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A Novel Benzenesulfonylurea-Substituted Pyridazinone Derivative with Antidiabetic Effect as the Peroxisome Proliferator-activated Receptor (PPAR-γ) Agonist Fatisa, Yuni; Yasthophi, Arif; Elviyenti, Elviyenti; Ikhtiaruddin, Ihsan; Frimayanti, Neni; Teruna, Hilwan Yuda; Jasril, Jasril
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.42187

Abstract

Peroxisome Proliferator-activated Receptor (PPAR-γ) protein is one of the target proteins for insulin sensitivity therapy in Type 2 DM. PPAR-γ has a key role as a nuclear receptor that regulates the expression of several metabolism-related genes. This research aims to   synthesize a novel   benzenesulfonylurea-substituted   pyridazinone     derivative, namely (E)-N'-(1-(4-(3-(4-methoxyphenyl)-6-oxopyridazin-1(6H)- yl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide (8) and predicted it activity as the PPAR-γ agonist using a molecular docking approach and ADMET profiles. The compound 8 was obtained through a Schiff base condensation reaction between compound 6, p-tosyl hydrazine, and a glacial acetic acid catalyst using monowave. The purity of the compound was determined by TLC test, and melting point measurement. The structure was confirmed through FTIR, 1H-NMR, C-NMR and HRMS analysis. Molecular docking studies were carried out on the crystal structure of the human PPAR-γ Ligand Binding Domain target protein in complex with the α-aryloxyphenyl acetic acid agonist (PDB ID 1ZEO). The results of the docking show that compound 8 has a lower binding free energy than rosiglitazone (positive control) with a free energy value (S score) = -13.513 kcal/mol and -8.3089 kcal/mol, respectively. Compound 8 can form two hydrogen bonds with residues His323 and Ser289, π-π interactions with Phe363 and π-H interactions with Cys285.  The interactions are similar to the interaction between the native ligand agonists α-aryloxyphenyl acetic acid and rosiglitazone with the target protein. Furthermore, compound 8 is predicted to have a moderate ADME profile. The results support that compound 8 can be developed as a PPAR-γ agonist candidate for the antidiabetic therapeutic agent.
Pelatihan Mindfulness Based Cognitive Therapy bagi Guru Bimbingan dan Konseling untuk Mereduksi Kecanduan Judi Online dan Agresivitas Remaja Ardi, Zadrian; Jasril, Ilmiyati Rahmy; Guspa, Anindra; Yendi, Frischa Meivilona; Putra, Ade Herdian
Counseling and Humanities Review Vol 5, No 2 (2025): Counseling and Humanities Review
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/0001326chr2025

Abstract

Online counseling training based on Mindfulness-Based Cognitive Therapy (MBCT) for guidance and counseling teachers was conducted in response to the increasing phenomenon of online gambling addiction and aggressive behavior among adolescents. This phenomenon has become a serious concern in Payakumbuh City because it affects students' academic, psychological, and social aspects. This Community Service Program aims to improve the capacity of guidance and counseling teachers in understanding, internalizing, and applying the MBCT approach in school counseling services. The training was held on August 9, 2025, at the Payakumbuh City Education Office Hall, involving guidance and counseling teachers from various schools. The implementation method consisted of two stages, namely an introduction to online counseling for online gambling addiction and aggressive behavior in adolescents, as well as training in MBCT techniques through practical simulations and group discussions. Evaluation was carried out using pre-test and post-test instruments to measure participants' understanding and skills. The training results showed an increase in understanding from 52 percent to 91 percent and in skills from 48 percent to 88 percent. Participants also developed plans to implement MBCT in their respective schools and built a collaborative network among guidance counselors. These findings indicate that participatory training combining theory and practice is effective in strengthening the professional competence of guidance counselors. The MBCT approach is considered relevant as a strategy for preventing and intervening in risky adolescent behavior, especially when combined with online counseling technology that expands access to services in schools.
Pemberdayaan Ibu-Ibu PKK Desa Suka Ramai, Kec. Tapung Hulu, Kab. Kampar dengan Produk Facemist Berbahan Dasar Aloevera Dan Ekstrak Green Tea Hilma, Rahmiwati; Prasetya, Prasetya; Syahri, Jufrizal; `Nasution, Hasmalina; Syafri, Rahmadini; Siregar, Sri Hilma; Perdana , Fitra
Jurnal Pengabdian UntukMu NegeRI Vol. 5 No. 2 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i2.3067

