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All Journal E-JUPEKhu Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) E-Dimas: Jurnal Pengabdian kepada Masyarakat AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal ABDINUS : Jurnal Pengabdian Nusantara JATI (Jurnal Mahasiswa Teknik Informatika) BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Farmasi dan Herbal Jurnal Cahaya Mandalika UNES Journal of Swara Justisia Jurnal Pengabdian Masyarakat (ABDIRA) Jurnal PkM (Pengabdian kepada Masyarakat) J-KIP (Jurnal Keguruan dan Ilmu Pendidikan) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Pendidikan Indonesia (Japendi) Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Pharmacy and Natural Product Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia JITAA : Journal Of International Taxation, Accounting And Auditing Jurnal Pengabdian Kepada Masyarakat Bangun Cipta, Rasa, & Karsa (Jurnal PKM BATASA) Jurnal Pengabdian Farmasi dan Sains Jurnal Ilmiah Kesehatan Journal of Community Development and Empowerment Kajian Ilmiah Mahasiswa Administrasi Publik (KIMAP)
Nining, Nining
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
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Journal : JURNAL FARMASIMED (JFM)

 1 
KINETICS OF PIROXICAM RELEASE THROUGH IONTOPHORESIS AT VARIOUS PHS FROM POLYELECTROLYTE HYDROGELS WITH SODIUM ALGINATE-TRAGACANTH GUM POLYMER Nining, Nining; Fith Khaira Nursal; Abu Rijal Algifari
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1904

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used to treat symptoms of osteoarthritis and rheumatoid arthritis. This drug can irritate the stomach as a side effect of oral administration. One strategy to overcome these side effects is transdermal delivery in polyelectrolyte hydrogel with iontophoresis. This research aims to study the pH-varying effect of polyelectrolyte hydrogel on piroxicam release from hydrogel via iontophoresis using a Franz diffusion cell. The formulation was made with pH variations, namely 4.2 (F1), 5.5 (F2), 6.4 (F3), and 7.4 (F4). Evaluations include organoleptics, pH, homogeneity, spreadability, viscosity, flow properties, conductivity, and diffusion tests. The polyelectrolyte hydrogel obtained was yellow and homogeneous with a pH variation of 4.2 ± 0.02 to 7.42±0.02, spreadability of 4.22±0.21 cm to 4.35±0.28 cm, viscosity 47,378 cps to 59,297 cps; flow properties include thixotropic plasticity; and conductivity 8.01±0.78 ms/cm to 9.58±1.00 ms/cm. Moreover, piroxicam was released from the hydrogel assisted by DC-type iontophoresis with flux values of 634.52 ?g/cm2 (F1), 427.91 ?g/cm2 (F2), 205.76 ?g/cm2 (F3), and 253.56 ?g/cm2 (F4). Statistical analysis showed that decreasing pH had a significant effect (sig<0.05) on increasing piroxicam release from hydrogel based on flux value. The release kinetic behavior of all formulas (F1-F4) does not show the same type of kinetic model based on the correlation coefficient value approach, which is closest to 1. Keywords: Diffusion, flux, drug release, release kinetics.
Co-Authors Abu Rijal Algifari Agustin Yumita Andriani, Kris Andriyani, Agnes Aga Anisa Amalia anisa amalia Ari Sartinah, Ari Ari Widayanti Armadany, Fery Indradewi Aulia, Rizma Benita, Clara Budi Setiawati Dania Athaya Putri Devi Puspita Sari Dinaianti, Adelia Ema Dewanti Etin Diah Permanasari Euis Erlin Fadillah Sabri Fith Khaira Nursal Fitria Nugrahaeni Fujianti Fujianti Gantini, Sri Nevi Hadi Sunaryo Hamsiati, Hamsiati Hapsari, Fadjriah Hariyanti Hariyanti hasbi, andi Ilmiyati, Nur Inding Gusmayadi Khaira Nursal, Fith Kori Yati Larasati, Kinanti Dara Laszairina, Andra Yunita MAHMUDAH, RIFA'ATUL Maspupah, Meti Mega Iswari Mone, Ansyari Naniek Setiadji Radjab Nugrahaeni, Fitria Palensia, Fadhilah Poppy Mutiara Indah Pramulani Mulya Lestari Pramulani Mulya Lestari Putri Nabila Zulvianti Putri, Dania Athaya Putri, Riska Damayanti Rahmatullah, Rizki Ridwan Zamzany, Faizal Rismawati Rismawati Ristianti Azharita Riyanto, Raditya Naufal Romansyah, Febri Romdiyah Romdiyah, Romdiyah Saleh Wikarsa Saleh Wikarsa, Saleh Sawitri, Feny Eka Seowandhi, Sundani Nurono Septia Handayani, Lidra Setiani, Fibrinika Tuta Sirewati, Sirewati Siska Elvandari Solihah, Solihah Sri Hartati Sri Nevi Gantini Sundani Nurono Seowandhi Supandi Supandi Tahyatul Bariroh Tyarini, Indrawati Aris Widati, Endah Winda Sulistiyaningrum Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Zeinora, Zeinora