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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Jurnal Penelitian Kesehatan Suara Forikes Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Health and Medical Journal Human Care Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Mandala of Health : A Scientific Journal Oftalmologi: Jurnal Kesehatan Mata Indonesia

Husnil Kadri

Universitas Andalas

Author-ID : 283583

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Veterinary Other

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Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012 Rahmat Feryadi; Delmi Sulastri; Husnil Kadri
Jurnal Kesehatan Andalas Vol 3, No 2 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i2.89

AbstrakHipertensi merupakan masalah kesehatan yang banyak dijumpai pada masyarakat dan berkorelasi dengan penyakit lainnya. Banyak faktor penyebab terjadinya hipertensi, salah satunya adalah gangguan profil lipid. Profil lipid dapat memicu terjadinya hipertensi melalui berbagai mekanisme, baik secara langsung atau tidak langsung. Penelitian ini bertujuan untuk meneliti lebih lanjut tentang hubungan obesitas dengan kejadian hipertensi. Penelitian dilakukan pada masyarakat Etnik Minangkabau di 8 kelurahan di kota Padang. Ini adalah studi komparatif menggunakan desain cross sectional study, dengan jumlah subjek 160 responden. Pengumpulan data responden dilakukan dengan wawancara. Pengukuran tekanan darah dilakukan berdasarkan cara yang direkomendasikan WHO dan penetapan nilainya berdasarkan JNC VII. Profil lipid diukur dilaboratorium dengan acuan penilaian berdasarkan NCEP ATP III. Analisis statistik yang digunakan adalah uji chi square. Hasil penelitian ini menunjukkan bahwa sebagian besar gangguan kadar kolesterol terdapat pada penderita hipertensi dari pada normotensi. Uji statistik chi square menunjukkan hubungan yang bermakna antara kadar kolesterol dan trigliserida dengan kejadian hipertensi (total kolesterol p < 0,05; OR = 2,40, trigliserida p< 0,05; OR = 2,49). Kadar HDL dan LDL tidak menunjukkan hubungan yang bermakna terhadap kejadian hipertensi (p > 0,05). Dari hasil tersebut dapat disimpulkan bahwa sebagian fraksi profil lipid mempengaruhi kejadian hipertensi pada etnik Minangkabau yang berada di kota Padang, yaitu kadar kolesterol total dan trigliserida.Kata kunci: Hipertensi, kolestertol total, HDL, LDL, Trigliserida, etnik Minangkabau.AbstractHypertension is a common disease in the community and have correlation with other diseases. Many factor can leads hypertension, such as disturbance of lipid profile. Lipid profile can lead hypertension through a variety of mechanism, either directly or indirectly. This study aims to investigate the lipid profile relation with the incident of hypertension. The research was conducted at the Minangkabau ethnic communities in 8 district in Padang city. This was s a comparative study using a cross sectional study in 160 respondents. Data was collected by interview to get respondent characteristics. Measurement of blood preasure waist and carried out by the WHO recommended and appointment value based on JNC VII. Profile lipid was measured in laboratory and appointment value based on NCEP ATP III. The statistical analysis used chi square test. The result found that the disturbance of total cholesterol and trigliceride more existed in hypertension than normotension population. Chi square statistical test showed there was relation between total cholesterol and triglycerides with hypertension incident (total cholesterol p < 0,05; OR = 2,40 , triglycerides p < 0,05 ; OR = 2,49 ). HDL and LDL had not significant relation with hypertension incident (p > 0.05). The conclusion of this study is some of profil lipid effected hypertension incident at Minangkabau Ethnic in Padang, especially total cholesterol and triglycerides.Keywords: Hypertension, total cholesterol, HDL, LDL, triglycerides, Minangkabau Ethnic

Penggunaan Obat Antihipertensi pada Pasien Hipertensi Esensial di Poliklinik Ginjal Hipertensi RSUP DR. M. Djamil Tahun 2011 Heri Fitrianto; Syaiful Azmi; Husnil Kadri
Jurnal Kesehatan Andalas Vol 3, No 1 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i1.24

