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Muhammad Hanafiah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Heca Journal of Applied Sciences

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Investigating Scabies Pathogenesis and Therapeutic Potential of Nutmeg Extract in Experimental Animals Erizal, Erizal; Hanafiah, Muhammad; Mudatsir, Mudatsir; Helmi, Teuku Zahrial
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026 (In Press)
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.333

Abstract

Nutmeg (Myristica fragrans) is one of Indonesia’s agricultural commodities with recognized health benefits as a traditional medicine. In addition, nutmeg has potential as a natural treatment for scabies. This study aimed to evaluate the effectiveness of nutmeg fruit bioactive compounds in scabies treatment. Nutmeg extraction was conducted using three different solvents: ethanol, ethyl acetate, and n-hexane. The extract with the most dominant phytochemical composition was further analyzed for bioactive compounds using GC-MS and antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Subsequently, the extract was tested against Sarcoptes scabiei mites obtained from 15 stray cats. The effectiveness of nutmeg extract was evaluated in a spray formulation by observing mite mortality and lesion reduction. The results demonstrated that the ethanol extract of nutmeg fruit contained the most abundant phytochemicals, with 3-Methyl-2,5-Furandione (21.26%) and Maleic Anhydride (14.21%) as the dominant compounds. The ethanol extract also exhibited strong antioxidant activity with an IC₅₀ value of 21.41 ppm. In vitro testing showed 100% mite mortality at a 25% extract concentration within 24 hours, while in vivo testing on scabies-infected cats treated with the nutmeg spray extract revealed a significant reduction in scab lesions compared to the control group. These findings indicate that nutmeg extract possesses potent acaricidal and antioxidant properties, making it a promising alternative treatment for scabies. Further studies are required to refine the formulation and explore its clinical applications.
Co-Authors Abd. Rasyid Syamsuri Adam S, Koji Al Amalia Sutriana arif gumilar Arman Sayuti Armia, Yasser Aulia Malik Fajar Aza Annisa Utami Baehaqi Basri A. Gani, Basri A. Dwinna Aliza Dwinna Aliza Emi Minarni Erdiansyah Rahmi Erdiansyah Rahmi Erizal Erizal Fadrial Karmil Farid Wajidi Farida Athaillah Farida Farida Farida Farida Hamdani Budiman Hamdani Budiman Ilham Ilham Indra Wahyudi, Indra Ismail Ismail Joko Prastowo Juli Melia M. Hasan Maulida, Sri Mudatsir Mudatsir Mufti Kamaruddin Mufti Kamaruddin Muhammad Bahi Muhammad Hambal Muhammad Hambal Muhammad Jalalluddin N. Nazaruddin Nur Afriyanti Nuraini Latif Nurdianti - NURLIANA NURLIANA Nurul Hidayati Nuzul Asmilia Pratama, Said Mirza R. Rusli Rastina Rastina Rusli . Rusli Rusli Rusli Sulaiman Salim, Muhammad Nur Sembiring, Rinawati Sri Hartati Sri Hartati Subhaini Jakfar Sugito Sugito Sugito Sugito Sukarni Sukarni Sulastri, S t fadrial karmil Teuku Armansyah Teuku Reza Ferasyi Teuku Reza Ferasyi Teuku Zahrial Helmi Widya Nanda Winaruddin Winaruddin Wisnu Nurcahyo Wisnu Nurcahyo Yudha Fahrimal Yundari, Yundari