Article Per Year (5 Year)
p-Index From 2020 - 2025
3.096
P-Index
This Author published in this journals
All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Jurnal Penelitian Kesehatan Suara Forikes Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Health and Medical Journal Human Care Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Mandala of Health : A Scientific Journal Oftalmologi: Jurnal Kesehatan Mata Indonesia
Husnil Kadri
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Veterinary Other

Published : 44 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 44 Documents
Search

 1   2   3   4   5 
Pengaruh Pemberian Mesenchymal Stem Cell Wharton’s Jelly Terhadap Kadar Malondialdehid Tikus Wistar Hiperglikemia Nadhira Isza Qushoyyi; Endrinaldi Endrinaldi; Miftah Irramah; Husnil Kadri; Aswiyanti Asri; Rahmani Welan; Husna Yetti
Jurnal Penelitian Kesehatan SUARA FORIKES 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14nk112

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, which causes damage to tissues and organs through the process of oxidative stress. Malondialdehyde (MDA) as a biomarker of oxidative stress has a significant increase in hyperglycemia. Stem cell therapy can be an option for diabetes mellitus such as Wharton's jelly mesenchymal stem cells. This study aimed to determine the effect of MSC-WJ administration on serum MDA levels of hyperglycemic Wistar rats. This experimental study applied a post-test only design with a control group. The sample consisted of 21 male Wistar rats divided into 3 groups, including the negative control group (K-), namely the group that was only given a standard feed diet, the positive control group (K+), namely the group that was injected with alloxan with a dose of 0.2 ml intraperitoneally, and the treatment group (P), which was the alloxan-induced group, and was given MSC-WJ at a dose of 3 million cells intravenously in the rat tails. In all three groups, blood was taken from the retro orbital plexus to measure serum MDA levels with the TBARS test. The results of the analysis showed that the mean serum MDA levels of the K-, K+, and P groups were 1.83 nmol/ml, 2.97 nmol/ml, and 1.73 nmol/ml, respectively. The results of the comparison test showed a value of p = 0.000. It was concluded that there was a significant difference in serum MDA levels between the three groups, which indicated that MSC-WJ administration could reduce alloxan-induced hyperglycemia Wistar rats serum MDA levels.Keywords: hyperglycemia; malondialdehyde; Wharton's jelly mesenchymal stem cells ABSTRAK Diabetes mellitus adalah gangguan metabolik yang ditandai dengan hiperglikemia, yang menyebabkan kerusakan jaringan dan organ melalui proses stress oksidatif. Malondialdehid (MDA) sebagai biomarker stress oksidatif mengalami peningkatan signifikan pada hiperglikemia. Terapi stem cell dapat menjadi pilihan untuk diabetes mellitus seperti mesenchymal stem cell wharton’s jelly. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian MSC-WJ terhadap kadar MDA serum tikus wistar hiperglikemia. Penelitian eksperimental ini menerapkan rancangan post-test only with control group. Sampel adalah 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok, di antaranya kelompok kontrol negatif (K-) yaitu kelompok yang hanya diberi diet pakan standar, kelompok kontrol positif (K+) yaitu kelompok yang diinjeksi aloksan dengan dosis 0,2 ml secara intraperitoneal, dan kelompok perlakuan (P) yaitu kelompok yang diinduksi aloksan, serta diberi MSC-WJ dengan dosis 3 juta sel secara intravena pada ekor tikus. Pada ketiga kelompok dilakukan pengambilan darah dari pleksus retro orbitalis untuk pengukuran kadar MDA serum dengan tes TBARS. Hasil analisis menunjukkan kadar rerata MDA serum kelompok K-, K+, dan P secara berturut-turut adalah 1,83 nmol/ml, 2,97 nmol/ml, dan 1,73 nmol/ml. Hasil uji perbandingan menunjukkan nilai p = 0,000. Disimpulkan bahwa terdapat perbedaan kadar MDA serum yang bermakna di antara ketiga kelompok, yang menunjukkan bahwa pemberian MSC-WJ dapat menurunkan kadar MDA serum tikus wistar hiperglikemia yang diinduksi aloksan.Kata kunci: hiperglikemia; malondialdehid; mesenchymal stem cell wharton’s jelly
EFEK EKSTRAK DAUN KEMANGI (Ocimum basilicum L.) TERHADAP KADAR HIGH-DENSITY LIPOPROTEIN TIKUS (Rattus norvegicus) MODEL ATEROSKLEROSIS Mazara, Fitria; Mahata, Liganda Endo; Kadri, Husnil; Putri, Biomechy Oktomalio; Ali, Hirowati; Khaira, Fathiyyatul; Rusjdi, Dina Arfiani
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11432