AbstrakPenyakit hipertensi tidak dapat disembuhkan dan berkaitan erat dengan penurunan usia harapan hidup. Penderita hipertensi juga sering kali disertai oleh penyakit penyerta. Umumnya, golongan obat antihipertensi yang dikenal yaitu, diuretik, ACE Inhibitor, Angiotensin Reseptor Bloker, Canal Calcium Blocker, and Beta Blocker. Terapi yang diberikan pada penderita hipertensi tanpa penyakit penyerta dan dengan penyakit penyerta tentunya berbeda. Tujuan penelitian ini adalah mengetahui penggunaan obat antihipertensi antara pasien hipertensi esensial dengan penyakit penyerta dan yang tidak disertai dengan penyakit penyerta di poliklinik RSUD Dr. M. Djamil, Padang. Metode penelitian yang digunakan adalah deskriptif dengan mengambil data dari rekam medik. Data dari 380 pasien yang dikumpulkan selama periode Januari 2011 sampai dengan Desember 2011. Jumlah subjek ditentukan dengan teknik total sampling. Dari data penelitian didapatkan bahwa 277 pasien hipertensi tanpa penyakit penyerta dan sebanyak 103 pasien hipertensi dengan penyakit penyerta. Komposisi dari 103 pasien hipertensi dengan penyakit penyerta yaitu 63 pasien dengan diabetes melitus, 13 pasien dengan PJK, 13 pasien dengan stroke, 7 pasien dengan gagal jantung, 4 pasien dengan pasca infark miokard, 3 pasien dengan gagal ginjal kronik. Berdasarkan data penelitian didapatkan penggunaan obat antihipertensi yang sering digunakan yaitu Hidroklortiazid (35,5%), Captopril (26,2%), Valsartan (20,6%), Amlodipin (15,2%), dan obat antihipertensi lain (2,5%). Berdasarkan hasil penelitian disimpulkan bahwa hipertensi dengan penyakit penyerta terbanyak adalah diabetes melitus dan penggunaan obat terbanyak berasal dari golongan diuretik yaitu penggunaan Hidroklortiazid.Kata kunci: obat antihipertensi, hipertensi, diuretikAbstractHypertension can not be cured and is closely related to a decrease in life expectancy. Patients with hypertension are also often accompanied by complience indication. Generally, antihypertensive drug classes are known, namely, diuretic, ACE Inhibitor, Angiotensin Reseptor Bloker, Canal Calcium Blocker, and Beta Blocker. Therapy which given to patients with or without complience indications is certainly different. The objective of this study was to determine the usage of anti-hypertension medicine in essential hypertension patients with or without complience indications in policlinic of General Hospital Dr. M. Djamil Padang. This was a descriptive study which the data were taken from medical record. The 380 patient’s data in period January 2011 – December 2011. The number of subjects was determined by the total sampling. The data showed 277 hypertension patients without complience indications and 103 hypertension patients with complience indications. Compositions of 103 hypertension patients with complience indications are 63 patients with diabetes mellitus, 13 patients with PJK, 13 patients with stroke, 7 patients with heart failure, 4 patients with post-infarct myocardium, and 3 patients with chronic kidney failure. Concerning the usage of anti-hypertension medicines which were frequently i.e. Hidroclortiazid (35,5%), Captopril (26,2%), Valsartan (20,6%), Amilodipin (15,2%), and other anti-hypertension drugs (2,5%). Based on the results of this study are concluded that complience indications suffered by most hypertension patients is diabetes mellitus and the usage of medicine by most patients is from diuretic which is Hidroclortiazid.Keywords: antihypertension drugs, hypertension, diuretics

Hubungan Konsumsi Makanan Sumber Antioksidan dan Omega-3 Terhadap Tekanan Darah Masyarakat di Sumatera Barat Harris Putra Reza; Nur Indrawati Lipoeto; Husnil Kadri
Jurnal Kesehatan Andalas Vol 5, No 2 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i2.531

