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All Journal HAYATI Journal of Biosciences JURNAL ILMIAH PLATAX Jurnal Bios Logos JSME MIPA UNIMA Abdimas Ngayah: Majalah Aplikasi IPTEKS Animal Production : Indonesian Journal of Animal Production Jurnal Biologi Tropis JURNAL PENGABDI Dinamisia: Jurnal Pengabdian Kepada Masyarakat MATAPPA: Jurnal Pengabdian Kepada Masyarakat JURNAL PENDIDIKAN TAMBUSAI Jurnal Pembelajaran dan Biologi Nukleus SOSCIED Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Bakti Cendana: Jurnal Pengabdian Masyarakat Jurnal Dedikasi Bioscientist : Jurnal Ilmiah Biologi Abdimas : Jurnal Pengabdian Kepada Masyarakat Seminar Nasional Pengabdian Kepada Masyarakat Indonesian Biodiversity Journal Jurnal Pengabdian Masyarakat dan Riset Pendidikan Indonesian Biodiversity Journal Servitium Smart Journal
Revolson Mege
Biology Department, Faculty Of Mathematics And Natural Sciences, Manado State University
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Journal : Jurnal Pembelajaran dan Biologi Nukleus

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In Vitro Antidiabetic Activity Of Apis dorsata Binghami Nest Extract Pratasik, Veronika; Mege, Revolson; Yermia, Mokosuli Semuel
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 8, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2022
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v8i3.3196

Abstract

Indonesia is ranked 7th out of 10 countries with the highest number of people with diabetes mellitus, which is estimated to increase every year.α -amylase is an enzyme that catalyzes the hydrolysis of α-1,4 glycosidic bonds of polysaccharides to produce dextrins, oligosaccharides, maltose and D-glucose. Apis dorsata Binghami honeycomb contains secondary metabolites that have antidiabetic potential, including inhibiting the action of the α-amylase enzyme. The purpose of this study was to determine the in vitro antidiabetic potential of Apis dorsata binghami nest extract. This study uses a descriptive research method where the research data are obtained through laboratory experiments. Honeycomb extraction using maceration method. Analysis of total flavonoid content using UV-Vis spectrophotometric method. Antidiabetic potency test using -amylase enzyme inhibition method. The results of the extraction study showed that the % yield of the extract was 11.82% with a brownish yellow color. Analysis of the total flavonoid content showed the results of 3.33 mgQE/g. The inhibitory activity of the -amylase enzyme, the IC50 value of the extract obtained was 158.48±7.42 g/mL, the acarbose value was 165.96±7.08 g/mL. These results indicate that the extract of A.dorsata Binghami nest has hyperglycemic activity by inhibiting complex carbohydrate hydrolyzing enzymes such as inhibition of the -amylase enzyme which is better than acarbose because the IC50 value of the extract is smaller. If the IC50 value is smaller then the enzyme inhibition is stronger. For further research, it is recommended to use a more specific enzyme, namely the -glucosidase enzyme.
Co-Authors A. Nurfitriani Alberto Y T Allo Alfonds Andrew Maramis Alfrina Mewengkang Aprelia Martina Tomasoa, Aprelia Martina Arifin Arifin Armstrong F. Sompotan Arrijani - Aser Yalindua Azhari, Deidy Balansa, Hendra Balansa, Walter Banea, Agnes Buyang, Dalle Christny Ferdina Evie Rompas Danny Ch Posumah Dany Posumah Debby Jacqualine Jochebed Rayer Dino Rahardiyan Diswal Takasaheng Edwin Mangore Emma M Moko Emma Mauren Moko Fadly Steven Jefry Rumondor Fanny Nella Nanlohy Femmy Nurul Akbar Femmy Roosje Kawuwung Ferencia Esananda Rattu Fitriani, A. Nur Frans Gruber Ijong Frets Jonas Rieuwpassa Friska Mery Montolalu Grace Jenny Soputan Grichelle Tampi Gua, Siskarli Helen J Lawalata Herry Maurits Sumampouw Ika Okhtora Angelia IRIANI SETYAWATI Iriani Setyawati Janne Ticoh Jantje Ngangi Jantje Pelealu Jaqueline E.M Tangkau Jeane Mantiri Jeane Tuilan Jennifer Pangulimang Johanna Zusye Wantania Jonathan Polandos Julduz Ruland Paus julduz ruland paus Juninho Siwu Kezia Andries Laksono Trisnantoro Lensehe, Febby Anggini Livana Dethris Rawung Maharani Angelika Elshadai Rori Maidangkay, Vonny Maiko Polandos Manampiring, Noni Manampiring, Nonny Mansyur, Djailani Maria Helena Mariane Pangandaheng Mario Tulenan Parinsi Max Tulung Megawati Weken Meity Nelltje Tanor Mellinia Tawas Mervin Tooy, Stephanie Meyer Worang Matey Misgter Gidion Maru Mokosuli Yermia Samuel Mundaeng, Camel Gantonio N Kusumorini, N NASTITI KUSUMORINI Nerni Potolangi Nonny Manampiring Nova L.I.M Ogi Palawe, Jaka F. P. Patricia S. M Mantiri Paulus Boli Pomalingo, Moh Fikri Pratasik, Stralen Pratasik, Veronika Pricilia Joice Pesak Purba, Gandi YS Quido Conferti Kainde Rahel Kimbal Rampengan, Mercy Maggy Franky Recky H.E. Sendouw Rieuwpassa, Fredrik Rieuwpassa, Frets J. Rolef Rumondor Rolef Rumondor Rompas, Christny Ferdina Evie Roring, Verawaty Ida Yani Rymond Jusuf Rumampuk Sakul, Ernest Hanny Sambeka, Delvino Sasauw, Dien A. Semuel Lasut SH Nasution, SH Sigit Prafiadi Sintia Djafar Sukmarayu Gedoan Sukmarayu P. Gedoan Syahira, Syahira SYAHRUN HAMDANI NASUTION Toheni, Fredrik Tomasoa, Aprelia M. Umboh, Aprillia V. Utari Satiman Vanessa Dagasina Verawati I Y Roring Verawati Ida Yani Roring Veronika Waroka Verra E. J. Mawitjere W Manalu Walter Balansa Wasmen Manalu Wendy Alexander Tanod Wisda Nurjannah Abdullah Wiska Baharuddin Cahdeso Wulandari Wulandari