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All Journal HAYATI Journal of Biosciences Medicina Sport and Fitness Journal E-Jurnal Medika Udayana Jurnal Veteriner Majalah Ilmiah Fisioterapi Indonesia Jurnal Ilmu Kedokteran (Journal of Medical Science) E-Jurnal Udayana Medica Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Jurnal Penelitian Pendidikan IPA (JPPIPA) ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Global Health research Bali Anatomy Journal Jurnal Ilmiah Medicamento Essential: Essence of Scientific Medical Journal Jurnal Kepelatihan Olahraga MAHESA : Malahayati Health Student Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Hang Tuah Medical Journal Physical Therapy Journal of Indonesia Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan
Ni Made Linawati
Departemen Histologi, Fakultas Kedokteran Universitas Udayana, Denpasar, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Inflammation Marker and Leukocyte Parameter Ratio on Erythropoiesis Activity of Pediatric Acute Lymphoblastic Leukemia Wande, I Nyoman; Linawati, Ni Made; Dewi, Pande Putu Ayu Patria; Ariawati, Ketut
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2395

Abstract

Acute leukemia is the most common malignancy found in children. A Complete Blood Count (CBC) examination can calculate the lymphocyte-to-leukocyte ratio, neutrophil-to-leukocyte ratio, and neutrophil-to-lymphocyte ratio to monitor the progress of Acute Lymphoblastic Leukemia (ALL). C-reactive protein is a marker of inflammation and can determine disease progression during treatment. The study's analytical design was observational, with a cross-sectional design conducted at the laboratory of the Clinical Pathology Faculty of Medicine, University of Udayana, and Ngoerah Hospital from March to August 2020. The study included 48 subjects, divided into three phases: induction, consolidation, and maintenance, in ALL patients. Specimen collection was collected in 2 tubes. Kolmogorov-Smirnov statistical analysis was used to assess normality, and homogeneity was evaluated with Levene’s test. The difference test was performed using the Kruskal-Wallis test. This study aimed to determine the relationship between parameters was performed with Spearman correlation. This study showed a strong correlation between hemoglobin levels and neutrophil/lymphocyte ratio (r= 0.358, p=0.015), hemoglobin and lymphocyte/leukocyte ratio (r= -0.287, p=0.048), hemoglobin and CRP (r= -0.493, p=0.000). Significant correlation between reticulocyte percentage and neutrophil/lymphocyte ratio (r= 0.505, p=0.000), neutrophil/lymphocyte ratio and CRP (r= -0.870, p=0.000), neutrophil/leukocyte ratio and lymphocyte/leukocyte ratio (r= 0.960, p=0.000). Significant correlations have been found between hemoglobin levels and the neutrophil/lymphocyte ratio (NLR), which is a measure of the lymphocyte/leukocyte ratio (LLeu-ratio), along with CRP. This relationship has been connected to inflammation in ALL patients following chemotherapy. CBC is an easy-to-use test to determine whether inflammation is present in ALL patients following chemotherapy.
Analisis Bibliometrik : Mekanisme Aksi dan Efektifitas Flavonoid Terhadap Gagal Ginjal Mathar, Muhammad Ashhabul Kahfi; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Widianti, I Gusti Ayu
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.19-28

Abstract

Flavonoids have strong antioxidant properties, which can reduce cell damage that can worsen kidney function. By reducing cellular oxidation, flavonoids help protect the kidneys from damage and inflammation that can lead to kidney failure. In addition, flavonoids also have anti-inflammatory properties to reduce chronic inflammation in the kidneys. Inflammation plays a key role in diseases such as kidney injury, diabetes, asthma, cardiovascular disease and cancer. Diet can affect various stages of inflammation and can have a significant impact on several inflammatory diseases. Increasing scientific evidence suggests that polyphenolic compounds, such as flavonoids, found in fruits, vegetables, nuts, or chocolate, can have anti-inflammatory properties. This reason clearly proves the importance of flavonoid antioxidant activity in inflammation therapy. The method used in this literature review is a bibliometric analysis by searching data through the PubMed database, and Google Scholar and Scopus. The search results of 10 appropriate journals, found that flavonoid compounds can inhibit regulatory enzymes or transcription factors that are important for controlling mediators involved in inflammation. 
Light physical activity and vitamin D improve sperm quality of male Rattus norvegicus exposed to cigarette smoke Amaral, Meriana Barreto; Satriyasa, Bagus Komang; Yasa, I Wayan Putu Sutirta; Sudarmaja, I Made; Jawi, I Made; Manuaba, Ida Bagus Putra; Linawati, Ni Made; Widiyanti, I Gusti Ayu
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.261

