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All Journal Journal of Food and Pharmaceutical Science Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medicina MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Brawijaya Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Journal of Biomedicine and Translational Research Journal of Innovation and Applied Technology Research Journal of Life Science The Journal of Pure and Applied Chemistry Research MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Medical Laboratory Technology Journal Indonesian Journal of Rheumatology Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) International Journal of Community Service Learning YARSI Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Narra J CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Journal of Food and Pharmaceutical Sciences Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan Folia Medica Indonesiana
Kusworini Handono
Department Of Clinical Pathology, Faculty Of Medicine Brawijaya University/Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Assessing Knowledge of Systemic Lupus Erythematosus Among Patients and Caregivers Insights from a Qualitative Inquiry Pratama, Mirza Zaka; Handono, Kusworini; Wahono, Cesarius Singgih; Rahman, Perdana Aditya; Wulandari, Dessy
Clinical and Research Journal in Internal Medicine Vol. 6 No. 2 (2025): Volume 6 No 2, November 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.02.04

Abstract

Background: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease requiring comprehensive patient knowledge for effective management. However, gaps in understanding and educational challenges persist among patients and caregivers. Aim: This study aimed to explore the knowledge, perceptions, and educational needs of SLE patients and their caregivers through a qualitative approach. Methods: Semi-structured interviews and focus group discussions were conducted with 15 patients and 10 caregivers from rheumatology clinics at Saiful Anwar General Hospital. Participants were selected using purposive sampling. Data were analyzed using thematic analysis, identifying key themes related to understanding of SLE, sources of information, knowledge gaps, and educational needs. Results: Participants demonstrated a basic understanding of SLE, but significant misconceptions were identified, particularly regarding the disease's multi-systemic impact. Healthcare providers were the primary source of information, though time constraints limited the depth of understanding. Patients and caregivers frequently turned to online sources, encountering challenges in identifying reliable information. Complex medical terminology and the emotional burden of SLE management were significant barriers. There was a clear preference for simplified, visual educational materials and a need for ongoing, continuous education and support. Conclusion: The study highlights persistent knowledge gaps and the need for enhanced educational strategies tailored to the needs of SLE patients and caregivers. Improving communication, providing reliable resources, and offering continuous education could significantly improve disease management and patient outcomes.
Serological Profiles of Systemic Lupus Erythematosus in Humanized Mice and Pristane-Induced Lupus Models Chilmi, Syahrul; Airlangga, Dimas Ikhsan; Susianti, Hani; Handono, Kusworini
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study compared the serological markers of pristane-induced mice to humanized mouse models of lupus achieved by transplanting stem cells from lupus patients, which is a novel method in Indonesia. 2. This study will allow for more accurate research into the pathophysiology of the disease and the development of new lupus treatment strategies. Abstract More studies related to systemic lupus erythematosus (SLE) therapy are urgently needed because of the current insufficiency in treatment effectiveness. However, due to ethical limitations, researchers use experimental animals as a substitute for conducting studies on humans. Models commonly used to study lupus include the pristane-induced mouse model and the recently developed humanized mouse model. The second model involves implanting human immune cells into immunodeficient mice. This study compared the serologic profiles of lupus antibodies, the antinuclear antibodies (ANA) and anti-double stranded DNA (anti-dsDNA), in both mouse models. The aim was to determine which one is more promising for use as a lupus animal model. Thirty BALB/c mice (Mus musculus) were used as subjects and divided into three groups: K1, K2, and K3. K1 served as the control group, consisting of healthy mice that received a placebo. The K2 mice were intraperitoneally injected with 0.5 cc of pristane. The K3 mice were transplanted with stem cell cultures from SLE patients, resulting in humanized mice with immune deficiencies. The mice were observed for 16 weeks, during which the ANA and anti-dsDNA levels in their serum were obtained for analysis using the Kruskal-Wallis test (p<0.05). The comparison revealed differences in the average ANA and anti-dsDNA levels among the three groups. K3 had the highest ANA and anti-dsDNA levels, followed by K1 and K2. The Kruskal-Wallis test indicated that the differences were not significant in the mean levels of ANA (p=0.156) and anti-dsDNA (p=0.061). In conclusion, the humanized mouse model has higher ANA and anti-dsDNA antibody levels compared to the pristane-induced mouse model, albeit without a significant difference. This suggests a positive picture of the humanized mouse model of lupus, making it an invaluable tool for studying the disease and testing potential therapeutic interventions.
The role of serum ferritin as a biomarker of iron and inflammation in anemia: a systematic literature review Kedaton, Rafi Andyah Arum; Devi, Nabila Sinta; Kusworini, Kusworini; Wardani, Diadjeng Setya
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.4137

