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Uji Potensi Antituberkulosis Ekstrak N-Heksan dan Ekstrak Etanol Daun Jeruk Nipis (Citrus Aurantiifolia) secara in Vitro Putri, Alya Rosandiyus; Fatimah, Cut; Gunawan, Muhammad; Safriana, Safriana
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6181

Abstract

Tuberculosis is a disease caused by Mycobacterium tuberculosis which is widely suffered and causes death. Currently, antituberculosis treatment using synthetic chemicals has been widely resistant. The purpose of this study was to test the potential of lime extract to inhibit the growth of tuberculosis bacteria. This research method uses a quantitative approach and is experimental. The results of the study showed that the results of the phytochemical screening test showed the same group of chemical compounds in fresh leaves, simplex and ethanol extract of lime leaves, namely alkaloids, flavonoids, tannins, saponins, steroids and glycosides. While the n-hexane extract only contains steroids and glycosides. Then the effectiveness of antituberculosis can be seen from the ethanol extract being stronger than the n-hexane extract, namely in the 1st week there was inhibition while the n-hexane extract from the 1st week to the 4th week had bacterial growth.
Formulasi Hair Tonic Ekstrak Etanol Kulit Buah Pepaya (Carica Papaya L.) dan Uji Efektivitas Pertumbuhan Rambut pada Marmut Jantan (Cavia porcellus) Candani, Mella; Gunawan, Muhammad; Tanjung, Siti Aisyah; Bagas, Muhammad
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6198

Abstract

Hair for humans has an important role, in addition to protecting the skin from adverse environments, hair also plays an important role in a person's appearance. Losing a lot of hair due to hair loss can cause a lack of self-confidence, disappointment, and frustration, so it must be addressed immediately so as not to worsen the condition that can cause baldness. This study aims to determine whether there is a content of secondary metabolite compounds in fresh herbal medicine, herbal medicine powder and ethanol extract of papaya fruit skin; ethanol extract of papaya fruit skin (Carica papaya L.) can be formulated in the form of hair tonic preparations; whether the difference in concentration of ethanol extract of papaya fruit skin (Carica papaya L.) provides different activities in triggering hair growth in guinea pigs. This research method uses a quantitative approach and is experimental with independent variables, namely papaya fruit skin, herbal medicine, and ethanol extract of papaya fruit skin with concentrations of 10%, 20%, 30%. Research stages: phytochemical screening of fresh papaya fruit peel, powdered simplicia and ethanol extract, hair tonic formulation containing ethanol extract of papaya fruit peel 10%, 20% and 30%, hair tonic evaluation includes: organoleptic, viscosity, stability, pH, irritation, and preference test. And hair growth activity test on male guinea pigs. The results showed that the ethanol extract of papaya fruit peel contains alkaloids, flavonoids, saponins, steroids, and glycosides, can be formulated into hair tonic (EEKP) that meets physical quality requirements. Hair tonic EEKP 30% is the best because it has high hair growth activity, which is an average of 16.375 mm where this EEKP 30% hair tonic has almost the same hair growth activity as the positive control, which is an average of 16.782 mm.
Penetapan Kadar Besi dan Seng Air Sumur Gali dan Sumur Bor pada Daerah Lenggadai Hilir secara Spektrofotometri Serapan Atom Anwar, Laila; Fatimah, Cut; Bagas F, Muhammad; Gunawan, Muhammad
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6302

