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Journal : medical laboratory technology journal

Identıfıcatıon of KRAS Mutatıons in Colorectal Carcınoma Patıents at Dr. M. Djamıl Hospıtal, West Sumatra-Indonesıa Rita Maliza; Hevi Horiza; Sumaryati Syukur; Allimuddin Tofrizal; Bramadi Arya
Medical Laboratory Technology Journal Vol. 9 No. 2 (2023): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v9i2.535

Abstract

Kirsten rat sarcoma viral oncogene (KRAS) gene mutations lead to abnormal activation of the RAS signalling pathway and have been associated with poor prognosis and resistance to some therapeutics. This study aimed to identify mutation characteristics of the KRAS genes codon 12 and 13 in colorectal cancer patients in West Sumatra. KRAS mutations were analyzed in 20 DNA of colorectal cancer patients' tissue samples by using polymerase chain reaction (PCR) with specific primer and direct sequencing analysis. Our findings showed five samples (25%) with mutated KRAS at codons 12 and 13 (including three samples with GGT→GAT, one sample with GGT→GTT in codon 12, and one sample with GGC→GAC in codon 13). In conclusion, we found two variations of amino acid changes at codon 12 (G12D and G12V) and one at codon 13 (G13D). More research with many samples is required to obtain conclusive data on the relationship between these gene mutations and colorectal cancer response to therapy and prognosis.
Co-Authors Adam Raihan Priambada Adi Wira Septama Adilla, Ardis Trianita Adnan, Adnan Afdhal Raihan Afdhal Raihan Afif , Muhamad Aini, Wardahtul Aini, Wardatul Aldi Tamara Rahman Aldi Tamara Rahman Alfiatul Laila Alimuddin Tofrizal Allimuddin Tofrizal Alponsin Alponsin Amelia Roza, Amelia Ananda Fitriana Andani Eka Putra Angga Illahi Kurnia Illahi Angga Kurnia Illahi Anggun Sophia Anisa Nova Puspitaningrum Anthoni Agustien Aprilia Cassa Nova Aprilia, Kharisma Annisa Aris Setiawan Arthauly Yopita Sinurat Asful, Ferdhinal Ashrifurrahman Ashrifurrahman Ashrifurrahman Ashrifurrahman Ashrifurrahman, Ashrifurrahman Asih, Enda Tarni Aszareta, Muhammad Andoni Athika Darumas Putri Aulia Rahmi Aulia, Annisa Ayu Rosemeilia Dewi Aziz, M. Abdul Azizah Amatu Zikrah Azizah Amatu zikrah Azzahra, Layla Bayu Tri Murti Bramadi Arya Cahyani, Dini Chairunnisa Azzahra Azzahra H Cheung, Rocky Dahelmi Dahelmi Diana Fadhilah Diani Fatmawati Dyah Aryani Perwitasari Efa Refiani Efrizal Efrizal Eli Ratni Elisa, Tasya Putri Pratama Elni Fatimah Elsa Alfiyanti Era Refiani Esa Savitri Eti Yerizel Fadhilah, Diana Fadil, Muhammad Syukri Fadillah Fadillah Fadillah Fadillah Fajri Hidayat Febriofca Galih Yatalaththov Ferdhinal Asful Firmansyah, Tio Galih Yatalaththov, Febriofca Gina Noor Djalilah Haafizah Dania Haafizah Dania Haafizah Dania Hamdani, Afif Hamdi Ibrahim, Muhammad Haris Setiawan HARIZQI AZRI Harry Nugroho Eko Surniyantoro Hendra Kusuma Henny Herwina HENNY HERWINA Horiza, Hevi Hulrahma, Mifta Husna Fitri Husna Fitri Husna Fitri Husna Fitri Hutri Dinda Syabila Hylda Ibrahim, Muhammad Hamdi Idris, Muhamma Ika Wahyuni Ikrimah Nisa Utami Ilham Samudra, Muhammad Ilham, Kurniadi Illahi, Angga Illahi Kurnia Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Indah Fajarwati Inggita Utami Irwan , Reziq Marchellino Ivan Petrovsky Ivan Petrovsky Jabang Nurdin Jannati Aulah Janra, Muhammad Nazri Jasmi JASMI JASMI Jefrial Santoso Jihan Aprilia Nawawi Kania Agustina Kiky Martha Ariesaka Kurniadi Ilham Lalu Muhammad Irham Lestari, Mardiana Puji Liana Fairuzannah Mahdiana Listiatie Budi Utami Lutfi Sukma Pratiwi M.Nazri Janra Made Ary Sarasmita Mahardika, Riris Srikandi Mansyurdin Marchellino Irwan, Reziq Melinda Widianingrum Melinda Widianingrum Melinda Widyaningrum Melodia Rezadhini Miftahul Ilmi Mifthahul Jannah Mildawati Mildawati Moh. Mirza Nuryady Mohammad Abrar Mohsin Rafique Muhammad Afif Muhammad Hamdi Ibrahim Muhammad Idris Muhammad Idris Muhammad Idris Muhammad Idris Muhammad Ilham Hisbullah Muhammad Samudra Ilham Nabilah Adzra Fahlevi Nabilah Rahmachila Azura Nadjmir, Mikail Nanik Sulistyani Nastiti Rahajeng Nelvi, Dennisa Arra Ni Made Ary Sarasmita Nofrita Nofrita Nofrita Nofrita Nopiyanti, Tita Nur Aida Nur Rahmah Hidayati Nurul Annisa Nurwijayanti Oktira Roka Aji Petrovsky, Ivan Pradika, Jaka Pratama Elisa, Tasya Putri Pratama, Kharisma Pratama, Raihan Anugrah Puspitaningrum, Anisa Nova Puti Khairunnajwa Amar Putra Santoso Putri Lestari Putri Pratama Elisa, Tasya Putri, Fadilatul Rahmi Putri, Syntia Mai Rahimi Syaidah Raihan, Afdhal Ramadanti, Dhea Rarastoeti Pratiwi Rauza Sukma Rita Resti Rahayu Rezadhini, Melodia Reziq Marchellino Irwan Reziq Marchellino Irwan Ridho, Muhammad Syifa'ur Rifai, Fauziah Novita Putri Rihadatul Aisyah Rihadatul Aisyah Rilwan Efendi Rismayani, Dessy Rizaldi Rizaldi Rizma Nurul Akhlas Robby Jannatan Rocky Cheung Rocky Cheung Saraswati, Utami Sinurat, Arthauly Yopita Siti Rokhimah Sumaryati Syukur Sutri Wulansari Safril Syafruddin Ilyas Syaiful Adam Maulana Syaifullah Syaifullah Syakira Tiara Rezvi Syamsuardi Syamsuardi Sylvia Nabila Tasya Putri Pratama Elisa Tasya Putri Pratama Elisa Tio Firmansyah Tofrizal Tofrizal , Allimuddin Tofrizal, Alimuddin Tur Rahardjo Utami Saraswati Wardatul Aini Wilson Novarino Wirawan Adikusuma Yanti Lusiyanti Yanti, Windi Nofri Yashiro, Takashi Yeni Alfiana Ratnasari Yudha Rizky Nuari Yustia Tuti Zaini Zaini Zikrah, Azizah Amatu Zozy Aneloi Noli Zozy Aneloi Noni Zuhir, Elvina Zulfikri, Elzam Naufal