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All Journal ComEngApp : Computer Engineering and Applications Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Teknika SEMIRATA 2015 Jurnal CoreIT Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JURNAL PENDIDIKAN TAMBUSAI J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Building of Informatics, Technology and Science Jurnal Yustitia JOURNAL OF INFORMATION SYSTEM RESEARCH (JOSH) Jurnal Pengabdian kepada Masyarakat Nusantara Information System Journal (INFOS) Aksara: Jurnal Ilmiah Pendidikan Bahasa dan Sastra Indonesia KLIK: Kajian Ilmiah Informatika dan Komputer JUSTIN (Jurnal Sistem dan Teknologi Informasi) Dinamika Lingkungan Indonesia Makara Journal of Science Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Counseling and Humanities Review Jurnal Aplikasi IPTEK Indonesia AHKAM : Jurnal Hukum Islam dan Humaniora Mestaka: Jurnal Pengabdian Kepada Masyarakat Journal Of Artificial Intelligence And Software Engineering Journal of Hypermedia & Technology-Enhanced Learning Jurnal Kesehatan Masyarakat
Jasril Jasril
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Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Red Ginger Essential Oil (Zingiber officinale var. Rubrum) as a Biolarvicide in the Control of Aedes Aegypti Mosquitoes Denai Wahyuni; Sari, Wulan; Jasril, Jasril; Syahri, Jufrizal
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.1558

Abstract

Synthetic larvicides are often used to control Aedes aegypti mosquitoes, but they are detrimental to humans, the environment, and the occurrence of resistance. The purpose of the study was to determine the influence and effectiveness of red ginger essential oil (Zingiber officinale var. Rubrum) as the biolarvicide of Ae. Aegypti and the most effective concentration (LC50). A total of 25 instar 3 larvae with concentrations of 200, 400, 600, and 800 ppm and K+(temephos), K-(aquaade), four repetitions every 30 minutes of observation for 3 HSPs. The results of the study showed that red ginger essential oil affected the death of Ae. Aegypti larvae. There was a significant difference in mortality rates between concentrations (Kruskal-Wallis test, p = 0.001). Likewise, there was a moderate but significant correlation between concentration and mortality (Spearman correlation: r = +0.503, p = 0.001). The probit analysis, LC50 was 257.89 ppm, most effectively influencing mortality in Ae. Aegypti larvae based on LC50. Red ginger essential oil (Zingiber officinale var. Rubrum) is effective and effective as a bio-larvicide to control Ae. aegypti so that it can reduce dengue fever cases.
A Novel Benzenesulfonylurea-Substituted Pyridazinone Derivative with Antidiabetic Effect as the Peroxisome Proliferator-activated Receptor (PPAR-γ) Agonist Fatisa, Yuni; Yasthophi, Arif; Elviyenti, Elviyenti; Ikhtiaruddin, Ihsan; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril, Jasril
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.42187

Abstract

Peroxisome Proliferator-activated Receptor (PPAR-γ) protein is one of the target proteins for insulin sensitivity therapy in Type 2 DM. PPAR-γ has a key role as a nuclear receptor that regulates the expression of several metabolism-related genes. This research aims to   synthesize a novel   benzenesulfonylurea-substituted   pyridazinone     derivative, namely (E)-N'-(1-(4-(3-(4-methoxyphenyl)-6-oxopyridazin-1(6H)- yl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide (8) and predicted it activity as the PPAR-γ agonist using a molecular docking approach and ADMET profiles. The compound 8 was obtained through a Schiff base condensation reaction between compound 6, p-tosyl hydrazine, and a glacial acetic acid catalyst using monowave. The purity of the compound was determined by TLC test, and melting point measurement. The structure was confirmed through FTIR, 1H-NMR, C-NMR and HRMS analysis. Molecular docking studies were carried out on the crystal structure of the human PPAR-γ Ligand Binding Domain target protein in complex with the α-aryloxyphenyl acetic acid agonist (PDB ID 1ZEO). The results of the docking show that compound 8 has a lower binding free energy than rosiglitazone (positive control) with a free energy value (S score) = -13.513 kcal/mol and -8.3089 kcal/mol, respectively. Compound 8 can form two hydrogen bonds with residues His323 and Ser289, π-π interactions with Phe363 and π-H interactions with Cys285.  The interactions are similar to the interaction between the native ligand agonists α-aryloxyphenyl acetic acid and rosiglitazone with the target protein. Furthermore, compound 8 is predicted to have a moderate ADME profile. The results support that compound 8 can be developed as a PPAR-γ agonist candidate for the antidiabetic therapeutic agent.
Pelatihan Mindfulness Based Cognitive Therapy bagi Guru Bimbingan dan Konseling untuk Mereduksi Kecanduan Judi Online dan Agresivitas Remaja Ardi, Zadrian; Jasril, Ilmiyati Rahmy; Guspa, Anindra; Yendi, Frischa Meivilona; Putra, Ade Herdian
Counseling and Humanities Review Vol 5, No 2 (2025): Counseling and Humanities Review
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0001326chr2025

