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All Journal International Journal of Public Health Science (IJPHS) E-Journal Of Cultural Studies JURNAL PROMOSI KESEHATAN INDONESIA Media Kesehatan Masyarakat Indonesia JURNAL ILMIAH KESEHATAN KEPERAWATAN Jurnal Kebijakan Kesehatan Indonesia Jurnal Ilmu keperawatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Disease Prevention and Public Health Journal Jurnal Kesehatan Masyarakat Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Journal of Health Education Jurnal Kesehatan GIZI INDONESIA Jurnal Gizi Klinik Indonesia Window of Health : Jurnal Kesehatan Jurnal Kesehatan Reproduksi Journal of Epidemiology and Public Health Jurnal Ilmu Kebidanan (Journal of Midwivery Science) Unnes Journal of Public Health Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Kebidanan Indonesia Majalah Kesehatan Indonesia Jurnal Cakrawala Promkes Jurnal Kesehatan Primer Masker Medika Basic and Applied Nursing Research Journal Journal of Information Systems for Public Health Berita Kedokteran Masyarakat Prosiding University Research Colloquium Journal of Health Technology Assessment in Midwifery Women Midwives and Midwifery Indonesian Journal of Pharmacology and Therapy Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Mohammad Hakimi
Unknown Affiliation
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Indonesian Journal of Pharmacology and Therapy

 1 
Potential neurological applications of Centella asiatica: a brief review Gofir, Abdul; Wibowo, Samekto; Hakimi, Mohammad
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1693

Abstract

Centella asiatica (C. asiatica) or gotu kola has been used traditionally in many Asian countries as herbal medicines for many conditions, such as headache, asthma and memory enhancement. Centella asiatica has been also widely investigated for its neuroprotective effects in animal disease model including epilepsy, Alzheimer’s and Parkinson’s diseases. A brief review of neurological effects studies of C. asiatica in animal model was reported. Eligible studies published through December 2020 from PubMed and EMBASE journal data base were collected. Any keywords related to C. asiatica or gota kola AND neurological conditions were used. The results showed that several experimental studies concerning the neuroprotective properties of C. asiatica have been reported. Phytochemical studies reported that C. asiatica contained many bioactive compounds in which triterpenoids are the most identified. Furthermore, the triterpenoids have proven to have neuroprotective effect due to their effects of anti-inflammatory, antioxidant, improvement of mitochondrial dysfunctions, and increased brain-derived neurotrophic factors. Further studies are needed to investigate the neuroprotective mechanisms of C. asiatica. In conclusion, C. asiatica might have potential as an alternative medicine for neurological conditions, such as stroke, epilepsy, Alzheimer’s and Parkinson’s disease.
The effect of Centella asiatica L. Urban. and Curcuma longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity Gofir, Abdul; Ar Rochmah, Mawaddah; Wibowo, Samekto; Hakimi, Mohammad; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1765

