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All Journal ComEngApp : Computer Engineering and Applications Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Teknika Jurnal Riset Kimia SEMIRATA 2015 Jurnal Pengabdian UntukMu NegeRI Jurnal Surya Medika Jurnal CoreIT Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JURNAL PENDIDIKAN TAMBUSAI J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Building of Informatics, Technology and Science Jurnal Yustitia Zonasi: Jurnal Sistem Informasi JOURNAL OF INFORMATION SYSTEM RESEARCH (JOSH) Journal of Computer System and Informatics (JoSYC) Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Information System Journal (INFOS) KLIK: Kajian Ilmiah Informatika dan Komputer JUSTIN (Jurnal Sistem dan Teknologi Informasi) Dinamika Lingkungan Indonesia Makara Journal of Science MASALIQ: Jurnal Pendidikan dan Sains Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Counseling and Humanities Review Jurnal Aplikasi IPTEK Indonesia AHKAM : Jurnal Hukum Islam dan Humaniora Mestaka: Jurnal Pengabdian Kepada Masyarakat Journal Of Artificial Intelligence And Software Engineering Journal of Hypermedia & Technology-Enhanced Learning Jurnal Pengabdian Nusantara JKM: Jurnal Kemitraan Masyarakat Jurnal Kesehatan Masyarakat
Jasril Jasril
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SINTESIS CALKON ((E)-1,3-DI(NAPHTHALEN-2-YL)PROP-2-EN-1-ONE) DAN AKTIVITASNYA SEBAGAI ANTIOKSIDAN Rahmiwati Hilma; Jasril -; Hilwan Yuda Teruna
Sistem Informasi Vol 3 No 1 (2012): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v3i1.143

Abstract

Study on chalcone calkon (E)-1,3-di(naphthalen-2-yl)prop-2-en-1-one synthesis have been carried out with stirrer methode. These compounds can be used as intermediate compound to synthesize others compounds which was reported having antimicrobial, anti-inflammatory, anti-depressant, anti-tumour. The of chalcones synthesis vatives were reported in acid and alkali condition. In this study, chalcone and its derivates were synthesized by using stirrer method in alkaline condition in room temperature. the compounds subjected to somes analyses including melting point measurement, thin layer chromatography and HPLC. Scavenging free radical by using DPPH methode showed Scavenging free radical with LC50 >80 μg/ml min potent activity while the ascorbat acid LC50 89,79 μg/ml.
AKTIVITAS ANTI BAKTERI DAN ANTI JAMUR SENYAWA CALKON(E)-1-(naftalen-1-il)-3-(naftalen)prop-2-1-on Rahmiwati Hilma; Jasril -; Isnaniar -
Sistem Informasi Vol 4 No 1 (2013): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v4i1.169

Abstract

Pada penelitian ini dilakukan Uji aktivitas antibakteri dan anti jamur terhadap senyawa turunan calkon E)-1-(naftalen-1-il)-3-(naftalen)prop-2-1-on (senyawa A) menggunakan metoda difusi.Bakteri yang digunakan adalah Staphylococcus aureus sebagai bakteri grampositif) dan Escherichia colisebagai bakteri gram negatifdan terhadap senyawa calkon tersebut juga dilakukan uji aktivitas anti jamur menggunakan jamur Candida albicans. Hasil Uji antibakteri terhadap senyawa calkon E)-1-(naftalen-1-il)-3-(naftalen)prop-2-1-on (A) memperlihatkan bahwa senyawa calkon A tidak aktif terlihat dengan tidak adanya zona bening disekitar cakram yang ditetesi dengan sampel calkon. Hasil uji aktivitas antijamur senyawa calkon (E)-1-(naftalen-1-il)-3-(naftalen)prop-2-1-on (senyawa A)memperlihatkan aktivitas antijamur yang baik pada konsentrasi 10 μg/disk dengan diameter zona hambat yang dihasilkan yaitu sebesar 17, 08 mm
AKTIVITAS ANTIRADIKAL BEBAS SENYAWA TURUNAN CALKON DAN TURUNAN BENZOTIAZEPIN Sulismayati -; Jasril -; Christine Jose; Rahmiwati Hilma
Sistem Informasi Vol 4 No 2 (2014): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v4i2.174