Abstract

Many people in Lenggadai Hilir Village, Rimba Melintang District, Rokan Hilir Regency, Riau use dug well water and drilled well water as clean water, drinking water and household needs that look cloudy, colored and slightly odorous, possibly containing metals such as Fe and Zn. The content of Fe and Zn metals in clean water has the requirements of the Regulation of the Minister of Health of the Republic of Indonesia Number 416 / Menkes / PER / IX / 1990, namely a maximum of 1.0 mg / l Fe and a maximum of 15 mg / l Zn. The purpose of this study was to determine the levels of Fe and Zn in the water used by the population. This research method is descriptive quantitative. Determination of Fe and Zn levels in water samples in the village was carried out using Atomic Absorption Spectrophotometry (AAS), which were previously destroyed with nitric acid. Before determining the levels, it began with an identification test with several chemical reactions to ensure the presence of Fe and Zn content in the samples. The results showed that all samples tested contained Fe and Zn. All samples of drilled wells contain Fe, the levels of which do not meet the requirements and all Zn samples meet the requirements, from 8 dug well samples there are 6 dug well samples contaminated with Fe, namely dug well 1 (1), dug well 1 (2), dug well 2 (1), dug well 2 (2), dug well 3 (1) and dug well 3 (2). Thus, the water used by the community as clean water and household needs should not be used for household water needs and drinking water before processing and filtering before consumption.
Formulasi Sediaan Masker Gel Ekstrak Etanol dari Daun Kembang Sepatu (Hibiscus Rosa-Sinensis L.) Sebagai Pelembab Kulit: Formulation of Ethanol Extract Gel Mask Preparation from Hibiscus Leaves (Hibiscus Rosa-Sinensis L.) as a Skin Moisturizer Sari, Secillia May; Tanjung, Siti Aisyah; Gunawan, Muhammad; Safriana, Safriana
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6503

Abstract

Skin often dries out due to evaporation and loss of moisture due to dry air, hot weather, aging, skin diseases, etc., so that the skin surface becomes scaly and wrinkled. Moisturizers consist of ingredients that can form and change the texture of dry and rough skin and reduce water evaporation from the skin. The purpose of this study was to analyze the formulation of a gel mask preparation of ethanol extract from hibiscus leaves (Hibiscus Rosa-Sinensis L.) as a skin moisturizer. This study was conducted using an experimental method using hibiscus leaves (Hibiscus rosa-sinensis L.) as a test material obtained by maceration using 80% ethanol solvent which had previously been tested for phytochemical screening and characterization of simplicia. The stages of this study include: making hibiscus leaf extract, making gel mask preparations, organoleptic tests, homogeneity tests, stability tests, viscosity tests, pH tests, spreadability tests, drying time tests, irritation tests, preference tests and skin moisturizer effectiveness tests. Phytochemical screening results showed that hibiscus leaves contain alkaloids, flavonoids, tannins, saponins, steroids and glycosides. Preparations with concentrations of 5%, 10%, 15% produced a homogeneous and stable gel mask from the first day to the 4th week, the pH of the preparation ranged from 6.30-6.56, the viscosity test produced 4.116-5.067, the spreadability test 6.2-6.7 cm, the dry time preparation test 20-22 minutes, the irritation test on volunteers showed no irritation and itching, the preference test value produced by the panelists liked the preparation from a concentration of 15% in terms of color, aroma and shape, and the effectiveness test as a skin moisturizer for water content taken from the highest concentration of 15% obtained an average result of 32.97 ± 2.93%, and for a decrease in oil content obtained 36.71 ± 6.89%.
INFLUENCES OF INCUBATION TIME AND SUCROSE CONCENTRATION ON MICE (Mus musculus L.) OOCYTE VIABILITY FOR ENUCLEATING PROCEDURE Kaiin, Ekayanti Mulyawati; Gunawan, Muhammad; Madihah, Madihah; Nafisah, Ghina
Jurnal Kedokteran Hewan Vol 12, No 3 (2018): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v12i3.10896