Abstrak Pengaturan tekanan darah melibatkan banyak sistem seperti endotelium melalui aktifitas nitrit oksida. Produksi dan aktivitas nitrit oksida dapat dipengaruhi oleh pola makan, terutama asupan makanan sumber antioksidan dan omega-3. Tujuan penelitian ini adalah menentukan hubungan antara makanan sumber antioksidan dan omega-3 terhadap tekanan darah masyarakat di Sumatera barat. Penelitian ini merupakan penelitian dengan data sekunder yang berasal dari penelitian Lipoeto et al (2008) yaitu “Faktor Determinan Hipertensi di Sumatera Barat”. Subyek penelitian berjumlah 400 orang yang diwawancarai menggunakan formulir Food Frequency Questioner (FFQ) dan pemeriksaan tekanan darah dengan sphygmomanometer air raksa. Penelitian ini dilaksanakan dari Maret sampai Mei 2014. Hasil penelitian menunjukkan bahwa rerata konsumsi sayur dan buah masyarakat di Sumatera Barat lebih tinggi dari rerata Internasional, tapi lebih rendah dari rerata nasional dengan rerata 200.7 ± 128.11 gram/orang/hari, rerata konsumsi ikan masyarakat di Sumatera Barat lebih tinggi dari rerata nasional dan internasional yakni 101.26 ± 62.18 gram/orang/hari. Prevalensi hipertensi di Sumatera Barat mengalami kenaikan menjadi sebesar 41.76%. Tingkat konsumsi makanan sumber antioksidan dan omega-3 masyarakat Sumatera Barat lebih tinggi daripada rerata internasional. Terjadi peningkatan prevalensi hipertensi di Sumatera Barat. Kesimpulan hasil studi ini adalah tidak terdapat hubungan antara konsumsi makanan sumber antioksidan dan omega-3 terhadap tekanan darah.Kata kunci: antioksidan, omega-3, tekanan darah Abstract Blood pressure regulation involves many systems, one of the most important is endothelial system through nitric oxide activity. Nitric oxide is also known to be affected by diet, especially dietary intake of antioxidants and omega-3. The objective of this study was to determine the correlation between consumption of food source of antioxidant and omega-3 on blood pressure to people in West Sumatra. This study used secondary data from research by Lipoeto et al (2008) in "Determinant Factors of Hypertension in West Sumatra". Subjects were 400 people who were interviewed using Food Frequency Questionnaire (FFQ) form and examination of blood pressure using mercury sphygmomanometer. This research was conducted from March to May 2014. The result showed that the average consumption of vegetables and fruits of West Sumatran people is higher than international average, but lower than national average with a mean of 200.7 ± 128.11 g / person / day, the average consumption of fish of West Sumatran people is higher than the national and international average ie, 101.26 ± 62.18 g / person / day. The prevalence of hypertension in West Sumatra was increased to 41.76%. This study obtained the level of consumption of food sources of antioxidants and omega-3 of West Sumatran people is higher than international average. There is prevalence increasing of hypertension in West Sumatra. The conclusion is no correlation between the consumption of food sources of antioxidants and omega-3 on blood pressure.Keywords: antioxidant, omega-3, blood pressure

UPAYA PENINGKATAN PENGETAHUAN TENTANG MAKANAN JAJANAN DAN PEMERIKSAAN GOLONGAN DARAH PADA MURID SD NEGERI 11 LOLONG BELANTI DI KECAMATAN PADANG UTARA Yustini Alioes; Husnil Kadri
BULETIN ILMIAH NAGARI MEMBANGUN Vol 3 No 1 (2020)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Community service on the decision-making process in foreign policy aims to improve awareness of high school students in Padang on the importance of foreign policy. Foreign policy is often identified with complexity and far from public sphere. The community service team expects this activity could help high school students understand the decision making process in foreign policy. The community service is conducted with lecture and role-play method of formulating foreign policy. The approach used in this program is Graham Allison’s concept regarding process of foreign policy- making. This activity is designed in several stages. In the initial stages, the team prepares working plans. The second stage is socialization and the last stage is program implementation. It can be concluded that this community service has increased the student’s understanding in regards to the importance of foreign policy. Result of this activity indicates that students’ knowledge on foreign policy is improving. This is calculated based on several indicators i.e understanding on the role of actors in formulating foreign policy, factors affecting foreign policy and impact on the state’s strategy to pursue its national interest.

EDUKASI KESEHATAN DAN PEMERIKSAAN GOLONGAN DARAH PADA MURID SD NEGERI 13 DI DESA TUNGKAL SELATAN KECAMATAN PARIAMAN UTARA Yustini Alioes; Husnil Kadri; Eti Yerizel; Hirowati Ali; Rauza Sukma Rita; Desy Arisanti
BULETIN ILMIAH NAGARI MEMBANGUN Vol 4 No 2 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i2.289