Abstract

Senyawa calkon merupakan flavonoid rantai terbuka dengan cincin aromatik yang dihubungkan oleh tiga atom karbon dengan system α, β karbonil keton tidak jenuh. Calkobn juga merupakan senyawa antara untuk membuat senyawa lain salah satunya adalah benzotiazepin. Benzotiazepin adalah senyawa heterosiklik yang mengandung nitrogen dan sulfur. Hasil uji aktivitas anti radikal bebas dari senyawa calkon Y1 dan senyawa benzotiazepin Bt1 memperlihatkan aktivitas yang sangat lemah, ditandai dengan nilai IC50 yang lebih besar dari 1000 ppm jika dibandingkan dengan standar yang digunakan yaitu vitamin C dengan nilai IC50 33,539 ppm. Hal ini mungkin disebabkan karena tidak adanya substituen ataupun gugus yang dapat menyumbangkan proton pada kedua senyawa hasil sintesis sehingga menyebabkan kedua senyawa tersebut tidak aktif sebagai antiradical bebas.
SINTESIS DAN ANALISIS SPEKTRUM SENYAWA PIRAZOLIN DARI KALKON 4-KLORO INTI NAFTALEN Laila Desviana; Hilwan Yuda Teruna; - Jasril
Sistem Informasi Vol 6 No 01 (2015): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v6i01.481

Abstract

Senyawa pirazolin 5-(4-klorofenil)-3-naftalen-2-il-4,5-dihidro-1H-pirazol (PH CN2-4Cl) telah disintesis melalui reaksi siklisasi senyawa 3-(4-kloro-fenil)-1-naftalen-2-il-propenon dan hidrazin hidrat menggunakan katalis asam sulfat dengan diiradiasi gelombang mikro selama 3,5 menit. Senyawa yang diperoleh berupa kristal bening dengan berat 0,11 g dan rendemen yang dihasilkan sebesar 69,20%. Senyawa tersebut menunjukkan rendemen yang baik dan telah dikarakterisasi menggunakan spektrofotometri UV-Vis dan FTIR.
SINTESIS DAN IDENTIFIKASI SENYAWA 5-(4-FLUOROFENIL)-3-(NAFTALEN-2-IL)-4,5-DIHIDRO-1H-PIRAZOL Tri Windarti; Hilwan Yuda Teruna; - Jasril
Sistem Informasi Vol 6 No 01 (2015): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v6i01.484

Abstract

Pirazolin merupakan metabolit sekunder golongan alkaloid yang telah dilaporkan memiliki berbagai macam bioaktivitas seperti antimikroba, antiinflamasi, antioksidan dan antikanker. Oleh karena itu, pirazolin banyak dijadikan sebagai model struktur senyawa target oleh para peneliti. Senyawa pirazolin yaitu 5-(4-fluorofenil)-3-(naftalen-2-il)-4,5-dihidro-1H-pirazol telah disintesis dari (E)-3-(4-fluorofenil)-1-(naftalen-2-il)prop-2-en-1-on dengan hidrazin hidrat dan menggunakan katalis asam asetat serta diiradiasi gelombang mikro. Kemurnian senyawa telah diuji menggunakan KLT, uji titik leleh dan analisis HPLC. Struktur senyawa pirazolin diidentifikasi berdasarkan interpretasi data spektroskopi UV dan IR. Hasil senyawa sintesis tersebut adalah 67,45%.
SINTESIS DAN UJI AKTIVITAS ANTIOKSIDAN SENYAWA 3-(4-METOKSIFENIL)-5-NAFTALEN-1-IL-1-FENIL-4,5-DIHIDRO-PIRAZOL - Aisyah; - Jasril; Hilwan Yuda Teruna
Sistem Informasi Vol 8 No 01 (2017): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v8i01.520