Abstract

This study aimed to find out the optimum incubation time to complete mouse oocyte maturation at Metaphase II (MII) stage and determine the optimum sucrose concentration enabling to induce nuclear swelling for visualization that is important for enucleating process at the initial procedure of somatic cell nuclear transfer (SCNT). In this current study, mice were used as animal model. Completely randomized design was arranged, consists of 2 trials with 4 treatments and 7 replications. In the first trial, the oocytes were cultured at 0-2, 4-6, 8-10, and 12-14 h in 5% CO2 incubator at 37 C. Second, the MII oocytes obtained from previous trial were cultured in M199 medium containing different concentrations of sucrose (0, 1.5, 3, and 6%). The parameters measured were the oocyte viability at various stages, i.e germinal vesicle (GV), metaphase I (MI), anaphase/telophase I (A/T I), and metaphase II (MII), and the viability of swollen nuclear oocytes using Hoechst/PI staining. The results showed that the optimum incubation time required by oocytes to reach MII stage was 12-14 h with a percentage of 57.1412.67%, while the optimum sucrose concentration for nuclear swelling was found at 3% with a percentage of 1000.00%. Our findings provided preliminary results related to the maturation process of the mouse oocyte nucleus, which is meaningful for the initial procedure of SCNT.
PERKEMBANGAN EMBRIO SAPI SETELAH FERTILISASI MENGGUNAKAN METODE INTRACYTOPLASMIC SPERM INJECTION (ICSI) DAN AKTIVASI DENGAN STRONTIUM Gunawan, Muhammad; Fahrudin, Mokhamad; Boediono, Arief
Jurnal Kedokteran Hewan Vol 8, No 2 (2014): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i2.2651

Abstract

Penelitian ini bertujuan mengetahui pengaruh kombinasi intracytoplasmic sperm injection (ICSI) dan aktivasi dengan strontium untuk mengetahui perkembangan pronukleus dan perkembangan embrio sampai tahap blastosis. Kombinasi ICSI dan strontium 20 mM meningkatkan perkembangan pronukleus 2-PN mencapai 43,59%. Hasil perkembangan embrio pada perlakuan kombinasi ICSI dan strontium 20 mM mencapai tingkat perkembangan 2-4 sel (50,5%), 8-16 sel (43,73%), dan blastosis (15,63%). Kesimpulan dari hasil penelitian ini adalah kombinasi ICSI dengan aktivasi strontium 20 mM mampu menghasilkan perkembangan in vitro embrio sapi yang lebih baik.
Improving Ustaz and Ustazah Communication Skills for Students at TPQ Rojaul Khoir Griya Mijen Permai Semarang Firmansyah, Asep; Kasmuri, Kasmuri; Gunawan, Muhammad; Lijea, Isma Ae; Ahmed, Tanjeel
Prosperity: Journal of Society and Empowerment Vol. 4 No. 2 (2024): December
Publisher : Universitas Islam Negeri Walisongo Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/prosperity.v4i2.20553