Elementary school students are consumers who are among those who consume the most food and beverages. Food and drinks sold around the school contain many hazardous substances such as dyes that have been banned from circulating (Rhodamine B in iced drinks, jelly drinks, and so on) and other additives such as formalin which is used as a chewy substance in meatballs sold in carts and restaurants that can cause acute poisonings such as allergies, coughs and chronic poisonings such as cancer of the liver, kidneys and other organs. The purpose of this activity is to increase knowledge about substances in food and an introduction to blood group examination. This activity was carried out at SD Negeri 13 Tungkal Selatan Village in North Pariaman District. The method of activity is in the form of counseling and demonstration. According to the survey before the blood group examination, it turned out that most of the elementary school students did not know their blood type. Before the blood group examination, the students were also given knowledge about determining a person's blood type. After this counseling was carried out, respondents became more aware of the impact of food/snacks on health, and respondents knew their respective blood types. Of the 64 students, there are 22 A, 17 B, 12 AB, 13 O. To avoid problems related to food and blood type. There is a need for continuous health education for elementary school students.

Hubungan Tingkat Pengetahuan Ibu dengan Pemberian Imunisasi Dasar Campak di Kelurahan Balai Gadang Wilayah Kerja Puskesmas Air Dingin Kota Padang Addina Fitri Islami; Rosfita Rasyid; Husnil Kadri
Majalah Kedokteran Andalas Vol 44, No 4 (2021): Online September 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i4.p206-214.2021

The lowest immunization coverage in Padang is in area of Puskesmas Air Dingin Padang. Mother’s knowledge is one of the factor that influence the provision of immunization. Objectives: To determined correlation between mother’s knowledge of measles immunization and provision of measles immunization in area of Puskesmas Air Dingin Padang. Methods: This was an analytic study with cross-sectional design. The population were all of mothers with babies age 9-48 months in the area of Puskesmas Air Dingin Padang. The 139 of samples were taken by purposive sampling. Data were collected by interviews using questionnaires. Computerized data processing and analysis permormed by Chi-square test. Results: This study obtained 59,7 % of respondents gave measles immunization to their childen and 89,9% of respondents have sufficient knowledge about measles immunization. There was significant correlation between two variables (p=0,001). Conclusion: There is a significant correlation between mother’s knowledge of measles immunization and provision of measles immunization in Balai Gadang area of Puskesmas Air Dingin Padang, therefore needs to be improved counseling about measles and measles immunization to the community.

HUBUNGAN POLA MAKAN DENGAN TEKANAN DARAH PADA ORANG DEWASA DI SUMATERA BARAT Miftah Nur Andamsari; Nur Indrawati Lipoeto; Husnil Kadri
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakTerdapat banyak faktor yang mempengaruhi tekanan darah pada orang dewasa, salah satunya adalah pola makan. Makanan dapat memicu kenaikan atau penurunan tekanan darah. Penelitian ini bertujuan untuk meneliti lebih lanjut tentang hubungan pola makan dengan tekanan darah. Penelitian ini dilakukan pada masyarakat yang bertempat tinggal di Padang Pariaman, Padang, Solok dan Padang Panjang. Penelitian ini merupakan studi cross-sectional dengan jumlah sampel 250 orang. Pengumpulan data responden dilakukan dengan wawancara dan pengukuran tekanan darah. Analisis statistic yang digunakan adalah uji korelasi Spearman. Hasil penelitian ini menunjukkan bahwa 20% responden menderita hipertensi. Uji korelasi Spearman menunjukkan adanya hubungan antara konsumsi lemak dengan tekanan darah sistolik (p<0,05). Sementara konsumsi lemak dengan tekanan darah diastolik tidak menunjukkan adanya hubungan (p>0,05). Konsumsi kalori, vitamin C dan kalsium juga tidak menunjukkan hubungan dengan tekanan darah (p>0,05). Kesimpulan dari penelitian ini adalah walaupun tidak terdapat hubungan yang signifikan antara pola makan lemak, kalori, vitamin C dan kalsium dengan tekanan darah, tapi ada kecenderungan terdapat korelasi yang negatif. Diperlukan penelitian lebih lanjut dengan memperhitungkan faktor resiko lain yang mempengaruhi tekanan darah.AbstractThere are many factors that have correlation with blood pressure in adult, one of them is food intake. Food can leads the blood pressure to increase or decrease. The objective of the study aims to further investigation the correlation of food intake with the blood pressure.The research was conducted to the people who live in Padang Pariaman, Padang, Solok and Padang Panjang. This research was a cross-sectional study with 250 subject of people. Data collection had done through the interview and measurement of blood. The statistical analysis was Spearman correlation test.The result of this research found that 20% of respondent was categorized into Hypertension. Spearman correlation test showed that there’s a relation between fat intake and systolic blood pressure (p<0,05). While there’s no relation between fat intake and diastolic blood pressure (p>0,05). The intake of calorie, vitamine C and calcium showed no relation too with blood pressure (p>0,05). The conclusion of this research is eventhough there was no relationship between intake of fat, calorie, vitamine C and calcium with blood pressure, but they have a negative correlation. There is a need to make same research about this topic with another risk factor that influence blood pressure.

