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A New Insight Into Toxicity of Database Compounds from Ginger (Zingiber officinale) by Modelling Study Frimayanti, Neni; Febrina, Mira; Yuri Amalia, Annisa
Jurnal Riset Kimia Vol. 15 No. 1 (2024): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i1.638

Abstract

Dengue haemorrhagic fever (DHF) is an infectious disease caused by the dengue virus. The dengue virus is transmitted through female mosquitoes, especially Aedes aegypti and Aedes albopictus. Indonesia is a dengue endemic country, and almost all provinces in Indonesia are infected with dengue. However, targeted antiviral drugs against dengue virus (DENV) are not yet available. This study aimed to determine the potential of three compounds isolated from ginger (Zingiber officinale) as dengue NS2B/NS3 inhibitors, and to predict the physicochemical properties (drug-likeness) and potential toxicity of drug candidates. Ginger isolates in the form of [8]-gingerol, [6]-paradol, shogaol were obtained from the Natural Discovery Database (NADI). Toxicity and drug-likeness predictions were performed using ProTox-II and SwissADME, and Molecular Operating Environment (MOE) 2022.0901 was used for the molecular docking process. Results: The results showed that the ginger compound (Zingiber officinale), [8]-Gingerol, [6]-Paradol, and Shogaol, had binding free energy of -7.18, -7.10 and -6.88 kcal/mol, respectively. It is indicated that three compounds had  potentiality to inhibit the NS2B/NS3 protein complex with a binding free energy that was almost equivalent to that of the positive control, panduratin A, and similar to that of the positive control, which can be seen in superimposition. In addition, three compounds isolated from ginger met the drug-likeness parameters. Based on the analysis of in silico toxicity studies, the three compounds isolated from ginger showed different levels of toxicity. Therefore, based on the safety level of oral use, the [8]-gingerol compound is safer to develop as a dengue antiviral drug, where the LD50 value of [8]-gingerol is 2.580 mg/kg with a class V toxicity level that is practically nontoxic.
OPTIMALISASI PENGGUNAAN OBAT MAAG DAN GERD SELAMA BULAN PUASA: EDUKASI KESEHATAN BAGI SISWA MAN 3 KOTA PEKANBARU Iskandar, Benni; Frimayanti, Neni; Ulfa, Rodhia; Maulana, Irfan; Anggraini, Haryeni Sastra; Sisilawati, Kolista; Azela, Lala; Anabesi, Mazaya Putri; Rizki, Mulia; Salsabillah, Mutiara; Ramadhani, Nadea Zahra; Putri, Nadila; Novrianti, Nisa
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 2 (2025): Volume 6 No. 2 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i2.44093