Abstract

This research aims, firstly, to provide knowledge and understanding to ustaz and ustazah about the importance of communication while at the same time providing reinforcement on how to apply communication skills in the learning process to santri or students and secondly to find out the results of implementing the communication skills that teachers have in the learning process. The method used in this research is descriptive-analytical using a participatory approach. The research instrument used interviews. The subject of the activity is the teachers and the field of education. Activities to improve the communication skills of ustaz and ustazah for students of TPQ Rojaul Khoir, Mijen Semarang were carried out for four days and were attended by 40 participants consisting of teachers, prayer teachers in the field of education, and other managers. After carrying out a workshop to improve communication skills for ustaz and ustazah, the activity continued with evaluating and preparing a follow-up program using brainstorming. The importance of communication strategies taught by students at TPQ Rojaul Khoir to improve learning quality is a common concern, so communication skills should be part of implementing activity programs at TPQ Rojaul Khoir. After communication skills were implemented in learning activities, there was a change for the better; namely, the class was more controlled, and the learning process was more meaningful.
Development of Mice Embryo (Mus musculus L.) after Closed Pulled Straw Vitrification in CZB Medium Gunawan, Muhammad; Kaiin, Ekayanti Mulyawati; Rusherdiannita, Raden Cindy; Alipin, Kartiawati
Annales Bogorienses Vol. 23 No. 2 (2019): Annales Bogorienses
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The objective of our present experiment was to investigate the effects of closed pulled straw (CPS) vitrification on the viability and development of mouse embryo. The experiment was arranged according to completely randomized design (CRD) consisting of 4 treatments, namely not vitrification (NV) is control, CPS 1 (mCZB Hepes + 20% Bovine Serum Albumin (BSA) +0.5 M sucrose + 10% EG + 10% DMSO), CPS 2 (mCZB Hepes + 20% BSA + 0.5 M sucrose + 15% EG + 15% DMSO), and CPS 3 (mCZB Hepes + 20% BSA +0.5 M sucrose + 20% EG + 20% DMSO) with 6 replications. The viability of embryos (%) was determined after 24 - 72 h of the culture period, while we also observed the percentage of embryos reaching the blastocyst stage (early blastocyst, expanded, hatching, and hatched). As a result, the treatments did not give a significant difference in the viability of embryos (P<0,05) but showed significant effects on embryo development (P<0,05). Furthermore, this present work conclusively found that CPS vitrification in CZB medium with cryoprotectants ethylene glycol (EG) and dimethyl sulfoxide (DMSO) noticeably influenced the development of mice embryo to reach the blastocyst stage, but showed no remarkable difference in the viability of embryo after culture for 24 – 72 h.
Makna Dakwah dalam Lirik Lagu “Eling-Eling Umat”: Analisis Deskriptif terhadap Representasi Ketundukan dan Keutamaan Salat dalam Media Musik Populer Firmansyah, Asep; Gunawan, Muhammad
FASTABIQ: JURNAL STUDI ISLAM Vol 6, No 2 (2025): Fastabiq: Jurnal Studi Islam
Publisher : Fakultas Agama Islam Universitas Muhammadiyah Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47281/fas.v6i2.236

Abstract

This study examines the da‘wah messages embedded in the song “Eling-Eling Umat” by Ebith Beat A, focusing on how its lyrics promote the obligation of ṣalāh and cultivate spiritual awareness among listeners. Using a qualitative descriptive-analytical approach, this research draws on document analysis grounded in the theory of fiqh al-ṣalāh and da‘wah through creative media. The findings indicate that the song conveys explicit messages regarding the mandatory nature of ṣalāh and implicit messages related to its spiritual virtues and the consequences of negligence. The lyrics integrate normative religious teachings with creative da‘wah strategies expressed through popular musical forms, enabling broader public engagement. The study concludes that popular religious music can function as an effective medium for strengthening awareness of ṣalāh and for enhancing the community’s spiritual connection to Islamic values.Keywords: Ṣalāh; da‘wah; religious music; Ebith Beat A; fiqh of ṣalāh; popular culture.
Menggali Genealogi dan Transformasi Vihara Sima 2500 Buddha Jayanti: Dari Situs Sejarah ke Pusat Spiritualitas Modern Maulidah, Farikhatul; Gunawan, Muhammad; Rohmiyati, Yuli; Pramudyo, Gani Nur; Irhandayaningsih, Ana; Bramiana, Chelly Novia
Sabda: Jurnal Kajian Kebudayaan Vol 20, No 2 (2025): Sabda: Jurnal Kajian Kebudayaan Vol. 20 No. 2
Publisher : Fakultas Ilmu Budaya Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/sabda.20.2.101-109

Abstract

This study examines the genealogy, history, and transformation of Vihara Sima 2500 Buddha Jayanti as a center of spirituality and social engagement within the context of the Buddhist revival in Indonesia. Established in 1958 to commemorate 2500 years of the Buddha's passing, the vihara plays a strategic role in strengthening national and international religious and cultural networks. Using a qualitative and descriptive-analytical approach, this research reveals the process of revitalizing the vihara from its period of prominence through decline, to its renewed function as a meditation and community development hub that is open and inclusive. The findings indicate that the vihara functions not only as a place of worship but also as a social, educational, and multicultural space capable of addressing modern societal challenges. This revitalization demonstrates that traditional religious institutions can successfully build relevant spiritual identities and respond to Indonesia's social dynamics.