Abstract

Atherosclerosis is the cardiovascular disease’s main pathological mechanism. Basil leaves are food companion that s widely consumed by Indonesians and contains phenolic and flavonoid bioactive compounds that can increase HDL levels. The purpose of this study was to see the effect of basil leaves extract (Ocimum basilicum L.) on HDL levels in atherosclerosis model rat. This study was conducted using the post test only control group design method on 29 rats. The rats were divided into 5 groups, K-, K+, P1, P2, and P3. K- is group of rats without treatment. K+ was treated with partial carotid ligation (PCL) and high fat diet (HFD), P1 was treated with PCL, HFD and given a dose of 100 mg/kgB basil leaves extract, P2 was treated with PCL, HFD and given a dose of 200 mg/kgBB basil leaves extract, P3 was treated with PCL, HFD and given simvastatin 1.5 mg/rat/day. HFD was given for 7 days, basil leaves extract and simvastatin given for 14 days using oral feeding tube. HDL levels tested with CHOD-PAP method using a microlab 300 spectrophotometer. The result from this study were analyzed by Saphiro-Wilk test, and Kruskal-Wallis test. The mean HDL levels obtained in the K- group were 52,65(49,70‒68.10) mg/dL, K+ 49,67±8,77 mg/dL, P1 52.70±1.58 mg/dL, P2 54.40±9.94 mg/dL, P3 58,05 ±5,34 mg/dL. The results showed there was a non-significant increase in HDL levels (p=0.377) in atherosclerosis model rat by giving basil leaves extract on both dose, and simvastatin.
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1361-1375.2024

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
Hubungan Pemakaian Obat Antiinflamasi Nonsteroid (OAINS) dengan Derajat Keparahan Dispepsia pada Pasien Osteoartritis di Wilayah Kerja Puskesmas Kuranji Kota Padang Muhammad Fadli; Rustam, Erlina; Syahrul, Muhammad Zulfadli; Usman, Elly; Miro, Saptino; Kadri, Husnil
Majalah Kedokteran Andalas Vol. 48 No. 4 (2025): MKA October 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i4.p400-409.2025

Abstract

Osteoartritis (OA) adalah bentuk peradangan pada sendi yang sangat umum dan menjadi salah satu penyebab utama rasa nyeri di dunia dengan kondisi jangka panjang. Nyeri akibat OA dapat diterapi dengan obat antiinflamasi nonsteroid (OAINS) yang memiliki efek samping dispepsia. Dispepsia diklasifikasikan menjadi tiga, yaitu dispepsia ringan, dispepsia sedang, dan dispepsia berat. Penelitian ini bertujuan untuk mengetahui hubungan pemakaian OAINS dengan derajat keparahan dispepsia pada pasien osteoartritis di wilayah kerja Puskesmas Kuranji Kota Padang. Penelitian cross sectional menggunakan data primer dengan mewawancarai pasien OA terapi OAINS dengan kuesioner di Puskesmas Kuranji Kota Padang dengan jumlah responden 101 orang. Uji analisis yang digunakan adalah uji chi square. Hasil uji univariat menghasilkan pasien OA didominasi oleh kelompok usia >60 tahun (54,5%), berjenis kelamin perempuan (79,2%), dengan jenis OAINS Natrium Diklofenak (84,2%), lama penggunaan OAINS >3 bulan (56,4%). Uji bivariat didapatkan hubungan pemakaian OAINS dengan dispepsia dengan nilai p=0,000, serta hubungan lama pemakaian OAINS dengan derajat keparahan dispepsia dengan nilai p=0,001. Penelitian ini menyimpulkan bahwa terdapat hubungan pemakaian OAINS dengan dispepsia dan terdapat hubungan lama pemakaian OAINS dengan derajat keparahan dispepsia pada pasien OA terapi OAINS di Puskesmas Kuranji Kota Padang.
Co-Authors Addina Fitri Islami Afifah Alfyanita Afifah Aqilatul Faridah Putri Wirza Afriwardi Afriwardi Almurdi Almurdi Anggy Afriani Annisa Yuda Mahdiyah Ansharina, Hafiznie Aristya Rahadiyan Budi Astuti, Bunga Aswiyanti Asri Azzahra Velia Delmi Sulastri Desmawati Desmawati Desmiwarti Desmiwarti Desrida Desrida Dessy Arisanty Desy Arisanti Desy Arisanti Dia Rofinda, Zelly Dia Dian Pertiwi Dina Arfiani Rusjdi Efrida Efrida Elmatris Elmatris Elmatris Sy Endrinaldi Erlina Rustam Eti Yerizel Ezy Julianx Jarit Fathiyyatul Khaira, Fathiyyatul Fauzan Arisyi Koto Febiyola Ratu Khairani Febria Prima Utari Gusti Revilla Hadi Oktafiano Harris Putra Reza Hendriati, Hendriati Heri Fitrianto Hildya Kusmi Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Ilahi, Fitratul Indah Lisfi Julizar Julizar Kemala Sayuti Kirbi Vira Akesa Mahata, Liganda Endo Mayetti Mayetti Mazara, Fitria Merisca Gayatri Ryosa Miftah Irramah Miftah Nur Andamsari Millah Fithriyah Zindany Moestafa Nur Muhammad Fadli Mulfa Satria Asnel Nadhira Isza Qushoyyi Nur Indrawati Lipoeto Nursal Asbiran Nurul Syifa Kurnia Nurul Syifa Kurnia Nuzulia Irawati Pratiwi Dian Pramana Putri, Biomechy Oktomalio Rahmani Welan Rahmat Feryadi Rana Zara Athaya Ranti Verdiana Rauza Sukma Rita Rini Gusya Liza, Rini Gusya Rita Hamdani Rose Dinda Martini Rosfita Rasyid Roza Mulyana Saptino Miro, Saptino Septi, Annisa Susila Sastri Syahrul, Muhammad Zulfadli Syaiful Azmi Syandrez Prima Putra Tofrizal Tofrizal Tofrizal Tofrizal Warman, Fadil Ahmadhia Yulia, Dwi Yusri, Elfira Yustini Alioes Yustini Alioes