Abstract

Pandemik Covid-19 memberikan dampak yang signifikan terhadap tatanan kehidupan sosial dan ekonomi masyarakat global, termasuk masyarakat di Desa Suka Ramai, Kec. Tapung, Kab, Kampar. Tingginya harga obat-obatan termasuk kosmetik, krisis ekonomi yang belum juga berangsur pulih menimbulkan depresi bagi masyarakat, terutama bagi Ibu-ibu. Pada kegiatan ini dilakukan pemberdayaan berupa penyuluhan dan pelatihan bagi Ibu-ibu PKK, kader posyandu dan remaja putri untuk memproduksi sendiri produk facemist multiguna untuk kesehatan dan kecantikan. Dibidang Kesehatan produk ini bersifat antidepresan dan kecantikan memberikan kesegaran, bersifat sebagai antioksidan, antiaging dan mengurangi jerawat pada wajah. Kegiatan ini dilakukan secara luring dengan protokol kesehatan yang ketat. Kegiatan terlaksana dengan baik, terlihat dengan antusias peserta akan materi-materi pelatihan, jumlah peserta yang tidak berubah dari awal kegiatan sampai selesai. Dari kegiatan ini dihasilkan produk facemist “ESM” yang diproduksi oleh peserta pelatihan. Ibu-ibu PKK dan Bapak Kepala Desa Suka Ramai, sangat berterima ksih atas terlaksananya kegiatan di Desa mereka dan berharap akan ada kegiatan lain yang juga dilaksanakan di Desa tersebut.
Workshop Sertifikasi Pranata Laboratorium Untuk Guru Sains Tingkat SLTA Se-Provinsi Riau Siregar, Sri Hilma; Prasetya, Prasetya; Nasution, Hasmalina; Hilma, Rahmiwati; Perdana, Fitra; Syafri, Rahmadini; Syahri, Jufrizal
Jurnal Pengabdian UntukMu NegeRI Vol. 7 No. 1 (2023): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v7i1.4932

Abstract

Saat ini banyak sekolah tingkat SLTA se-Provinsi Riau dan sekitarnya tidak memiliki pranata laboratorium pendidikan yang berkompeten dibidangnya. Hal ini menyebabkan banyak sekolah yang memiliki laboratorium tapi tidak digunakan secara maksimal, dan siswa siswi tidak dapat melaksanakan praktikum yang semestinya di laboratorium. Laboratorium hanya menjadi tempat pajangan alat peraga dan instrumentasi. Berdasarkan hal tersebut, kami merasa perlu memfasilitasi para pranata laboratorium pendidikan dengan memberikan pelatihan pengelolaan dan penggunaan laboratorium untuk praktikum siswa siswi di sekolah. Sehingga dihasilkan lulusan yang berkompeten. Kegiatan dirancang dalam bentuk pengembangan wawasan keilmuan melalui pemberian berbagai teori selama 2 hari dan dilanjutkan dengan praktik dan penugasan pada 2 hari berikutnya. Materi yang diberikan kepada peserta diantaranya tentang inovasi hasil penelitian, pengenalan dan pengelolaan laboratorium, praktikum ciri-ciri reaksi kimia, hokum kekekalan massa, reaksi zat makanan. pemahaman dan kemampuan guru terhadap materi pelatihan, yang nantinya dapat digunakan sebagai acuan dalam melaksanakan praktikum di laboratorium sekolah. Kegiatan workshop ini mendapat sambutan yang baik dari peserta dan berhasil dengan baik. Keadaan ini dapat dilihat dari kehadiran peserta yang hampir mencapai 100%. Peserta terdiri guru dan pranata laboratrium pendidikan ingkat SLTA se-Provinsi Riau.
EKSPLORASI FITUR FASTTEXT, TF-IDF DAN INDOBERT PADA METODE K-NEAREST NEIGHBOR UNTUK KLASIFIKASI SENTIMEN Putri, Atika; Agustian, Surya; Jasril, Jasril; Afrianty, Iis
ZONAsi: Jurnal Sistem Informasi Vol. 7 No. 1 (2025): Publikasi artikel ZONAsi: Jurnal Sistem Informasi Periode Januari 2025
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/zn.v7i1.24779