PENGARUH EKSTRAK MENGKUDU TERHADAP KADAR MALONDIALDEHID DARAH DAN AKTIVITAS KATALASE TIKUS DM YANG DIINDUKSI ALOKSAN Rauza Sukma Rita; Eti Yerizel; Nursal Asbiran; Husnil Kadri
Majalah Kedokteran Andalas Vol 33, No 1: April 2009
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakPenelitian yang menyimpulkan bahwa stres oksidatif meningkat pada penyakit diabetes mellitus telah cukup banyak. Stres oksidatif tersebut dapat diartikan sebagai suatu ketidakseimbangan antara prooksidan (radikal bebas) dengan antioksidan, karena antioksidan tidak mampu meredam peningkatan prooksidan. Penelitian ini bertujuan mengkaji pengaruh asupan ekstrak mengkudu (Morinda citrifolia linn) yang berfungsi sebagai antioksidan terhadap kadar malondialdehid (penanda prooksidan) dan enzim katalase (penanda antioksidan) pada tikus diabetes karena induksi aloksan.Penelitian eksperimental ini dilakukan pada 12 ekor tikus putih dengan berat badan 200-250 gram yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif (hanya diberi makan dan minum), kelompok kontrol positif (makan dan minum,serta diinduksi aloksan), kelompok perlakuan (makan dan minum, diinduksi aloksan, dan diberi ekstrak mengkudu (500 mg/kg BB/hari) selama 12 hari. Data yang diperoleh dianalisa secara statistik dengan uji Anova dengan derajat kepercayaan 95%.Hasil penelitian menunjukkan terdapat perbedaan bermakna antar kelompok (p<0,05), dimana rerata kadar MDA darah kelompok kontrol negatif (4,2610,427 nmol/ml), kelompok kontrol positif (5,6050,391 nmol/ml), kelompok perlakuan (4,2610,427 nmol/ml) dan rerata aktivitas katalase kelompok kontrol negatif (6,5800,277 unit/mg), kelompok kontrol positif (4,9540,485 unit/mg), kelompok perlakuan (6,3140,651 unit/mg).Kesimpulan dari penelitian ini adalah pemberian ekstrak mengkudu dapat menu-runkan kadar MDA darah dan meningkatkan aktivitas enzim katalase tikus DM yang diinduksi aloksan.Kata kunci: ekstrak mengkudu – kadar MDA – aktivitas katalase – aloksan – tikus diabetesAbstractThere were so many study concluded that oxidative stress increased in diabetes mellitus. Oxidative stress can be defined as an imbalance between prooxidants and antioxidants, because antioxidants could not quench overARTIKEL PENELITIAN55production of prooxidants. This study investigated the effect of mengkudu extract (Morinda citrifolia linn) as antioxidant on malondialdehyde (MDA) level (prooxidant marker) and catalase (antioxidant marker) in alloxan induced diabetic rats.This experimental study had been carried out to 12 rats with 200-250 gram weight which divided into three group of four rats each, i.e. negative control, positive control (alloxan induced), and the group was treated by alloxan induced which followed by mengkudu extract oral (500mg/weight/day) for 12 days. The result was analyzed by using one way Anova with confidence interval 95%.There were significantly different in groups (p<0,05). The MDA level in negative control group is 4,2610,427 nmol/ml, positive control group is 5,6050,391 nmol/ml, and the group was treated by alloxan induced which followed by mengkudu extract oral is 4,2610,427 nmol/ml. Catalase activity in negative control group is 6,5800,277 unit/mg, positive control group is 4,9540,485 unit/mg, and the last group is 6,3140,651 unit/mg.The conclusion is mengkudu extract has capability to quench MDA level and increasing catalase activity in alloxan induced diabetic rats.Keywords : mengkudu extract – MDA level – catalase activity – aloksan – diabetic rats

