (2026): April 2026
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Ichsan Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59713/9q2xbv25

Abstract

Low public awareness regarding routine health monitoring remains one of the major contributing factors to the increasing prevalence of non-communicable diseases such as hypertension, diabetes, and metabolic disorders. This condition is evident among the community of Gunung Ulin Village and the Sunday Morning Paguyaga Mitra Praja area in Banjarbaru, where most individuals are informal workers, vendors, and visitors with limited time and access to health services. This community service program aimed to improve health awareness and understanding through free health screening including blood pressure, blood glucose, uric acid, and cholesterol accompanied by consultation and education regarding the interpretation of results. The program was conducted on May 18 and 28, 2025, involving lecturers and students as facilitators. A total of 84 participants took part in the activity, with findings showing that most participants had elevated blood pressure, while the results for glucose, uric acid, and cholesterol varied according to individual health histories. The educational component increased participants’ understanding of their health status and encouraged preventive actions. Overall, the program was effective in enhancing health literacy, early detection awareness, and healthy behavior within the community. Future programs are expected to be conducted in more conducive locations to optimize service quality and participant comfort.
Co-Authors Achyadi, Ryan Aditya Maulana P.P Aditya Maulana P.P Aditya Maulana Perdana Putra AHMAD RIDUAN Akbar, Nabila Hadiah Andini, Rizka Syawal Anggi Fridewini Anggi Fridewini Anna Khumaira Sari Apriyanti, Anna Ariranur Haniffadli Arnida Arnida Arnida Arnida Aulia Rahmah Ayulia Dwi Sandi, Dita Azizah, Marshanda Wan Buih, Putri Helena Junjung Catherina Adeline Kurniawan Dahlia, Norita Dania, Sri Rahmah Deni Setiawan DENI SETIAWAN Desy Fitriyana Nabila Putri Diah Aulia Rosanti Difa Intannia Dinna Fitria Kumala Dwi Aulina Ega Rezkyan Khalid Ester Novella br Tobing Fery Ramadhan Feteriyani, Rina Fikriyati, Nirmala Firdarima Salsabila Fitria Handayani Fitrian Desmana Hafizah, Noor Hakim, Ade Syarif Hamida Syaputri, Kharin Hastuti Hastuti Hayatun Izma Helsawati Helsawati Helsawati Henni Selvina Herningtyas Nautika Lingga Indah Maharati Zoan Indah Pebriani Putri Izma, Hayatun Jenah, Rina Astiyani Khairunnida Khairunnida Khalid, Ega Rezkyan Khalifah, Sefa Nur Khoerul Anwar Khoirunnisa Muslimawati Khoirunnisa Muslimawati Kurniasari, Winda Tri Luthfia Azzahra Madani, Al Mahendra, Rachul Ridho Maryani, Henny Muhammad Andin Muhammad Ikhwan Rizki Muhammad Ridho Maulana Muhammad Syihab Setia Budi Mulia, Radha Eka Muliani, Putri Sari Nadya Rahmi Nadya Rahmi Nahdha Nahdha Nahdha Nahdiya Rahmah Nanda Hesti Rahmawati Nani Kartinah Nani Kartinah Nashrul Wathan Noor Cahaya Noor Hafizah Noor Hafizah Noor Rizkiyah Normaidah, Normaidah Nurul Huda Nurul Mardiati Nurul Mardiati Nurul Savira Fahira P.P, Aditya Maulana Pratiwi, Desy Pretty Wulan Sari Putra, Aditya Maulana Perdana Putri Nur Azizah, Putri Nur Putri, Indah Pebriani Rachul Ridho Mahendra Rahmatillah, Mustafa Rahmatullah, Satrio Wibowo Rama Agni Gutawa Ramadhan, Fery Rina Astiyani Jenah Rina Astiyani Jenah Risye Hendry Rollah Muhammad Arasy Hasan Rosanti, Diah Aulia Salsabila Salsabila, Risma Zahra Salwa, Helmina Samsul Hadi Sandra Putri Wijaya Santoso, Trias Budi Saragih, Triando Hamonangan Sari, Risa Purnama Sari, Sindwi Rinanda Sari, Sri Oktaviani Setiawan, Muhammad Irwan Sindwi Rinanda Sari Siti Najwa Siti Urbayatun Sofia Sofia, Sofia Sri Oktaviana Sari Syahrul Yaiis Abdul Rahman Syaputri, Kharin Hamida Tira, Khairunisa Tjitradi, Sukhito Yohanes Trias Budi Santoso Triastanti, Aulia Rahmah Yusrine Wasiaturrahmah Yusrinie Wasiaturrahmah Zahra, Dina Fadhila Zukhruf Saputri