Abstract

Sentiment classification is essential for analyzing public opinion, particularly on social media issues. One of the main challenges in sentiment classification is the limited amount of training data, which often affects the model's ability to make accurate predictions. This study examines Kaesang Pengarep's appointment as PSI chairman using feature extraction methods such as FastText, TF-IDF, and IndoBERT, alongside the K-Nearest Neighbor (KNN) algorithm. Optimization steps include adding external data, refining text preprocessing, applying data scaling, and tuning parameters. The baseline model achieved 44% accuracy and 39% F1-score using FastText. After optimization and switching to IndoBERT, the optimal model achieved 57% accuracy and 49% F1-score, showing a 10% improvement. These findings demonstrate that optimizations, such as advanced feature extraction and parameter tuning, significantly impact sentiment classification. Future research could focus on advanced optimization techniques to address data limitations and enhance sentiment analysis performance. Keywords: Sentiment Classification, Model Optimisation, K-Nearest Neighbor, FastText, TF-IDF, IndoBERT.
KLASIFIKASI SENTIMEN MENGGUNAKAN BIDIRECTIONAL LSTM DAN INDOBERT DENGAN DATASET TERBATAS Illahi, Ridho; Agustian, Surya; Jasril, Jasril; Yanto, Febi
ZONAsi: Jurnal Sistem Informasi Vol. 7 No. 1 (2025): Publikasi artikel ZONAsi: Jurnal Sistem Informasi Periode Januari 2025
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/zn.v7i1.25091

Abstract

Untuk mendapatkan informasi melalui media sosial mengenai popularitas termasuk juga sentimen masyarakat terhadap para tokoh politik, masalah waktu menjadi krusial. Oleh karena itu, menganalisis hal tersebut menggunakan komputer menjadi pilihan. Namun menyediakan data yang berlabel cukup untuk pembelajaran mesin dalam kasus analisis sentimen dan tingkat kepopuleran dari media sosial, akan menyebabkan waktu yang dibutuhkan menjadi lebih lama. Penelitian ini mengembangkan model Bi-LSTM (Bidirectional Long Short-Term Memory) yang dipadukan dengan IndoBERT sebagai fitur representasi teks, untuk menganalisis sentimen dengan data training yang terbatas. Isu utama mengenai pengangkatan Kaesang sebagai ketua umum Partai Solidaritas Indonesia (PSI), hanya menyediakan 300 – 600 tweet berlabel positif, negatif dan netral untuk training. Data tweet setelah melalui tahap preprocessing dan vektorisasi BERT, dilatih pada metode klasifikasi Bi-LSTM. Langkah-langkah optimasi dilakukan sampai kepada hyperparameter tuning untuk menemukan model terbaik. Meski jumlah data train terbatas, model yang diusulkan berhasil mencapai F1-score sebesar 71% pada data validasi, dan 59% pada pengujian data test. Hasil penelitian mendemonstrasikan keefektifan metode Bi-LSTM dan fitur IndoBERT dalam mengukur opini masyarakat di media sosial. Framework metode klasifikasi yang diusulkan sangat potensial sebagai alat untuk menganalisis respons masyarakat terhadap isu politik terkini.
Pembuatan Nugget Dari Biji Nangka Upaya Mengoptimalkan Sumber Daya Masyarakat Desa Kualu Nenas Nasution, Hasmalina; Putri, Rahmayani Indah; Hidayati, Retno; Prasetya, Prasetya; Perdana, Fitra; Syafri, Rahmadini; Syahri, Jufrizal; Hilma, Rahmiwati; Siregar, srihilma; Ramadhanti, Aulia Rizki
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 4 No. 4 (2023): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kualu Nenas Village is a village that produces quite a lot of jackfruit flesh in the form of chips for sale. UMKM that process jackfruit as the main ingredient will have an impact on the amount of easily damaged organic solid waste from the jackfruit itself, such as jackfruit seeds. However, in processing jackfruit seeds are more often just boiled or fried as a snack. One way to process jackfruit seed waste is to make nuggets. Socialization and nugget making training activities were carried out in Kualu Nenas Village with the PPK Ormawa HIMAKI team. The aim of this activity is to increase knowledge and skills for the people of Kualu Nenas Village in processing waste, optimizing natural resources, and improving the community's economy by selling jackfruit seed nuggets. The activity began with a presentation through socialization of material about waste jackfruit seeds and nuggets in general, then continued with practical training in making nuggets from waste jackfruit seeds. The results obtained from this community service activity are that the community can understand the techniques for processing jackfruit seed waste into nuggets well as shown by the achievement percentage ≤ 74%.
Rancang Bangun Media Pembelajaran Interaktif Mata Pelajaran Pemrograman dan Aplikasi Mikrokontroler Hamdan, Umar; Jasril, Ilmiyati Rahmy
MASALIQ Vol 5 No 5 (2025): SEPTEMBER
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i5.6965