Abstract

Background: Male infertility is a significant global health issue, with rising prevalence linked to environmental factors such as secondhand smoke, which impairs sperm quality. This study aimed to examine how light physical activity and vitamin D supplementation improved sperm quality in rats exposed to cigarette smoke. Methods: This study used a randomized experimental design with 38 rats, divided into two groups. The control group was exposed to cigarette smoke and received vitamin D at 18 IU/kg body weight (BW) daily. The treatment group was exposed to cigarette smoke, received the same vitamin D dose, and underwent light physical activity. The 35-day research period involved the analysis of evaluated parameters. Differences between these parameters were assessed using an independent t-test, with statistical significance set at a P-value < 0.05. Results: Compared to the control group (p-values< 0.001), the treatment group, receiving light physical activity and vitamin D supplementation, exhibited significantly lower malondialdehyde (MDA) levels (0.96 ± 0.14 nmol/mL), higher vitamin D receptor expression (2.44 ± 0.58 cells/HPF), and increased testosterone levels (4.33 ± 0.76 ng/dL). Sperm quality was also significantly improved in the treatment group, showing higher sperm count (2.24 ± 0.81 × 10⁶/mL), motility (4.20 ± 0.23%), viability (3.07 ± 0.39%), and normal morphology (5.34 ± 0.17%) (p-values< 0.001). Conclusion: Light physical activity and vitamin D supplementation improved sperm quality in cigarette smoke-exposed male rats, correlating with reduced MDA and elevated vitamin D receptor expression and testosterone. Further clinical trials are warranted to explore human applications.
Review Article: Histological Description of Hepars that Experience Fatty Liver Mulianti, Rizki; Linawati, Ni Made
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3593

Abstract

The liver is one of the most vital organs and the largest gland, weighing approximately 1500 grams or 2.5% of the total adult body weight. One of the liver's functions is to metabolize nutrients such as fat, protein, and carbohydrates. Fats are synthesized from carbohydrates and proteins, mainly in the liver. Fat function as a source of energy provides essential fatty acids, and plays an important role in dissolving vitamins. A high-fat diet (HFD) is a diet that involves consuming fatty and high-cholesterol foods which can have the risk of causing an increase in lipid levels in the blood, known as hyperlipidemia. Excessive accumulation of fat in liver cells is called fatty liver. Histologically, Non-alcoholic Fatty Liver Disease (NAFLD) is categorized into two types, namely Non-alcoholic Fatty Liver (NAFL) which shows fatty liver without evidence of inflammation in the form of swelling of hepatocyte cells, and Non-alcoholic Steatohepatitis (NASH), namely the presence of fatty liver accompanied by inflammation in the form of swelling of hepatocyte cells, with or without fibrosis.
A Review on the Effect of Cell Phone Electromagnetic Radiation on Histological Testicles Farmananda, Irsandi Rizki; Farindra, Irmawan; Linawati, Ni Made
MAHESA : Malahayati Health Student Journal Vol 4, No 12 (2024): Volume 4 Nomor 12 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i12.15546

Abstract

ABSTRACT Cell phones have become an essential possession for individuals in today's society. Nevertheless, beneath their widespread use lies a potential hazard in the form of electromagnetic radiation. The level of radiation emitted varies, along with its impact on the human body, particularly on the reproductive system. This research aims to consolidate findings from existing studies on the influence of cell phone electromagnetic radiation on the histological makeup of the testes. A review of literature was conducted following a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) approach, utilizing the PubMed and Scopus journal publication databases. A total of 133 articles were identified through the database search, with inclusion and exclusion criteria established based on the PICOS framework. Following the screening process, six articles met the predetermined criteria and were deemed suitable for analysis. The results of the study demonstrate that exposure to electromagnetic radiation led to alterations in the histological structure of the testes in experimental animals. In conclusion, prolonged exposure to electromagnetic radiation has an impact on the histological composition of the testes in experimental animals. Keywords: Electromagnetic Radiation, Histology, Testicles, Cell Phone
The Role of Alpha Linolenic Acid on Neuroinflammation: A Systemic Review Wijaya, Debby Chesilya; Linawati, Ni Made
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.6173

Abstract

Neuroinflammation, an inflammatory response within the central nervous system (CNS), plays a critical role in various neurological disorders, including neurodegenerative diseases. Alpha linolenic acid (ALA), an essential omega-3 polyunsaturated fatty acid, has shown promising health benefits due to its antioxidant and anti-inflammatory properties. This article aims to thoroughly examine the potential effects of ALA in reducing neuroinflammation, emphasizing its roles as an anti-inflammatory and antioxidant agent. The review focuses on studies published between 2018 and 2023, sourced from reputable academic databases such as PubMed, Semantic Scholar, Google Scholar, and ScienceDirect, with nine key papers selected. The findings indicate that ALA significantly mitigates neuroinflammation by decreasing reactive oxygen species (ROS) via the Nrf-2/HO-1/JNK signaling pathway. Additionally, ALA reduces inflammatory cytokines by inhibiting p-JNK activation, disrupting lipid rafts, blocking the pro-inflammatory transcription factor NF-κB, and altering cell membrane phospholipid composition. The review concludes that ALA may have potential therapeutic effects in reducing neuroinflammation through its antioxidant and anti-inflammatory actions, offering possible benefits for various neurological conditions, including Alzheimer's and Parkinson's diseases.
Euphorbia milii and propolis combination tea reduced hepatic steatosis and hepatocyte apoptosis in high-fat diet rat model Linawati, Ni Made; Sundari, Luh Putu Ratna; Widarta, I Wayan Rai; Arijana, I Gusti Kamasan Nyoman; Wande, I Nyoman; Luvianto, Juven
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art10