PENGARUH PEMBERIAN MINYAK BUAH MERAH (Pandanus conoideus lam) TERHADAP KADAR GLUKOSA DARAH DAN MALONDIALDEHID SERUM MENCIT YANG DIINDUKSI ALOKSAN Husnil Kadri; Ezy Julianx Jarit; Erlina Rustam
Majalah Kedokteran Andalas Vol 34, No 1 (2010): Published in April 2010
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakTujuan penelitian ini adalah untuk menentukan efek pemberian minyak buah merah (pandanus conoideus lam) terhadap kadar glukosa darah dan malondialdehid (MDA) serum mencit yang diinduksi dengan aloksan. Induksi aloksan ini menyebabkan hiperglikemia yang dapat mencetuskan stres oksidatif. Minyak buah merah yang mengandung banyak antioksidan dapat mengendalikan stres oksidatif yang akhirnya dapat menurunkan kadar glukosa darah dan MDA serum.Penelitian eksperimental ini menggunakan 15 ekor mencit jantan yang diseleksi secara random. Hewan coba dibagi menjadi 3 kelompok masing-masing terdiri 5 ekor mencit, yaitu; kelompok kontrol negatif yang hanya diberikan makan dan minum, kelompok kontrol positif yang diinduksi aloksan, dan kelompok perlakuan (diberi minyak buah merah oral) yang diinduksi aloksan. Setelah perlakuan hari ke-14, darah mencit diambil untuk diperiksa kadar glukosa darah dan MDA serum.Hasil penelitian menunjukkan rerata kadar glukosa darah kelompok kontrol negatif adalah 141,20 ± 13,10 mg/dl. Rerata kadar glukosa darah kelompok kontrol positif adalah 266,00 ± 111,10 mg/dl. Rerata kadar glukosa darah kelompok perlakuan adalah 194,80 ± 27,00 mg/dl. Rerata kadar MDA serum kelompok kontrol negatif adalah 0,91 ± 0,10 nmol/ml. Rerata kadar MDA serum kelompok kontrol positif adalah 1,49 ± 0,34 nmol/ml. Rerata kadar MDA kelompok perlakuan adalah 0,97 ± 0,14 nmol/ml. Perbedaan bermakna kadar glukosa darah hanya antara kelompok kontrol negatif dengan kelompok perlakuan (p<0.05). Analisis statistik kadar MDA serum menunjukkan terdapat perbedaan bermakna antara kelompok kontrol positif dengan kelompok perlakuan (p< 0,05).Kesimpulan dari penelitian ini ialah minyak buah merah tidak mampu menurunkan kadar glukosa darah pada kelompok perlakuan, tetapi minyak buah merah mampu menurunkan kadar MDA serum pada kelompok perlakuan.Kata kunci: minyak buah merah, glukosa darah, MDA serum, mencit, aloksanARTIKEL PENELITIAN80AbstractThe objective of this studi was to determine the effect of red fruit oil (pandanus conoideus lam) on blood glucose and serum malondialdehyde in alloxan induced diabetic mice. Hyperglycemia in this mice could lead to oxidative stress. Red fruit oil contains high antioxidants that have capability to control oxidative stress, so blood glucose and serum MDA is reduced.This experimental study had been carried out to 15 rats (randomized group design) which divided into three group of five rats each, i.e. negative control, positive control (alloxan induced), and the group was treated by alloxan induced which followed by red fruit oil orally for 14 days. The result was analyzed by using one way Anova with confidence interval 95%.The result show that blood glucose in negative control was 141.20 ± 13.10 mg/dl. Blood glucose in positive control was 266.00 ± 111.10 mg/dl. Blood glucose in the group was treated by alloxan induced which followed by red fruit orally is 194.80 ± 27.00 mg/dl. The MDA level in negative control group is 0.91 ± 0.10 nmol/ml, positive control group is 1.49 ± 0.34 nmol/ml, and the group was treated by alloxan induced which followed by red fruit orally is 0.97 ± 0.14 nmol/ml. Blood glucose was significantly different between negative control and treated group (p<0.05). Serum MDA was significantly different between positive control group and the group was treated by alloxan induced which followed by red fruit orally (p<0.05).The conclusion is red fruit oil cannot reduce blood glucose level in the group was treated by alloxan induced which followed by red fruit orally, but it has capability to quench serum MDA level in this group.Key word: red fruit oil – blood glucose – serum MDA – mice – alloxan