Abstract

Education plays a crucial role in developing students’ potential, and with the rapid advancement of information and communication technology, innovation in learning media has become increasingly relevant in creating practical, engaging, and interactive learning experiences. This study aims to design and develop interactive learning media using Adobe Animate for the subject "Microcontroller Programming and Applications" for Grade XI students majoring in Audio Video Engineering at SMK Negeri 1 Sumatera Barat. The method employed is Research and Development (R&D) using the 4-D development model, which includes the stages of Define, Design, Develop, and Disseminate. Validation was conducted by two subject matter experts, resulting in a validity score of 94.7%, and by a media expert with an average validity score of 100%, both categorized as “Highly Valid.” A practicality test involving 15 students showed a practicality level of 96%, classified as “Highly Practical.” The results of this study indicate that the developed interactive learning media is suitable and effective for use in the learning process and supports the achievement of student competencies in microcontroller-related material.
Rancang Bangun Alat Pengering Cabai Merah secara Elektrik Berbasis Internet of Things A, Muhammad Rizki; Jasril, Ilmiyati Rahmy
MASALIQ Vol 5 No 5 (2025): SEPTEMBER
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i5.7143

Abstract

This study is motivated by the importance of utilizing the Internet of Things (IoT) to support the control of an electric red chili drying system. The research aims to address the challenges of efficiency, quality stability, and post-harvest system modernization, while also contributing to the national food security agenda through the application of appropriate technology in the agricultural and agro-industrial sectors. The method used was the waterfall model, comprising needs analysis, hardware design, software design, tool fabrication, and testing. Testing was conducted on the LCD function, IoT module, chili drying process, temperature stability, and software performance. The drying process was tested in 16 trials, with results showing that the system operated effectively and efficiently. The initial heating stage recorded temperatures from 30.2°C to 51.1°C within 5–15 minutes; the optimal heating stage showed a slower temperature rise to 56–57°C within 30–35 minutes; the stabilization and temperature control stage maintained 57.8–59.9°C for 40–70 minutes; and the final stage reached 60°C at the 75th minute. The system was able to detect the maximum temperature and stop heating to prevent overheating. It is concluded that the application of IoT in the ESP32 microcontroller-based electric red chili dryer significantly improves time efficiency and product quality compared to conventional methods.
Pelatihan Menulis Berita bagi Siswa SMA Negeri 2 Painan Kabupaten Pesisir Selatan, Sumatera Barat Jasril, Jasril; Asmawati, Asmawati; Ulya, Ridha Hasnul