Abstract

Online counseling training based on Mindfulness-Based Cognitive Therapy (MBCT) for guidance and counseling teachers was conducted in response to the increasing phenomenon of online gambling addiction and aggressive behavior among adolescents. This phenomenon has become a serious concern in Payakumbuh City because it affects students' academic, psychological, and social aspects. This Community Service Program aims to improve the capacity of guidance and counseling teachers in understanding, internalizing, and applying the MBCT approach in school counseling services. The training was held on August 9, 2025, at the Payakumbuh City Education Office Hall, involving guidance and counseling teachers from various schools. The implementation method consisted of two stages, namely an introduction to online counseling for online gambling addiction and aggressive behavior in adolescents, as well as training in MBCT techniques through practical simulations and group discussions. Evaluation was carried out using pre-test and post-test instruments to measure participants' understanding and skills. The training results showed an increase in understanding from 52 percent to 91 percent and in skills from 48 percent to 88 percent. Participants also developed plans to implement MBCT in their respective schools and built a collaborative network among guidance counselors. These findings indicate that participatory training combining theory and practice is effective in strengthening the professional competence of guidance counselors. The MBCT approach is considered relevant as a strategy for preventing and intervening in risky adolescent behavior, especially when combined with online counseling technology that expands access to services in schools.
Co-Authors - Aisyah - Nurlaili -, Sulismayati Abdul Aziz Adel Zamri Adel Zamri Afrita, Indra agistia, nesa Agustian, Surya Ahmad Fauzan Aisyah Aisyah Aisyah, - Akbar, Unggul Al Fiqri, M. Faiz Alfarabi.B, Alif Ananda, Sherly Anggita, Anggi Fisi Anori, Sartika Aprilia, Tasya Asmawati Asmawati Bintal Amin Christine Jose Christine Jose Darian Alfatos Delsina Faiza Denai Wahyuni Denai Wahyuni Desviana, Laila Dewi, Erna Puspita Elin Haerani Elka Yuslinda Elvia Budianita Elviyenti, Elviyenti Fadhilah Syafria Fawrin, Heralda Fernando, Rivan Fiffah, Chainul Fitri Insani Fitria Novitasari Frischa Meivilona Yendi Guspriadi, Yan Haiyul Fadhli Haresman, Haresman Hasmalina Nasution Hendra, Rudi Hilwan Yuda Teruna Ihsan Ikhtiarudin Ikhtiaruddin, Ihsan Indah Wulandari Işık, Kenan Isnaniar Iswantir M Iwan Iskandar Jufrizal Syahri Kurnia Gusti, Siska Laila Desviana Lestari Handayani Mar'arif, Muhammad Mulky Masykur HZ Masykur Hz Muhammad Affandes, Muhammad Muhammad Irsyad Muhdarina Muhdarina Muhdarina Muliani, Sarifah Muslim Syaifullah, Mhd Nazir, Alwis Nazruddin Safaat H Negara, Benny Sukma Neni Frimayanti Novianty, Riryn Nuraini Ramadhani Nurhayati Nurlaili Nurlaili Nurlaili, - Oktavia, Lola Pranata, Joni Prasetya Prasetya, Prasetya Putra, Ade Herdian Putra, Rido Rahayu, Anggi Putri Rahma Dona Rahmadini Syafri Rahmita, Rahmita Rahmiwati Hilma Ramadhani, Eka Ramadhani, Siti Rudi Hendra Sardi, Hajra Sari, Meidita Kemala Sari, Nila Puspita Silvera Devy Siregar, Sri Hilma Soeci Izzati Adlya Sofyan Husein Siregar Sulismayati - Suwanto Sanjaya Sya'ban, Andrian Nur Thamrin Tri Windarti Tri Windarti Tria Harlianti Triana, Yeni Veithzal Rivai Zainal Wan, Xue Wenni, Osriza Wulan Sari, Wulan Yasthophi, Arif Yeni, Wila Mutiara Yuana Nurulita Yuca, Verlanda Yuharmen - Yum Eryanti Yuni Fatisa Zadrian Ardi Zahra, Fadhila Az Zahri, Firman