Abstract

Background: Anemia remains a major global health concern, particularly in low- and middle-income countries where distinguishing Iron Deficiency Anemia (IDA) from Anemia of Inflamation (AI) remains diagnostically challenging. Hemoglobin alone cannot differentiate these conditions, necessitating more specific biomarkers. Serum ferritin, the primary iron-storage protein, reflects body iron reserves but is also elevated during inflammation through interleukin-6-mediated hepcidin induction. Objective: This review examines the dual role of ferritin as an iron biomarker and an inflammatory marker. Methods: A literature search was conducted in PubMed, ScienceDirect, SpringerLink, and the Cochrane Library with a ten-year publication limit. Of the 89 articles identified, only eight studies met the inclusion criteria and directly evaluated the relationship between ferritin, iron status, and inflammatory processes. Results: Ferritin remains a key indicator of iron reserves, but its interpretation needs to take into account the inflammatory status. Conclusion: The combination of ferritin with inflammatory biomarkers such as C-Reactive Protein (CRP)and Alpha-1-acid glycoprotein (AGP) improves the diagnostic accuracy for anemia related to both iron deficiency and inflammation.
Elevated TLR4 as Potential Biomarker for RMT-positive Subclinical Tuberculosis Priyono, Riski Irawan Putra; Handono, Kusworini; Djajalaksana, Susanthy; Santosaningsih, Dewi
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4066