Hubungan Tumor Infiltrating Lymphocytes dengan Jenis Kelamin, Usia, dan Tipe Histopatologi Karsinoma Azzahra Velia; Tofrizal Tofrizal; Husnil Kadri
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 4 (2021): Desember 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i4.434

Latar belakang: Karsinoma tiroid merupakan keganasan pada kelenjar tiroid yang paling sering dijumpai di organ endokrin. Beberapa faktor yang berhubungan dengan karsinoma tiroid adalah jenis kelamin, usia, dan tipe histopatologi. Pada proses pembentukan sel kanker, terjadi mekanisme inflamasi dan proliferasi yang menyebabkan tubuh mengeluarkan imun pada area tersebut. Limfosit yang berperan pada respon imun seluler kanker disebut Tumor Infiltrating Lymphocytes (TILs). Objektif: Mengetahui hubungan TILs dengan jenis kelamin, usia, dan tipe histopatologi karsinoma tiroid. Metode: Penelitian ini merupakan penelitian analitik dengan desain pendekatan cross sectional. Pengambilan sampel dilakukan dengan teknik total sampling pada penderita karsinoma tiroid tahun 2018-2019 di Sentra Diagnostik Patologi Anatomi Fakultas Kedokteran Universitas Andalas dari bulan Februari-Desember 2020. Hasil: Hasil penelitian berdasarkan analisis uji bivariat Chi-square antara TILs dengen jenis kelamin (p=0.306), usia (p=0.306), dan tipe histopatologi karsinoma tiroid (p=0.034). Kesimpulan: Kesimpulan penelitian ini adalah terdapat hubungan bermakna antara TILs dengan tipe histopatologi karsinoma tiroid. Selanjutnya, tidak terdapat hubungan bermakna antara TILs dengan jenis kelamin dan usia penderita karsinoma tiroid.

Co-Authors Addina Fitri Islami Afifah Alfyanita Afifah Aqilatul Faridah Putri Wirza Afriwardi Afriwardi Almurdi Almurdi Anggy Afriani Annisa Yuda Mahdiyah Ansharina, Hafiznie Aristya Rahadiyan Budi Astuti, Bunga Aswiyanti Asri Azzahra Velia Delmi Sulastri Desmawati Desmawati Desmiwarti Desmiwarti Desrida Desrida Dessy Arisanty Desy Arisanti Desy Arisanti Dia Rofinda, Zelly Dia Dian Pertiwi Dina Arfiani Rusjdi Efrida Efrida Elmatris Elmatris Elmatris Sy Endrinaldi Erlina Rustam Eti Yerizel Ezy Julianx Jarit Fathiyyatul Khaira, Fathiyyatul Fauzan Arisyi Koto Febiyola Ratu Khairani Febria Prima Utari Gusti Revilla Hadi Oktafiano Harris Putra Reza Hendriati, Hendriati Heri Fitrianto Hildya Kusmi Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Ilahi, Fitratul Indah Lisfi Julizar Julizar Kemala Sayuti Kirbi Vira Akesa Mahata, Liganda Endo Mayetti Mayetti Mazara, Fitria Merisca Gayatri Ryosa Miftah Irramah Miftah Nur Andamsari Millah Fithriyah Zindany Moestafa Nur Muhammad Fadli Mulfa Satria Asnel Nadhira Isza Qushoyyi Nur Indrawati Lipoeto Nursal Asbiran Nurul Syifa Kurnia Nurul Syifa Kurnia Nuzulia Irawati Pratiwi Dian Pramana Putri, Biomechy Oktomalio Rahmani Welan Rahmat Feryadi Rana Zara Athaya Ranti Verdiana Rauza Sukma Rita Rini Gusya Liza, Rini Gusya Rita Hamdani Rose Dinda Martini Rosfita Rasyid Roza Mulyana Saptino Miro, Saptino Septi, Annisa Susila Sastri Syahrul, Muhammad Zulfadli Syaiful Azmi Syandrez Prima Putra Tofrizal Tofrizal Tofrizal Tofrizal Warman, Fadil Ahmadhia Yulia, Dwi Yusri, Elfira Yustini Alioes Yustini Alioes

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