Abstract

A pyrazoline analog, 3-(4-methoxy-phenyl)-5-naphtalen-1-yl-1-phenyl-4,5-dihydro-pyrazole (PF CA-4OMe) has been synthesized via intermolecular cyclization between substituted chalcones and phenylhydrazine using glacial acetic acid as a catalyst under microwave irradiation. The structure of the compound was characterized based on the interpretation of UV, FTIR, HRMS, 1H-NMR, 13C-NMR, HSQC and HMBC spectra. The antioxidant test was carried out by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result show that PF CA-4OMe was proved to have antioxidant activity with IC50 387,64 µg/mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TERSUBSTITUSI METOKSI Rahma Dona; Adel Zamri; - Jasril
Sistem Informasi Vol 5 No 2 (2015): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v5i2.579

Abstract

tumbuhan dalam jumlah yang relatif sedikit. Senyawa ini merupakan prekursor untuk biosintesis flavonoid dan isoflavonoid. Senyawa kalkon telah dilaporkan memiliki berbagai aktivitas biologis yang menarik seperti antimikrob, antitumor, antioksidan, antiinflamasi, antimalaria, dan antikanker. Aktivitas senyawa kalkon dipengaruhi oleh gugus α,β-tak jenuh dan substituen yang terdapat pada cincin aromatiknya. Pada penelitian ini, tiga analog kalkon tersubstitusi mono-metoksi pada cincin A aromatik dan cincin B aromatiknya telah disintesis menggunakan metode iradiasi microwave dengan katalis KOH dan pelarut etanol. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
UJI AKTIVITAS ANTIOKSIDAN SENYAWA PIRAZOLIN 3-(2- METOKSI-FENIL)-5-NAFTALEN-1-IL-4,5-DIHIDRO-1H-PIRAZOL - Nurlaili; - Jasril; Hilwan Yuda Teruna
Sistem Informasi Vol 8 No 2 (2018): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v8i2.716

Abstract

Pyrazoline compounds are reported to have many useful biological activities such as antimicrobials, antihyperglycemia, antioxidants, anti-inflammatory, anticancer and anticonvulsants. The pyrazoline analogues of 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-4,5-dihydro-1H-pyrazol were synthesized usingglacial acetic acid as catalyst and assisted by microwave irradiation. The structures of the compounds were obtainedby UV, IR and HRMS spectroscopy data. Antioxidant activity test using DPPH method showed that pyrazoline compound had IC50 value of 27.41 μg/mL.
Microwave Assisted Synthesis and Evaluation of Toxicity and Antioxidant Activity of Pyrazoline Derivatives Jasril Jasril; Hilwan Yuda Teruna; Aisyah Aisyah; Nurlaili Nurlaili; Rudi Hendra
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.72 KB) | DOI: 10.22146/ijc.34285

Abstract

Four pyrazoline analogues, 3-(4-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (3), 3-(4-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (4), 3-(2-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (5) and 3-(2-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (6) were synthesized via intermolecular cyclization between substituted chalcones and hydrazine derivatives. The compounds were synthesized in two steps. In the first step, the chalcones were synthesized by Claisen-Schmidt reaction. In the second step, they were cyclized with some hydrazine derivatives to form pyrazolines by using glacial acetic acid as a catalyst and assisted by microwave irradiation. The toxicity analysis showed that compound 1 and 2 were toxic with LC50 values of 11.47 and 0.97 μg/mL, respectively. Furthermore, only compound 6 showed high antioxidant activity by using DPPH with an IC50 value of 4.47 μg/mL.
Analisis Status Mutu Air Sungai Berdasarkan Metode STORET Sebagai Pengendalian Kualitas Lingkungan (Studi Kasus: Dua Aliran Sungai di Kecamatan Tembilahan Hulu, Kabupaten Indragiri Hilir, Riau) Masykur HZ; Bintal Amin; Jasril Jasril; Sofyan Husein Siregar
Dinamika Lingkungan Indonesia Vol 5, No 2 (2018)
Publisher : Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.46 KB) | DOI: 10.31258/dli.5.2.p.84-96