Abstract

Background: Dyslipidemia can cause various organ disorders, such as fatty liver disease. Over time, fatty liver disease has become more commonplace worldwide and may cause mortality if the progression worsens. Natural components from Euphorbia milii (E. milii) and propolis (EMP) have been demonstrated as immunomodulators that reduce total cholesterol levels.Objective: To prove the effect of EMP tea on inhibiting fatty liver and hepatocyte apoptosis in high-fat diet (HFD)-induced rats.Methods: This study applied a post-test-only control group design using 18 Wistar rats, which were divided into three groups: K0 (received standard feed), KN (received HFD of 2 g/200 g Body weight (BW) in a day), and P (received HFD of 2 g/200 g BW in a day and EMP of tea 40 mg/100 g BW in a day). The interventions were conducted for 30 days, followed by termination on day 31 for liver tissue collection and analysis. We calculated the hepatic steatosis with the help of hematoxylin-eosin (HE) staining. Hepatocyte apoptosis was also determined with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.Results: The K0 group had a lower hepatic steatosis percentage (17.87 ± 1.81) than KN (63.75 ± 15.88). We also found no hepatocyte apoptosis in the K0 but a high hepatocyte apoptosis index in the KN (3.98 ± 0.29). The combination of EMP tea in HFD-induced rats significantly reduced hepatic steatosis and apoptosis percentage (25.33 ± 1.17 and 0.91 ± 0.61, respectively). Conclusion: We demonstrated that combining EMP tea reduced hepatic steatosis and hepatocyte apoptotic index in HFD-induced rats, suggesting its potential as a treatment for these conditions.                                       
The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. However, TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
Co-Authors A.A.A. Biantari Apsari Trinaya ADNYANA PUTRA, I GEDE AGUS DIVA Adnyana, I Made Diatmika Agus Eka Darwinata Ali Djamhuri Amaral, Meriana Barreto Anak Agung Ngurah Subawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, I.G Kamasan Nyoman Arijana, IGK Nyoman Bagus Komang Satriyasa Dakshayani Vijayan Dewa Agung Gina Andrini Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewa Putu Gede Purwa Samatra Dewi, Pande Putu Ayu Patria Etik Nurhidayati Eugenia Meidy Farmananda, Irsandi Rizki Febrina, Jessica Fedik Abdul Ratam Gede Wirata Harinder Kaur I Dewa Gede Angga Triadi Nata I Dewa Made Agus Paramarta Putra I Gde Haryo Ganesha I Gusti Ayu Artini I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Ketut Tunas I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Made Sudarmaja I Nyoman Wande I Nyoman Wande I Putu Dema Prasetya I Wayan Juli Sumadi I Wayan Putu Sutirta Yasa I Wayan Rai Widarta I Wayan Sugiritama I Wayan Sugiritama I Wayan Sugiritama I Wayan Sumardika I.A.A. Widhiartini Ida Ayu Ika Wahyuniari Ida Bagus Putra Manuaba Intan Syahirah Bt Abdul Rauap Irmawan Farindra Jaspreet Kaur Juven Luvianto Ketut Ariawati Komang Ayu Trisnadewi Luh Made Indah Sri Handari Adiputra Luh Made Mas Rusyati Luh Putu Ratna Sundari Luvianto, Juven Muhammad Ashhabul Kahfi Mathar Mulianti, Rizki N. Adiputra Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Kadek Ayu Satya Dewanti Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Rustini Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Nuril Hidayah Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi Putu Ayu Asri Damayanti Putu Ayu Sita Saraswati Putu Diah Pratiwi Radjibu, Gabriela Anastasya Viorezky Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Sawitri, Anak Agung Sagung Sianny Herawati Sidauruk, Dona Uli Sugijanto - Sugijanto - Susy Purnawati Tjokorda Gede Oka Tohjiwa, G. Raditya Vania Lannisa Haestidyatami Wahyuddin, Wahyuddin Wicaksana, I Dewa Agung Gede Oka Dwi Widianti, I Gusti Ayu Widiyanti, I Gusti Ayu Wijaya, Debby Chesilya Wilianto Wilianto Yusuf Nasirudin