Abstract

BACKGROUND: Subclinical tuberculosis (TB) is often underdiagnosed due to the limited sensitivity of sputum-based diagnostics. Host-response biomarkers, particularly pattern recognition receptors (PRRs), offer a potential alternative. Toll-like receptor 4 (TLR4), scavenger receptor class B type 1 (SR-B1), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) are involved in the early recognition of Mycobacterium tuberculosis and may reflect initial immune activation under conditions of low bacillary burden and absent clinical symptoms. However, their diagnostic value in subclinical TB remains unclear. Therefore, this study was conducted to investigate their potential as biomarkers for subclinical TB.METHODS: Eighty-eight asymptomatic adults with a radiographic suspicion of pulmonary TB were classified into rapid molecular test (RMT)-positive and RMT-negative groups based on GeneXpert MTB/Rifampicin (RIF) results, which served as the reference standard. Blood samples were collected from the subjects, and their serum levels of TLR4, SR-B1, and DC-SIGN were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: TLR4 levels were significantly higher in the RMT-positive group (p=0.011), whereas SR-B1 and DC-SIGN showed no significant differences. TLR4 was the only biomarker with strong correlation with subclinical TB status (r=0.861, p<0.001). Based on logistic regression results, TLR4 was identified as the superior predictor with an area under the curve (AUC) of 0.937, 91.3% sensitivity, and 89.8% accuracy. Combining SR-B1 and DC-SIGN with TLR4 did not materially improve diagnostic performance over the TLR4-only model.CONCLUSION: TLR4 is a promising biomarker associated with RMT-positive status among individuals with suspected subclinical TB, with strong diagnostic performance. Patients with both RMT-positive results and elevated TLR4 levels may require closer monitoring for potential progression to active disease.KEYWORDS: subclinical tuberculosis, PRRs, TLR4, SR-B1, DC-SIGN, tuberculosis biomarker
Co-Authors Abd. Rasyid Syamsuri Abdurrachman Abdurrachman Achmad Rifa’i, Achmad Achmad Rudijanto Achmad Rudijanto Agustina T Endharti, Agustina T Agustina Tri E Agustina Tri Endharti Ahmad Bayhaqi Nasir Aslam Airlangga, Dimas Ikhsan Albaar, Thoha M. Alfandy, Tommy N. Asih, Sari Wulan Athaya Febriantyo Purnomo Ati Rastini Atma Gunawan Atma Gunawan Atma Gunawan Aulanni'am, Aulanni'am Balindra, Fredlina Rossa Bambang Rahardjo Benny A Pradana, Benny A Bowo Hery Prasetyo, Bowo Hery BP Putra Suryana BP Putra Suryana Cesarius Singgih Wahono Dalhar, Mochamad Daniel Happy Putra Dantara, Tri W.I. Dany Farida Desfryda, Elynca Putri Dessy Setiawati Dessy Wulandari, Dessy desy wulandari Devi, Nabila Sinta Dewi Santosaningsih Dewi, Elvira S. Dhani, Fauzan K. Dhian E. P. Harnandari Diadjeng Setya Wardani Dian Ayu Wulansari, Dian Ayu Dian Hasanah Dian Sukma Hanggara Dimas Ikhsan Airlangga Djajalaksana, Susanthy Djoko W. Soeatmadji Dona Marisa, Dona Dwinadella, Sephia Eko, Mudjiwijono Handaru Elvira Sari Dewi Ema Pristi Yunita Ema Pristi Yunita, Ema Pristi Engli, Katherina Enny Listyawati Erawati, Dini Rachma Erna Amin Faisal Faisal Farida ** Fatchiyah Fatchiyah Firdaningrum, Nimas Eka Gizta, Aura Bella Gunawan Gunawan Handono Kalim Hani Susanti, Hani Hani Susianti Hanik Ruliani Haribowo, A S Hidayat Sujuti HMS Chandra Kusuma I Putu A.S Ibrahim Njoto Ihda Dian Kusuma Indah Jayani Ivan A Hartono, Ivan A Janasti, Laksmitha Kedaton, Rafi Andyah Arum Krisni Subandiyah Kurnianingsih, Nia L Enggar Fitri Laksmi Karunia Tanuwijaya Laksmi Karunia Tanuwijaya Lisyani Suromo Loeki Enggar Fitri M Rasjad Indra Machlusil Husna, Machlusil Maghfirah, Halimi Bidaimi Marsetyawan HNE Soesatyo Muhammad Anshory, Muhammad Muhammad Masyhur Nelly Ismayasih Nurdiana Nurdiana Nurhadi, Pradana Nurwijayanti Perdana Aditya Rahman Poetri, Levrita Nindya Pramadhani, Almira Prasetyo, Dwi A. Pratama, Mirza Z. Pratama, Mirza Zaka Priyono, Riski Irawan Putra Purwanto Adipireno Putri, Choirinnisa Meilia Ayu Putu A. Herliawati R.I R.I Radhitio A Nugroho, Radhitio A Rahmawati, Hanifa Rizky Ria Famuji, Siti Roziah Rifa’i, A Rizky Fachry, Ade Wlidan Rossy Meilani Rulli Rosandi Safrina Dewi Ratnaningrum, Safrina Dewi Sari, Riana Trinovita Sari, Tita Luthfia Satrio Wibowo Singgih Wahono Solly Aryza Sri Andarini Indreswari Sri Poeranto, Sri Subandi Subandi Subandi Subandi Suharyo Hadisaputro Sulistomo, Hikmawan Wahyu Sulistyorini Sulistyorini Sumarno . Sumarta, Norma Hanifah Suryana, Bagus Putu Putra Sutrisno Sutrisno Suwito, Mat Syahrul Chilmi Syahrul Chilmi, Syahrul Tatit Nurseta Tatit Nurseta Torajasa Achamar Tri Yudani Mardining Raras VALENTINA YURINA VALENTINA YURINA Wahono, Caesarius Singgih Wahono, Cesarius S. Wahono, Cesarius Singgih Wisnu Barlianto Wisnu Barlianto Wisnu Barlianto Yahya Irwanto Yona One Sidarta, Yona One Yudhanto, Hendy Setyo Yuliana Salman Zaenal Kusuma