Abstract

District of Tembilahan Hulu is the capital of Indragiri Hilir Regency which has two rivers, namely the Sungai Parit 11 and Sungai Parit 13. These rivers has a tidal type with the estuary on the Indragiri River. The function of these rivers is used as a rain water drainage that existence is not be separated from human activities around the watershed. Characteristics of rivers that cross urban areas are susceptible to decreasing water quality and environmental pollution from the effects of high anthropogenic activities. This study aims to analyze the status of water quality in two rivers that cross district of Tembilahan Hulu, Indragiri Regency. Sungai Parit 11 as the research area has a length of ±5 km and Sungai Parit 13 has a length of ±6 km, each of which is divided into 3 locations of sampling points representing the condition of tides and low tides. The placement of each sampling point is determined based on the representation of the upstream, middle and downstream of the river. Analysis of water quality status of the rivers is made using STORET method which comprehensive by Decree of the Minister of Environment of the Republic of Indonesia Number 115 Year 2003. The results showed the status of water quality of Sungai Parit 11 and Sungai Parit 13 in District of Tembilahan Hulu, Indragiri Hilir regency in heavily polluted conditions.
Co-Authors - Aisyah - Nurlaili -, Sulismayati A, Muhammad Rizki Abdul Aziz Adel Zamri Adel Zamri Afrita, Indra agistia, nesa Ahmad Fauzan Ainil Mardiyah Aisyah Aisyah Aisyah, - Akbar, Unggul Al Fiqri, M. Faiz Alfarabi.B, Alif Ananda, Muthia Ananda, Sherly Anggita, Anggi Fisi Anori, Sartika Aprilia, Tasya Asmawati Asmawati Bintal Amin Christine Jose Christine Jose Dampang, Hasria Darian Alfatos Delsi K Delsi K Delsina Faiza Denai Wahyuni Denai Wahyuni Desviana, Laila Dewi, Erna Puspita Elin Haerani Elka Yuslinda Elvia Budianita Elviyenti, Elviyenti Fadhilah Syafria Fadhli, Irfan Faladhin, Johan Fauzi, Faradiba Kamilia Fawrin, Heralda Febi Yanto Fernando, Rivan Fiffah, Chainul Firmathoina, Aisyah Fitra Perdana Fitri Insani Fitria Novitasari Frischa Meivilona Yendi Guspriadi, Yan Haiyul Fadhli Hamersat, Danu Haresman, Haresman Hariansyah, Jul Hasmalina Nasution Hendra, Rudi Hilwan Yuda Teruna Hurria, Hurria Ihsan Ikhtiarudin Iis Afrianty Ika Parma Dewi Ikhtiaruddin, Ihsan Illahi, Ridho Indah Wulandari Işık, Kenan Isnaniar Iswantir M Jufrizal Syahri Kurnia Gusti, Siska Laila Desviana Lazulva Lazulva, Lazulva Lestari Handayani Lisa Utami Mar'arif, Muhammad Mulky Masykur HZ Masykur Hz Muhammad Affandes Muhammad Irsyad Muhdarina Muhdarina Muhdarina Muliani, Sarifah Muslim Syaifullah, Mhd Nazir, Alwis Nazruddin Safaat H Negara, Benny Sukma Neni Frimayanti Nofirda, Fitri Ayu Novianty, Riryn Nuraini Ramadhani Nurhayati Nurlaili Nurlaili Nurlaili, - Nurwijayanti Oktavia, Lola Perdana , Fitra Pranata, Joni Prasetya Prasetya, Prasetya Putra, Ade Herdian Putra, Rido Putri, Atika Putri, Rahmayani Indah Rahayu, Anggi Putri Rahma Dona Rahmadini Syafri Rahmiwati Hilma Ramadhani, Eka Ramadhani, Siti Ramadhanti, Aulia Rizki Retno Hidayati Rudi Hendra Sardi, Hajra Sari, Meidita Kemala Sari, Nila Puspita Silvera Devy Siregar, Alfi Salimah Siregar, Sri Hilma Siregar, srihilma Soeci Izzati Adlya Sofyan Husein Siregar Sulismayati - Surya Agustian Suwanto Sanjaya Sya'ban, Andrian Nur Thamrin Tri Windarti Tri Windarti Tria Harlianti Triana, Yeni Umar Hamdan, Umar Veithzal Rivai Zainal Wan, Xue Wenni, Osriza Wulan Sari, Wulan Yasthophi, Arif Yeni, Wila Mutiara Yuana Nurulita Yuca, Verlanda Yuharmen - Yum Eryanti Yuni Fatisa Zadrian Ardi Zahra, Fadhila Az Zahri, Firman Zikra, Nadila `Nasution, Hasmalina