Abstract

Post-stroke cognitive impairment involves memory, visuoconstructional, and spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both well-known herbs in South and South-East Asia countries that are believed to possess neuroprotective properties as memory enhancers. This study aimed to investigate the effects of C. asiatica L. Urban. and C. longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity. Twenty-five Wistar rats underwent transient bilateral common carotid artery occlusion. Y-maze pre-test was performed 24 h after the occlusion. The rats were then divided into five groups i.e. Group 1 received NaCMC dilution, Group 2 received donepezil 0. 7 mg/kg BW/day, and Groups 3, 4, and 5 received the extracts combination with dose of 59; 118; and 236 mg/kg BW/day, respectively. Y-maze post-test was performed 24 h after the last dose had been given. Spontaneous alternation behavior was used as the indicator of working memory measurement. The fixed-dose method according to OECD Guideline was used to estimate the LD50 in acute toxicity testing on Wistar rats. There was a significant difference in the delta spontaneous alternation percentage among groups tested (p<0. 05). Group 1 had significant difference with any other group (compared to Groups 2 to 5; p<0.05). No significant difference could be found between groups of the extracts combination and donepezil group suggesting that the effect is not more inferior nor dose-dependent in improving memory performance. The extracts combination at a single dose of 2000 mg/kg BW did not show related signs of toxicity or mortality in any of the rats during the 14-day observation period. In conclusion, the C. asiatica L. Urban. and C. longa L. extracts combination can improve performance of memory on stroke model animal. According to Globally Harmonized Classification System, the extracts combination can be classified as Category 5/unclassified.
Co-Authors - Anggorowati Abd Rahman Abdul Gofir Adi Utarini Agung Suhadi Ahmad Husein Asdie Aji Setiawan Ambar Relawati, Ambar Anak Agung Istri Sri Wiadnyani Andina Vita Sutanto Andy Muharry Anggarini, Inge Anggi Anjarwati Anjarwati, Anjarwati Anna Marie Wattie Annisa Nurrachmawati Astuti, Andari Wuri Astuti, Bariana Widitia Astuti, Dyah Puji Basri, Mubasysyir Hasan Batubara, Rini Amalia Bernadette Josephine Istiti Kandarina Cahyaningtyas, Ayu Cahyawati, Safitri Putri Carla R. Marchira Claudia Banowati Subarto Deny Eka Widyastuti, Deny Eka Detty Siti Nurdiati Dewanto, Agung Dewi, Zidna Akmala Djauhar Ismail Donal Donal Dyah Pradnyaparmita Duarsa Eddy Tiro Elli Nur Hayati Emiliana Mariyah Fadillah Fadillah Fitri Fitri Fitriahadi, Enny Ganap, Eugenius Phyowai Hamam Hadi Hani EN, Umu Harahap, Yanna Wari Hari Kusnanto Hartono Hartono Helmyati, Siti Herta Masthalina, Herta Hidayat, Asri I Wayan Ardika Ibrahim Rahmat Irine Christiany, Irine Iswardani, Octaldina Jumiati, Raodiatul khusnul khotimah Khusnul Khotimah Kurnia, Arif Rahmat Kusmaryanto Kusmaryanto, Kusmaryanto Lestari, Abriana Lia Nurcahyani Luluk Rosida Lutfan Lazuardi Madarina Julia Mappaware, Nasrudin Andi Mappaware, Nasrudin Andi Mardjan Mardjan Mawaddah Ar-Rochmah Mayasari, Ade Tyas Meiry Nasution, Meiry Moniz, Maria De Fatima Mora Claramita Mubasysyir Hasanbasri Mufdlilah, M Mufdlilah, Mufdlilah Mursyid, Muhammad Mustofa Mustofa Nana Diana Ni Komang Yuni Rahyani Ninuk Sri Hartini, Ninuk Sri Nofrisa Mutia P, Nofrisa Noor Pramono Noor Pramono Nunuk Pusorowati, Nunuk Nur Siyam NURUL HIDAYAH Ova Emilia Perwitasari Perwitasari Phyowai Ganap, Eugenius Popy Irawati Pratiwi, Cesa Septiana Putri Hidayati Rahmansyah, Ardian Retno Heru Rina Triasih Rini Amalia Batubara Rini, Ika Sulistya Riris Andono Ahmad Risanto Siswosudarmo Riska Dwi Pramita Sari Rofita, Desi Rukmono Siswishanto Rustam Sunaryo Samekto Wibowo Saraswati, Putu Ayu Dina Sari Sudarmiati Setyonugroho, Winny Shinta Prawitasari Siswanto Agus Wilopo Siti Solekah Soenarto Sastrowijoto, Soenarto Soerjo Hadijono Soetrisno Soetrisno Soewadi Soewadi Sofiana, Juni SRI SETIYARINI, SRI Sri Wahyuni Subarda, Subarda Suci Musvita Ayu Sulistyaningsih Sulistyaningsih Susetyo, Dwi Susetyowati T. Ninuk Sri Hartini Titih Huriah Toto Sudargo Tri Wahyudi Ulva, Siti Maria Umar Malinta umi laelatul qomar Utami, Iis Tri Verayanti Albertina Bata Veronica Silalahi Veronika Evita Setianingrum Wahida Yuliana Wahyuni, Budi Wahyuni, Budi Willopo, Siswanto Agus Wisotowardono, Ossie Sosodoro Wiwin Lismidiati Yayi Suryo Prabandari Yayu Yuliarti Yuli Isnaeni Yuni Purwati Zulaidah, Hana Shafiyyah