Abstract

Selama bulan Ramadan, individu Muslim yang menderita penyakit maag dan gastroesophageal reflux disease (GERD) mengalami perubahan pola konsumsi obat akibat periode puasa yang berlangsung antara 11 hingga 18 jam. Penyesuaian jadwal ini dapat memengaruhi farmakokinetik obat, berpotensi mengurangi efektivitas terapi jika tidak dikelola dengan baik. Oleh karena itu, edukasi kesehatan menjadi krusial untuk memastikan pemahaman yang tepat mengenai aturan dan waktu penggunaan obat selama berpuasa guna mencapai efek terapi yang optimal. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan siswa MAN 3 Kota Pekanbaru tentang penggunaan obat maag dan GERD yang rasional selama bulan Ramadan. Metode yang digunakan mencakup penyuluhan interaktif yang didukung dengan media edukasi berupa leaflet dan presentasi PowerPoint. Efektivitas edukasi diukur melalui pre-test dan post-test dengan lembar checklist sebagai instrumen evaluasi. Hasil analisis menggunakan uji Wilcoxon menunjukkan peningkatan signifikan dalam tingkat pengetahuan siswa setelah edukasi, dengan nilai p = 0,000 (p < 0,05). Temuan ini menegaskan bahwa penyuluhan berbasis ceramah, didukung oleh leaflet, secara efektif meningkatkan pemahaman siswa tentang penggunaan obat maag dan GERD selama bulan puasa.
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Frimayanti, Neni; Peng-Wei, Ching; Khairani, Sondang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine, showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Co-Authors Abdi Wira Septama Abdi Wira Septama Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel zamri Adel Zamri Adel Zamri adli husin, Raja agistia, nesa Agustini, Tiara Tri alhamdania Balqis, Salsabila Alifah Nurul Khusnah Amanda, Denisya Amrina Rossada Septilapani Anabesi, Mazaya Putri Anfasa Mashudi, Fristio Anggraeni, Ica Winanda Anggraini, Haryeni Sastra Anita Lukman Antasya, Vaylia Armon Fernando Arsad, Larasati Aulia Wibowo, Selvi Azela, Lala Azlin, Kiranti Bella Parina, Ana BENNI ISKANDAR Daniel Sialagan Dea Dwi Putri Difa, Faradini Ramsanjami Efendi, Apriyani Eka Marisa Putri Elsa Etavianti Elsa Natia Elvi Khairani, Mai Elviyenti, Elviyenti Emma Susanti Enda Mora Etavianti, Elsa Fatmalia, Anggun Ferdy Firmansya Ferdy Firmansyah Fikri Maulana Fikri Maulana, Fikri Fina Aryani, Fina Fitriani, R. Rizatita Fitriani, Rizda Fri Murdiya, Fri Furi, Mustika Guntur Guntur Haiyul Fadhli Hamzah, Hasyrul Hendra, Rudi Herfindo, Nofal Herfindo, Noval Hery Widijanto Hilwan Y. Teruna Hilwan Yuda Teruna Husnawati Husnawati Ihsan Ikhtiarudin Ikhtiaruddin, Ihsan Irfan Maulana, Irfan Iriani, Revy Jasril , Jasril Jasril Jasril Kirana, Fharisti Kurniawan Putri, Nurafika Livia Nathania Meiriza Djohari, Meiriza Melzi Octaviani Meri Ernilawati Meridona Mira Febrina, Mira Muharani, Siska Muhtadi, Wildan Khairi Musyirna Rahmah Nasution Muttaqin, Fauzan Zein Nahdiah Nahdiah Nahdiah Nahdiah, Nahdiah Nasution, Musyirna Rahmah Nelly Oscifiani Nelly Oscifiani Ningsih, Yozi Fiedya Nofriyanti Nova Tantri Silalahi Noval Herfindo Noval Herfindo Noval Herfindo Noval Herfindo Noval Herfindo Noval Herfindo Novrianti, Nisa Nurul fadillah, Nurul Nurul Susianti Oscifiani, Nelly Panjaitan, Pretty Farida Peng-Wei, Ching Putri Rizki Rahmadani Putri, Monica Rifa Putri, Nadila Qurnia Pratiwi, Putri Rabiatul Adawiyah Rahayu Rahayu Rahayu Rahayu Rahayu Rahayu Rahayu Utami Rahim, Fatma Rahma Dona Rahma Dona, Rahma Rahmah, Rizka I’zaa Ramadhani, Nadea Zahra Ricardo, Nadira Atiqah Rickha Octavia Rindiyani Rindiyani Riska Prasetiawati Rizki Anugrah Rizki, Mulia Rohim, Muhammad Rosnita Dewi Rahmawati Rossi Passarella Ruska, Shinta Liana Rusnedy, Rahmayati S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Salsabila, Aulia Salsabillah, Mutiara Sari, Rinita Shafira Melsonia Silalahi, Nova Tantri Siregar, Lisa Andriyani Sisilawati, Kolista Sitanggang, Sarah Dianora Solihin, Tabah Teguh Utama Tria Harlianti Ulfa, Rodhia Vasmawati, Della Vella kurnia Wahyuni Veza Azteria viola Afrilizetira, Garnis Wahyuni, Dilla Widya Ari Sandi Winda Yusma Ameliah Wulandari, Zertiks Yasthophi, Arif Yueflen, Fadiyah Yuli Haryani Yum Eryanti Yum Eryanti Yum Eryanti Yuni Fatisa Yuri Amalia, Annisa Zafarani, Welly Zahirah Ananda, Salsabila