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pengabdian kepada masyarakat yang telah dilaksanakan ini bertujuan meningkatkan keterampilan menulis berita pada siswa SMA Negeri 2 Painan, Kabupaten Pesisir Selatan, Sumatera Barat. Keterampilan menulis berita sangat penting bagi siswa sebagai bagian dari kemampuan literasi dan komunikasi, terutama dalam era informasi saat ini. Pelatihan ini diselenggarakan untuk memberikan pemahaman dasar mengenai teknik menulis berita yang baik dan benar, mulai dari penulisan judul, lead, hingga struktur berita yang jelas dan informatif. Selain itu, pelatihan ini juga bertujuan untuk meningkatkan kreativitas siswa dalam menyusun berita yang relevan dan menarik. Metode yang digunakan dalam pelatihan ini adalah pendekatan partisipatif, melalui pelibatan siswa secara langsung dalam proses menulis berita dengan bimbingan fasilitator. Hasil pelatihan menunjukkan adanya peningkatan kemampuan siswa menulis berita dilihat dari pengetahuan menulis berita, kemampuan praktis menulis berita, dan kreativitas dalam menulis. Selain itu, terdapat peningkatan pemahaman siswa tentang etika jurnalisme dan cara memvalidasi informasi yang akan disampaikan. Dengan adanya pelatihan ini, siswa SMA Negeri 2 Painan, Kabupaten Pesisir Selatan dapat lebih percaya diri dalam menulis berita yang berkualitas dan dapat memanfaatkannya sebagai sarana untuk berkomunikasi dan berbagi informasi di masyarakat.
Co-Authors - Aisyah - Nurlaili -, Sulismayati A, Muhammad Rizki Abdul Aziz Adel Zamri Adel Zamri Afrita, Indra agistia, nesa Ahmad Fauzan Ainil Mardiyah Aisyah Aisyah Aisyah, - Akbar, Unggul Al Fiqri, M. Faiz Alfarabi.B, Alif Ananda, Muthia Ananda, Sherly Anggita, Anggi Fisi Anori, Sartika Aprilia, Tasya Asmawati Asmawati Ayasrah, Firas Tayseer Baehaqi Bintal Amin Christine Jose Christine Jose Dampang, Hasria Darian Alfatos Delsi K Delsi K Delsina Faiza Denai Wahyuni Denai Wahyuni Desviana, Laila Dewi, Erna Puspita Elin Haerani Elka Yuslinda Elvia Budianita Elviyenti, Elviyenti Fadhilah Syafria Fadhli, Irfan Faladhin, Johan Fatila, Mutia Fauzi, Faradiba Kamilia Fawrin, Heralda Febi Yanto Fernando, Rivan Fiffah, Chainul Firmathoina, Aisyah Fitra Perdana Fitri Insani Fitria Novitasari Frischa Meivilona Yendi Guspriadi, Yan Gusti, Siska Kurnia Haiyul Fadhli Hamersat, Danu Hardiansyah, Muhammad Vio Haresman, Haresman Hariansyah, Jul Hasmalina Nasution Hendra, Rudi Hilwan Yuda Teruna Hurria, Hurria Ihsan Ikhtiarudin Iis Afrianty Ika Parma Dewi Ikhtiaruddin, Ihsan Iktiarudin, Ihsan Illahi, Ridho Indah Wulandari Insani (Scopus ID: 57190404820), Fitri Işık, Kenan Isnaniar Iswantir M Jufrizal Syahri Laila Desviana Lazulva Lazulva, Lazulva Lestari Handayani Lisa Utami Mar'arif, Muhammad Mulky Marzalius, Lira Rahma Masykur Hz Masykur HZ Muhammad Affandes Muhammad Irsyad Muhdarina Muhdarina Muhdarina Muliani, Sarifah Muslim Syaifullah, Mhd Nazir, Alwis Nazruddin Safaat H Negara, Benny Sukma Neni Frimayanti Nofirda, Fitri Ayu Novianty, Riryn Nuraini Ramadhani Nurhayati Nurlaili Nurlaili Nurlaili, - Nurwijayanti Oktavia, Lola Pranata, Joni Prasetya Prasetya, Prasetya Putra, Ade Herdian Putra, Rido Putri, Atika Putri, Rahmayani Indah Rahayu, Anggi Putri Rahma Dona Rahmadini Syafri Rahmiwati Hilma Ramadhani, Eka Ramadhani, Siti Ramadhanti, Aulia Rizki Retno Hidayati Rudi Hendra Sardi, Hajra Sari, Meidita Kemala Sari, Nila Puspita Silvera Devy Siregar, Alfi Salimah Siregar, Sri Hilma Siregar, srihilma Soeci Izzati Adlya Sofyan Husein Siregar Sulismayati - Surya Agustian Suwanto Sanjaya Sya'ban, Andrian Nur Syaifullah, Mhd Muslim Thamrin Tri Windarti Tri Windarti Tria Harlianti Triana, Yeni Ulhukmi, Nisa Umar Hamdan, Umar Veithzal Rivai Zainal Wan, Xue Wenni, Osriza Wulan Sari, Wulan Yasthophi, Arif Yeni, Wila Mutiara Yuana Nurulita Yuca, Verlanda Yuharmen - Yum Eryanti Yuni Fatisa Zadrian Ardi Zahra, Fadhila Az Zahri, Firman Zikra, Nadila `Nasution, Hasmalina